Publications
By Year
Now showing items 21-40 of 3123 records
Changing dietary approaches to prevent cardiovascular disease.
Paul J Nestel; Lawrence J Beilin; Trevor A Mori
CURRENT OPINION IN LIPIDOLOGY - 29 Sep 2020
We have focused on recent research relevant to effects of dietary patterns and major food groups on cardiovascular outcomes, taking into account guidelines and position statements from expert authorities, with an emphasis on important changes in recommendations, some of which remain controversial.Major findings include: refocusing on qualitative patterns of food consumption replacing quantitati...
Differential sympathetic response to lesion-induced chronic kidney disease in rabbits.
Yusuke Sata; Sandra L Burke; Anna M D Watson; Jay C Jha; Cindy Gueguen; Nina Eikelis; Kyungjoon Lim; Kristy L Jackson; Gavin W Lambert; Karin A M Jandeleit-Dahm; Kate M Denton; Murray D Esler; Markus P Schlaich; Geoffrey A Head
KIDNEY INTERNATIONAL - 01 Oct 2020
Chronic kidney disease (CKD) is associated with greater sympathetic nerve activity but it is unclear if this is a kidney-specific response or due to generalized stimulation of sympathetic nervous system activity. To determine this, we used a rabbit model of CKD in which quantitative comparisons with control rabbits could be made of kidney sympathetic nerve activity and whole-body norepinephrine...
Built environment correlates of objectively-measured sedentary behaviours in densely-populated areas.
Mohammad Javad Koohsari; Ai Shibata; Kaori Ishii; Sayaka Kurosawa; Akitomo Yasunaga; Tomoya Hanibuchi; Tomoki Nakaya; Suzanne Mavoa; Gavin R McCormack; Koichiro Oka
HEALTH & PLACE - 01 Nov 2020
Few studies examine associations between objectively-calculated neighbourhood built environment attributes and objectively-assessed sedentary behaviour in different geographical locations, especially in highly-populated environments. Additionally, no study, to our knowledge, has investigated associations between objective measures of neighbourhood built environment attributes and objectively-as...
Long-Term Outcomes Stratified by Body Mass Index in Patients Undergoing Transcatheter Aortic Valve Implantation.
Edward J Quine; Misha Dagan; Jeremy William; Shane Nanayakkara; Luke P Dawson; Stephen J Duffy; Julia Stehli; Ron J Dick; Nay M Htun; Dion Stub; Antony S Walton
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Dec 2020
Transcatheter aortic valve implantation (TAVI) is emerging as the default strategy for older patients with severe, symptomatic, and trileaflet aortic stenosis. Increased body-mass index (BMI) is associated with a protective effect in patients undergoing percutaneous coronary intervention. We assessed whether elevated BMI was associated with a similar association in TAVI. We evaluated prospectiv...
Changes in prevalence of diabetes over 15 years in a rural Australian population: The Crossroads Studies.
David Simmons; Kristen Glenister; Dianna J Magliano; Lisa Bourke
DIABETES RESEARCH AND CLINICAL PRACTICE - 08 Oct 2020
Secular trends in diabetes prevalence vary globally. We compared the prevalence of diabetes in two surveys 15 years apart in rural Australia.Two cross-sectional household surveys and clinics (biomedical assessments including oral glucose tolerance tests (OGTTs)) in 2001-2003 (Crossroads) and 2016-2018 (Crossroads-II).Four rural Victorian towns.Residents of randomly selected households (Crossroa...
Endothelial specific overexpression of cationic amino acid transporter-1 prevents loss of renal function in cardiorenal syndrome type 2.
Beverly Giam; Haru Nomura; Sanjaya Kuruppu; Po-Yin Chu; Sumia Essid; Helen Kiriazis; Xiao-Jun Du; David Kaye; Niwanthi W Rajapakse
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 09 Oct 2020
Heart failure (HF) is associated with impaired L-arginine transport. In the present study, we tested the hypothesis that augmented L-arginine transport prevents the loss of kidney function in HF. Renal function was assessed in wild-type mice (WT), transgenic mice with HF (DCM) and double transgenic mice (HFCAT-1) with HF and endothelial specific overexpression of the predominant L-arginine tran...
Medical Evaluation of Athletes: Further Imaging Modalities—Stress Echo, CT and MRI
Guido Claessen; Andre La Gerche
TEXTBOOK OF SPORTS AND EXERCISE CARDIOLOGY - 01 Jan 2020
Switzerland: Springer International Publishing
Machine Learning Applied To Energy Waveform ECG for Prediction of Stage B Heart Failure in the Community
Elizabeth Potter; Carlos J Rodriguez; David Ascher; Tom Marwick
J AM COLL CARDIOL - 01 Mar 2020
Energy waveform (ew) ECG uses continuous wavelet transforms (CWT) to create time-frequency energy characterizations. Although ewECG changes reflect myocardial disease, optimal features for prediction of subclinical left ventricular dysfunction (Stage B heart failure [SBHF]) are unclear. Using machine learning (ML), we investigated whether ewECG could predict SBHF in at-risk community subjects t...
New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics.
Crisdion Krstevski; Charles D Cohen; Alexander R Pinto; Malathi Imiyage Dona
BIOCHEMICAL SOCIETY TRANSACTIONS - 01 Dec 2020
Single-cell transcriptomics enables inference of context-dependent phenotypes of individual cells and determination of cellular diversity of complex tissues. Cardiac fibrosis is a leading factor in the development of heart failure and a major cause of morbidity and mortality worldwide with no effective treatment. Single-cell RNA-sequencing (scRNA-seq) offers a promising new platform to identify...
mmCSM-AB: guiding rational antibody engineering through multiple point mutations.
Yoochan Myung; Douglas E V Pires; David B Ascher
NUCLEIC ACIDS RESEARCH - 02 Jul 2020
While antibodies are becoming an increasingly important therapeutic class, especially in personalized medicine, their development and optimization has been largely through experimental exploration. While there have been many efforts to develop computational tools to guide rational antibody engineering, most approaches are of limited accuracy when applied to antibody design, and have largely bee...
mCSM-membrane: predicting the effects of mutations on transmembrane proteins.
Douglas E V Pires; Carlos H M Rodrigues; David B Ascher
NUCLEIC ACIDS RESEARCH - 02 Jul 2020
Significant efforts have been invested into understanding and predicting the molecular consequences of mutations in protein coding regions, however nearly all approaches have been developed using globular, soluble proteins. These methods have been shown to poorly translate to studying the effects of mutations in membrane proteins. To fill this gap, here we report, mCSM-membrane, a user-friendly...
Repositioning of the global epicentre of non-optimal cholesterol.
Jonathan E Shaw; Dianna J Magliano
NATURE - 01 Jun 2020
High blood cholesterol is typically considered a feature of wealthy western countries. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which h...
High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies.
Habtamu B Beyene; Gavriel Olshansky; Adam Alexander T Smith; Corey Giles; Kevin Huynh; Michelle Cinel; Natalie A Mellett; Gemma Cadby; Joseph Hung; Jennie Hui; John Beilby; Gerald F Watts; Eric K Moses; Jonathan E Shaw; Dianna J Magliano; Peter J Meikle
PLOS BIOLOGY - 01 Sep 2020
Obesity and related metabolic diseases show clear sex-related differences. The growing burden of these diseases calls for better understanding of the age- and sex-related metabolic consequences. High-throughput lipidomic analyses of population-based cohorts offer an opportunity to identify disease-risk-associated biomarkers and to improve our understanding of lipid metabolism and biology at a p...
Isolation of Lipid Rafts from Cultured Mammalian Cells and Their Lipidomics Analysis.
Nigora Mukhamedova; Kevin Huynh; Hann Low; Peter J Meikle; Dmitri Sviridov
BIO-PROTOCOL - 05 Jul 2020
Lipid rafts are distinct liquid-ordered domains of plasma membranes of most eukaryotic cells providing platform for signaling pathways. Lipid composition of rafts is critical for their structural integrity and for regulation of signaling pathways originating from rafts. Here we provide a protocol to isolate lipid rafts from cultured human and animal cells and comprehensively analyse their lipid...
Targeting Lipid Rafts-A Potential Therapy for COVID-19.
Dmitri Sviridov; Yury I Miller; Rami A Ballout; Alan T Remaley; Michael Bukrinsky
FRONTIERS IN IMMUNOLOGY - 01 Jan 2020
COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems. Historically, very few viruses have ever been eradicated. Instead, the virus may persist in communities causing recurrent local outbreaks of the acute inf...
Comparison of Circulating Biomarkers in Predicting Diabetic Kidney Disease Progression With Autoantibodies to Erythropoietin Receptor.
Megumi Oshima; Akinori Hara; Tadashi Toyama; Min Jun; Carol Pollock; Meg Jardine; Stephen Harrap; Neil Poulter; Mark E Cooper; Mark Woodward; John Chalmers; Vlado Perkovic; Muh Geot Wong; Takashi Wada
KIDNEY INTERNATIONAL REPORTS - 01 Feb 2021
Several circulating markers, including autoantibodies to erythropoietin receptor (anti-EPOR antibodies), have been identified as useful biomarkers in predicting diabetic kidney disease progression. However, a direct comparison of their utility is lacking. We aimed to validate and to compare the prognostic value of anti-EPOR antibodies with that of other known biomarkers, using the ADVANCE trial...
Vitamin A levels are decreased but not influenced by glucose- or lipid-lowering medications in subjects with type 2 diabetes.
Jalal Taneera; Samir Awadallah; Abdul Khader Mohammed; Hema Unnikannan; Nabil Sulaiman
SAUDI JOURNAL OF BIOLOGICAL SCIENCES - 01 Jan 2021
Type 2 diabetes (T2D) is a complex polygenic disease with unclear mechanisms. Clinical studies on the association of vitamin A with T2D in humans are still controversial. Herein, we aimed to investigate the plasma levels of vitamin A, predictor factors, and its correlations with clinical phenotypes in Emirati population. The effect of glucose-and lipid-lowering medications on vitamin A levels w...
Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries.
Jasmin Chendi Li; Anida Velagic; Cheng Xue Qin; Mandy Li; Chen Huei Leo; Barbara K Kemp-Harper; Rebecca H Ritchie; Owen L Woodman
FRONTIERS IN PHARMACOLOGY - 01 Jan 2020
Endothelial dysfunction is a major risk factor for several of the vascular complications of diabetes, including ischemic stroke. Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO•), is resistant to scavenging by superoxide, but the role of HNO in diabetes mellitus associated endothelial dysfunction in the carotid artery remains unknown. To assess how diabetes aff...
Mercury methylation by metabolically versatile and cosmopolitan marine bacteria.
Heyu Lin; David B Ascher; Yoochan Myung; Carl H Lamborg; Steven J Hallam; Caitlin M Gionfriddo; Kathryn E Holt; John W Moreau
THE ISME JOURNAL - 01 Jun 2021
Microbes transform aqueous mercury (Hg) into methylmercury (MeHg), a potent neurotoxin that accumulates in terrestrial and marine food webs, with potential impacts on human health. This process requires the gene pair hgcAB, which encodes for proteins that actuate Hg methylation, and has been well described for anoxic environments. However, recent studies report potential MeHg formation in subox...
Detailed post-resuscitation debrief reports: A novel example from a large EMS system.
Melanie Villani; Ziad Nehme; Steffi Burns; Jocasta Ball; Karen Smith
RESUSCITATION - 01 May 2021
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