Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

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Publications
By Year
Now showing items 1-20 of 2599 records
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017.
Roy Burstein; Nathaniel J Henry; Michael L Collison; Laurie B Marczak; Amber Sligar; Stefanie Watson; Neal Marquez; Mahdieh Abbasalizad-Farhangi; Masoumeh Abbasi; Foad Abd-Allah; Amir Abdoli; Mohammad Abdollahi; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Michael R M Abrigo; Dilaram Acharya; Oladimeji M Adebayo; Victor Adekanmbi; Davoud Adham; Mahdi Afshari; Mohammad Aghaali; Keivan Ahmadi; Mehdi Ahmadi; Ehsan Ahmadpour; Rushdia Ahmed; Chalachew Genet Akal; Joshua O Akinyemi; Fares Alahdab; Noore Alam; Genet Melak Alamene; Kefyalew Addis Alene; Mehran Alijanzadeh; Cyrus Alinia; Vahid Alipour; Syed Mohamed Aljunid; Mohammed J Almalki; Hesham M Al-Mekhlafi; Khalid Altirkawi; Nelson Alvis-Guzman; Adeladza Kofi Amegah; Saeed Amini; Arianna Maever Loreche Amit; Zohreh Anbari; Sofia Androudi; Mina Anjomshoa; Fereshteh Ansari; Carl Abelardo T Antonio; Jalal Arabloo; Zohreh Arefi; Olatunde Aremu; Bahram Armoon; Amit Arora; Al Artaman; Anvar Asadi; Mehran Asadi-Aliabadi; Amir Ashraf-Ganjouei; Reza Assadi; Bahar Ataeinia; Sachin R Atre; Beatriz Paulina Ayala Quintanilla; Martin Amogre Ayanore; Samad Azari; Ebrahim Babaee; Arefeh Babazadeh; Alaa Badawi; Soghra Bagheri; Mojtaba Bagherzadeh; Nafiseh Baheiraei; Abbas Balouchi; Aleksandra Barac; Quique Bassat; Bernhard T Baune; Mohsen Bayati; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Meysam Behzadifar; Yared Belete Belay; Brent Bell; Michelle L Bell; Dessalegn Ajema Berbada; Robert S Bernstein; Natalia V Bhattacharjee; Suraj Bhattarai; Zulfiqar A Bhutta; Ali Bijani; Somayeh Bohlouli; Nicholas J K Breitborde; Gabrielle Britton; Annie J Browne; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A Butt; Josip Car; Rosario Cárdenas; Carlos A Castañeda-Orjuela; Ester Cerin; Wagaye Fentahun Chanie; Pranab Chatterjee; Dinh-Toi Chu; Cyrus Cooper; Vera M Costa; Koustuv Dalal; Lalit Dandona; Rakhi Dandona; Farah Daoud; Ahmad Daryani; Rajat Das Gupta; Ian Davis; Nicole Davis Weaver; Dragos Virgil Davitoiu; Jan-Walter De Neve; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Kebede Deribe; Rupak Desai; Aniruddha Deshpande; Hanna Demelash Desyibelew; Sagnik Dey; Samath Dhamminda Dharmaratne; Meghnath Dhimal; Daniel Diaz; Leila Doshmangir; Andre R Duraes; Laura Dwyer-Lindgren; Lucas Earl; Roya Ebrahimi; Soheil Ebrahimpour; Andem Effiong; Aziz Eftekhari; Elham Ehsani-Chimeh; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Ziad El-Khatib; Mohammad Hassan Emamian; Shymaa Enany; Sharareh Eskandarieh; Oghenowede Eyawo; Maha Ezalarab; Mahbobeh Faramarzi; Mohammad Fareed; Roghiyeh Faridnia; Andre Faro; Ali Akbar Fazaeli; Mehdi Fazlzadeh; Netsanet Fentahun; Seyed-Mohammad Fereshtehnejad; João C Fernandes; Irina Filip; Florian Fischer; Nataliya A Foigt; Masoud Foroutan; Joel Msafiri Francis; Takeshi Fukumoto; Nancy Fullman; Silvano Gallus; Destallem Gebremedhin Gebre; Tsegaye Tewelde Gebrehiwot; Gebreamlak Gebremedhn Gebremeskel; Bradford D Gessner; Birhanu Geta; Peter W Gething; Reza Ghadimi; Keyghobad Ghadiri; Mahsa Ghajarzadeh; Ahmad Ghashghaee; Paramjit Singh Gill; Tiffany K Gill; Nick Golding; Nelson G M Gomes; Philimon N Gona; Sameer Vali Gopalani; Giuseppe Gorini; Bárbara Niegia Garcia Goulart; Nicholas Graetz; Felix Greaves; Manfred S Green; Yuming Guo; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian James Hall; Samer Hamidi; Hamidreza Haririan; Josep Maria Haro; Milad Hasankhani; Edris Hasanpoor; Amir Hasanzadeh; Hadi Hassankhani; Hamid Yimam Hassen; Mohamed I Hegazy; Delia Hendrie; Fatemeh Heydarpour; Thomas R Hird; Chi Linh Hoang; Gillian Hollerich; Enayatollah Homaie Rad; Mojtaba Hoseini-Ghahfarokhi; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Mohamed Hsairi; Olayinka Stephen Ilesanmi; Mohammad Hasan Imani-Nasab; Usman Iqbal; Seyed Sina Naghibi Irvani; Nazrul Islam; Sheikh Mohammed Shariful Islam; Mikk Jürisson; Nader Jafari Balalami; Amir Jalali; Javad Javidnia; Achala Upendra Jayatilleke; Ensiyeh Jenabi; John S Ji; Yash B Jobanputra; Kimberly Johnson; Jost B Jonas; Zahra Jorjoran Shushtari; Jacek Jerzy Jozwiak; Ali Kabir; Amaha Kahsay; Hamed Kalani; Rohollah Kalhor; Manoochehr Karami; Surendra Karki; Amir Kasaeian; Nicholas J Kassebaum; Peter Njenga Keiyoro; Grant Rodgers Kemp; Roghayeh Khabiri; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Ejaz Ahmad Khan; Junaid Khan; Muhammad Shahzeb Khan; Young-Ho Khang; Khaled Khatab; Amir Khater; Mona M Khater; Alireza Khatony; Mohammad Khazaei; Salman Khazaei; Maryam Khazaei-Pool; Jagdish Khubchandani; Neda Kianipour; Yun Jin Kim; Ruth W Kimokoti; Damaris K Kinyoki; Adnan Kisa; Sezer Kisa; Tufa Kolola; Soewarta Kosen; Parvaiz A Koul; Ai Koyanagi; Moritz U G Kraemer; Kewal Krishan; Kris J Krohn; Nuworza Kugbey; G Anil Kumar; Manasi Kumar; Pushpendra Kumar; Desmond Kuupiel; Ben Lacey; Sheetal D Lad; Faris Hasan Lami; Anders O Larsson; Paul H Lee; Mostafa Leili; Aubrey J Levine; Shanshan Li; Lee-Ling Lim; Stefan Listl; Joshua Longbottom; Jaifred Christian F Lopez; Stefan Lorkowski; Sameh Magdeldin; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Azeem Majeed; Afshin Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A Mamun; Navid Manafi; Ana-Laura Manda; Morteza Mansourian; Francisco Rogerlândio Martins-Melo; Anthony Masaka; Benjamin Ballard Massenburg; Pallab K Maulik; Benjamin K Mayala; Mohsen Mazidi; Martin McKee; Ravi Mehrotra; Kala M Mehta; Gebrekiros Gebremichael Meles; Walter Mendoza; Ritesh G Menezes; Atte Meretoja; Tuomo J Meretoja; Tomislav Mestrovic; Ted R Miller; Molly K Miller-Petrie; Edward J Mills; George J Milne; G K Mini; Seyed Mostafa Mir; Hamed Mirjalali; Erkin M Mirrakhimov; Efat Mohamadi; Dara K Mohammad; Aso Mohammad Darwesh; Naser Mohammad Gholi Mezerji; Ammas Siraj Mohammed; Shafiu Mohammed; Ali H Mokdad; Mariam Molokhia; Lorenzo Monasta; Yoshan Moodley; Mahmood Moosazadeh; Ghobad Moradi; Masoud Moradi; Yousef Moradi; Maziar Moradi-Lakeh; Mehdi Moradinazar; Paula Moraga; Lidia Morawska; Abbas Mosapour; Seyyed Meysam Mousavi; Ulrich Otto Mueller; Atalay Goshu Muluneh; Ghulam Mustafa; Behnam Nabavizadeh; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Azin Nahvijou; Farid Najafi; Vinay Nangia; Duduzile Edith Ndwandwe; Nahid Neamati; Ionut Negoi; Ruxandra Irina Negoi; Josephine W Ngunjiri; Huong Lan Thi Nguyen; Long Hoang Nguyen; Son Hoang Nguyen; Katie R Nielsen; Dina Nur Anggraini Ningrum; Yirga Legesse Nirayo; Molly R Nixon; Chukwudi A Nnaji; Marzieh Nojomi; Mehdi Noroozi; Shirin Nosratnejad; Jean Jacques Noubiap; Soraya Nouraei Motlagh; Richard Ofori-Asenso; Felix Akpojene Ogbo; Kelechi E Oladimeji; Andrew T Olagunju; Meysam Olfatifar; Solomon Olum; Bolajoko Olubukunola Olusanya; Mojisola Morenike Oluwasanu; Obinna E Onwujekwe; Eyal Oren; Doris D V Ortega-Altamirano; Alberto Ortiz; Osayomwanbo Osarenotor; Frank B Osei; Aaron E Osgood-Zimmerman; Stanislav S Otstavnov; Mayowa Ojo Owolabi; Mahesh P A; Abdol Sattar Pagheh; Smita Pakhale; Songhomitra Panda-Jonas; Animika Pandey; Eun-Kee Park; Hadi Parsian; Tahereh Pashaei; Sangram Kishor Patel; Veincent Christian Filipino Pepito; Alexandre Pereira; Samantha Perkins; Brandon V Pickering; Thomas Pilgrim; Majid Pirestani; Bakhtiar Piroozi; Meghdad Pirsaheb; Oleguer Plana-Ripoll; Hadi Pourjafar; Parul Puri; Mostafa Qorbani; Hedley Quintana; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Zohreh Rahimi; Vafa Rahimi-Movaghar; Shadi Rahimzadeh; Fatemeh Rajati; Sree Bhushan Raju; Azra Ramezankhani; Chhabi Lal Ranabhat; Davide Rasella; Vahid Rashedi; Lal Rawal; Robert C Reiner; Andre M N Renzaho; Satar Rezaei; Aziz Rezapour; Seyed Mohammad Riahi; Ana Isabel Ribeiro; Leonardo Roever; Elias Merdassa Roro; Max Roser; Gholamreza Roshandel; Daem Roshani; Ali Rostami; Enrico Rubagotti; Salvatore Rubino; Siamak Sabour; Nafis Sadat; Ehsan Sadeghi; Reza Saeedi; Yahya Safari; Roya Safari-Faramani; Mahdi Safdarian; Amirhossein Sahebkar; Mohammad Reza Salahshoor; Nasir Salam; Payman Salamati; Farkhonde Salehi; Saleh Salehi Zahabi; Yahya Salimi; Hamideh Salimzadeh; Joshua A Salomon; Evanson Zondani Sambala; Abdallah M Samy; Milena M Santric Milicevic; Bruno Piassi Sao Jose; Sivan Yegnanarayana Iyer Saraswathy; Rodrigo Sarmiento-Suárez; Benn Sartorius; Brijesh Sathian; Sonia Saxena; Alyssa N Sbarra; Lauren E Schaeffer; David C Schwebel; Sadaf G Sepanlou; Seyedmojtaba Seyedmousavi; Faramarz Shaahmadi; Masood Ali Shaikh; Mehran Shams-Beyranvand; Amir Shamshirian; Morteza Shamsizadeh; Kiomars Sharafi; Mehdi Sharif; Mahdi Sharif-Alhoseini; Hamid Sharifi; Jayendra Sharma; Rajesh Sharma; Aziz Sheikh; Chloe Shields; Mika Shigematsu; Rahman Shiri; Ivy Shiue; Kerem Shuval; Tariq J Siddiqi; João Pedro Silva; Jasvinder A Singh; Dhirendra Narain Sinha; Malede Mequanent Sisay; Solomon Sisay; Karen Sliwa; David L Smith; Ranjani Somayaji; Moslem Soofi; Joan B Soriano; Chandrashekhar T Sreeramareddy; Agus Sudaryanto; Mu'awiyyah Babale Sufiyan; Bryan L Sykes; P N Sylaja; Rafael Tabarés-Seisdedos; Karen M Tabb; Takahiro Tabuchi; Nuno Taveira; Mohamad-Hani Temsah; Abdullah Sulieman Terkawi; Zemenu Tadesse Tessema; Kavumpurathu Raman Thankappan; Sathish Thirunavukkarasu; Quyen G To; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Khanh Bao Tran; Irfan Ullah; Muhammad Shariq Usman; Olalekan A Uthman; Amir Vahedian-Azimi; Pascual R Valdez; Job F M van Boven; Tommi Juhani Vasankari; Yasser Vasseghian; Yousef Veisani; Narayanaswamy Venketasubramanian; Francesco S Violante; Sergey Konstantinovitch Vladimirov; Vasily Vlassov; Theo Vos; Giang Thu Vu; Isidora S Vujcic; Yasir Waheed; Jon Wakefield; Haidong Wang; Yafeng Wang; Yuan-Pang Wang; Joseph L Ward; Robert G Weintraub; Kidu Gidey Weldegwergs; Girmay Teklay Weldesamuel; Ronny Westerman; Charles Shey Wiysonge; Dawit Zewdu Wondafrash; Lauren Woyczynski; Ai-Min Wu; Gelin Xu; Abbas Yadegar; Tomohide Yamada; Vahid Yazdi-Feyzabadi; Christopher Sabo Yilgwan; Paul Yip; Naohiro Yonemoto; Javad Yoosefi Lebni; Mustafa Z Younis; Mahmoud Yousefifard; Hebat-Allah Salah A Yousof; Chuanhua Yu; Hasan Yusefzadeh; Erfan Zabeh; Telma Zahirian Moghadam; Sojib Bin Zaman; Mohammad Zamani; Hamed Zandian; Alireza Zangeneh; Taddese Alemu Zerfu; Yunquan Zhang; Arash Ziapour; Sanjay Zodpey; Christopher J L Murray; Simon I Hay
NATURE - 01 Oct 2019
Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2-to end preventable child deaths by 2030-we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000-2017, t...
Hyper transmission of Beijing lineage Mycobacterium tuberculosis: Systematic review and meta-analysis.
Malancha Karmakar; James M Trauer; David B Ascher; Justin T Denholm
THE JOURNAL OF INFECTION - 01 Oct 2019
The globally distributed "Beijing" lineage of Mycobacterium tuberculosis has been associated with outbreaks worldwide. Laboratory based studies have suggested that Beijing lineage may have increased fitness; however, it has not been established whether these differences are of epidemiological significance with regards to transmission. Therefore, we undertook a systematic review of epidemiologic...
Iron Deficiency in Acute Decompensated Heart Failure.
Anna Beale; Davis Carballo; Jerome Stirnemann; Nicolas Garin; Thomas Agoritsas; Jacques Serratrice; David Kaye; Philippe Meyer; Sebastian Carballo
JOURNAL OF CLINICAL MEDICINE - 01 Oct 2019
The aim of this study was to characterize iron deficiency (ID) in acutely decompensated heart failure (ADHF) and identify whether ID is associated with dyspnea class, length of stay (LOS), biomarker levels, and echocardiographic indices of diastolic function in patients with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). Consecutive patients admitted with ADHF a...
Left Atrial Mechanical Dispersion Assessed by Strain Echocardiography as an Independent Predictor of New-Onset Atrial Fibrillation: A Case-Control Study.
Hiroshi Kawakami; Satish Ramkumar; Mark Nolan; Leah Wright; Hong Yang; Kazuaki Negishi; Thomas H Marwick
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Oct 2019
Left atrial (LA) enlargement is associated with atrial fibrillation (AF), but new-onset AF often occurs in the absence of LA enlargement. AF may be related to myocardial fibrosis, and even though left ventricular fibrosis is associated with mechanical dispersion, this phenomenon is not well studied in AF. We hypothesized that detection of LA dysfunction and mechanical dispersion using strain ec...
Echocardiographic Risk Assessment to Guide Screening for Atrial Fibrillation.
Satish Ramkumar; Ayame Ochi; Hiroshi Kawakami; Hong Yang; Elizabeth L Potter; Nicholas D'Elia; Tomoko Negishi; Kazuaki Negishi; Thomas H Marwick
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Oct 2019
Although atrial fibrillation (AF) is a significant population health burden, and an avoidable cause of stroke, AF screening remains controversial. The aim of this study was to investigate whether coincidental echocardiography could provide information about patients at risk for AF.Asymptomatic participants ≥65 years of age with more than one AF risk factor (N = 445) undergoing echocardiography ...
Association between socioeconomic status and incident atrial fibrillation.
Satish Ramkumar; Ayame Ochi; Hong Yang; Nitesh Nerlekar; Nicholas D'Elia; Elizabeth L Potter; Isabella C Murray; Nishee Nattraj; Ying Wang; Thomas H Marwick
INTERNAL MEDICINE JOURNAL - 01 Oct 2019
Low socioeconomic status is associated with cardiovascular diseases, and an association with atrial fibrillation (AF) could guide screening.To investigate if indices of advantage/disadvantage (IAD), index of education/occupation (IEO) and index of economic resources were associated with incident AF, independent of risk factors and cardiac function.We studied community-based participants aged ≥6...
Impact of sex, socio-economic status, and remoteness on therapy and survival in heart failure.
Sarah J Gutman; Ben T Costello; Stavroula Papapostolou; Leah Iles; Johnson Ja; James L Hare; Andris Ellims; Thomas H Marwick; Andrew J Taylor
ESC HEART FAILURE - 01 Oct 2019
This study aims to determine if traditional markers of disadvantage [female sex, low socio-economic status (SES), and remoteness] are associated with lower prescription of evidence-based therapy and higher mortality among patients with moderate-severe heart failure with reduced ejection fraction.We recruited 452 consecutive class II-III heart failure with reduced ejection fraction patients. Bas...
Exposure to Bisphenol A and Bisphenol S and Incident Type 2 Diabetes: A Case-Cohort Study in the French Cohort D.E.S.I.R.
Fanny Rancière; Jérémie Botton; Rémy Slama; Marlène Z Lacroix; Laurent Debrauwer; Marie Aline Charles; Ronan Roussel; Beverley Balkau; Dianna J Magliano;
ENVIRONMENTAL HEALTH PERSPECTIVES - 01 Oct 2019
The question of whether exposure to bisphenol A (BPA) contributes to the development of type 2 diabetes is still unresolved. Most epidemiological evidence on the association between BPA and diabetes is from cross-sectional studies or longitudinal studies with single urinary measurements. No prospective study has examined exposure to BPA analogs such as bisphenol S (BPS) in relation to incident ...
Circulating MIF Levels Predict Clinical Outcomes in Patients With ST-Elevation Myocardial Infarction After Percutaneous Coronary Intervention.
Qian Zhao; Li Men; Xiao-Mei Li; Fen Liu; Chun-Fang Shan; Xin-Rong Zhou; Ning Song; Jia-Jun Zhu; Xiao-Li Gao; Yi-Tong Ma; Xiao-Jun Du; Xiao-Ming Gao; Yi-Ning Yang
THE CANADIAN JOURNAL OF CARDIOLOGY - 01 Oct 2019
The purpose of the study was to assess the value of admission macrophage migration inhibitory factor (MIF) levels in predicting clinical outcomes in ST-elevation myocardial infarction (STEMI) patients.For this study we recruited 498 STEMI patients after they received percutaneous coronary intervention (PCI), 40 with stable angina pectoris and 137 healthy participants. Plasma MIF levels were mea...
Right ventricular strain rate during exercise accurately identifies male athletes with right ventricular arrhythmias.
Mathias Claeys; Guido Claessen; Piet Claus; Ruben De Bosscher; Christoph Dausin; Jens-Uwe Voigt; Rik Willems; Hein Heidbuchel; Andre La Gerche
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 03 Oct 2019
Athletes with right ventricular (RV) arrhythmias, even in the absence of desmosomal mutations, may have subtle RV abnormalities which can be unmasked by deformation imaging. As exercise places a disproportionate stress on the right ventricle, evaluation of cardiac function and deformation during exercise might improve diagnostic performance.We performed bicycle stress echocardiography in 17 app...
Use of echocardiography to stratify the risk of atrial fibrillation: comparison of left atrial and ventricular strain.
Hiroshi Kawakami; Satish Ramkumar; Faraz Pathan; Leah Wright; Thomas H Marwick
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 03 Oct 2019
Although both left atrial (LA) and ventricular (LV) dysfunction has been accepted as an important risk factor of atrial fibrillation (AF), usefulness of LA and LV strain has not been fully compared for prediction of AF. The aims of this study were to clarify the associations of both LA and LV strain with AF and to compare their predictive values in the risk stratification for AF.We evaluated 53...
Birth outcomes in women with gestational diabetes managed by lifestyle modification alone: The PANDORA study.
E Cheng; D K Longmore; F Barzi; E L M Barr; I L Lee; C Whitbread; J A Boyle; J Oats; C Connors; H D McIntyre; M Kirkwood; K Dempsey; X Zhang; S Thomas; D Williams; P Zimmet; A D H Brown; J E Shaw; L J Maple-Brown;
DIABETES RESEARCH AND CLINICAL PRACTICE - 03 Oct 2019
To assess outcomes of women in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) cohort with gestational diabetes mellitus (GDM) managed by lifestyle modification compared with women without hyperglycaemia in pregnancy.Indigenous (n = 97) and Europid (n = 113) women managed by lifestyle modification were compared to women without hyperglycaemia (n = 235). Multivariate l...
Neighbourhood environments and risk of incident atrial fibrillation: limitations and future directions.
Mohammad Javad Koohsari; Koichiro Oka
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 04 Oct 2019
Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts.
Ari V Ahola-Olli; Linda Mustelin; Maria Kalimeri; Johannes Kettunen; Jari Jokelainen; Juha Auvinen; Katri Puukka; Aki S Havulinna; Terho Lehtimäki; Mika Kähönen; Markus Juonala; Sirkka Keinänen-Kiukaanniemi; Veikko Salomaa; Markus Perola; Marjo-Riitta Järvelin; Mika Ala-Korpela; Olli Raitakari; Peter Würtz
DIABETOLOGIA - 04 Oct 2019
Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case-control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adults.NMR metabolomics was used to quantify 229 circulating metabolic measures in 11,896 individuals from four Finn...
Physical Activity and Sedentary Behavior 6 Months After Musculoskeletal Trauma: What Factors Predict Recovery?
Christina L Ekegren; Rachel E Climie; Pamela M Simpson; Neville Owen; David W Dunstan; William Veitch; Belinda J Gabbe
PHYSICAL THERAPY - 07 Oct 2019
Physical activity is increasingly recognized as an important marker of functional recovery following fracture.The objectives of this study were to measure sedentary behavior and physical activity 2 weeks and 6 months following fracture and to determine associated demographic and injury factors.This was an observational study.Two weeks and 6 months following fracture, 83 adults who were 18 to 69...
Progressive Hypertension and Severe Left Ventricular Outflow Tract Obstruction.
Alan C Cameron; Ninian N Lang; Anna F Dominiczak; Garry L R Jennings; Daniel Batlle; Michael Bursztyn; Atul R Chugh; John S Floras; Sandra J Taler; Rhian M Touyz; Christian Delles
HYPERTENSION (DALLAS, TEX. : 1979) - 07 Oct 2019
Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review.
Mark J Sarnak; Kerstin Amann; Sripal Bangalore; João L Cavalcante; David M Charytan; Jonathan C Craig; John S Gill; Mark A Hlatky; Alan G Jardine; Ulf Landmesser; L Kristin Newby; Charles A Herzog; Michael Cheung; David C Wheeler; Wolfgang C Winkelmayer; Thomas H Marwick;
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 08 Oct 2019
Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD). As well as their high prevalence of traditional CAD risk factors, such as diabetes and hypertension, persons with CKD are also exposed to other nontraditional, uremia-related cardiovascular disease risk factors, including inflammation, oxidative stress, and abnormal calcium-phosphorus metabolism. CKD and end-...
Early Adaptive CD4+ T cell Immunity in Atherosclerosis goes Local.
Tin Kyaw; Alex Bobik
CARDIOVASCULAR RESEARCH - 11 Oct 2019
Management of frailty: opportunities, challenges, and future directions.
Elsa Dent; Finbarr C Martin; Howard Bergman; Jean Woo; Roman Romero-Ortuno; Jeremy D Walston
LANCET (LONDON, ENGLAND) - 12 Oct 2019
Frailty is a complex age-related clinical condition characterised by a decline in physiological capacity across several organ systems, with a resultant increased susceptibility to stressors. Because of the heterogeneity of frailty in clinical presentation, it is important to have effective strategies for the delivery of care that range across the continuum of frailty severity. In clinical pract...
Low Tregs: A targetable risk factor for life-threatening cardiovascular complications after major noncardiac surgery.
Tin Kyaw; Alex Bobik
JOURNAL OF LEUKOCYTE BIOLOGY - 14 Oct 2019
Discussion on Tregs that have anti-inflammatory and anti-atherogenic properties as an ideal therapeutic target to reduce fatal cardiovascular deaths following major noncardiac surgery.
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