Publications
Now showing items 5361-5380 of 5385 records
Diabetes in pregnancy among indigenous women in Australia, Canada, New Zealand and the United States
DIABETES METAB RES REV - 01 May 2013
Recently proposed international guidelines for screening for gestational diabetes mellitus (GDM) recommend additional screening in early pregnancy for sub-populations at a high risk of type 2 diabetes mellitus (T2DM), such as indigenous women. However, there are criteria that should be met to ensure the benefits outweigh the risks of population-based screening. This review examines the publishe...
A randomized controlled trial of a multiple health behavior change intervention delivered to colorectal cancer survivors: effects on sedentary behavior
CANCER - 01 Sep 2014
BACKGROUND:
Sedentary behavior may independently contribute to morbidity and mortality among survivors of colorectal cancer. In the current study, the authors assessed whether a telephone-delivered multiple health behavior change intervention had an effect on the sedentary behavior of recently diagnosed colorectal cancer survivors.
METHODS:
A total of 410 participants were recruited through ...
Endothelial transcriptome in response to pharmacological methyltransferase inhibition
CHEMMEDCHEM - 01 Aug 2014
The enzymatic activities of protein methyltransferases serve to write covalent modifications on histone and non-histone proteins in the control of gene transcription. Here, we describe gene expression changes in human endothelial cells caused by treatment with methyltransferase inhibitors 7,7'-carbonylbis (azanediyl) bis(4-hydroxynaphthalene-2 -sulfonic acid (AMI-1) and disodium-2-(2,4,5,7- tet...
Glycosylation of pramlintide: synthetic glycopeptides that display in vitro and in vivo activities as amylin receptor agonists
CHEMISTRY - 04 Nov 2013
Glycosylated analogues of pramlintide, in which specific Asn residues bear extended N-glycan structures, may be accessed by a combination of solid-phase peptide synthesis and highly efficient enzymatic glycosylation (see scheme; ENGases=endo-β-N-acetylglucosaminidases). Glycopeptides display both in vitro and in vivo activity as amylin receptor agonists and effect ‘smoothing’ of blood glucose.
Acute kidney injury following peripheral angiography and endovascular therapy: a systematic review of the literature
CATHETER CARDIOVASC INTERV - 01 Aug 2016
INTRODUCTION:
Radiographic contrast administration is a major cause of acute kidney injury (AKI), worldwide. Currently, contrast induced acute kidney injury (CI-AKI) is the third leading cause of hospital acquired renal failure in the United States. Over 50% of these cases are the result of contrast exposure during cardiac catheterization. The predictive risk factors for and clinical impact ...
The use of the AVERT system to limit contrast volume administration during peripheral angiography and intervention
CATHETER CARDIOVASC INTERV - 01 Dec 2015
BACKGROUND:
The AVERT(TM) Contrast Modulation System (AVERT) (Osprey Medical, MN) is designed to reduce contrast volume administration during angiography. The AVERT provides an adjustable resistance circuit which decreases the pressure head delivering contrast towards the patient. The AVERT has not been previously studied in patients undergoing peripheral digital subtraction angiography (DSA...
Utility of rotational atherectomy and outcomes over an eight-year period
CATHETER CARDIOVASC INTERV - 01 Oct 2015
OBJECTIVES:
To evaluate outcomes of patients undergoing rotational atherectomy (RA) in a multicenter percutaneous coronary intervention (PCI) registry.
BACKGROUND:
RA remains an important technique for plaque modification in PCI, particularly with complex calcification.
METHODS:
The study population consisted of consecutive patients undergoing PCI in nine major Australian hospitals, ...
Reducing iodinated contrast volume by manipulating injection pressure during coronary angiography
CATHETER CARDIOVASC INTERV - 01 Apr 2014
OBJECTIVE:
To evaluate the impact of a device-mediated modification of the injection pressure profile on iodinated contrast volumes during coronary angiography and percutaneous coronary intervention (PCI).
BACKGROUND:
The development of iodinated contrast-induced acute kidney injury (AKI) is associated with significant morbidity and mortality in patients undergoing coronary angiography and i...
Bio-click chemistry: enzymatic functionalization of PEGylated capsules for targeting applications
ANGEW CHEM INT ED ENGL - 16 Jul 2012
All sorted: The enzyme Sortase A was used to catalyze functionalization of PEGylated capsules with an activation-specific anti-platelet single-chain antibody (scFv). This enzymatic method allows fast, covalent, and site-directed functionalization of delivery vehicles under mild conditions. Activation-specific anti-platelet scFv-coated PEGylated capsules exhibited a high level of selective bindi...
Modulating myosin restores muscle function in a mouse model of nemaline myopathy
ANN NEUROL - 01 May 2016
OBJECTIVE:
Nemaline myopathy, one of the most common congenital myopathies is associated with mutations in various genes including ACTA1. This disease is also characterised by various forms/degrees of muscle weakness with most cases being severe and resulting in death in infancy. Recent findings have provided valuable insight into the underlying pathophysiological mechanisms. Mutations in AC...
Multifunctional thrombin-activatable polymer capsules for specific targeting to activated platelets
ADV MATER - 16 Sep 2015
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide
ADV HEALTHC MATER - 01 Oct 2015
Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporous CaCO3 template particles. The particles have potential for the diagnostic detection of endogenous levels of H2 O2 ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe3+ in the particles to break down H2 O2 to O2...
Boronate-phenolic network capsules with dual response to acidic pH and cis-diols
ADV HEALTHC MATER - 26 Aug 2015
Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials. The BPN capsules are stable in the presence of competing carbohydrates, but dissociate at acidic pH or in the presence of competing cis-diols at physiological pH. This engineered capsule system provides a platform for a wide range of biological and biomedical appli...
Relationship between mental health and foot pain
ARTHRITIS CARE RES - 01 Aug 2014
OBJECTIVE:
Although mental health is related to the persistence of musculoskeletal pain, our understanding of the relationship between mental health and foot pain is limited. Subsequently, we conducted a 3-year longitudinal study to examine the relationship between mental health and foot pain in a community-based population.
METHODS:
Eighty-three community-dwelling participants (mean ± S...
Association of weight gain with incident knee pain, stiffness, and functional difficulties: a longitudinal study
ARTHRITIS CARE RES - 01 Jan 2013
OBJECTIVE:
To examine the longitudinal association between significant weight change and change in knee symptoms (pain, stiffness, and function), and to determine whether the effects differ in those who are obese and those with osteoarthritis (OA).
METHODS:
Two hundred fifty subjects ranging from normal weight to obese (body mass index range 16.9-59.1 kg/m(2) ) and no significant musculoskel...
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection
FEBS LETT - 01 Oct 2017
High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in CD4+Glut1+ T cells from HIV+ subjects. TCR engagement of CD4+Glut1+ T cells from HIV+ subjects demonstrates hyperresponsive PI3K-mammalian target of rapamycin signaling. High ...
Association of diabetic macular edema and proliferative diabetic retinopathy with cardiovascular disease a systematic review and meta-analysis
JAMA OPHTHALMOL - 01 Jun 2017
Importance:
Previous studies on the relationship between diabetic retinopathy (DR) and cardiovascular disease (CVD) focused on the early stages of DR. Understanding whether patients with type 2 diabetes and severe stages of DR (diabetic macular edema [DME] and proliferative diabetic retinopathy [PDR]) have a higher risk of CVD will allow physicians to more effectively counsel patients.
Obje...
Association of neighborhood demographics with out-of-hospital cardiac arrest treatment and outcomes: where you live may matter
JAMA CARDIOL - 01 Oct 2017
Importance:
We examined whether resuscitation care and outcomes vary by the racial composition of the neighborhood where out-of-hospital cardiac arrests (OHCAs) occur.
Objective:
To evaluate the association between bystander treatments (cardiopulmonary resuscitation and automatic external defibrillation) and timing of emergency medical services personnel on OHCA outcomes according to the...
Predictive score for 30-day readmission or death in heart failure
JAMA CARDIOL - 01 Jun 2016
Readmissions shortly after heart failure (HF) are common, expensive, and usually considered preventable. However, despite the use of several interventions, rates of readmission after HF remain stable. An effective risk score might permit the targeting of resource-intensive interventions (such as disease-management programs) specifically on high-risk patients. We sought to determine the combinat...
Association of cardiometabolic multimorbidity with mortality
JAMA - 07 Jul 2015
IMPORTANCE:
The prevalence of cardiometabolic multimorbidity is increasing.
OBJECTIVE:
To estimate reductions in life expectancy associated with cardiometabolic multimorbidity.
DESIGN, SETTING, AND PARTICIPANTS:
Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689,300 particip...
