Bio-click chemistry: enzymatic functionalization of PEGylated capsules for targeting applications
Hagemeyer, CE; Johnston, AP; Peter, K; Leung, MK; Ardipradja, K; Gonzales, C; Such, GK; Kamphuis, MM; Caruso, F
Abstract
All sorted: The enzyme Sortase A was used to catalyze functionalization of PEGylated capsules with an activation-specific anti-platelet single-chain antibody (scFv). This enzymatic method allows fast, covalent, and site-directed functionalization of delivery vehicles under mild conditions. Activation-specific anti-platelet scFv-coated PEGylated capsules exhibited a high level of selective binding to thrombi, thus suggesting their potential for thrombosis therapy.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
| Journal | ANGEW CHEM INT ED ENGL |
| ISSN | 1433-7851 |
| Published | 16 Jul 2012 |
| Volume | 51 |
| Issue | 29 |
| Pages | 7132-6 |
| DOI | 10.1002/anie.201203612 |
| Type | Journal Article |
| Sponsorship |
ARC: FT0992210; NHMRC: 472665, 1017670, 472668, 472668; Other
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