Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

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Publications
By Year
Now showing items 1-20 of 2514 records
Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet.
Belal Chami; Farjaneh Hossain; Thomas W Hambly; Xiaoping Cai; Roshanak Aran; Genevieve Fong; Abigail Vellajo; Nathan J J Martin; XiaoSuo Wang; Joanne M Dennis; Arpeeta Sharma; Waled A Shihata; Jaye P F Chin-Dusting; Judy B de Haan; Alexandra Sharland; Carolyn L Geczy; Ben Freedman; Paul K Witting
FRONTIERS IN IMMUNOLOGY - 01 Jan 2019
Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE) mice. Male ApoE mice received vehicle (control), low-level lipopolysaccharide (LPS), or recombinant human SAA by . injection every third day for 2 weeks. Heart, ao...
Trends in Incidence of ESKD in People With Type 1 and Type 2 Diabetes in Australia, 2002-2013.
Digsu N Koye; Dianna J Magliano; Christopher M Reid; Meda E Pavkov; Steven J Chadban; Stephen P McDonald; Kevan R Polkinghorne; Sarah White; Christine Paul; Jonathan E Shaw
AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION - 01 Mar 2019
The number of people with diabetes and end-stage kidney disease (ESKD) is increasing worldwide, but it is unknown whether this indicates an increasing risk for ESKD in people with diabetes. We examined temporal trends in the incidence of ESKD within the Australian population with diabetes from 2002 to 2013.Follow-up study using a national health care services registry.Registrants with type 1 or...
Muscle sympathetic nerve activity and hemodynamic responses to venous distension: does sex play a role?
Daniel E Mansur; Monique O Campos; João D Mattos; Adrielle C S Paiva; Marcos P Rocha; Rogerio L R Videira; Vaughan G Macefield; Antonio C L Nóbrega; Igor A Fernandes
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Mar 2019
Peripheral venous distension mechanically stimulates type III/IV sensory fibers in veins and evokes pressor and sympathoexcitatory reflex responses in humans. As young women have reduced venous compliance and impaired sympathetic transduction, we tested the hypothesis that pressor and sympathoexcitatory responses to venous distension may be attenuated in women compared with men. Mean arterial p...
Lipidomic profiling reveals early-stage metabolic dysfunction in overweight or obese humans.
Aya Mousa; Negar Naderpoor; Natalie Mellett; Kirsty Wilson; Magdalena Plebanski; Peter J Meikle; Barbora de Courten
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS - 01 Mar 2019
Advances in mass spectrometry and lipidomics techniques are providing new insights into the role of lipid metabolism in obesity-related diseases. However, human lipidomic studies have been inconsistent, owing to the use of indirect proxy measures of metabolic outcomes and relatively limited coverage of the lipidome. Here, we employed comprehensive lipid profiling and gold-standard metabolic mea...
Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis.
Annas Al-Sharea; Man K S Lee; Alexandra Whillas; Danielle L Michell; Waled A Shihata; Alyce J Nicholls; Olivia D Cooney; Michael J Kraakman; Camilla Bertuzzo Veiga; Ann-Maree Jefferis; Kristy Jackson; Prabhakara R Nagareddy; Gavin Lambert; Connie H Y Wong; Karen L Andrews; Geoff A Head; Jaye Chin-Dusting; Andrew J Murphy
HAEMATOLOGICA - 01 Mar 2019
Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated blood pressure. We aimed to determine how the sympathetic nervous system direct...
Comparison of Magnetic Resonance Analysis of Myocardial Scarring With Biomarker Release Following S-T Elevation Myocardial Infarction.
Benedict T Costello; Dion Stub; James Hare; Andris H Ellims; Xinyu Wang; Karen Smith; Stephen Bernard; Ziad Nehme; Michael Stephenson; Janet E Bray; Peter Cameron; Bill Barger; Ian T Meredith; David M Kaye; Leah Iles; Andrew J Taylor;
HEART, LUNG & CIRCULATION - 01 Mar 2019
Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) is commonly assumed to represent myocardial fibrosis; however, comparative human histological data are limited, and there is no consensus on the most accurate method for LGE quantitation. We evaluated the relationship between CMR assessment of regional fibrosis and infarct size assessment using serial biomarkers after ST el...
Renal nerves contribute to hypertension in Schlager BPH/2J mice.
Cindy Gueguen; Kristy L Jackson; Francine Z Marques; Nina Eikelis; Sarah Phillips; Emily R Stevenson; Fadi J Charchar; Gavin W Lambert; Pamela J Davern; Geoffrey A Head
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 01 Mar 2019
Schlager mice (BPH/2J) are hypertensive due to a greater contribution of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). The kidneys of BPH/2J are hyper-innervated suggesting renal nerves may contribute to the hypertension. We therefore determined the effect of bilateral renal denervation (RD) on hypertension in BPH/2J. Mean arterial pressure (MAP) was measured by radio...
Bariatric Surgery Worldwide: Baseline Demographic Description and One-Year Outcomes from the Fourth IFSO Global Registry Report 2018.
Richard Welbourn; Marianne Hollyman; Robin Kinsman; John Dixon; Ronald Liem; Johan Ottosson; Almino Ramos; Villy Våge; Salman Al-Sabah; Wendy Brown; Ricardo Cohen; Peter Walton; Jacques Himpens
OBESITY SURGERY - 01 Mar 2019
Since 2014, the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) has produced an annual report of all bariatric surgery submitted to the Global Registry. We describe baseline demographics of international practice from the 4th report.The IFSO Global Registry amalgamated data from 51 different countries, 14 of which provided data from their national registries. ...
CXCR4 Antagonism Reduces Cardiac Fibrosis and Improves Cardiac Performance in Dilated Cardiomyopathy.
Po-Yin Chu; Mandar S Joshi; Duncan Horlock; Helen Kiriazis; David M Kaye
FRONTIERS IN PHARMACOLOGY - 01 Jan 2019
Myocardial fibrosis is a key pathologic finding in the failing heart and is implicated as a cause of increased ventricular stiffness and susceptibility to ventricular arrhythmia. Neurohormonal mediators such as aldosterone and angiotensin II are known to cause fibrosis in experimental models, however, clinical evidence for the reversal of fibrosis with relevant antagonists is limited. Recent st...
Comparative analysis reveals a role for TGF-β in shaping the residency-related transcriptional signature in tissue-resident memory CD8+ T cells.
Artika P Nath; Asolina Braun; Scott C Ritchie; Francis R Carbone; Laura K Mackay; Thomas Gebhardt; Michael Inouye
PLOS ONE - 01 Jan 2019
Tissue-resident CD8+ memory T (TRM) cells are immune cells that permanently reside at tissue sites where they play an important role in providing rapid protection against reinfection. They are not only phenotypically and functionally distinct from their circulating memory counterparts, but also exhibit a unique transcriptional profile. To date, the local tissue signals required for their develo...
A Multi-Center Comparison of O Trainability Between Interval Training and Moderate Intensity Continuous Training.2peak
Camilla J Williams; Brendon J Gurd; Jacob T Bonafiglia; Sarah Voisin; Zhixiu Li; Nicholas Harvey; Ilaria Croci; Jenna L Taylor; Trishan Gajanand; Joyce S Ramos; Robert G Fassett; Jonathan P Little; Monique E Francois; Christopher M Hearon; Satyam Sarma; Sylvan L J E Janssen; Emeline M Van Craenenbroeck; Paul Beckers; Véronique A Cornelissen; Nele Pattyn; Erin J Howden; Shelley E Keating; Anja Bye; Dorthe Stensvold; Ulrik Wisloff; Ioannis Papadimitriou; Xu Yan; David J Bishop; Nir Eynon; Jeff S Coombes
FRONTIERS IN PHYSIOLOGY - 01 Jan 2019
There is heterogeneity in the observed O response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study was to combine data from different laboratories to compare O trainability between various volumes of interval training and Moderate Intensity Continuous Training (MICT). For interval training, volume...
Relation of Alcohol Consumption to Left Ventricular Fibrosis Using Cardiac Magnetic Resonance Imaging.
Aleksandr Voskoboinik; Benedict T Costello; Andre La Gerche; Sandeep Prabhu; Geoff Wong; Michael D Flannery; Chrishan Nalliah; Hariharan Sugumar; Fabian Springer; Jonathan M Kalman; Andrew J Taylor; Peter M Kistler
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Feb 2019
Light-to-moderate regular alcohol consumption has been associated with reduced mortality, heart failure, and sudden death, with a well described "U-shaped" relationship. We sought to determine whether markers of diffuse ventricular fibrosis as assessed by cardiac magnetic resonance imaging (CMR) T mapping differ between nondrinkers and regular drinkers. We prospectively recruited 165 participan...
Cardiovascular and other competing causes of death among patients with cancer from 2006 to 2015: An Australian population-based study.
Yuanzi Ye; Petr Otahal; Thomas H Marwick; Karen E Wills; Amanda L Neil; Alison J Venn
CANCER - 01 Feb 2019
With improved cancer survivorship, cardiovascular disease (CVD) and other noncancer events compete with cancer as the underlying cause of death, but the risks of mortality in competing-risk settings have not been well characterized.The authors identified 21,637 individuals who had a first cancer registered between 2006 and 2013, with follow-up to 2015, in the Australian population-based Tasmani...
Acute metabolic and cardiovascular effects of mirabegron in healthy individuals.
Rebecca K C Loh; Melissa F Formosa; Andre La Gerche; Anne T Reutens; Bronwyn A Kingwell; Andrew L Carey
DIABETES, OBESITY & METABOLISM - 01 Feb 2019
To quantify acute energy expenditure, supraclavicular skin temperature and cardiovascular responses to four doses of the β3-adrenoceptor agonist, mirabegron.A total of 17 individuals (11 men, six women) participated in this ascending-dose study, receiving single 50-, 100-, 150- and 200-mg doses of mirabegron on four separate days with 3 to 14 days wash-out between each dose. All variables were ...
Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients.
Erin J Howden; Ashley Bigaran; Rhys Beaudry; Steve Fraser; Steve Selig; Steve Foulkes; Yoland Antill; Sophie Nightingale; Sherene Loi; Mark J Haykowsky; André La Gerche
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 01 Feb 2019
Anthracycline chemotherapy may be associated with decreased cardiac function and functional capacity measured as the peak oxygen uptake during exercise ( peak). We sought to determine (a) whether a structured exercise training program would attenuate reductions in peak and (b) whether exercise cardiac imaging is a more sensitive marker of cardiac injury than the current standard of care resti...
Cardioversion of atrial fibrillation in obese patients: Results from the Cardioversion-BMI randomized controlled trial.
Aleksandr Voskoboinik; Jeremy Moskovitch; George Plunkett; Jason Bloom; Geoffrey Wong; Chrishan Nalliah; Sandeep Prabhu; Hariharan Sugumar; Ramanathan Paramasweran; Alex McLellan; Liang-Han Ling; Cheng-Yee Goh; Samer Noaman; Himawan Fernando; Michael Wong; Andrew J Taylor; Jonathan M Kalman; Peter M Kistler
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 01 Feb 2019
Obesity is associated with higher electrical cardioversion (ECV) failure in persistent atrial fibrillation (PeAF). For ease-of-use, many centers prefer patches over paddles. We assessed the optimum modality and shock vector, as well as the safety and efficacy of the Manual Pressure Augmentation (MPA) technique.Patients with obesity (BMI ≥ 30) and PeAF undergoing ECV using a biphasic defibrillat...
Influence of maternal adiposity, preterm birth and birth weight centiles on early childhood obesity in an Indigenous Australian pregnancy-through-to-early-childhood cohort study.
K G Pringle; Y Q Lee; L Weatherall; L Keogh; C Diehm; C T Roberts; S Eades; A Brown; R Smith; E R Lumbers; L J Brown; C E Collins; K M Rae
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE - 01 Feb 2019
Childhood obesity rates are higher among Indigenous compared with non-Indigenous Australian children. It has been hypothesized that early-life influences beginning with the intrauterine environment predict the development of obesity in the offspring. The aim of this paper was to assess, in 227 mother-child dyads from the Gomeroi gaaynggal cohort, associations between prematurity, Gestation Rela...
Central-to-brachial blood pressure amplification in type 2 diabetes: a systematic review and meta-analysis.
Rachel E Climie; Martin G Schultz; James W Fell; Lorena Romero; Petr Otahal; James E Sharman
JOURNAL OF HUMAN HYPERTENSION - 01 Feb 2019
Due to systolic blood pressure (SBP) amplification, brachial SBP may not accurately reflect central SBP, the pressure the organs are exposed to. Patients with type 2 diabetes (T2D) have vascular irregularities that may affect blood pressure (BP) amplification and central BP indices (i.e. augmentation index [AIx] and augmentation pressure [AP]). By systematic review and meta-analysis, this study...
Accuracy of blood pressure monitoring devices: a critical need for improvement that could resolve discrepancy in hypertension guidelines.
James E Sharman; Thomas H Marwick
JOURNAL OF HUMAN HYPERTENSION - 01 Feb 2019
Hypertension is the most significant modifiable risk factor for cardiovascular disease and contributes to the highest global burden of disease. Blood pressure (BP) measurement is among the most important of all medical tests, and it is critical for BP monitoring devices to be accurate. Comprehensive new evidence from meta-analyses clearly shows that many BP monitoring devices (including oscillo...
Development and validation of a non-invasive assessment tool for screening prevalent undiagnosed diabetes in middle-aged and elderly Chinese.
Jingzhu Wu; Xuhong Hou; Lei Chen; Peizhu Chen; Li Wei; Fusong Jiang; Yuqian Bao; Weiping Jia
PREVENTIVE MEDICINE - 01 Feb 2019
To develop a non-invasive assessment tool and compare it to other assessment tools among middle-aged and elderly Shanghainese, 15,309 individuals, who were 45-70 years old, not previously diagnosed with diabetes, and from a cross-sectional survey conducted between April 2013 and August 2014 in Shanghai, were selected into this study. The participants were randomly assigned to either the explora...
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