Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

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Publications
By Year
Now showing items 1-20 of 3288 records
The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation.
Samuel A Lambert; Laurent Gil; Simon Jupp; Scott C Ritchie; Yu Xu; Annalisa Buniello; Aoife McMahon; Gad Abraham; Michael Chapman; Helen Parkinson; John Danesh; Jacqueline A L MacArthur; Michael Inouye
NATURE GENETICS - 10 Mar 2021
Prognosis of Severe Low-Flow, Low-Gradient Aortic Stenosis by Stroke Volume Index and Transvalvular Flow Rate.
Jonathan Sen; Quan Huynh; Dion Stub; Christopher Neil; Thomas H Marwick
JACC. CARDIOVASCULAR IMAGING - 10 Mar 2021
This study determined whether flow state classified by stroke volume index (SVi) or transvalvular flow rate (FR) improved risk stratification of all-cause mortality, hospitalization due to heart failure, and aortic valvular interventions for patients with severe aortic stenosis (AS).SVi is a widely accepted classification for flow state in severe low-flow, low-gradient (LFLG) AS. Recent studies...
Using compositional data analysis to explore accumulation of sedentary behavior, physical activity and youth health.
Simone J J M Verswijveren; Karen E Lamb; Josep A Martín-Fernández; Elisabeth Winkler; Rebecca M Leech; Anna Timperio; Jo Salmon; Robin M Daly; Ester Cerin; David W Dunstan; Rohan M Telford; Richard D Telford; Lisa S Olive; Nicola D Ridgers
JOURNAL OF SPORT AND HEALTH SCIENCE - 15 Mar 2021
This study aimed to describe youth time-use compositions, focusing on time spent in shorter and longer bouts of sedentary behavior and physical activity (PA), and to examine associations of these time-use compositions with cardiometabolic biomarkers.Accelerometer and cardiometabolic biomarker data from 2 Australian studies involving youths 7-13 years old were pooled (complete cases with acceler...
Traditional markers of cardiac toxicity fail to detect marked reductions in cardiorespiratory fitness among cancer patients undergoing anti-cancer treatment.
Erin J Howden; Steve Foulkes; Hayley T Dillon; Ashley Bigaran; Leah Wright; Kristel Janssens; Prue Comie; Benedict Costello; André La Gerche
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 22 Mar 2021
Left ventricular ejection fraction (LVEF) is standard of care for evaluating chemotherapy-associated cardiotoxicity, although global longitudinal strain (GLS) offers advantages. However, neither change in LVEF or GLS has been associated with short-term symptoms, functional capacity, or long-term heart failure (HF) risk. We sought to determine whether an integrative measure of cardiovascular fun...
Increase in Bioavailability of Nitric Oxide After Renal Denervation Improves Kidney Function in Sheep With Hypertensive Kidney Disease.
Reetu R Singh; Zoe M McArdle; Lindsea C Booth; Clive N May; Geoff A Head; Karen M Moritz; Markus P Schlaich; Kate M Denton
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Apr 2021
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Can patterns of medication use explain the increasing incidence of End Stage Kidney Disease among people with diabetes in Australia?
Oyunchimeg Buyadaa; Digsu N Koye; Richard Ofori-Asenso; Jenni IIomaki; Stephen J Wood; Jonathan E Shaw; Dianna J Magliano
DIABETES RESEARCH AND CLINICAL PRACTICE - 18 Dec 2020
Recently, an increase in the incidence of end-stage kidney disease (ESKD) among people with type 2 diabetes (T2D) aged <50 years and ≥80 years has been observed in Australia. We examined whether patterns of medication use are likely to explain these trends.Among National Diabetes Services Scheme registrants, we determined the annual prevalence of dispensed glucose-lowering (GL), blood-pressure-...
The International Diabetes Federation's Guide for Diabetes Epidemiological Studies.
Pablo Aschner; Suvi Karuranga; Steven James; David Simmons; Abdul Basit; Jonathan Shaw; Sarah H Wild; Katherine Ogurtsova; Pouya Saeedi;
DIABETES RESEARCH AND CLINICAL PRACTICE - 18 Dec 2020
Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis.
Qin Wang; Clare Oliver-Williams; Olli T Raitakari; Jorma Viikari; Terho Lehtimäki; Mika Kähönen; Marjo-Riitta Järvelin; Veikko Salomaa; Markus Perola; John Danesh; Johannes Kettunen; Adam S Butterworth; Michael V Holmes; Mika Ala-Korpela
EUROPEAN HEART JOURNAL - 22 Dec 2020
Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. To investigate the molecular effects of genetic mimicry of ANGPTL3 and ANGPTL4 inhibition and compare them to the effects of genetic mimicry of LPL enhancement.Associations of genetic variants in ANGPTL3 (rs...
Effects of whey protein plus vitamin D supplementation combined with resistance training on glycemic control, body composition, muscle function and cardiometabolic risk factors in middle-aged and older overweight/obese adults with type 2 diabetes? A 24-week randomized controlled trial.
Eliza G Miller; Caryl A Nowson; David W Dunstan; Deborah A Kerr; David Menzies; Robin M Daly
DIABETES, OBESITY & METABOLISM - 23 Dec 2020
To determine the effect of whey-protein plus vitamin D supplementation combined with progressive resistance training (PRT) on glycemic control, body composition, muscle function and cardiometabolic risk factors in middle-aged and older adults with type 2 diabetes (T2D).In this 24-week, randomized controlled trial, 198 overweight/obese adults (50-75 years) with T2D undertook PRT (2-3 d/week) wit...
The Tandem Stenosis Mouse Model: Towards Understanding, Imaging and Preventing Atherosclerotic Plaque Instability and Rupture.
Jonathan Noonan; Alex Bobik; Karlheinz Peter
BRITISH JOURNAL OF PHARMACOLOGY - 23 Dec 2020
The rupture of unstable/vulnerable atherosclerotic plaques is the major cause of cardiovascular mortality/morbidity. Despite significant limitations in our understanding and ability to identify unstable plaque pathology and prevent plaque rupture, most atherosclerosis research utilises preclinical animal models exhibiting stable atherosclerosis. Here, we introduce the Tandem Stenosis (TS) mouse...
Platelet CXCL14: introducing a new player and potential therapeutic target in thromboinflammation.
James D McFadyen; Karlheinz Peter
CARDIOVASCULAR RESEARCH - 26 Dec 2020
The influence of aerobic exercise on mitochondrial quality control in skeletal muscle.
Ashleigh M Philp; Nicholas J Saner; Michael Lazarou; Ian G Ganley; Andrew Philp
THE JOURNAL OF PHYSIOLOGY - 28 Dec 2020
Mitochondria are dynamic organelles, intricately designed to meet cellular energy requirements. To accommodate alterations in energy demand, mitochondria have a high degree of plasticity, changing in response to transient activation of numerous stress-related pathways. This adaptive response is particularly relevant in highly metabolic tissues such as skeletal muscle, where mitochondria support...
A Protocol for Isolation, Purification, Characterization, and Functional Dissection of Exosomes.
Alin Rai; Haoyun Fang; Monique Fatmous; Bethany Claridge; Qi Hui Poh; Richard J Simpson; David W Greening
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2021
Extracellular vesicles (EVs) are membrane-enclosed vesicles released by cells. They carry proteins, nucleic acids, and metabolites which can be transferred to a recipient cell, locally or at a distance, to elicit a functional response. Since their discovery over 30 years ago, the functional repertoire of EVs in both physiological (e.g., organ morphogenesis, embryo implantation) and pathological...
Human Plasma Extracellular Vesicle Isolation and Proteomic Characterization for the Optimization of Liquid Biopsy in Multiple Myeloma.
Antonia Reale; Tiffany Khong; Rong Xu; Maoshan Chen; Sridurga Mithraprabhu; Nicholas Bingham; Andrew Spencer; David W Greening
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2021
Cancer cells secrete membranous extracellular vesicles (EVs) which contain specific oncogenic molecular cargo (including oncoproteins, oncopeptides, and RNA) into their microenvironment and the circulation. As such, EVs including exosomes (small EVs) and microvesicles (large EVs) represent important circulating biomarkers for various diseases, including cancer and its progression. These circula...
Prediction of AF in Heart Failure With Preserved Ejection Fraction: Incremental Value of Left Atrial Strain.
Ewelina Jasic-Szpak; Thomas H Marwick; Erwan Donal; Monika Przewlocka-Kosmala; Quan Huynh; Anna Gozdzik; Anna K Woznicka; Ewa A Jankowska; Piotr Ponikowski; Wojciech Kosmala
JACC. CARDIOVASCULAR IMAGING - 01 Jan 2021
This study sought to identify the factors associated with incident atrial fibrillation (AF) in a well-characterized heart failure with preserved ejection fraction (HFpEF) population, with special focus on left atrial (LA) strain.AF is associated with HFpEF, with adverse consequences. Effective risk evaluation might allow the initiation of protective strategies.Clinical evaluation and echocardio...
Author Correction: Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource.
Stephanie Portelli; Moshe Olshansky; Carlos H M Rodrigues; Elston N D'Souza; Yoochan Myung; Michael Silk; Azadeh Alavi; Douglas E V Pires; David B Ascher
NATURE GENETICS - 04 Jan 2021
The Association of TV Viewing Time with 2-h Plasma Glucose is Modified by a Prudent Dietary Pattern.
Yingting Cao; David W Dunstan; Parneet Sethi; Neville Owen
JOURNAL OF DIABETES - 05 Jan 2021
TV viewing is associated with elevated plasma glucose, but it's not clear whether such associations can be modified by dietary patterns.We examined the interactions of TV viewing time and dietary patterns in relation to fasting and 2-h plasma glucose. Cross-sectional analyses were performed among participants (n= 3081; 44.7% male; mean age 57.8 years) from the 2011-2012 Australian Diabetes, Obe...
Reducing occupational sitting time in adults with type 2 diabetes: Qualitative experiences of an office adapted mHealth intervention.
M Brännholm Syrjälä; E Fharm; P C Dempsey; M Nordendahl; P Wennberg
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 08 Jan 2021
Understanding barriers and facilitators for limiting occupational sitting and what impact it has on health on those with Type 2 diabetes (T2D) is essential for future trials and intervention development in primary health care settings. This study aimed to explore the feasibility and acceptability of an intervention using mobile health (mHealth) technology, together with counselling by a diabete...
Catheter Ablation Versus Medication in Atrial Fibrillation and Systolic Dysfunction: Late Outcomes of CAMERA-MRI Study.
Hariharan Sugumar; Sandeep Prabhu; Ben Costello; David Chieng; Sonia Azzopardi; Aleksandr Voskoboinik; Ramanathan Parameswaran; Geoffrey R Wong; Robert Anderson; Ahmed M Al-Kaisey; Liang-Han Ling; Emily Kotschet; Andrew J Taylor; Jonathan M Kalman; Peter M Kistler
JACC. CLINICAL ELECTROPHYSIOLOGY - 14 Dec 2020
This study sought to determine the long-term outcomes of restoring sinus rhythm with catheter ablation (CA).The CAMERA-MRI (Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Heart Failure-An MRI-Guided Multicenter Randomized Controlled Trial) study demonstrated that restoration of sinus rhythm with CA significantly improved left ventricular ejection fraction (LVEF) compar...
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