Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs.
Its purpose is to make our research findings available to the widest possible audience.
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This open access repository contains the full text of articles, subject to copyright constraints.
Now showing items 1-20 of 3288 records
Prognosis of Severe Low-Flow, Low-Gradient Aortic Stenosis by Stroke Volume Index and Transvalvular Flow Rate.
JACC. CARDIOVASCULAR IMAGING - 10 Mar 2021
This study determined whether flow state classified by stroke volume index (SVi) or transvalvular flow rate (FR) improved risk stratification of all-cause mortality, hospitalization due to heart failure, and aortic valvular interventions for patients with severe aortic stenosis (AS).SVi is a widely accepted classification for flow state in severe low-flow, low-gradient (LFLG) AS. Recent studies...
The influence of aerobic exercise on mitochondrial quality control in skeletal muscle.
THE JOURNAL OF PHYSIOLOGY - 28 Dec 2020
Mitochondria are dynamic organelles, intricately designed to meet cellular energy requirements. To accommodate alterations in energy demand, mitochondria have a high degree of plasticity, changing in response to transient activation of numerous stress-related pathways. This adaptive response is particularly relevant in highly metabolic tissues such as skeletal muscle, where mitochondria support...
A Protocol for Isolation, Purification, Characterization, and Functional Dissection of Exosomes.
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2021
Extracellular vesicles (EVs) are membrane-enclosed vesicles released by cells. They carry proteins, nucleic acids, and metabolites which can be transferred to a recipient cell, locally or at a distance, to elicit a functional response. Since their discovery over 30 years ago, the functional repertoire of EVs in both physiological (e.g., organ morphogenesis, embryo implantation) and pathological...
Prediction of AF in Heart Failure With Preserved Ejection Fraction: Incremental Value of Left Atrial Strain.
JACC. CARDIOVASCULAR IMAGING - 01 Jan 2021
This study sought to identify the factors associated with incident atrial fibrillation (AF) in a well-characterized heart failure with preserved ejection fraction (HFpEF) population, with special focus on left atrial (LA) strain.AF is associated with HFpEF, with adverse consequences. Effective risk evaluation might allow the initiation of protective strategies.Clinical evaluation and echocardio...
The Association of TV Viewing Time with 2-h Plasma Glucose is Modified by a Prudent Dietary Pattern.
JOURNAL OF DIABETES - 05 Jan 2021
TV viewing is associated with elevated plasma glucose, but it's not clear whether such associations can be modified by dietary patterns.We examined the interactions of TV viewing time and dietary patterns in relation to fasting and 2-h plasma glucose. Cross-sectional analyses were performed among participants (n= 3081; 44.7% male; mean age 57.8 years) from the 2011-2012 Australian Diabetes, Obe...