Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 5596 records
Expanding the Search for Primary Aldosteronism in Clinical Settings.
HYPERTENSION (DALLAS, TEX. : 1979) - 14 Aug 2025
Increased plasma levels of erythropoietin after renal denervation in patients with resistant hypertension.
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 14 Aug 2025
Erythropoietin (Epo) plays a crucial role in the formation and maturation of erythrocytes and is produced primarily by peritubular cells in the renal cortex. Previous studies suggest that renal sympathetic nerve activity (RSNA) may influence Epo regulation. Catheter-based renal denervation (RDN) has been shown to reduce renal noradrenaline spillover and blood pressure in patients with resistant...
Galectin-3 gene deletion alters lipid profile in healthy and cardiomyopathy mouse hearts.
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS - 04 Aug 2025
Galectin-3 (Gal3) is known to interact with glycans of proteins and lipids. In cardiovascular disease, the elevated expression of Gal3 mediates inflammation, hypertrophy and fibrosis. We explored the effect of Gal3 on the cardiac lipid profile in healthy mice or in mice with dilated cardiomyopathy (DCM). Using lipidomics and gene-targeted mouse models, we studied the influence of Gal3 gene dele...
Development of a novel therapy for systolic heart failure.
EMBO MOLECULAR MEDICINE - 04 Aug 2025
Heart failure presents a critical health challenge with a 5-year mortality rate of up to 50%. Conventional treatments often lead to bradycardia or hypotension due to their impact on patient hemodynamics. To address this issue, we utilized high-throughput drug screening combined with structure-activity relationship-based medicinal chemistry to develop a novel drug-like compound that effectively ...
Triage tools to inform the prioritisation of physical health services following a diagnosis of cancer: a scoping review.
SUPPORTIVE CARE IN CANCER : OFFICIAL JOURNAL OF THE MULTINATIONAL ASSOCIATION OF SUPPORTIVE CARE IN CANCER - 06 Aug 2025
Many people face multiple cancer- and treatment-related sequalae. Triage and referral to physical health services can manage such consequences, but a comprehensive understanding of available triage tools is lacking. This review (i) identifies tools used to triage to physical health services, (ii) maps tool characteristics and application outcomes and (iii) summarises existing gaps. A systematic...
The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts.
EBIOMEDICINE - 29 Jul 2025
Preeclampsia is a serious complication of pregnancy. We did an observational study using seven tissue bank/cohorts to examine the association between circulating SIGLEC6 and preeclampsia. We included samples from participants with preterm disease (delivering <34 weeks gestation in Australia), examined whether levels altered with clinical disease severity (samples collected in South Africa) and ...
Recurrent Ventricular Fibrillation Due to Coronary Vasospasm Without Preceding ST-Segment Elevation or Chest Pain.
JACC. CASE REPORTS - 30 Jul 2025
Coronary vasospasm (CV) is a rare cause of malignant ventricular arrhythmia and cardiac arrest. It typically presents with chest pain and marked ST-segment elevation. We present the case of a 61-year-old man with recurrent malignant ventricular arrhythmia and implantable defibrillator shocks without preceding chest pain. The diagnosis of CV remained elusive for 3 months despite extensive invest...
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis.
THE LANCET. PUBLIC HEALTH - 01 Aug 2025
Despite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily steps and health outcomes including all-cause mortality, cardiovascular disease, cancer, type 2 diabetes, cognitive outco...
Targeting renal nerves for arterial hypertension - The path to renal denervation.
AUTONOMIC NEUROSCIENCE : BASIC & CLINICAL - 19 Jun 2025
Renal nerves are critical in regulation of blood pressure and renal function. The concept of renal denervation is based on solid pathophysiologic principles and both experimental and human data. Renal denervation has consistently shown to reduce blood pressure in patients with resistant hypertension and complex to manage blood pressure. This occurs both in the clinical trial environment and in ...
Associations between health literacy, well-being and general health in adults with type 2 diabetes, considering culturally and linguistically diverse background: Results from the first diabetes MILES Australia study.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 17 Jun 2025
To examine the relationships between health literacy, well-being and general health among adults with type 2 diabetes (T2DM) in Australia, overall and separately for those reporting culturally and linguistically diverse (CALD) backgrounds. Data were analyzed from 1962 adults with T2DM (aged 59 ± 9 years; 51% men) from the Diabetes MILES-1 survey. Participants completed the Health Literacy Manag...
Bidirectional relationships between television viewing and loneliness in middle-aged and older men and women.
JOURNAL OF AFFECTIVE DISORDERS - 19 Jun 2025
There is growing evidence that both sedentary behaviour and loneliness have adverse health consequences; however, the potential relationships between sedentary behaviour and loneliness are unclear. Accordingly, we examined the relationship and the directionality of prospective relationships between television (TV) viewing time (a ubiquitous leisure-time sedentary behaviour) and loneliness in mi...
Online tool for cross-sectional and longitudinal comparison of socio-economic status indices based on postcodes in Australia.
INTERNAL MEDICINE JOURNAL - 20 Jun 2025
Socio-economic status (SES) is strongly associated with health outcomes, yet it remains relatively difficult to measure, particularly for longitudinal comparisons. We have developed an interactive online tool (available at bit.ly/SEIFA-POA) that facilitates SES assessment based on postcodes (POA). By utilising percentiles of socio-economic indices for areas (SEIFA) derived from postcode-based r...
Microelectrode recordings from the human cervical vagus nerve during maximal breath-holds.
EXPERIMENTAL PHYSIOLOGY - 11 Jun 2025
Voluntary breath-holds can be sustained for a long time following training, but ultimately, regardless of duration, the asphyxic break-point is reached and the apnoea terminated. The physiological changes occurring during the apnoea include a marked increase in sympathetically-mediated vasoconstriction in non-essential organs, such as skeletal muscle, spleen and kidney, while the brain is prote...
Heart failure hospitalisation from recurrent AF is uncommon following catheter ablation in patients with HFrEF.
HEART RHYTHM - 12 Jun 2025
Heart failure with reduced ejection fraction (HFrEF) in the presence of atrial fibrillation (AF) is common, with concerns AF recurrence will precipitate acute decompensation. However, the impact of AF recurrence following catheter ablation (CA) on HF is not well understood. We sought to examine the clinical outcomes and hospitalisation patterns in AF HFrEF patients following CA. This multicentr...
11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050.
THE LANCET. DIABETES & ENDOCRINOLOGY - 15 Dec 2025
Diabetes is a major global cause of morbidity and mortality. The aim of the 11th edition of the International Diabetes Federation (IDF) Diabetes Atlas is to provide national, regional, and global diabetes prevalence estimates for 2024, with projections to 2050. Diabetes (diagnosed and undiagnosed) prevalence among adults aged 20-79 years was estimated in 215 countries and territories, using 246...
Smartphone Cardiac Rehabilitation, Assisted Self-Management (SCRAM) Versus Usual Care: Multicenter Randomized Controlled Trial.
JMIR MHEALTH AND UHEALTH - 17 Mar 2026
Accessibility barriers contribute to low participation in center-based cardiac rehabilitation. We developed an innovative, comprehensive, dual-phase telerehabilitation program to address this gap (Smartphone Cardiac Rehabilitation, Assisted Self-Management; SCRAM). The study aimed to determine the effectiveness of SCRAM for increasing maximal aerobic exercise capacity (VO2max). A multicenter, p...
Shrunken Pore Syndrome and Risk of Cardiovascular Disease and All-Cause Mortality in Individuals With Type 1 Diabetes With and Without Albuminuria.
DIABETES CARE - 17 Mar 2026
To investigate the association between "shrunken pore syndrome" (SPS), defined as a large discrepancy between estimated glomerular filtration rates based on cystatin C (eGFRcys) and creatinine (eGFRcr), and coronary artery disease (CAD), stroke, peripheral artery disease (PAD), heart failure (HF), and all-cause mortality in individuals with T1D with and without albuminuria. The study comprised ...
Clinical risk score for cardiac death or heart failure hospitalization in moderate aortic stenosis.
ECHO RESEARCH AND PRACTICE - 16 Mar 2026
The association between moderate aortic stenosis (AS) and adverse cardiovascular outcomes is heterogeneous. Outcomes are likely dependent on clinical factors but no formal means of integrating these variables has been defined. This study aims to develop and validate a risk score to predict 5-year cardiac mortality or heart failure (HF)-related hospitalization in moderate AS. This was a retrospe...
Prevalence and Incidence of Type 1 Diabetes Among Children and Adults in the United States and Comparison With Other Countries
ACADEMIC PRESS - 29 Dec 2025
Type 1 diabetes is one of the most common chronic diseases of childhood in the United States, although it can manifest at any age. In 2017, based on data from the SEARCH for Diabetes in Youth study (SEARCH), the overall prevalence of type 1 diabetes among U.S. youth age <20 years was 215 cases per 100,000 population. Type 1 diabetes prevalence was similar by sex but increased with age. In 2017–...
β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction.
NATURE COMMUNICATIONS - 11 Apr 2026
Neutrophils rapidly accumulate in the heart after myocardial infarction (MI), yet bone marrow granulopoiesis peaks later, suggesting an alternative early source. Here we show in male mice that the first wave of neutrophils recruited to the ischemic heart arises from the vascular marginated pool rather than newly generated cells in the bone marrow or spleen. Using hematopoietic stem cell ablatio...
