Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 5582 records
11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050.
THE LANCET. DIABETES & ENDOCRINOLOGY - 15 Dec 2025
Diabetes is a major global cause of morbidity and mortality. The aim of the 11th edition of the International Diabetes Federation (IDF) Diabetes Atlas is to provide national, regional, and global diabetes prevalence estimates for 2024, with projections to 2050. Diabetes (diagnosed and undiagnosed) prevalence among adults aged 20-79 years was estimated in 215 countries and territories, using 246...
Smartphone Cardiac Rehabilitation, Assisted Self-Management (SCRAM) Versus Usual Care: Multicenter Randomized Controlled Trial.
JMIR MHEALTH AND UHEALTH - 17 Mar 2026
Accessibility barriers contribute to low participation in center-based cardiac rehabilitation. We developed an innovative, comprehensive, dual-phase telerehabilitation program to address this gap (Smartphone Cardiac Rehabilitation, Assisted Self-Management; SCRAM). The study aimed to determine the effectiveness of SCRAM for increasing maximal aerobic exercise capacity (VO2max). A multicenter, p...
Shrunken Pore Syndrome and Risk of Cardiovascular Disease and All-Cause Mortality in Individuals With Type 1 Diabetes With and Without Albuminuria.
DIABETES CARE - 17 Mar 2026
To investigate the association between "shrunken pore syndrome" (SPS), defined as a large discrepancy between estimated glomerular filtration rates based on cystatin C (eGFRcys) and creatinine (eGFRcr), and coronary artery disease (CAD), stroke, peripheral artery disease (PAD), heart failure (HF), and all-cause mortality in individuals with T1D with and without albuminuria. The study comprised ...
Clinical risk score for cardiac death or heart failure hospitalization in moderate aortic stenosis.
ECHO RESEARCH AND PRACTICE - 16 Mar 2026
The association between moderate aortic stenosis (AS) and adverse cardiovascular outcomes is heterogeneous. Outcomes are likely dependent on clinical factors but no formal means of integrating these variables has been defined. This study aims to develop and validate a risk score to predict 5-year cardiac mortality or heart failure (HF)-related hospitalization in moderate AS. This was a retrospe...
Prevalence and Incidence of Type 1 Diabetes Among Children and Adults in the United States and Comparison With Other Countries
ACADEMIC PRESS - 29 Dec 2025
Type 1 diabetes is one of the most common chronic diseases of childhood in the United States, although it can manifest at any age. In 2017, based on data from the SEARCH for Diabetes in Youth study (SEARCH), the overall prevalence of type 1 diabetes among U.S. youth age <20 years was 215 cases per 100,000 population. Type 1 diabetes prevalence was similar by sex but increased with age. In 2017–...
β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction.
NATURE COMMUNICATIONS - 11 Apr 2026
Neutrophils rapidly accumulate in the heart after myocardial infarction (MI), yet bone marrow granulopoiesis peaks later, suggesting an alternative early source. Here we show in male mice that the first wave of neutrophils recruited to the ischemic heart arises from the vascular marginated pool rather than newly generated cells in the bone marrow or spleen. Using hematopoietic stem cell ablatio...
First in Human Feasibility Study of an Insulin Patch Pump Combined With CGM-Insulin Delivery Cannula.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY - 09 Apr 2026
Combining a patch pump (PP) with a single-insertion glucose-sensing cannula (continuous glucose monitor with an insulin set [CGM-IS]) may reduce user burden compared with tethered insulin pumps or multiple daily injections. We aimed to determine feasibility of a combined device. This feasibility study evaluated a PP with a CGM-IS (PP-CGM-IS) with manual bolus insulin dosing in T1D adults with i...
The nationwide prevalence of anaemia and the associated factors in the general adult population in Malaysia.
BMC PUBLIC HEALTH - 07 Apr 2026
Author Correction: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans.
COMMUNICATIONS MEDICINE - 06 Apr 2026
Plasma lipid trajectories improve prediction of future Alzheimer's disease.
JOURNAL OF ALZHEIMER'S DISEASE : JAD - 06 Apr 2026
BackgroundEarly identification of individuals at elevated risk for Alzheimer's disease (AD) is critical for prevention. Blood-based biomarkers offer scalable alternatives to cerebrospinal fluid and imaging, but the prognostic value of longitudinal plasma lipid trajectories remains unclear.ObjectiveTo evaluate whether multi-year plasma lipid trajectories improve prediction of AD conversion beyon...
Deprescribing in Older People: A Clinical Practice Guideline Summary.
THE MEDICAL JOURNAL OF AUSTRALIA - 01 Apr 2026
Older people face higher risks of medicine-related harm due to polypharmacy and the use of potentially inappropriate medicines. Current treatment guidelines rarely specify when to stop medicines, leading to medicines often being continued indefinitely without a clear deprescribing plan. While deprescribing guidelines exist for some medicine classes, limited guidance is a major barrier to depres...
sAlpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2026
The incidence and prevalence of heart failure (HF) with preserved ejection fraction (HFpEF) continue to rise, yet evidence-based therapy remains limited. Due to the complexity of HFpEF pathology, traditional HF medication has shown inconsistent efficacy in improving clinical outcomes and reducing morbidity. Therefore, highlighting the urgent need for novel interventions. The αlpha-7 nicotinic a...
Comparing dementia prevalence in Australians with and without diabetes across sociodemographic groups: Findings from the 2021 national census.
JOURNAL OF ALZHEIMER'S DISEASE : JAD - 17 Apr 2026
BackgroundDiabetes is a recognized risk factor for dementia, but its impact on dementia burden across sociodemographic groups in Australia is not well characterized.ObjectiveTo compare prevalence of dementia among Australians with and without diabetes and examine variation across key sociodemographic factors.MethodsWe conducted a cross-sectional analysis of the 2021 Australian national census a...
Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle.
ELIFE - 17 Apr 2026
Intermittent fasting (IF) has emerged as a powerful dietary intervention with profound metabolic benefits, yet the tissue-specific molecular mechanisms underlying these effects remain poorly understood. In this study, we employed comprehensive proteomics and transcriptomics analysis to investigate the systemic and organ-specific adaptations to IF in male C57BL/6 mice. Following a 16 hr daily fa...
Ultra-mild bisulphite sequencing for DNA methylation analysis from low-input clinical specimens.
CLINICAL EPIGENETICS - 16 Apr 2026
In a recent paper published in Nature Communications, Dai and colleagues offer a practical re-engineering of a workhorse: ultra-mild bisulphite sequencing (UMBS-seq), which re-tunes classical bisulphite conversion so that fragmented, low-input clinical DNA can yield methylomes that are not merely usable, but technically reliable. In this commentary, we set the advance in its proper frame-less a...
Waist-to-Height Ratio Is Associated With the Risk of Coronary Artery Disease in Type 1 Diabetes: A 19-Year Cohort Study.
DIABETES CARE - 14 Apr 2026
Obesity, kidney disease, and coronary artery disease (CAD) are interconnected. Here, the relationship between central obesity and CAD across albuminuria categories in type 1 diabetes was investigated. Data on 4,349 individuals without prior CAD from the Finnish Diabetic Nephropathy Study were analyzed. Central obesity was defined as waist-to-height ratio (WHtR) ≥0.5. Outcomes included acute myo...
Exercise effects on lean body mass, muscle strength and functional performance in patients with metastatic breast cancer: the randomized controlled PREFERABLE-EFFECT study.
BREAST CANCER RESEARCH : BCR - 13 Apr 2026
Beyond CABG vs. PCI: Contemporary and Future Coronary Revascularisation from Historical Evolution to Artificial Intelligence, Robotics, and Hybrid Strategies.
JOURNAL OF CLINICAL MEDICINE - 01 Apr 2026
Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are the two dominant revascularisation strategies for obstructive coronary artery disease, yet their relative roles continue to shift because they address coronary pathophysiology differently with ever-evolving techniques. PCI has advanced through iterative improvements, including balloon angioplasty, bare-metal...
Current evidence for diagnosis and management of cardiac vasculitis.
HEART (BRITISH CARDIAC SOCIETY) - 20 Apr 2026
Cardiac vasculitis represents a heterogeneous group of immune-mediated disorders that can involve the coronary vessels, myocardium, valvular apparatus and pericardial tissues. Despite its rarity, cardiac vasculitis may result in significant clinical sequelae such as acute coronary syndrome, heart failure, cardiac arrhythmias and pericarditis. Diagnosis is challenging because symptoms are often ...
Risk Prediction in Cardio-Oncology: Conceptual and Methodological Considerations: JACC: CardioOncology State-of-the-Art Review.
JACC. CARDIOONCOLOGY - 01 Apr 2026
Risk prediction models can guide prevention, monitoring, and treatment decisions in cardio-oncology, but their development requires careful attention to methodological challenges unique to cardiovascular disease arising in the context of cancer. In this state-of-the-art review, the authors use case scenarios to illustrate how prediction objectives, index dates, and time horizons must align with...
