Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs.
Its purpose is to make our research findings available to the widest possible audience.
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This open access repository contains the full text of articles, subject to copyright constraints.
Now showing items 1-20 of 3010 records
Prehospital opioid dose and myocardial injury in patients with ST elevation myocardial infarction.
OPEN HEART - 01 Jul 2020
To characterise the relationship between opioid dose and myocardial infarct size in patients with ST elevation myocardial infarction (STEMI).Patients given opioid treatment by emergency medical services with confirmed STEMI were included in this secondary, retrospective cohort analysis of the Air versus Oxygen in Myocardial Infarction (AVOID) study. Patients with cardiogenic shock were excluded...
Left Atrial Strain as a Predictor of New-Onset Atrial Fibrillation in Patients With Heart Failure.
JACC. CARDIOVASCULAR IMAGING - 09 Jul 2020
This study sought to identify whether left atrial strain can predict new-onset atrial fibrillation (NOAF) in patients with heart failure (HF) and sinus rhythm.Both HF and atrial fibrillation have common risk factors, and HF is a risk factor for the development of atrial fibrillation and vice versa.Among 4,312 consecutive patients with acute HF from 3 tertiary hospitals, 2,461 patients with sinu...
Targeting CD83 in mantle cell lymphoma with anti-human CD83 antibody.
CLINICAL & TRANSLATIONAL IMMUNOLOGY - 01 Jan 2020
Effective antibody-drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma. Our objective was to determine CD83 expression on non-Hodgkin lymphoma (NHL) and its therapeutic potential to treat mantle cell lymphoma (MCL) which is currently an incurable NHL.We analysed CD83 expre...
Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas.
CIRCULATION RESEARCH - 17 Jul 2020
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta-analysis, we confirm 4 known macrophage subsets-resident, inflammatory, interferon-inducible cell, and Trem2 (triggering receptor expressed on myeloid cells-2) foamy macrophages-and identify a new macrophage subset resemblin...
Frailty Combined with Loneliness or Social Isolation: An Elevated Risk for Mortality in Later Life.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY - 23 Jul 2020
Frailty, loneliness, and social isolation are all associated with adverse outcomes in older adults, but little is known about their combined impact on mortality.Prospective cohort study.The Longitudinal Aging Study Amsterdam.Community-dwelling older adults aged 65 and older (n = 1,427).Frailty was measured with the frailty phenotype (Fried criteria). Loneliness was assessed with the De Jong Gie...
Antithrombotic Therapy in Myocardial Infarction: Historic Perils and Current Challenges-A 70-Year Journey.
THROMBOSIS AND HAEMOSTASIS - 01 Oct 2020
There have been numerous and intriguing advancements in antithrombotic therapy for myocardial infarction since it was described in the earliest issues of . In this article, we revisit historical breakthroughs and describe the four most challenging contemporary themes relating to antithrombotic therapy in myocardial infarction. In all four, the challenge is to find the best balance of reducing s...