Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

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Publications
By Year
Now showing items 1-20 of 2676 records
Proteomic Insights into Endometrial Receptivity and Embryo-Endometrial Epithelium Interaction for Implantation; Critical Determinants of Fertility.
Jemma Evans; Jennifer Hutchison; Lois A Salamonsen; David W Greening
PROTEOMICS - 11 Dec 2019
In vitro fertilization has overcome infertility issues for many couples. However, achieving implantation of a viable embryo into the maternal endometrium remains a limiting step in optimizing pregnancy success. The molecular mechanisms which characterize the transient state of endometrial receptivity, critical in enabling embryo-endometrial interactions, and proteins which underpin adhesion at ...
Fears of a Big Bang for Rugby Players, Urgent Validation Required.
André La Gerche; Aaron L Baggish; Ben D Levine; Paul D Thompson
HEART, LUNG & CIRCULATION - 11 Dec 2019
Epicardial and subcutaneous adipose tissue in Indigenous and non-Indigenous individuals: Implications for cardiometabolic diseases.
David F Sun; Nadarajah Kangaharan; Benedict Costello; Stephen J Nicholls; Connor A Emdin; Rexson Tse; Celine Gallagher; Amrina Kaur; Kurt C Roberts-Thomson; Rajiv Mahajan; Dennis H Lau; Prashanthan Sanders; Christopher X Wong
OBESITY RESEARCH & CLINICAL PRACTICE - 12 Dec 2019
Obesity is prevalent in Indigenous populations who exhibit significant differences in body fat composition. While excess regional adiposity can be partially inferred from clinical measurements, noninvasive imaging allows for direct quantification of specific fat depots. Epicardial fat is a visceral adipose tissue that has been strongly associated with cardiometabolic disease in other population...
Polygenic risk scores and the prediction of common diseases.
Mika Ala-Korpela; Michael V Holmes
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 12 Dec 2019
Sympathetic activation in congestive heart failure: an updated overview.
Guido Grassi; Fosca Quarti-Trevano; Murray D Esler
HEART FAILURE REVIEWS - 12 Dec 2019
Conclusive evidence demonstrates that the sympathetic nervous system activation is a hallmark of congestive heart failure. This has been shown via a variety of biochemical, neurophysiological, and neuroimaging approaches for studying human sympathetic neural function. The sympathetic activation appears to be an early phenomenon in the clinical course of the disease, closely related to its sever...
Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium.
Fabian J Brunner; Christoph Waldeyer; Francisco Ojeda; Veikko Salomaa; Frank Kee; Susana Sans; Barbara Thorand; Simona Giampaoli; Paolo Brambilla; Hugh Tunstall-Pedoe; Marie Moitry; Licia Iacoviello; Giovanni Veronesi; Guido Grassi; Ellisiv B Mathiesen; Stefan Söderberg; Allan Linneberg; Hermann Brenner; Philippe Amouyel; Jean Ferrières; Abdonas Tamosiunas; Yuriy P Nikitin; Wojciech Drygas; Olle Melander; Karl-Heinz Jöckel; David M Leistner; Jonathan E Shaw; Demosthenes B Panagiotakos; Leon A Simons; Maryam Kavousi; Ramachandran S Vasan; Robin P F Dullaart; S Goya Wannamethee; Ulf Risérus; Steven Shea; James A de Lemos; Torbjørn Omland; Kari Kuulasmaa; Ulf Landmesser; Stefan Blankenberg;
LANCET (LONDON, ENGLAND) - 14 Dec 2019
The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term probabilities for...
Sex differences in heart failure.
Carolyn S P Lam; Clare Arnott; Anna L Beale; Chanchal Chandramouli; Denise Hilfiker-Kleiner; David M Kaye; Bonnie Ky; Bernadet T Santema; Karen Sliwa; Adriaan A Voors
EUROPEAN HEART JOURNAL - 14 Dec 2019
The overall lifetime risk of heart failure (HF) is similar between men and women, however, there are marked sex differences in the landscape of this condition that are both important and under-recognized. Men are predisposed to HF with reduced ejection fraction (HFrEF), whereas women predominate in HF with preserved ejection fraction (HFpEF). Sex differences are also notable in the penetrance o...
Assessment of Predictors of Left Atrial Volume Response to a Transcatheter InterAtrial Shunt Device (from the REDUCE LAP-HF Trial).
Thomas C Hanff; David M Kaye; Christopher S Hayward; Martijn C Post; Filip Malek; Gerd Hasenfuβ; Finn Gustafsson; Daniel Burkhoff; Sanjiv J Shah; Sheldon E Litwin; Rami Kahwash; Scott L Hummel; Barry A Borlaug; Scott D Solomon; Carolyn S P Lam; Jan Komtebedde; Frank E Silvestry;
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Dec 2019
In patients with heart failure and preserved or mildly reduced ejection fractions (EF ≥40%), implantation of an interatrial shunt device (IASD) resulted in heterogenous changes of the left atrial (LA) volume. Baseline characteristics that correlate with a favorable decrease in LA volume are unknown. We hypothesized that a larger ratio of left to right atrial volume at baseline would correlate s...
The Australia and New Zealand Cardio-Oncology Registry (ACOR): evaluation of chemotherapy-related cardiotoxicity in a national cohort of paediatric cancer patients.
Daniel Lapirow; Andre La Gerche; Claudia Toro; Emma Masango; Ben Costello; Enzo Porello; Louise Ludlow; Glenn Marshall; Toby Trahair; Marion Mateos; Jeremy Lewin; Jennifer Byrne; Rose Boutros; Rebecca Manudhane; John Heath; Julian Ayer; Melissa Gabriel; Thomas Walwyn; Jelena Saundankar; Jonathon Forsey; Ha Le; Kylie Mason; David Celermajer; Peter Downie; Roderick Walker; Lucy Holland; Michelle Martin; Lorna McLeman; Yonatan Diamond; Maurizio Marcocci; Susan Donath; Michael Cheung; David A Elliott; Rachel Conyers
INTERNAL MEDICINE JOURNAL - 16 Dec 2019
Cancer therapy related cardiac dysfunction (CTRCD) is an area of increasing focus, particularly during the survivorship period, for paediatric, adolescent and adult cancer survivors. With the advent of immunotherapy and targeted therapy, there is a new set of mechanisms from which paediatric and young adult patients with cancer may suffer cardiovascular injury. Furthermore, cardiovascular disea...
Gal-3 (Galectin-3) and K3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation.Ca
Gang She; Meng-Chen Hou; Yu Zhang; Yi Zhang; Yan Wang; Hui-Fang Wang; Bao-Chang Lai; Wei-Bo Zhao; Xiao-Jun Du; Xiu-Ling Deng
HYPERTENSION (DALLAS, TEX. : 1979) - 16 Dec 2019
Heart failure is associated with sympatho-βAR (β-adrenoceptor) activation and cardiac fibrosis. Gal-3 (galectin-3) and K3.1 channels that are upregulated in diverse cells of diseased heart are implicated in mediating myocardial inflammation and fibrosis. It remains unclear whether Gal-3 interacts with K3.1 leading to cardiac fibrosis in the setting of βAR activation. We tested the effect of K3....
Left atrial strain: a multi-modality, multi-vendor comparison study.
Faraz Pathan; Hafisyatul Aiza Zainal Abidin; Quang Ha Vo; Hui Zhou; Tommaso D'Angelo; Elen Elen; Kazuaki Negishi; Valentina O Puntmann; Thomas H Marwick; Eike Nagel
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 17 Dec 2019
Left atrial (LA) strain is a prognostic biomarker with utility across a spectrum of acute and chronic cardiovascular pathologies. There are limited data on intervendor differences and no data on intermodality differences for LA strain. We sought to compare the intervendor and intermodality differences between transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) derived LA s...
Cardiac Amyloidosis: Is This the Tip of the Iceberg?
James L Hare
JACC. CARDIOVASCULAR IMAGING - 18 Dec 2019
Can Quantitative CMR Tissue Characterization Adequately Identify Cardiotoxicity During Chemotherapy?: Impact of Temporal and Observer Variability.
Mustafa A Altaha; Mark Nolan; Thomas H Marwick; Emily Somerset; Christian Houbois; Eitan Amir; Paul Yip; Kim A Connelly; Maria Michalowska; Marshall S Sussman; Bernd J Wintersperger; Paaladinesh Thavendiranathan
JACC. CARDIOVASCULAR IMAGING - 18 Dec 2019
The purpose of this study was to investigate the effect of the temporal and observer variability of cardiac magnetic resonance (CMR)-measured native T, T, and extracellular volume fraction (ECV) and serum biomarkers for the detection of cancer-therapeutics-related cardiac dysfunction (CTRCD).1Biomarkers and serial quantitative CMR tissue characterization may help identify early myocardial chang...
Merkel Cell Carcinoma Update: The Case for Two Tumours.
A Nirenberg; H Steinman; J Dixon; A Dixon
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY : JEADV - 19 Dec 2019
Merkel cell carcinoma (MCC) is an aggressive tumour with neuroendocrine differentiation. Clinically significant differences within the entity we know as MCC are apparent. This review aims to evaluate the evidence for differences in tumours within Merkel cell carcinoma and to stratify these. A literature search of research pertaining to various characteristics MCC was undertaken from 1972, when ...
Arrhythmia recurrence is more common in females undergoing multiple catheter ablation procedures for persistent atrial fibrillation: Time to close the gender gap.
Hariharan Sugumar; Shane Nanayakkara; David Chieng; Geoffrey R Wong; Ramanathan Parameswaran; Robert D Anderson; Ahmed Al-Kaisey; Chrishan J Nalliah; Sonia Azzopardi; Sandeep Prabhu; Aleksandr Voskoboinik; Geoffrey Lee; Alex J McLellan; Liang-Han Ling; Joseph B Morton; Jonathan M Kalman; Peter M Kistler
HEART RHYTHM - 19 Dec 2019
Female gender is associated with an increase in recurrence of atrial fibrillation (AF) following catheter ablation (CA). Although AF is more common in men, women make up a significant proportion with persistent AF (PsAF).To determine if multiple ablation procedures improves arrhythmia outcomes in females with PsAF compared to men.We performed a multicentre observational study to determine the l...
Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.
Johannes Kettunen; Michael V Holmes; Elias Allara; Olga Anufrieva; Pauli Ohukainen; Clare Oliver-Williams; Qin Wang; Therese Tillin; Alun D Hughes; Mika Kähönen; Terho Lehtimäki; Jorma Viikari; Olli T Raitakari; Veikko Salomaa; Marjo-Riitta Järvelin; Markus Perola; George Davey Smith; Nish Chaturvedi; John Danesh; Emanuele Di Angelantonio; Adam S Butterworth; Mika Ala-Korpela
PLOS BIOLOGY - 20 Dec 2019
Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition of CETP on detailed lipoprotein measures and compare those to genetic inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). We used an allele associated with lower ...
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.
Gad Abraham; Rainer Malik; Ekaterina Yonova-Doing; Agus Salim; Tingting Wang; John Danesh; Adam S Butterworth; Joanna M M Howson; Michael Inouye; Martin Dichgans
NATURE COMMUNICATIONS - 20 Dec 2019
Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive power has been modest compared to established stroke risk factors. Here, using a meta-scoring approach, we develop a metaGRS for ischaemic stroke (IS) and analyse this score in the UK Biobank (n = 395,393; 3075 IS events by age 75). The metaGRS hazard ratio for IS (1.26...
Increased Myocardial Stiffness in Patients with High Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B HFpEF.
Michinari Hieda; Satyam Sarma; Christopher M Hearon; Katrin A Dias; Jose Martinez; Mitchel Samels; Braden Everding; Dean Palmer; Sheryl Livingston; Margot Morris; Erin Howden; Benjamin D Levine
CIRCULATION - 23 Dec 2019
Individuals with left ventricular hypertrophy (LVH) and elevated cardiac biomarkers in middle-age are at high risk for the development of heart failure with preserved ejection fraction (HFpEF). However, it is unknown what the pathophysiological underpinnings of this high risk state may be. We tested the hypothesis that patients with LVH and elevated cardiac biomarkers would demonstrate elevated...
Fat for fuel: lipid metabolism in haematopoiesis.
Gerard Pernes; Michelle C Flynn; Graeme I Lancaster; Andrew J Murphy
CLINICAL & TRANSLATIONAL IMMUNOLOGY - 01 Jan 2019
The importance of metabolic regulation in the immune system has launched back into the limelight in recent years. Various metabolic pathways have been examined in the context of their contribution to maintaining immune cell homeostasis and function. Moreover, this regulation is also important in the immune cell precursors, where metabolism controls their maintenance and cell fate. This review w...
Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk.
Charles E Matthews; Steven C Moore; Hannah Arem; Michael B Cook; Britton Trabert; Niclas Håkansson; Susanna C Larsson; Alicja Wolk; Susan M Gapstur; Brigid M Lynch; Roger L Milne; Neal D Freedman; Wen-Yi Huang; Amy Berrington de Gonzalez; Cari M Kitahara; Martha S Linet; Eric J Shiroma; Sven Sandin; Alpa V Patel; I-Min Lee
JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY - 26 Dec 2019
To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape of the dose-response relationship, and explore associations with moderate- and vigorous-intensity physical activity.Data from 9 prospective cohorts with self-reported leisure-time physical activity and follow...
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