Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

Visit the Baker Institute website for more information on Baker Institute research, lifestyle books and health fact sheets.

Follow our OAR Twitter account to keep in touch with our latest research publications.

This open access repository contains the full text of articles, subject to copyright constraints.

Publications
By Year
Now showing items 1-20 of 2807 records
Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID-19 pandemic?
Murray Esler; Danielle Esler
JOURNAL OF HYPERTENSION - 11 Mar 2020
Optimal Mechanical Unloading in Left Ventricular Assist Device Recipients Relates to Progressive Up-Titration in Pump Speed.
Jeremy William; Vivian Mak; Angeline Leet; David M Kaye; Shane Nanayakkara
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 12 Mar 2020
Left ventricular (LV) assist devices (LVADs) are known to elicit reverse remodeling by mechanically unloading the left ventricle. Current guidelines target a reduction in LV end-diastolic diameter (LVEDD) of 15% compared with pre-LVAD dimensions; however, there is significant heterogeneity in the degree of unloading achieved. We sought to investigate factors associated with mechanical unloading...
Evaluation of elevated heart rate as a sympathetic nervous system biomarker in essential hypertension.
Murray Esler; Gavin Lambert; Danielle Esler; Carolina Ika Sari; Ling Guo; Garry Jennings
JOURNAL OF HYPERTENSION - 13 Mar 2020
There is a need for an easily accessible biomarker of sympathetic nervous activation in essential hypertension, but none exists. Heart rate (HR) has been suggested, but requires validation, now doubly important as an elevated HR in hypertension has emerged as an independent cardiovascular risk factor.Isotope dilution methodology was used to measure total and regional noradrenaline spillover and...
Effects of a lifestyle intervention on cardiovascular risk among high-risk individuals for diabetes in a low- and middle-income setting: Secondary analysis of the Kerala Diabetes Prevention Program.
Mojtaba Lotfaliany; Thirunavukkarasu Sathish; Jonathan Shaw; Emma Thomas; Robyn Jennifer Tapp; Nitin Kapoor; Kavumpurathu Raman Thankappan; Brian Oldenburg
PREVENTIVE MEDICINE - 16 Mar 2020
We aimed to examine whether a lifestyle intervention was effective in reducing cardiovascular disease (CVD) risk in individuals at high-risk of developing diabetes in a low- and middle-income setting. The Kerala Diabetes Prevention Program was evaluated by a cluster-randomized controlled trial (2013-2016) of 1007 individuals (aged 30-60 years) at high-risk for diabetes (Indian Diabetes Risk Sco...
Site qualification and clinical interpretation standards for Tc-SPECT perfusion imaging in a multi-center study of MITNEC (Medical Imaging Trials Network of Canada).99m
Jennifer M Renaud; Manuja Premaratne; Marie-Claude Villeneuve; Vincent Finnerty; Francois Harel; Therèse Heinonen; Jean-Claude Tardif; Terrence D Ruddy; Robert A deKemp
JOURNAL OF NUCLEAR CARDIOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY - 17 Mar 2020
Qualification and interpretation standards are essential for establishing Tc-SPECT MPI accuracy vs. alternative modalities.99mRest-stress Tc-SPECT phantom scans were acquired on 35 cameras. LV defects were quantified with summed stress (SSS) and difference scores (SDS) at 2 core labs. SDS ≥ 2 in the right coronary artery (RCA) was the qualifying standard. Twenty rest (R)-stress (S) patient imag...
Left ventricular remodelling in elite and sub-elite road cyclists.
Benjamin Brown; Lynne Millar; John Somauroo; Keith George; Sanjay Sharma; Andre La Gerche; Lynsey Forsythe; David Oxborough
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS - 18 Mar 2020
Marked adaptation of left ventricular (LV) structure in endurance athletes is well established. However, previous investigations of functional and mechanical adaptation have been contradictory. A lack of clarity in subjects' athletic performance level may have contributed to these disparate findings. This study aimed to describe structural, functional and mechanical characteristics of the cycli...
International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health.
Ester Cerin; Anthony Barnett; Basile Chaix; Mark J Nieuwenhuijsen; Karen Caeyenberghs; Bin Jalaludin; Takemi Sugiyama; James F Sallis; Nicola T Lautenschlager; Michael Y Ni; Govinda Poudel; David Donaire-Gonzalez; Rachel Tham; Amanda J Wheeler; Luke Knibbs; Linwei Tian; Yih-Kai Chan; David W Dunstan; Alison Carver; Kaarin J Anstey
BMJ OPEN - 18 Mar 2020
Numerous studies have found associations between characteristics of urban environments and risk factors for dementia and cognitive decline, such as physical inactivity and obesity. However, the contribution of urban environments to brain and cognitive health has been seldom examined directly. This cohort study investigates the extent to which and how a wide range of characteristics of urban env...
Lipid rafts as a therapeutic target.
Dmitri Sviridov; Nigora Mukhamedova; Yury I Miller
JOURNAL OF LIPID RESEARCH - 23 Mar 2020
Lipid rafts regulate the initiation of cellular metabolic and signaling pathways by organizing the pathway components in ordered microdomains on the cell surface. Cellular responses regulated by lipid rafts range from physiological to pathological, and the success of a therapeutic approach targeting "pathological" lipid rafts depends on the ability of a remedial agent to recognize them and disr...
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.
Tom G Richardson; Eleanor Sanderson; Tom M Palmer; Mika Ala-Korpela; Brian A Ference; George Davey Smith; Michael V Holmes
PLOS MEDICINE - 01 Mar 2020
Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic instruments for lipoprotein lipid traits implemented through multivariable Mendelian randomisation (MR), we sought to compare their causal roles in the aetiology of CHD.We conducted a geno...
Short- and Long-term Outcomes of Out-Of-Hospital Cardiac Arrest Following ST-elevation Myocardial Infarction Managed with Percutaneous Coronary Intervention.
Luke P Dawson; Diem Dinh BAppSci; Stephen Duffy; Angela Brennan; David Clark; Christopher M Reid; David Blusztein; Dion Stub; Nick Andrianopoulos; Melanie Freeman; Ernesto Oqueli; Andrew E Ajani;
RESUSCITATION - 21 Mar 2020
Out-of-hospital cardiac arrest (OHCA) is frequently associated with ST-elevation myocardial infarction (STEMI) and has a high mortality. We aimed to identify differences in characteristics and very long-term outcomes for STEMI patients with and without OHCA managed with percutaneous coronary intervention (PCI).We analysed data from 12,637 PCI patient procedures for STEMI in the multi-centre Mel...
Young-onset type 2 diabetes mellitus - implications for morbidity and mortality.
Dianna J Magliano; Julian W Sacre; Jessica L Harding; Edward W Gregg; Paul Z Zimmet; Jonathan E Shaw
NATURE REVIEWS. ENDOCRINOLOGY - 20 Mar 2020
Accumulating data suggest that type 2 diabetes mellitus (T2DM) in younger people (aged <40 years), referred to as young-onset T2DM, has a more rapid deterioration of β-cell function than is seen in later-onset T2DM. Furthermore, individuals with young-onset T2DM seem to have a higher risk of complications than those with type 1 diabetes mellitus. As the number of younger adults with T2DM increa...
Type 2 Diabetes Mellitus Is Independently Associated With Decreased Neural Baroreflex Sensitivity: The Paris Prospective Study III.
Domonkos Cseh; Rachel E Climie; Lucile Offredo; Catherine Guibout; Frédérique Thomas; Luca Zanoli; Nicolas Danchin; James E Sharman; Stéphane Laurent; Xavier Jouven; Pierre Boutouyrie; Jean-Philippe Empana
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 19 Mar 2020
Impaired baroreflex function is an early indicator of cardiovascular autonomic imbalance. Patients with type 2 diabetes mellitus (T2D) have decreased baroreflex sensitivity (BRS), however, whether the neural BRS (nBRS) and mechanical component of the BRS is altered in those with high metabolic risk (HMR, impaired fasting glucose and metabolic syndrome) or with overt T2D, is unknown. We examined...
Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies.
Felix Mahfoud; Michel Azizi; Sebastian Ewen; Atul Pathak; Christian Ukena; Peter J Blankestijn; Michael Böhm; Michel Burnier; Gilles Chatellier; Isabelle Durand Zaleski; Guido Grassi; Michael Joner; David E Kandzari; Ajay Kirtane; Sverre E Kjeldsen; Melvin D Lobo; Thomas F Lüscher; John William McEvoy; Gianfranco Parati; Patrick Rossignol; Luis Ruilope; Markus P Schlaich; Atif Shahzad; Faisal Sharif; Andrew S P Sharp; Horst Sievert; Massimo Volpe; Michael A Weber; Roland E Schmieder; Costas Tsioufis; William Wijns
EUROPEAN HEART JOURNAL - 25 Mar 2020
Don't Take It With a Pinch of Salt: How Sodium Increases Blood Pressure via the Gut Microbiota.
Hamdi A Jama; Francine Z Marques
CIRCULATION RESEARCH - 27 Mar 2020
Exercise and Arrhythmogenic Right Ventricular Cardiomyopathy.
David Prior; Andre La Gerche
HEART, LUNG & CIRCULATION - 01 Apr 2020
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a group of cardiomyopathies associated with ventricular arrhythmias predominantly arising from the right ventricle, sudden cardiac death and right ventricular failure, caused largely due to inherited mutations in proteins of the desmosomal complex. Whilst long recognised as a cause of sudden cardiac death (SCD) during exercise, it has re...
Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes.
Darnel Prakoso; Miles J De Blasio; Mitchel Tate; Helen Kiriazis; Daniel G Donner; Hongwei Qian; David Nash; Minh Deo; Kate L Weeks; Laura J Parry; Paul Gregorevic; Julie R McMullen; Rebecca Helen Ritchie
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Apr 2020
Diabetic cardiomyopathy is a distinct form of heart disease that represents a major cause of death and disability in diabetic patients, particularly, the more prevalent type 2 diabetes patient population. In the current study, we investigated whether administration of recombinant adeno-associated viral vectors carrying a constitutively active phosphoinositide 3-kinase (PI3K)(p110α) construct (r...
Targeting CD300f to enhance hematopoietic stem cell transplantation in acute myeloid leukemia.
Edward Abadir; Pablo A Silveira; Robin E Gasiorowski; Murari Ramesh; Adelina Romano; Ahmed H Mekkawy; Tsun-Ho Lo; Karieshma Kabani; Sarah Sutherland; Geoffrey A Pietersz; P Joy Ho; Christian E Bryant; Stephen R Larsen; Georgina J Clark
BLOOD ADVANCES - 14 Apr 2020
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) significantly reduces the rate of relapse in acute myeloid leukemia (AML) but comes at the cost of significant treatment-related mortality. Despite the reduction in relapse overall, it remains common, especially in high-risk groups. The outcomes for patients who relapse after transplant remains very poor. A large proportion of the m...
Potential Therapeutic Use of Neurosteroids for Hypertension.
Geoffrey A Head; Kristy L Jackson; Cindy Gueguen
FRONTIERS IN PHYSIOLOGY - 01 Jan 2019
The sympathetic nervous system (SNS) contribution to long-term setting of blood pressure (BP) and hence hypertension has been a continuing controversy over many decades. However, the contribution of increased sympathetic vasomotor tone to the heart, kidney, and blood vessels has been suggested as a major influence on the development of high BP which affects 30-40% of the population. This is rel...
Management of heart failure with preserved ejection fraction.
Emma Gard; Shane Nanayakkara; David Kaye; Harry Gibbs
AUSTRALIAN PRESCRIBER - 01 Feb 2020
Show more...