Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 5702 records
Time trends in mortality from heart failure and atherosclerotic cardiovascular disease in people with and without diabetes: a multi-national population-based study.
THE LANCET. DIABETES & ENDOCRINOLOGY - 06 Nov 2025
Contemporary trends in cardiovascular disease (CVD) cause-specific mortality by diabetes status are inadequately described. We examined trends by diabetes status in coronary heart disease (CHD), cerebrovascular disease, and heart failure mortality, and mortality rate ratios (people with diabetes versus those without diabetes) across nine high-income jurisdictions. We assembled CVD cause-specifi...
Evaluation of the pharmacological cathepsin S inhibitor LY3000328 on autoimmune diabetes in mice.
BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE - 11 Nov 2025
There is an emerging role for the lysosomal protease cathepsin S (CTSS) in the pathogenesis of type 1 diabetes (T1D). This is supported by key findings, including that circulating levels of CTSS are increased in individuals with T1D, and that genetic ablation of Ctss in non-obese diabetic (NOD) mice - a well-established model of autoimmune diabetes - reduces both insulitis and diabetes incidenc...
Clinical and Cardiovascular Magnetic Resonance Characteristics of Veteran Male Endurance Athletes With Atrial Fibrillation: VENTOUX-AF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 04 Nov 2025
Older male endurance athletes exhibit an increased risk of atrial fibrillation (AF) of which the pathogenesis is unclear. We aimed to determine whether left atrial (LA) remodeling on cardiovascular magnetic resonance, blood pressure during exercise, and bradyarrhythmia on implantable loop recorder monitoring were associated with AF in athletes. VENTOUX-AF (Cardiac Magnetic Resonance Assessment ...
Effect of Empagliflozin on Whole Body, Cardiac, and Renal Sympathetic Outflows in Type 2 Diabetes.
07 Nov 2025
Sodium glucose co-transporter type 2 inhibitors improve cardiovascular outcomes in people with type 2 diabetes, though mechanisms by which this occurs remain unclear. The purpose of this study was to evaluate empagliflozin's effect on whole body, cardiac, and renal sympathetic activity in people with type 2 diabetes and cardiovascular disease or high cardiovascular risk. Adults with type 2 diab...
CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction.
JACC. BASIC TO TRANSLATIONAL SCIENCE - 14 Oct 2025
These preclinical trials provide the first evidence of cluster of differentiation 14 (CD14) blockade with a murine analogue of atibuclimab, a CD14-neutralizing antibody, preventing secondary immunological exacerbation of cardiac injury in a translational mouse model of reperfused ST-segment elevation myocardial infarction (STEMI), assessed using multiple clinical modalities. Multiomic studies s...
Genomic Risk Prediction of Incident Atrial Fibrillation in Older Individuals Without Prior Cardiovascular Disease.
21 Oct 2025
Polygenic risk scores (PRSs) may enhance atrial fibrillation (AF) risk prediction when added to conventional risk factors. Most AF-PRS studies, however, focus on individuals with existing cardiovascular disease, rather than initially healthy older adults followed prospectively. The objective of the study was to evaluate the predictive performance of a recent (2025) AF-PRS for incident AF in a c...
Improving support for people with mental health problems in China: a cluster randomised controlled trial of culturally adapted Mental Health First Aid training.
THE LANCET REGIONAL HEALTH. WESTERN PACIFIC - 01 Oct 2025
Culturally appropriate interventions that teach members of the public to provide early help towards a person developing a mental health problem or in a mental health crisis may improve access to services, social support, and mental health outcomes. This is the first study to evaluate the effectiveness of culturally adapted Mental Health First Aid (MHFA) Training for China. A two-arm wait-list p...
Selected miRNAs in Urinary Extracellular Vesicles Show Promise for Early and Specific Diagnostics of Diabetic Kidney Disease.
JOURNAL OF EXTRACELLULAR BIOLOGY - 01 Oct 2025
Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by sequencing or qPCR in two independent cohorts and six published datasets, including type 1 and 2 diabetes, and both sexes. We also val...
Use of artificial intelligence for detecting left ventricular dysfunction and predicting incident heart failure risk.
ESC HEART FAILURE - 15 Oct 2025
Effective medications are available for the prevention of heart failure (HF). While their use is indicated in patients with risk factors, engagement and adherence among 'at risk' individuals is challenging, as it is with atherosclerotic heart disease prevention. The detection of patients with subclinical cardiac dysfunction could provide a subgroup at heightened risk, warranting more intensive ...
Diabetic Platelets: Pathophysiology, Clinical Significance, and Therapeutic Perspectives.
06 Oct 2025
Platelets are crucial for haemostasis and thrombosis. They acquire a distinct prothrombotic and proinflammatory platelet phenotype in individuals with diabetes mellitus, particularly type 2 diabetes mellitus (T2DM). Such platelets in people with diabetes (diabetic platelets) contribute to the pathogenesis of micro- and macro-vascular complications in T2DM. Chronic hyperglycaemia, oxidative stre...
Combinatorial Discovery of RAFT Cationic Polymers for mRNA Delivery: Structure-Function Insights from High-Throughput Screening and Machine Learning.
BIOMACROMOLECULES - 06 Oct 2025
Cationic polymers are considered promising delivery systems for mRNA, offering potential advantages over lipid nanoparticles. Here a library of tertiary amine-containing, methacrylate-based cationic polymers with diverse molecular characteristics and properties were prepared by combinatorial RAFT polymerization for mRNA delivery. The ability of the synthesized cationic polymers to complex with ...
Long-Term Survival Advantage of Total Arterial Revascularization in Elderly Patients Following Coronary Artery Bypass Grafting.
08 Oct 2025
Despite the evidence of clinical benefit, total arterial revascularization (TAR) remains underutilized in elderly patients undergoing coronary artery bypass grafting due to concerns about perceived surgical complexity and limited life expectancy. The objective of the study was to evaluate long-term survival of TAR vs conventional non-TAR grafting strategies in elderly (≥70 years) and younger (<...
The association between enlarged perivascular spaces and muscle sympathetic nerve activity in normotensive and hypertensive humans.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 11 Oct 2025
Hypertension is characterised by both enlarged perivascular spaces (ePVS) and chronically elevated resting sympathetic outflow. ePVS is associated with heart rate variability, suggesting links to autonomic outflow; however, heart rate variability offers limited information on sympathetic nerve activity. Here, we assessed whether ePVS are associated with muscle sympathetic nerve activity (MSNA) ...
Retinal capillary rarefaction is associated with the systemic immune-inflammatory index in patients with hypertension.
JOURNAL OF HYPERTENSION - 15 Sep 2025
Rarefaction in capillary density is a hallmark of hypertension-mediated microvascular damage. This study aimed to assess the association between clinically accessible inflammatory markers, including the systemic immune-inflammation index (SII), and retinal capillary density, as well as other indicators of microvascular damage. We conducted a cross-sectional analysis of data from 132 consecutive...
Apolipoprotein C3 Promotes Angiogenesis in an Inflammatory Mouse Model of Peripheral Artery Disease.
FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY - 30 Sep 2025
Apolipoprotein C3 (ApoC3) regulates triglyceride metabolism and is associated with accelerated atherogenesis and adverse cardiovascular outcomes. However, its role in peripheral artery disease (PAD) remains unclear. We investigated whether Apoc3 deficiency impacts key features of PAD. Vascularization was assessed using an inflammatory periarterial cuff model (21 days) and a hind limb ischemia m...
Association between muscle sympathetic nerve activity and red blood cell distribution width in adults.
PHYSIOLOGICAL REPORTS - 01 Oct 2025
Measures obtained from the full blood count have been shown to vary around a set point, are stable over years, and provide an indication of disease risk and mortality. In this study, we examined the association between sympathetic nerve activity and components of the full blood count. We performed a retrospective analysis of data drawn from our clinical database. Subjects were included if avail...
A neurobiological taxonomy of sedentary behavior for brain health.
TRENDS IN NEUROSCIENCES - 01 Oct 2025
Growing evidence documents that the influence of sedentary behaviors on brain health is not universally beneficial or detrimental but rather context-dependent and nuanced. More specifically, recent findings suggest that mentally active sedentary behavior, such as video gaming, may benefit brain health, whereas mentally passive sedentary behavior, such as television viewing, may not convey such ...
A structured education program for improving cardiovascular risk and glycaemic control in type 2 diabetes mellitus (the SUGAR study).
PRIMARY CARE DIABETES - 01 Oct 2025
Structured community-based diabetes education programs may improve cardiometabolic outcomes, yet objective evidence remains limited. We evaluated the efficacy of a multidisciplinary education program in improving glycaemic control and cardiovascular risk factors in adults with type 2 diabetes mellitus (T2DM). Adults with T2DM participated in a four-week program comprising weekly two-hour sessio...
Advances and applications of organoid-on-a-chip in disease modeling.
THE ANALYST - 02 Oct 2025
Recent studies have emphasized the ability of organoids, a class of self-organizing mini-organs derived from various cell sources and tissue biopsies, to faithfully replicate the main anatomical features and physiological traits of internal organs. Because of the numerous avenues this technology has opened for biomedical research, there is a growing need for creative engineering approaches to c...
