Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
Visit the Baker Institute website for more information on Baker Institute research, lifestyle books and health fact sheets.
Follow our OAR Twitter account to keep in touch with our latest research publications.
This open access repository contains the full text of articles, subject to copyright constraints.
Publications
Now showing items 1-20 of 4533 records
The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.
CARDIOVASCULAR RESEARCH - 04 Jul 2023
The ageing heart naturally incurs a progressive decline in function and perfusion that available treatments cannot halt. However, some exceptional individuals maintain good health until the very late stage of their life due to favourable gene-environment interaction. We have previously shown that carriers of a longevity-associated variant (LAV) of the BPIFB4 gene enjoy prolonged health spans an...
Effect of Fibrosis Regionality on Atrial Fibrillation Recurrence: Insights from DECAAF II.
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 10 Jul 2023
The amount of fibrosis in the left atrium (LA) predicts atrial fibrillation (AF) recurrence after catheter ablation (CA). We aim to identify whether regional variations in LA fibrosis affect AF recurrence.This post-hoc analysis of the DECAAF II trial includes 734 patients with persistent AF undergoing first-time CA who underwent Late Gadolinium Enhancement Magnetic Imaging Resonance (LGE-MRI) w...
Challenging the status quo: a case for the lack of gut microbiota exacerbating hypertensive end-organ damage.
CARDIOVASCULAR RESEARCH - 04 Jul 2023
Gender Differences in Medical Student Perceptions of a Career in Cardiology.
HEART, LUNG & CIRCULATION - 05 Jul 2023
Worldwide, the cardiology profession has an under-representation of women. We assessed medical students' perceptions of cardiology as a career choice with the aim of identifying barriers to gender diversity.An anonymous survey was distributed to medical students studying at three Australian medical universities. Questions pertained to demographics, year and stage of medical training, desire to ...
The New South Wales Sudden Cardiac Arrest Registry: A Data Linkage Cohort Study.
HEART, LUNG & CIRCULATION - 05 Jul 2023
Sudden cardiac arrest (SCA) in young people aged 1 to 50 years often occurs with no presenting symptoms or risk factors prompting screening for cardiovascular disease prior to their cardiac arrest. Approximately 3,000 young Australians suffer from sudden cardiac death (SCD) each year, making this a major public health issue. However, there is significant variation in the way incidence is estima...
Lifelong endurance exercise and its relation with coronary atherosclerosis.
EUROPEAN HEART JOURNAL - 07 Jul 2023
The impact of long-term endurance sport participation (on top of a healthy lifestyle) on coronary atherosclerosis and acute cardiac events remains controversial.The Master@Heart study is a well-balanced prospective observational cohort study. Overall, 191 lifelong master endurance athletes, 191 late-onset athletes (endurance sports initiation after 30 years of age), and 176 healthy non-athletes...
Long-term cost-effectiveness of implementing a lifestyle intervention during pregnancy to reduce the incidence of gestational diabetes and type 2 diabetes.
DIABETOLOGIA - 01 Jul 2023
The aim of this study was to determine the long-term cost-effectiveness and return on investment of implementing a structured lifestyle intervention to reduce excessive gestational weight gain and associated incidence of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus.A decision-analytic Markov model was used to compare the health and cost-effectiveness outcomes for (1) a struc...
Asia-Pacific consensus recommendations for application of continuous glucose monitoring in diabetes management.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Jul 2023
Glucose monitoring has evolved from self-monitoring of blood glucose to glycated hemoglobin, and the latest continuous glucose monitoring (CGM). A key challenge to adoption of CGM for management of diabetes in Asia is the lack of regional CGM recommendations. Hence, thirteen diabetes-specialists from eight Asia-Pacific (APAC) countries/regions convened to formulate evidence-based, APAC-specific...
Weaponizing platelets for cancer treatment: Converting allies to deadly foes!
MATTER - 02 Aug 2023
The capability of platelets to adhere to cancer cells allows tumors/metastatic cells to camouflage and avoid immune recognition. This mechanism has been elegantly highjacked by Yang et al. for the delivery of cytotoxic reagents imitating the cancer-fighting action of cytotoxic T cells.
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021.
LANCET (LONDON, ENGLAND) - 15 Jul 2023
Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the...
Clinical Features and Outcomes Among Patients With Refractory Out-of-Hospital Cardiac Arrest and an Initial Shockable Rhythm.
CIRCULATION. CARDIOVASCULAR INTERVENTIONS - 26 Sep 2023
Clinical features among patients with refractory out-of-hospital cardiac arrest (OHCA) and initial shockable rhythms of ventricular fibrillation/pulseless ventricular tachycardia are not well-characterized.We compared clinical characteristics and coronary angiographic findings between patients with refractory OHCA (incessant ventricular fibrillation/pulseless ventricular tachycardia after ≥3 di...
Association between maternal hyperglycemia in pregnancy and offspring anthropometry in early childhood: the pandora wave 1 study.
INTERNATIONAL JOURNAL OF OBESITY (2005) - 01 Nov 2023
In-utero hyperglycemia exposure influences later cardiometabolic risk, although few studies include women with pre-existing type 2 diabetes (T2D) or assess maternal body mass index (BMI) as a potential confounder.To explore the association of maternal T2D and gestational diabetes mellitus (GDM) with childhood anthropometry, and the influence of maternal BMI on these associations.The PANDORA coh...
Role of Gut Microbiota in Statin-Associated New-Onset Diabetes-a Cross-Sectional and Prospective Analysis of the FINRISK 2002 Cohort.
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 16 Nov 2023
Dyslipidemia is treated effectively with statins, but treatment has the potential to induce new-onset type-2 diabetes. Gut microbiota may contribute to this outcome variability. We assessed the associations of gut microbiota diversity and composition with statins. Bacterial associations with statin-associated new-onset type-2 diabetes (T2D) risk were also prospectively evaluated.We examined sha...
Transcriptional Control of Endothelial Senescence and Vascular Repair.
CIRCULATION RESEARCH - 27 Oct 2023
Is "Normal for Age" a Legitimate Assessment?: Significance of Left Ventricular Dysfunction in the Elderly.
JACC. CARDIOVASCULAR IMAGING - 26 Jun 2023
Understanding the complementarity and plasticity of antibody-antigen interfaces.
BIOINFORMATICS (OXFORD, ENGLAND) - 29 Jun 2023
While antibodies have been ground-breaking therapeutic agents, the structural determinants for antibody binding specificity remain to be fully elucidated, which is compounded by the virtually unlimited repertoire of antigens they can recognise. Here, we have explored the structural landscapes of antibody-antigen interfaces to identify the structural determinants driving target recognition by as...
LEGO-CSM: a tool for functional characterisation of proteins.
BIOINFORMATICS (OXFORD, ENGLAND) - 29 Jun 2023
With the development of sequencing techniques, the discovery of new proteins significantly exceeds the human capacity and resources for experimentally characterising protein functions. LEGO-CSM is a comprehensive web-based resource that fills this gap by leveraging the well-established and robust graph-based signatures to supervised learning models using both protein sequence and structure info...
Catheter Ablation vs Antiarrhythmic Drug Therapy for Treatment of Premature Ventricular Complexes: A Systematic Review.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jun 2023
There is variability in treatment modalities for premature ventricular complexes (PVCs), including use of antiarrhythmic drug (AAD) therapy or catheter ablation (CA). This study reviewed evidence comparing CA vs AADs for the treatment of PVCs. A systematic review was performed from the Medline, Embase, and Cochrane Library databases, as well as the Australian and New Zealand Clinical Trials Reg...
Effect of Oral Contraception on Screening Tests for Primary Aldosteronism: A 10-Year Longitudinal Study.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 16 Jun 2023
Primary aldosteronism (PA) and oral contraception (OC) can both cause hypertension in young women. However, the effect of OC on the screening test for PA, the aldosterone to renin ratio (ARR), is not clear.We evaluated the impact of OC on the screening test for PA.In this retrospective cohort study, we analyzed data from the female offspring (Gen2) of women enrolled in the Raine Study, a popula...
The burden of type 2 diabetes in Australia during the period 1990-2019: Findings from the global burden of disease study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 May 2023
To describe morbidity and mortality trends of type 2 diabetes in Australia, from 1990 to 2019, compared with similar sociodemographic index (SDI) countries.Australia-specific Global Burden of Diseases data were used to estimate age-standardised, age-specific, and sex-specific rates for prevalence, years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life years (DAL...
