Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

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By Year
Now showing items 1-20 of 3013 records
Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction.
Andrew R Kompa; David W Greening; Anne M Kong; Paul J McMillan; Hoayun Fang; Ritika Saxena; Raymond C B Wong; Jarmon G Lees; Priyadharshini Sivakumaran; Andrew E Newcomb; Bakhos A Tannous; Cameron Kos; Lina Mariana; Thomas Loudovaris; Derek J Hausenloy; Shiang Y Lim
To establish pre-clinical proof of concept that sustained subcutaneous delivery of the secretome of human cardiac stem cells (CSCs) can be achieved in vivo to produce significant cardioreparative outcomes in the setting of myocardial infarction.Rats were subjected to permanent ligation of left anterior descending coronary artery and randomized to receive subcutaneous implantation of TheraCyte d...
Cardiorenal syndrome: Multi-organ dysfunction involving the heart, kidney and vasculature.
Feby Savira; Ruth Magaye; Danny Liew; Christopher Reid; Darren J Kelly; Andrew R Kompa; S Jeson Sangaralingham; John C Burnett; David Kaye; Bing H Wang
Cardiorenal syndrome (CRS) is a multi-organ disease, encompassing heart, kidney and vascular system dysfunction. CRS is a worldwide problem, with high morbidity, mortality, and inflicts a significant burden on the health care system. The pathophysiology is complex, involving interactions between neurohormones, inflammatory processes, oxidative stress and metabolic derangements. Therapies remain...
Development and piloting of a Checklist for healthy eating And Physical Activity in the Workplace (CEPAW).
Rosanne Freak-Poli; Margaret Brand; Tara Boelsen-Robinson; Oliver Huse; Maximilian de Courten; Anna Peeters
To develop and pilot a tool that assesses the infrastructure and policy workplace environment characteristics that may influence employee healthy eating and physical activity behaviours. A checklist was developed with reference to prior tools and piloted at eight worksites. Piloting of the tool demonstrated that it was generally feasible to use, took 1-2 hours to complete and appeared sensitive...
RE: ASK1, a new target in treating cardiorenal syndrome (CRS).
Feby Savira; Andrew R Kompa; Amanda J Edgley; Beat M Jucker; Robert N Willette; Darren J Kelly; Bing H Wang
Do physical activity and sedentary time mediate the association of the perceived environment with BMI? The IPEN adult study.
Delfien Van Dyck; Ester Cerin; Muhammad Akram; Terry L Conway; Duncan Macfarlane; Rachel Davey; Olga L Sarmiento; Lars Breum Christiansen; Rodrigo Reis; Josef Mitas; Ines Aguinaga-Ontoso; Deborah Salvo; James F Sallis
HEALTH & PLACE - 01 Jul 2020
The study's main aim was to examine whether adults' accelerometer-based physical activity and sedentary time mediated the associations of neighbourhood physical environmental perceptions with body mass index (BMI) and weight status across 10 high- and middle-income countries. Data from the IPEN Adult study, an observational multi-country study (n = 5712) were used. Results showed that sedentary...
Validation of the "Doorbell Test": A Novel Functional Test of Frailty and Clinical Status After Acute Decompensated Heart Failure.
James E Gunton; Savvy Nandal; Julieanne Jones; Derek P Chew; Thomas H Marwick; Carmine G De Pasquale
Acute decompensated heart failure (ADHF) carries a high event rate following discharge. The complex interplay between age, frailty and decongestion may lend itself to a functional test.In the doorbell test the patient simulates answering the doorbell. They are timed rising from a recumbent position, bending over twice and walking 10 metres, this time is added to the change in respiratory rate. ...
Prehospital opioid dose and myocardial injury in patients with ST elevation myocardial infarction.
Himawan Fernando; Ziad Nehme; Karlheinz Peter; Stephen Bernard; Michael Stephenson; Janet Bray; Peter Cameron; Andris Ellims; Andrew Taylor; David M Kaye; Karen Smith; Dion Stub;
OPEN HEART - 01 Jul 2020
To characterise the relationship between opioid dose and myocardial infarct size in patients with ST elevation myocardial infarction (STEMI).Patients given opioid treatment by emergency medical services with confirmed STEMI were included in this secondary, retrospective cohort analysis of the Air versus Oxygen in Myocardial Infarction (AVOID) study. Patients with cardiogenic shock were excluded...
Simultaneous epicardial-endocardial mapping of the sinus node in humans with structural heart disease: Impact of overdrive suppression on sinoatrial exits.
Ramanathan Parameswaran; Geoffrey Lee; Gwilym M Morris; Alistair Royse; John Goldblatt; Marco Larobina; Troy Watts; Chrishan J Nalliah; Geoffrey Wong; Ahmed M Al-Kaisey; Robert D Anderson; Aleksandr Voskoboinik; Hariharan Sugumar; David Chieng; Prashanthan Sanders; Peter M Kistler; Jonathan M Kalman
HEART RHYTHM - 02 Jul 2020
The 3-dimensional (3D) nature of sinoatrial node (SAN) function has not been characterized in the intact human heart.The purpose of this study was to characterize the 3D nature of SAN function in patients with structural heart disease (SHD) using simultaneous endocardial-epicardial (endo-epi) phase mapping.Simultaneous intraoperative endo-epi SAN mapping was performed during sinus rhythm at bas...
DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure.
Chris R Bain; Mark Ziemann; Antony Kaspi; Abdul Waheed Khan; Rachael Taylor; Hugh Trahair; Ishant Khurana; Harikrishnan Kaipananickal; Sophie Wallace; Assam El-Osta; Paul S Myles; Kiymet Bozaoglu
Natriuretic peptides are useful for diagnosis and prognostication of heart failure of any cause. Now, research aims to discover novel biomarkers that will more specifically define the heart failure phenotype. DNA methylation plays a critical role in the development of cardiovascular disease with the potential to predict fundamental pathogenic processes. There is a lack of data relating DNA meth...
Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC).
Jelena Čelutkienė; Radek Pudil; Teresa López-Fernández; Julia Grapsa; Petros Nihoyannopoulos; Jutta Bergler-Klein; Alain Cohen-Solal; Dimitrios Farmakis; Carlo Gabriele Tocchetti; Stephan von Haehling; Vassilis Barberis; Frank A Flachskampf; Indrė Čeponienė; Eva Haegler-Laube; Thomas Suter; Tomas Lapinskas; Sanjay Prasad; Rudolf A de Boer; Kshama Wechalekar; Markus S Anker; Zaza Iakobishvili; Chiara Bucciarelli-Ducci; Jeanette Schulz-Menger; Bernard Cosyns; Oliver Gaemperli; Yury Belenkov; Jean-Sébastien Hulot; Maurizio Galderisi; Patrizio Lancellotti; Jeroen Bax; Thomas H Marwick; Ovidiu Chioncel; Tiny Jaarsma; Wilfried Mullens; Massimo Piepoli; Thomas Thum; Stephane Heymans; Christian Mueller; Brenda Moura; Frank Ruschitzka; Jose Luis Zamorano; Giuseppe Rosano; Andrew J S Coats; Riccardo Asteggiano; Petar Seferovic; Thor Edvardsen; Alexander R Lyon
Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the He...
Main and interacting effects of physical activity and sedentary time on older adults' BMI: The moderating roles of socio-demographic and environmental attributes.
Delfien Van Dyck; Anthony Barnett; Jelle Van Cauwenberg; Casper J P Zhang; Cindy H P Sit; Ester Cerin
PLOS ONE - 01 Jan 2020
Our first aim was to examine the main and interacting effects of accelerometer-based sedentary time (ST) and moderate-to-vigorous physical activity (MVPA) with BMI and the likelihood of being overweight/obese in Hong Kong and Ghent (Belgium) older adults. Second, we examined whether these main associations and interactions between MVPA and ST were moderated by socio-demographics (gender, educat...
Left Atrial Strain as a Predictor of New-Onset Atrial Fibrillation in Patients With Heart Failure.
Jin Joo Park; Jae-Hyeong Park; In-Chang Hwang; Jun-Bean Park; Goo-Yeong Cho; Thomas H Marwick
This study sought to identify whether left atrial strain can predict new-onset atrial fibrillation (NOAF) in patients with heart failure (HF) and sinus rhythm.Both HF and atrial fibrillation have common risk factors, and HF is a risk factor for the development of atrial fibrillation and vice versa.Among 4,312 consecutive patients with acute HF from 3 tertiary hospitals, 2,461 patients with sinu...
Measurement of Functional Capacity to Discriminate Clinical from Subclinical Heart Failure in Patients ≥65 Years of Age.
Elizabeth Potter; Hong Yang; Leah Wright; Bing Wang; Thomas H Marwick
In order to show that reduced functional capacity in subclinical heart failure portends a higher risk of clinically overt (stage C) heart failure, we obtained the Duke activity status index (DASI) and 6-minute walk distance (6MWD) in 814 patients (age 70 [interquartile range 67 to 74] years, 51% female) with nonischemic subclinical heart failure. Reduced functional capacity was defined as: (1) ...
Targeting CD83 in mantle cell lymphoma with anti-human CD83 antibody.
Ziduo Li; Edward Abadir; Kenneth Lee; Candice Clarke; Christian E Bryant; Wendy Cooper; Geoffrey Pietersz; James Favaloro; Pablo A Silveira; Derek Nj Hart; Xinsheng Ju; Georgina J Clark
Effective antibody-drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma. Our objective was to determine CD83 expression on non-Hodgkin lymphoma (NHL) and its therapeutic potential to treat mantle cell lymphoma (MCL) which is currently an incurable NHL.We analysed CD83 expre...
Exercise as a diagnostic and therapeutic tool for preventing cardiovascular morbidity in breast cancer patients- the BReast cancer EXercise InTervention (BREXIT) trial protocol.
Stephen J Foulkes; Erin J Howden; Yoland Antill; Sherene Loi; Agus Salim; Mark J Haykowsky; Robin M Daly; Steve F Fraser; Andre La Gerche
BMC CANCER - 14 Jul 2020
Anthracycline chemotherapy (AC) is an efficacious (neo) adjuvant treatment for early-stage breast cancer (BCa), but is associated with an increased risk of cardiac dysfunction and functional disability. Observations suggest that regular exercise may be a useful therapy for the prevention of cardiovascular morbidity but it is yet to be interrogated in a large randomised trial. The primary aims o...
Cost-effectiveness of dapagliflozin in chronic heart failure: an analysis from the Australian healthcare perspective.
Feby Savira; Bing H Wang; Andrew R Kompa; Zanfina Ademi; Alice J Owen; Sophia Zoungas; Andrew Tonkin; Danny Liew; Ella Zomer
To assess the cost-effectiveness of dapagliflozin in addition to standard care versus standard care alone in patients with chronic heart failure and reduced ejection fraction.A Markov model was constructed based on the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial to assess the clinical outcomes and costs of 1000 hypothetical subjects with established heart failure and...
Transcatheter Versus Surgical Aortic Valve Replacement: An Updated Systematic Review and Meta-Analysis With a Focus on Outcomes by Sex.
Misha Dagan; Timothy Yeung; Julia Stehli; Dion Stub; Antony S Walton; Stephen J Duffy
Women at increased surgical risk have been shown to have better outcomes with transcatheter aortic valve implantation (TAVI) as compared to surgical valve replacement (SAVR). With the scope of TAVI moving into low-surgical risk patients, we aimed to update the current literature to include the new low-risk randomised controlled trial (RCT) data in investigating outcomes by sex.We systematically...
Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.
Anto P Rajkumar; Per Qvist; Julie G Donskov; Ross Lazarus; Jonatan Pallesen; Nicoletta Nava; Gudrun Winther; Nico Liebenberg; Sanne H la Cour; Veerle Paternoster; Tue Fryland; Johan Palmfeldt; Kim Fejgin; Arne Mørk; Mette Nyegaard; Bente Pakkenberg; Michael Didriksen; Jens R Nyengaard; Gregers Wegener; Ole Mors; Jane H Christensen; Anders D Børglum
The schizophrenia-associated gene, BRD1, encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health. Alterations in histone modifications and epigenetic regulation contribute to brain transcriptomic changes in affective disorders and preclinical data supports a role for BRD1 in psychopathology. However, the implication of BRD1 on affective ...
Renal denervation as a synergistic tool for the treatment of polymorphic ventricular ectopic beats: A case report.
Márcio Galindo Kiuchi; Shaojie Chen; Humberto Villacorta; Revathy Carnagarin; Janis M Nolde; Vance B Matthews; Markus P Schlaich
MEDICINE - 17 Jul 2020
Ventricular ectopic beats (VEBs) are very common and often occur in hypertensive or obese individuals, as well as in patients presenting with either sleep apnea or structural cardiac disease. Sympathetic overactivity plays a crucial role in the development, continuation, and exacerbation of ventricular arrhythmias. Recent studies have reported the relevance of sympathetic activation in patients...
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
Alma Zernecke; Holger Winkels; Clément Cochain; Jesse W Williams; Dennis Wolf; Oliver Soehnlein; Clint S Robbins; Claudia Monaco; Inhye Park; Coleen A McNamara; Christoph J Binder; Myron I Cybulsky; Corey A Scipione; Catherine C Hedrick; Elena V Galkina; Tin Kyaw; Yanal Ghosheh; Huy Q Dinh; Klaus Ley
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta-analysis, we confirm 4 known macrophage subsets-resident, inflammatory, interferon-inducible cell, and Trem2 (triggering receptor expressed on myeloid cells-2) foamy macrophages-and identify a new macrophage subset resemblin...
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