Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 5325 records
Glycaemic control and its related factors among people with type 2 diabetes in low- and middle-income countries: a systematic review and meta-analysis.
FRONTIERS IN CLINICAL DIABETES AND HEALTHCARE - 01 Jan 2025
To estimate the prevalence of inadequate glycaemic control and identify factors associated with it among people with type 2 diabetes mellitus (T2DM) living in low- and middle-income countries (LMICs). A systematic literature search was conducted in the Medline, Embase, CINAHL, PsychINFO, and Global Health databases for articles published between 1 January 2001 and 15 April 2025. Information was...
Cohort profile: The Multiethnic Lifestyle, Obesity and Diabetes Registry in Malaysia (MeLODY) retrospective cohort in a middle-income country in Southeast Asia.
PLOS ONE - 01 Jan 2025
There is a lack of longitudinal data on type 2 diabetes (T2D) in low- and middle-income countries. We leveraged the electronic health records (EHR) system of a publicly funded academic institution to establish a retrospective cohort with longitudinal data to facilitate benchmarking, surveillance, and resource planning of a multi-ethnic T2D population in Malaysia. This cohort included 15,702 adu...
Proportions and trends of global adolescent knowledge and attitudes toward tobacco smoking from 1999 to 2019.
FRONTIERS IN PUBLIC HEALTH - 01 Jan 2025
We aimed to assess the recent levels of knowledge and attitudes toward tobacco smoking among adolescents aged 12-16 years in 2010-2019, and to examine trends from 1999 to 2019. We used the most recent data from 145 countries/territories (hereafter "countries") that conducted at least one Global Youth Tobacco Survey (GYTS) between 2010 and 2019 to assess the current levels of knowledge and attit...
Paired blood and brain tissue methylation biomarkers in focal cortical dysplasia.
BRAIN COMMUNICATIONS - 01 Jan 2025
Focal Cortical Dysplasia (FCD) is a common cause of drug-resistant epilepsy. These abnormalities arise during embryonic development and are challenging to classify due to their complex nature. The most recent classification update of FCD incorporates genetic and epigenetic results with other clinical data for the management of epilepsy associated with these lesions. Mutations in the mechanistic...
Cardiometabolic Biomarkers and Prediction of Kidney Disease Progression: The eGFR Cohort Study.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE - 01 Jan 2025
Traditional markers modestly predict chronic kidney disease progression in Aboriginal and Torres Strait Islander people. Therefore, we assessed associations of cardiometabolic and inflammatory clinical biomarkers with kidney disease progression among Aboriginal and Torres Strait Islander people with and without diabetes. To identify cardiometabolic and inflammatory clinical biomarkers that pred...
C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2025
T cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection. Monomeric CRP (mCRP) is a known modulator of inflammation and particularly the innate immune response, however its interaction with T cells as part of the adaptive immune response rema...
Lymphatic uptake and pharmacokinetics of lipid conjugated brush PEG polymers is altered by interactions with albumin and lipoproteins.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2025
Increased recognition of the role of lymphatics in disease has brought increased focus on the design of lymph-directed delivery systems for imaging agents and therapeutics. Previously, we developed novel brush polyethylene glycol (PEG) polymers functionalized with different lipids and investigated their lymphatic uptake, plasma pharmacokinetics and tissue biodistribution. Diacylglycerol-conjuga...
Editorial: Targeting the interleukin-1β/interleukin-6/C-reactive protein pathway in clinical medicine - a road map to clinical trial design.
FRONTIERS IN CARDIOVASCULAR MEDICINE - 01 Jan 2025
C-reactive protein: the nexus between inflammation and protein misfolding diseases.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2025
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form called pCRP. Upon interaction with activated cell membranes, pCRP undergoes a transitional conformation change into activated pCRP (pCRP*) and...
Human Fcγ-receptors selectively respond to C-reactive protein isoforms.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2025
The pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ-receptors (FcγRs). Members of the FcγR family are characterized by the recognition of the Fc part of IgG antibodies. We utilized a mouse thymoma BW5147 reporter c...
The effectiveness of lifestyle interventions in reducing cardiovascular risk and risk factors in people with prediabetes: A systematic review and meta-analysis.
NUTRITION, METABOLISM, AND CARDIOVASCULAR DISEASES : NMCD - 15 May 2025
This systematic review and meta-analysis examined the effectiveness of lifestyle interventions in reducing cardiovascular disease (CVD) risk, CVD events, and related risk factors among individuals with prediabetes. We conducted a search of the MEDLINE, Embase, PsycINFO, CENTRAL, and Scopus databases, along with ClinicalTrials.gov, for lifestyle-based randomized controlled trials (RCTs) involvin...
Cardiovascular imaging in 2024: review of current research and innovations.
EUROPEAN HEART JOURNAL. IMAGING METHODS AND PRACTICE - 01 Jan 2025
Cardiovascular imaging saw significant advancements in 2024, impacting technology, pathophysiology, and clinical applications. This review provides a comprehensive summary of the most impactful research in cardiovascular imaging published in 2024, highlighting technological advancements, as well as research on ischaemic heart disease, valvular heart disease, cardiomyopathies, and heart failure....
Relationship between tobacco use and body mass index- a propensity score matching analysis of an indian National Survey.
PLOS ONE - 01 Jan 2025
Tobacco and obesity control is among the major health priorities. Previous studies have mixed opinions about their association. The present study was done to investigate the association between Body Mass Index (BMI) and tobacco use (smokers, smokeless tobacco users and dual users) among Indian adults. Secondary analysis of the fifth National Family Health Survey (2019-21) was conducted that inc...
Repurposed Nrf2 activator dimethyl fumarate rescues muscle inflammation and fibrosis in an aggravated mdx mouse model of Duchenne muscular dystrophy.
REDOX BIOLOGY - 14 May 2025
In inherited neuromuscular disease, Duchenne muscular dystrophy (DMD), glucocorticoids significantly slow disease progression yet impart side effects severe enough to preclude use in a significant proportion of patients. Extending our findings that acute treatment with FDA approved multiple sclerosis drug, dimethyl fumarate (DMF), rescues muscle pathology in juvenile mdx mice, we aimed to condu...
Design and Rationale of 'A pragmatic approach to the investigation of stable chest pain: a UK, multi-centre, randomised trial to assess patient outcomes, quality of life and cost effectiveness (CE-MARC 3)'.
AMERICAN HEART JOURNAL - 15 May 2025
The optimal non-invasive diagnostic imaging strategy for patients with suspected coronary artery disease (CAD) is widely debated. Computed Tomography Coronary Angiography (CTCA) and functional imaging are both guideline-recommended, although comparative effectiveness in patients with intermediate-high pre-test likelihood (PTL) is limited. Primary Hypothesis: We aim to establish if a personalise...
Markers of Early Liver Dysfunction Associate With Reduced Heart Rate Variability in Adolescents With Type 1 Diabetes.
PEDIATRIC DIABETES - 01 Jan 2025
<b>Aim:</b> Data on the impact of metabolic dysfunction-associated fatty liver disease (MAFLD) on diabetes complications in youth with type 1 diabetes are lacking. However, MAFLD is well known to contribute to cardiovascular disease (CVD) in people with type 2 diabetes. We aimed to investigate markers of MAFLD in youth with type 1 diabetes and their relationship with chronic complications. <b>M...
Effort Minimization and the Built Environment: Public Health Implications.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 09 May 2025
Promoting physical activity represents a major public health opportunity due to its significant impact on physical and mental health. Despite ongoing efforts, public health interventions often struggle to achieve sustainable behavioral changes. Instead of explicitly or implicitly attributing such failures to a lack of individual motivation, it is essential to consider the characteristics of con...
Influence of repeated plaque visualization on cardiovascular risk reduction after 3 years: a randomized controlled trial.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 12 May 2025
Helping people to understand their cardiovascular (CV) risk can influence the choices they make for risk reduction, including medication adherence and lifestyle modification. This study sought whether repeated visualization of coronary artery calcium (CAC) images was effective in sustaining long-term risk control in primary prevention, independent of a risk reduction programme. Asymptomatic, st...
Cell Type-Specific Secretome Analysis Reveals Liver-Heart Crosstalk in HFpEF.
CIRCULATION RESEARCH - 12 May 2025
Psychological and behavioural considerations for integrating polygenic risk scores for disease into clinical practice.
NATURE HUMAN BEHAVIOUR - 12 May 2025
A polygenic risk score (PRS) summarizes in one number an individual's estimated genetic association with a specific trait or disease based on the common DNA variants included in the score. Disease PRSs have the potential to positively affect population health by improving disease risk prediction, thereby also potentially improving disease prevention, early intervention and treatment. However, g...
