Publications
Now showing items 1201-1220 of 5027 records
Measurement of Noradrenaline and Serotonin Metabolites With Internal Jugular Vein Sampling: An Indicator of Brain Monoamine Turnover in Depressive Illness and Panic Disorder.
FRONTIERS IN PSYCHIATRY - 01 Jan 2022
In research spanning three decades we have estimated brain monoamine turnover (approximately equating with synthesis rate) with sampling from the internal jugular veins and measurement of trans-cerebral plasma monoamine metabolite concentration gradients. Here we report indices of brain noradrenaline and serotonin turnover in patients with major depressive illness (MDD) and panic disorder (PD)....
The Translation and Commercialisation of Biomarkers for Cardiovascular Disease-A Review.
FRONTIERS IN CARDIOVASCULAR MEDICINE - 01 Jan 2022
As a leading cause of mortality and morbidity worldwide, cardiovascular disease and its diagnosis, quantification, and stratification remain significant health issues. Increasingly, patients present with cardiovascular disease in the absence of known risk factors, suggesting the presence of yet unrecognized pathological processes and disease predispositions. Fortunately, a host of emerging card...
Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.
NATURE COMMUNICATIONS - 06 Jun 2022
We integrated lipidomics and genomics to unravel the genetic architecture of lipid metabolism and identify genetic variants associated with lipid species putatively in the mechanistic pathway for coronary artery disease (CAD). We quantified 596 lipid species in serum from 4,492 individuals from the Busselton Health Study. The discovery GWAS identified 3,361 independent lipid-loci associations, ...
Influence of the Human Lipidome on Epicardial Fat Volume in Mexican American Individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE - 01 Jan 2022
Cardiovascular disease (CVD) is the leading cause of mortality worldwide and is the leading cause of death in the US. Lipid dysregulation is a well-known precursor to metabolic diseases, including CVD. There is a growing body of literature that suggests MRI-derived epicardial fat volume, or epicardial adipose tissue (EAT) volume, is linked to the development of coronary artery disease. Interest...
Renin-Angiotensin Aldosterone System Inhibitors and COVID-19: A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 07 Jun 2022
Background Renin-angiotensin aldosterone system (RAAS) inhibitor-COVID-19 studies, observational in design, appear to use biased methods that can distort the interaction between RAAS inhibitor use and COVID-19 risk. This study assessed the extent of bias in that research and reevaluated RAAS inhibitor-COVID-19 associations in studies without critical risk of bias. Methods and Results Searches w...
The Impact of Ethnicity on Athlete ECG Interpretation: A Systematic Review.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE - 08 Jun 2022
Athlete ECG interpretation criteria have been developed and refined from research in athlete populations; however, current guidelines are based on available data primarily from Caucasian and Black athletes. This study aimed to assess the impact of ethnicity on ECG interpretation in athletes. A systematic review was conducted of the MEDLINE, EMBASE, Scopus, SPORTDiscus, and Web of Science databa...
Pathogenetic Link of Cardiac Rupture and Left Ventricular Thrombus Following Acute Myocardial Infarction: A Joint Preclinical and Clinical Study.
FRONTIERS IN CARDIOVASCULAR MEDICINE - 01 Jan 2022
Cardiac rupture (CR) and left ventricular thrombus (LVT) remain important complications of acute myocardial infarction (MI), and they are currently regarded as independent events. We explored the pathogenetic link between CR and LVT by investigating a murine model of MI with a high frequency of CR and in patients with acute MI.MI was induced in mice, the onset of CR was monitored, and the heart...
Effect of age and sex on the associations between potential modifiable risk factors and both type 2 diabetes and impaired fasting glycaemia among West African adults.
BMC PUBLIC HEALTH - 17 Jun 2022
Type 2 diabetes mellitus (T2DM) is becoming one of the leading causes of morbidity and mortality worldwide, including among Africans. Knowledge of the association between traditional risk factors and both diabetes and pre-diabetes, and whether these differ by age and sex, is important for designing targeted interventions. However, little is known about these associations for African populations...
Understanding and predicting the functional consequences of missense mutations in BRCA1 and BRCA2.
SCIENTIFIC REPORTS - 21 Jun 2022
BRCA1 and BRCA2 are tumour suppressor genes that play a critical role in maintaining genomic stability via the DNA repair mechanism. DNA repair defects caused by BRCA1 and BRCA2 missense variants increase the risk of developing breast and ovarian cancers. Accurate identification of these variants becomes clinically relevant, as means to guide personalized patient management and early detection....
Relative Contribution of Blood Pressure in Childhood, Young- and Mid-Adulthood to Large Artery Stiffness in Mid-Adulthood.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 21 Jun 2022
Background Blood pressure associates with arterial stiffness, but the contribution of blood pressure at different life stages is unclear. We examined the relative contribution of childhood, young- and mid-adulthood blood pressure to mid-adulthood large artery stiffness. Methods and Results The sample comprised 1869 participants from the Cardiovascular Risk in Young Finns Study who had blood pre...
Prognostic Value of Exercise Capacity in Kidney Transplant Candidates.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 21 Jun 2022
Background Exercise stress testing for cardiovascular assessment in kidney transplant candidates has been shown to be a feasible alternative to pharmacologic methods. Exercise stress testing allows the additional assessment of exercise capacity, which may have prognostic value for long-term cardiovascular outcomes in pre-transplant recipients. This study aimed to evaluate the prognostic value o...
F Site-Specific Labelling of a Single-Chain Antibody against Activated Platelets for the Detection of Acute Thrombosis in Positron Emission Tomography.18
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 21 Jun 2022
Positron emission tomography is the imaging modality of choice when it comes to the high sensitivity detection of key markers of thrombosis and inflammation, such as activated platelets. We, previously, generated a fluorine-18 labelled single-chain antibody (scFv) against ligand-induced binding sites (LIBS) on activated platelets, binding it to the highly abundant platelet glycoprotein integrin...
The dysfunctional right ventricle: the importance of multi-modality imaging.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 21 Jun 2022
Assessment of right ventricular (RV) function is crucial for the evaluation of the dyspnoeic patient and/or with systemic venous congestion and provides powerful prognostic insights. It can be performed using different imaging modalities including standard and advanced echocardiographic techniques, cardiac magnetic resonance imaging, computed tomography, and radionuclide techniques, which shoul...
Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
CIRCULATION - 21 Jun 2022
The insulin-like growth factor 1 (IGF1) pathway is a key regulator of cellular metabolism and aging. Although its inhibition promotes longevity across species, the effect of attenuated IGF1 signaling on cardiac aging remains controversial.We performed a lifelong study to assess cardiac health and lifespan in 2 cardiomyocyte-specific transgenic mouse models with enhanced versus reduced IGF1 rece...
Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial.
BMJ OPEN - 24 Jun 2022
The aim of this preplanned secondary analysis of a 12-month randomised controlled trial was to investigate the effects of a multicomponent exercise programme combined with daily whey protein, calcium and vitamin D supplementation on cognition in men with prostate cancer treated with androgen deprivation therapy (ADT).12-month, two-arm, randomised controlled trial.University clinical exercise ce...
Diastolic flow in the left ventricular outflow tract – A normal physiological and underappreciated echocardiographic finding
AUSTRALASIAN JOURNAL OF ULTRASOUND IN MEDICINE - 27 Jun 2022
Purpose:Diastolic waveforms in the left ventricular outflow tract (LVOT) are commonly observed with Doppler echocardiography.The incidence and mechanism are not well described.Methods:This was a retrospective observational study of 186 adult patients, athletes and non-athletes, free of known cardiacdisease, presenting for comprehensive transthoracic echocardiography at a research institute. We ...
Associations of park features with park use and park-based physical activity in an urban environment in Asia: A cross-sectional study.
HEALTH & PLACE - 01 May 2022
Park use is associated with health, yet our understanding of park features related to their use is limited. Singapore's parks were audited for 30 micro-features, then geospatial analysis characterized micro-features scores for parks nearest to participants' homes. Adults (3,435) reported their park use and park-based physical activity. Using linear regression models, we found living near a park...
Associations of Vigorous Gardening With Cardiometabolic Risk Markers for Middle-Aged and Older Adults.
JOURNAL OF AGING AND PHYSICAL ACTIVITY - 01 Jun 2022
This study investigates the associations of vigorous-intensity gardening time with cardiometabolic health risk markers. This cross-sectional study (AusDiab) analyzed 2011-2012 data of 3,664 adults (55% women, mean [range], age = 59.3 [34-94] years) in Australia. Multiple linear regression models examined associations of time spent participating in vigorous gardening (0, <150 min/week, ≥150 min/...
Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial.
LANCET (LONDON, ENGLAND) - 09 Apr 2022
Dietary restriction of sodium has been suggested to prevent fluid overload and adverse outcomes for patients with heart failure. We designed the Study of Dietary Intervention under 100 mmol in Heart Failure (SODIUM-HF) to test whether or not a reduction in dietary sodium reduces the incidence of future clinical events.SODIUM-HF is an international, open-label, randomised, controlled trial that ...
Talking about good vibrations.
THE JOURNAL OF PHYSIOLOGY - 01 May 2022
