Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

Visit the Baker Institute website for more information on Baker Institute research, lifestyle books and health fact sheets.

Follow our OAR Twitter account to keep in touch with our latest research publications.

This open access repository contains the full text of articles, subject to copyright constraints.

Publications
By Year
Now showing items 1-20 of 2838 records
How urban densification shapes walking behaviours in older community dwellers: a cross-sectional analysis of potential pathways of influence.
Ester Cerin; Anthony Barnett; Casper J P Zhang; Poh-Chin Lai; Cindy H P Sit; Ruby S Y Lee
INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS - 16 Apr 2020
Population growth, population ageing, and urbanisation are major global demographic trends that call for an examination of the impact of urban densification on older adults' health-enhancing behaviours, such as walking. No studies have examined the pathways through which urban densification may affect older adults' walking. This information is key to evidence-based, health-oriented urban and tr...
Independence of coronary artery disease to subclinical left ventricular dysfunction.
Prasanna Venkataraman; Leah Wright; Quan Huynh; Thomas H Marwick
ECHOCARDIOGRAPHY (MOUNT KISCO, N.Y.) - 21 Apr 2020
Epicardial atherosclerosis and heart failure while distinct clinical entities share common pathophysiological features including endothelial dysfunction and inflammation. Presence of subclinical disease could lead to early diagnosis and intervention in the other. The aim of our study was to assess the association between coronary calcium score (CCS), conventional cardiovascular risk factors, an...
Five-year kidney outcomes of bariatric surgery differ in severely obese adolescents and adults with and without type 2 diabetes.
Petter Bjornstad; Edward Nehus; Todd Jenkins; Mark Mitsnefes; Marva Moxey-Mims; John B Dixon; Thomas H Inge
KIDNEY INTERNATIONAL - 01 May 2020
Bariatric surgery improves markers of kidney health in severe obesity, yet it is unclear if kidney disease outcomes differ according to age at surgery. Therefore, we examined health effects of Roux-en-Y gastric bypass between 161 adolescents and 396 adults participating in two related but distinct studies. Primary outcomes were elevated urine albumin-to-creatinine ratio (UACR) of 30 mg/g or mor...
The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications.
Rami A Ballout; Dmitri Sviridov; Michael I Bukrinsky; Alan T Remaley
FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY - 05 May 2020
Drug repurposing is potentially the fastest available option in the race to identify safe and efficacious drugs that can be used to prevent and/or treat COVID-19. By describing the life cycle of the newly emergent coronavirus, SARS-CoV-2, in light of emerging data on the therapeutic efficacy of various repurposed antimicrobials undergoing testing against the virus, we highlight in this review a...
Biology of Lipid Rafts: Introduction to the Thematic Review Series.
Dmitri Sviridov; Yury I Miller
JOURNAL OF LIPID RESEARCH - 01 May 2020
Lipid rafts are organized plasma membrane microdomains, which provide a distinct level of regulation of cellular metabolism and response to extracellular stimuli, affecting a diverse range of physiologic and pathologic processes. This Thematic Review Series focuses on Biology of Lipid Rafts rather than on their composition or structure. The aim is to provide an overview of ideas on how lipid ra...
Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.
David M Kaye; Waled A Shihata; Hamdi A Jama; Kirill Tsyganov; Mark Ziemann; Helen Kiriazis; Duncan Horlock; Amrita Vijay; Beverly Giam; Antony Vinh; Chad Johnson; April Fiedler; Daniel Donner; Matthew Snelson; Melinda T Coughlan; Sarah Phillips; Xiao-Jun Du; Assam El-Osta; Grant Drummond; Gavin W Lambert; Tim D Spector; Ana M Valdes; Charles R Mackay; Francine Z Marques
CIRCULATION - 28 Apr 2020
High blood pressure (BP) continues to be a major, poorly controlled but modifiable risk factor for cardiovascular death. Among key Western lifestyle factors, a diet poor in fiber is associated with prevalence of high BP. The impact of lack of prebiotic fiber and the associated mechanisms that lead to higher BP are unknown. Here we show that lack of prebiotic dietary fiber leads to the developme...
The effect of lifelong endurance exercise on cardiovascular structure and exercise function in women.
Graeme Carrick-Ranson; Nikita M Sloane; Erin J Howden; Paul S Bhella; Satyam Sarma; Shigeki Shibata; Naoki Fujimoto; Jeffrey L Hastings; Benjamin D Levine
THE JOURNAL OF PHYSIOLOGY - 29 Apr 2020
The beneficial effects of sustained or lifelong (>25 years) endurance exercise on cardiovascular structure and exercise function have been largely established in men. The current findings indicate that committed (≥ 4 weekly exercise sessions) lifelong exercise results in substantial benefits in exercise capacity (V̇O max), cardiovascular function at submaximal and maximal exercise, left ventric...
Measurement of Global Myocardial Work with Exercise Testing.
Amera Halabi; Leah Wright; Thomas H Marwick
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 May 2020
Elevated exercise blood pressure in middle-aged women is associated with altered left ventricular and vascular stiffness.
Satyam Sarma; Erin Howden; Graeme Carrick-Ranson; Justin Lawley; Christopher Hearon; Mitchel Samels; Braden Everding; Sheryl Livingston; Beverley Adams-Huet; M Dean Palmer; Benjamin D Levine
JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) - 01 May 2020
Women are at higher risk for developing heart failure with preserved ejection fraction (HFpEF). We examined the utility of peak exercise blood pressure (BP) in identifying preclinical features of HFpEF, namely vascular and cardiac stiffness in middle-aged women. We studied 47 healthy, nonobese middle-aged women (53 ± 5 yr). Oxygen uptake (V̇o) and BP were assessed at rest and maximal treadmill ...
Highlights from the International Society of Hypertension's New Investigators Network during 2019.
Ruan Kruger; Mattias Brunström; Dylan Burger; Fadi Charchar; Rachel Climie; Katrina M Mirabito Colafella; Pablo Kempny; Lyudmila Korostovtseva; Francine Z Marques; Dean Picone; Cesar Romero; Ulrike M Steckelings; Elena Velkoska; Richard Wainford; Brandi M Wynne; Matias G Zanuzzi
JOURNAL OF HYPERTENSION - 01 May 2020
: The New Investigators Committee (NIC) of the International Society of Hypertension (ISH) is a dynamic group of junior doctors and scientists, actively involved in various society activities. This report highlights the events (scientific meetings and summer schools) and activities (social media, mentorship and networking) during 2019 including May Measurement Month and collaborative efforts wi...
White Coat Hypertension-A Case for Assessing Vascular Age?
Rachel E Climie; Elisabeth A Lambert; Markus P Schlaich; Gavin W Lambert
AMERICAN JOURNAL OF HYPERTENSION - 29 Apr 2020
Stand Out in Class: restructuring the classroom environment to reduce sitting time - findings from a pilot cluster randomised controlled trial.
Stacy A Clemes; Daniel D Bingham; Natalie Pearson; Yu-Ling Chen; Charlotte L Edwardson; Rosemary R C McEachan; Keith Tolfrey; Lorraine Cale; Gerry Richardson; Mike Fray; James Altunkaya; Stephan Bandelow; Nishal Bhupendra Jaicim; Jo Salmon; David W Dunstan; Sally E Barber
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 29 Apr 2020
Excessive sedentary behaviour (sitting) is a risk factor for poor health in children and adults. Incorporating sit-stand desks in the classroom environment has been highlighted as a potential strategy to reduce children's sitting time. The primary aim of this study was to examine the feasibility of conducting a cluster randomised controlled trial (RCT) of a sit-stand desk intervention within pr...
COVID-19 and Acute Heart Failure: Screening the Critically Ill - A Position Statement of the Cardiac Society of Australia and New Zealand (CSANZ).
Sean Lal; Christopher S Hayward; Carmine De Pasquale; David Kaye; George Javorsky; Peter Bergin; John J Atherton; Marcus K Ilton; Robert G Weintraub; Priya Nair; Mate Rudas; Lawrence Dembo; Robert N Doughty; Gayathri Kumarasinghe; Craig Juergens; Paul G Bannon; Nicole K Bart; Clara K Chow; Jo-Dee Lattimore; Leonard Kritharides; Richard Totaro; Peter S Macdonald
HEART, LUNG & CIRCULATION - 01 May 2020
Up to one-third of COVID-19 patients admitted to intensive care develop an acute cardiomyopathy, which may represent myocarditis or stress cardiomyopathy. Further, while mortality in older patients with COVID-19 appears related to multi-organ failure complicating acute respiratory distress syndrome (ARDS), the cause of death in younger patients may be related to acute heart failure. Cardiac inv...
Long-term exposure to ambient air pollution is associated with coronary artery calcification among asymptomatic adults.
Quan Huynh; Thomas H Marwick; Prasanna Venkataraman; Luke D Knibbs; Fay H Johnston; Kazuaki Negishi
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 01 May 2020
We investigated the effects of exposure to very low levels of particulate matter <2.5 µm (PM2.5) and nitrogen dioxide (NO2) on coronary calcium score (CCS) in asymptomatic adults who are free of coronary artery disease (CAD).This study included 606 asymptomatic adults (49% men, aged 56±7 years) recruited from communities in three states of Australia during 2017-2018. CCS was measured using coro...
A position statement on screening and management of prediabetes in adults in primary care in Australia.
Kirstine Bell; Jonathan E Shaw; Louise Maple-Brown; Wendy Ferris; Susan Gray; Giuliana Murfet; Rebecca Flavel; Bernie Maynard; Hannah Ryrie; Barry Pritchard; Rachel Freeman; Brett A Gordon
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 May 2020
Prediabetes has a high prevalence, with early detection essential to facilitate optimal management to prevent the development of conditions such as type 2 diabetes and cardiovascular disease. Prediabetes can include impaired fasting glucose, impaired glucose tolerance and elevated HbA1c. This position statement outlines the approaches to screening and management of prediabetes in primary care. ...
Associations of interruptions to leisure-time sedentary behaviour with symptoms of depression and anxiety.
Mats Hallgren; Thi-Thuy-Dung Nguyen; Neville Owen; Davy Vancampfort; Lee Smith; David W Dunstan; Gunnar Andersson; Peter Wallin; Elin Ekblom-Bak
TRANSLATIONAL PSYCHIATRY - 04 May 2020
Interruptions to time spent sitting can ameliorate detrimental metabolic-health consequences of high volumes of sedentary time, but their potential mental health benefits have not been examined. We used the Swedish Health Profile Assessment database, a general health assessment offered to all employees working for companies or organisations connected to occupational and health services. Cross-s...
Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes.
Cindy Gueguen; Sandra L Burke; Benjamin Barzel; Nina Eikelis; Anna M D Watson; Jay C Jha; Kristy L Jackson; Yusuke Sata; Kyungjoon Lim; Gavin W Lambert; Karin A M Jandeleit-Dahm; Mark E Cooper; Merlin C Thomas; Geoffrey A Head
DIABETOLOGIA - 05 May 2020
We determined whether empagliflozin altered renal sympathetic nerve activity (RSNA) and baroreflexes in a diabetes model in conscious rabbits.Diabetes was induced by alloxan, and RSNA, mean arterial pressure (MAP) and heart rate were measured before and after 1 week of treatment with empagliflozin, insulin, the diuretic acetazolamide or the ACE inhibitor perindopril, or no treatment, in conscio...
T mapping performance and measurement repeatability: results from the multi-national T mapping standardization phantom program (T1MES).1
Gabriella Captur; Abhiyan Bhandari; Rüdiger Brühl; Bernd Ittermann; Kathryn E Keenan; Ye Yang; Richard J Eames; Giulia Benedetti; Camilla Torlasco; Lewis Ricketts; Redha Boubertakh; Nasri Fatih; John P Greenwood; Leonie E M Paulis; Chris B Lawton; Chiara Bucciarelli-Ducci; Hildo J Lamb; Richard Steeds; Steve W Leung; Colin Berry; Sinitsyn Valentin; Andrew Flett; Charlotte de Lange; Francesco DeCobelli; Magalie Viallon; Pierre Croisille; David M Higgins; Andreas Greiser; Wenjie Pang; Christian Hamilton-Craig; Wendy E Strugnell; Tom Dresselaers; Andrea Barison; Dana Dawson; Andrew J Taylor; François-Pierre Mongeon; Sven Plein; Daniel Messroghli; Mouaz Al-Mallah; Stuart M Grieve; Massimo Lombardi; Jihye Jang; Michael Salerno; Nish Chaturvedi; Peter Kellman; David A Bluemke; Reza Nezafat; Peter Gatehouse; James C Moon;
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE - 07 May 2020
The T Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T measurement repeatability across centers describing sequence, magnet, and vendor performance.1Phantoms batch-manufactured in August 2015 underwe...
Factors associated with emergency medical service delays in suspected ST-elevation myocardial infarction in Victoria, Australia: A retrospective study.
Ahmad Alrawashdeh; Ziad Nehme; Brett Williams; Karen Smith; Michael Stephenson; Stephen Bernard; Peter Cameron; Dion Stub
EMERGENCY MEDICINE AUSTRALASIA : EMA - 09 May 2020
To assess the effect of patient and system characteristics on emergency medical service (EMS) delays prior to arrival at hospital in suspected ST-elevation myocardial infarction (STEMI).This was a retrospective observational study of 1739 patients who presented with suspected STEMI to the EMS in Melbourne, Australia between October 2011 and January 2014. Our primary outcome measure was call-to-...
Clusterin is regulated by IGF1-PI3K signaling in the heart: implications for biomarker and drug target discovery, and cardiotoxicity.
Sebastian Bass-Stringer; Jenny Y Y Ooi; Julie R McMullen
ARCHIVES OF TOXICOLOGY - 14 Mar 2020
Open-access gene expression data sets provide a useful resource for identifying novel drug targets and biomarkers. The IGF1-PI3K pathway is a critical mediator of physiological cardiac enlargement/hypertrophy and protection. This study arose after mining a gene microarray data set from a previous study that compared heart tissue from cardiac-specific PI3K transgenic mouse models. The top-ranked...
Show more...