Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

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Publications
By Year
Now showing items 1-20 of 2789 records
Potential Therapeutic Use of Neurosteroids for Hypertension.
Geoffrey A Head; Kristy L Jackson; Cindy Gueguen
FRONTIERS IN PHYSIOLOGY - 01 Jan 2019
The sympathetic nervous system (SNS) contribution to long-term setting of blood pressure (BP) and hence hypertension has been a continuing controversy over many decades. However, the contribution of increased sympathetic vasomotor tone to the heart, kidney, and blood vessels has been suggested as a major influence on the development of high BP which affects 30-40% of the population. This is rel...
Management of heart failure with preserved ejection fraction.
Emma Gard; Shane Nanayakkara; David Kaye; Harry Gibbs
AUSTRALIAN PRESCRIBER - 01 Feb 2020
SGLT2 Inhibitor-Induced Sympathoinhibition: A Novel Mechanism for Cardiorenal Protection.
Lakshini Y Herat; Aaron L Magno; Caroline Rudnicka; Jana Hricova; Revathy Carnagarin; Natalie C Ward; Angelique Arcambal; Marcio G Kiuchi; Geoff A Head; Markus P Schlaich; Vance B Matthews
JACC. BASIC TO TRANSLATIONAL SCIENCE - 01 Feb 2020
Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical denervation in neurogenic hypertensive Schlager (BPH/2J) mice reduced blood pressure, improved glucose homeostasis, and reduced renal SGLT2 protein expression. Inhibition of SGLT2 prevented weight gain, reduced blood pressure, significantly reduce...
HTLV-1c associated bronchiolitis in an Aboriginal man from central Australia.
Fabian Chiong; Hubertus Jersmann; Kim Wilson; Lloyd Einsiedel
IDCASES - 01 Jan 2020
We describe the first case of HTLV associated bronchiolitis to be associated with HTLV-1c subtype infection. An Aboriginal man with HTLV-1 infection was repeatedly admitted to Alice Springs Hospital, central Australia, with hypercapnic respiratory failure from the age of 28 years. High resolution CT chest findings were consistent with bronchiolitis and large numbers of lymphocytes were found in...
Apolipoprotein A-I concentrations and risk of coronary artery disease: A Mendelian randomization study.
Minna K Karjalainen; Michael V Holmes; Qin Wang; Olga Anufrieva; Mika Kähönen; Terho Lehtimäki; Aki S Havulinna; Kati Kristiansson; Veikko Salomaa; Markus Perola; Jorma S Viikari; Olli T Raitakari; Marjo-Riitta Järvelin; Mika Ala-Korpela; Johannes Kettunen
ATHEROSCLEROSIS - 14 Feb 2020
Apolipoprotein A-I (apoA-I) infusions represent a potential novel therapeutic approach for the prevention of coronary artery disease (CAD). Although circulating apoA-I concentrations inversely associate with risk of CAD, the evidence base of this representing a causal relationship is lacking. The aim was to assess the causal role of apoA-I using human genetics.We identified a variant (rs1222523...
[Lancet Commission on Hypertension Group position statement on the global improvement of accuracy standards for devices that measure blood pressurePosicionamento do Grupo da sobre a melhoria global dos padrões de acurácia para aparelhos que medem a pressão arterial].Lancet Commission on Hypertension
James E Sharman; Eoin O'Brien; Bruce Alpert; Aletta E Schutte; Christian Delles; Michael Hecht Olsen; Roland Asmar; Neil Atkins; Eduardo Barbosa; David Calhoun; Norm R C Campbell; John Chalmers; Ivor Benjamin; Garry Jennings; Stéphane Laurent; Pierre Boutouyrie; Patricio Lopez-Jaramillo; Richard J McManus; Anastasia S Mihailidou; Pedro Ordunez; Raj Padwal; Paolo Palatini; Gianfranco Parati; Neil Poulter; Michael K Rakotz; Clive Rosendorff; Francesca Saladini; Angelo Scuteri; Weimar Sebba Barroso; Myeong-Chan Cho; Ki-Chul Sung; Raymond R Townsend; Ji-Guang Wang; Tine Willum Hansen; Gregory Wozniak; George Stergiou;
REVISTA PANAMERICANA DE SALUD PUBLICA = PAN AMERICAN JOURNAL OF PUBLIC HEALTH - 01 Jan 2020
The Lancet Commission on Hypertension identified that a key action to address the worldwide burden of high blood pressure (BP) was to improve the quality of BP measurements by using BP devices that have been validated for accuracy. Currently, there are over 3 000 commercially available BP devices, but many do not have published data on accuracy testing according to established scientific standa...
Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy.
Matthew Snelson; Sih Min Tan; Gavin C Higgins; Runa S J Lindblom; Melinda T Coughlan
AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY - 01 Mar 2020
Alterations in gut homeostasis may contribute to the progression of diabetic nephropathy. There has been recent attention on the renoprotective effects of metabolite-sensing receptors in chronic renal injury, including the G protein-coupled receptor (GPR)109a, which ligates the short-chain fatty acid butyrate. However, the role of GPR109a in the development of diabetic nephropathy, a milieu of ...
Weight Loss and Health Status 5 Years After Adjustable Gastric Banding in Adolescents.
Lindel C Dewberry; Anahita Jalivand; Resmi Gupta; Todd M Jenkins; Andrew Beamish; Thomas H Inge; Anita Courcoulas; Michael Helmrath; Mary L Brandt; Carroll M Harmon; Mike Chen; John B Dixon; Margaret Zeller; Marc P Michalsky
OBESITY SURGERY - 02 Mar 2020
This prospective cohort analysis describes changes in weight, cardiometabolic health, and weight-related quality of life (WRQOL) following adolescent LAGB.Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) collected demographic, anthropometric, micronutrient, cardiometabolic risk, and WRQOL data for 242 adolescents. Data through 5 years were analyzed for 14 participants who underwent...
Defining the Progression of Diabetic Cardiomyopathy in a Mouse Model of Type 1 Diabetes.
Miles J De Blasio; Nguyen Huynh; Minh Deo; Leslie E Dubrana; Jesse Walsh; Andrew Willis; Darnel Prakoso; Helen Kiriazis; Daniel G Donner; John C Chatham; Rebecca H Ritchie
FRONTIERS IN PHYSIOLOGY - 01 Jan 2020
The incidence of diabetes and its association with increased cardiovascular disease risk represents a major health issue worldwide. Diabetes-induced hyperglycemia is implicated as a central driver of responses in the diabetic heart such as cardiomyocyte hypertrophy, fibrosis, and oxidative stress, termed diabetic cardiomyopathy. The onset of these responses in the setting of diabetes has not be...
Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.
Matthias Arnold; Kwangsik Nho; Alexandra Kueider-Paisley; Tyler Massaro; Kevin Huynh; Barbara Brauner; Siamak MahmoudianDehkordi; Gregory Louie; M Arthur Moseley; J Will Thompson; Lisa St John-Williams; Jessica D Tenenbaum; Colette Blach; Rui Chang; Roberta D Brinton; Rebecca Baillie; Xianlin Han; John Q Trojanowski; Leslie M Shaw; Ralph Martins; Michael W Weiner; Eugenia Trushina; Jon B Toledo; Peter J Meikle; David A Bennett; Jan Krumsiek; P Murali Doraiswamy; Andrew J Saykin; Rima Kaddurah-Daouk; Gabi Kastenmüller
NATURE COMMUNICATIONS - 02 Mar 2020
Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting stratified association analyses of 139 serum metabolites in 1,517 individuals from the AD Neuroi...
Targeting Treatment Refractory NET by EZH2 Inhibition in Postural Tachycardia Syndrome.
Harikrishnan Kaipananickal; Abdul Waheed Khan; Susan J Corcoran; Murray D Esler; Jun Okabe; Assam El-Osta
CIRCULATION RESEARCH - 03 Mar 2020
Joint international consensus statement for ending stigma of obesity.
Francesco Rubino; Rebecca M Puhl; David E Cummings; Robert H Eckel; Donna H Ryan; Jeffrey I Mechanick; Joe Nadglowski; Ximena Ramos Salas; Phillip R Schauer; Douglas Twenefour; Caroline M Apovian; Louis J Aronne; Rachel L Batterham; Hans-Rudolph Berthoud; Camilo Boza; Luca Busetto; Dror Dicker; Mary De Groot; Daniel Eisenberg; Stuart W Flint; Terry T Huang; Lee M Kaplan; John P Kirwan; Judith Korner; Ted K Kyle; Blandine Laferrère; Carel W le Roux; LaShawn McIver; Geltrude Mingrone; Patricia Nece; Tirissa J Reid; Ann M Rogers; Michael Rosenbaum; Randy J Seeley; Antonio J Torres; John B Dixon
NATURE MEDICINE - 04 Mar 2020
People with obesity commonly face a pervasive, resilient form of social stigma. They are often subject to discrimination in the workplace as well as in educational and healthcare settings. Research indicates that weight stigma can cause physical and psychological harm, and that affected individuals are less likely to receive adequate care. For these reasons, weight stigma damages health, underm...
Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes.
Jonathan R Davey; Emma Estevez; Rachel E Thomson; Martin Whitham; Kevin I Watt; Adam Hagg; Hongwei Qian; Darren C Henstridge; Helen Ludlow; Mark P Hedger; Sean L McGee; Melinda T Coughlan; Mark A Febbraio; Paul Gregorevic
FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY - 05 Mar 2020
Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating pancreatic β-cell function. The pro-inflammatory factor Activin has been implicated as a positive correlate of severity in T2D patients, and as a negative regulator of glucose uptake by skeletal muscle, and of pancreatic β-cell phenotype in mice. Accordingly, we sought t...
Enhanced Cardiac Phosphoinositide 3-Kinase (p110α) using Gene Therapy Attenuates Cardiac Remodeling in Type 2 Diabetic Mice.
Darnel Prakoso; Miles J De Blasio; Mitchel Tate; Helen Kiriazis; Daniel G Donner; Hongwei Qian; David Nash; Minh Deo; Kate L Weeks; Laura J Parry; Paul Gregorevic; Julie R McMullen; Rebecca Helen Ritchie
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 06 Mar 2020
Diabetic cardiomyopathy is a distinct form of heart disease that represents a major cause of death and disability in diabetic patients, particularly the more prevalent type-2 diabetic population. In the current study, we investigated administration of recombinant adeno-associated viral vectors carrying a constitutively-active PI3K(p110α) construct (rAAV6-caPI3K) at a clinically-relevant time po...
Effect of Salt Supplementation on Sympathetic Activity and Endothelial Function in Salt-Sensitive Type 2 Diabetes.
Sara Baqar; Yee Wen Kong; Angela X Chen; Christopher O'Callaghan; Richard J MacIsaac; Maree Bouterakos; Gavin W Lambert; George Jerums; Elisabeth E Lambert; Elif I Ekinci
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 01 Apr 2020
Lower sodium intake is paradoxically associated with higher mortality in type 2 diabetes (T2D).To determine whether sympathetic nervous system (SNS) activation and endothelial dysfunction contribute to these observations, we examined the effect of salt supplementation on these systems in people with T2D with habitual low sodium. We hypothesized that salt supplementation would lower SNS activity...
Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice.
Maria Jelinic; Nicola Kahlberg; Chen Huei Leo; Hooi Hooi Ng; Sarah Rosli; Minh Deo; Mandy Li; Siobhan Finlayson; Jesse Walsh; Laura J Parry; Rebecca H Ritchie; Cheng Xue Qin
BRITISH JOURNAL OF PHARMACOLOGY - 01 Apr 2020
Arterial stiffness, a characteristic feature of diabetes, increases the risk of cardiovascular complications. Potential mechanisms that promote arterial stiffness in diabetes include oxidative stress, glycation and inflammation. The anti-inflammatory protein annexin-A1 has cardioprotective properties, particularly in the context of ischaemia. However, the role of endogenous annexin-A1 in the va...
May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension.
Thomas Beaney; Michael A Weber; Ji-Guang Wang; Rhian Touyz; Maciej Tomaszewski; Aletta E Schutte; Markus P Schlaich; Agustin J Ramirez; Dorairaj Prabhakaran; Peter M Nilsson; Ruan Kruger; Albertino Damasceno; Suzie Cro; Fadi J Charchar; Rafael R Castillo; Louise M Burrell; Neil R Poulter; Melinda Carrington
EUROPEAN HEART JOURNAL - 01 Jul 2019
Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and c...
CODE RED: Overturning Australia’s cholesterol complacency.
Melinda Carrington; T Cao; M Moodie; L Gao; Stephanie R Yiallourou; Tom Marwick
BAKER HEART AND DIABETES INSTITUTE - 01 Feb 2020
Baker Heart and Diabetes Institute, Melbourne, Australia
Principles of Hormone / Behavior Relations
DW Pfaff; RT Rubin; J Schneider; Geoff A Head
23 Jan 2018
Elsevier Academic Press Principles of Hormone/Behavior Relations, Second Edition, provides an introduction to the underlying principles of endocrine regulation of behavior, a newly emerging area of research within neurobiology and endocrinology. It addresses the properties of hormone/behavior relations, including the influence of family background, timing issues, neuroanatomical features, cellu...
Off-target drug effects on platelet function: Protecting an Achilles heel of drug development
Karlheinz Peter; Himawan Fernando; James D McFadyen
CURRENT OPINION IN TOXICOLOGY - 01 Oct 2019
The development of new drugs is often limited or even halted by their side effects on platelet number or function. This review introduces the signalling pathways and the role of various platelet receptors, such as GPIIb/IIIa, GPIb-IX-V, GPVI and P-selectin. The large scope of platelet function tests are described, including aggregometry, flow cytometry, VerifyNow, adhesion and in vivo thrombosi...
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