Publications
By Year
Now showing items 21-40 of 4100 records
Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk.
Albert Dahdah; Robert M Jaggers; Gopalkrishna Sreejit; Jillian Johnson; Babunageswararao Kanuri; Andrew J Murphy; Prabhakara R Nagareddy
11 Oct 2022
Smoking is one of the most prominent addictions of the modern world, and one of the leading preventable causes of death worldwide. Although the number of tobacco smokers is believed to be at a historic low, electronic cigarette use has been on a dramatic rise over the past decades. Used as a replacement for cigarette smoking, electronic cigarettes were thought to reduce the negative effects of ...
Integrating the Biology of Cardiovascular Disease into the Epidemiology of Economic Decision Modelling via Mendelian Randomisation.
Zanfina Ademi; Jedidiah I Morton; Danny Liew; Stephen J Nicholls; Sophia Zoungas; Brian A Ference
PHARMACOECONOMICS - 01 Nov 2022
Health economic analyses are essential for health services research, providing decision-makers and payers with evidence about the value of interventions relative to their opportunity cost. However, many health economic approaches are still limited, especially regarding the primary prevention of cardiovascular disease (CVD). In this article, we discuss some limitations to current health economic...
How Dietary Fibre, Acting via the Gut Microbiome, Lowers Blood Pressure.
Chudan Xu; Francine Z Marques
CURRENT HYPERTENSION REPORTS - 01 Nov 2022
To discuss the interplay behind how a high-fibre diet leads to lower blood pressure (BP) via the gut microbiome.Compelling evidence from meta-analyses support dietary fibre prevents the development of cardiovascular disease and reduces BP. This relation is due to gut microbial metabolites, called short-chain fatty acids (SCFAs), derived from fibre fermentation. The SCFAs acetate, propionate and...
Cost-Effectiveness of Empagliflozin in Patients With Heart Failure and Preserved Ejection Fraction.
Jennifer Zhou; Danny Liew; David M Kaye; Sophia Zoungas; Dion Stub
CIRCULATION. CARDIOVASCULAR QUALITY AND OUTCOMES - 01 Oct 2022
Empagliflozin is the first medication to demonstrate clinical benefit in patients with heart failure with preserved ejection fraction, but its cost-effectiveness is unknown. We aimed to evaluate the cost-effectiveness of adding empagliflozin to standard therapy in patients with heart failure with preserved ejection fraction.A Markov model from the perspective of the Australian health care syste...
Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.
Keira Tucker; Leonardos Mageiros; Alno Carstens; Ludwig Bröcker; Edward Archer; Katrin Smith; Evangelos Mourkas; Ben Pascoe; Daan Nel; Guillaume Meric; Samuel K Sheppard; Barbara Kasprzyk-Hordern; Marelize Botes; Edward J Feil; Gideon Wolfaardt
MICROBIOLOGY SPECTRUM - 26 Oct 2022
With increasing emergence of antimicrobial resistant bacteria (ARB) and the risk this poses to public health, there are growing concerns regarding water pollution contributing to the spread of antimicrobial resistance (AMR) through inadequate amenities and the rapid rate of urbanization. In this study, the impact of different anthropogenic factors on the prevalence of AMR in the urban water cyc...
Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia.
Ellen Menkhorst; Wei Zhou; Leilani Santos; Jian-Guo Zhang; Yves St-Pierre; Morag J Young; Evdokia Dimitriadis
PREGNANCY HYPERTENSION - 26 Sep 2022
Preeclampsia is a life-threatening disorder of pregnancy unique to humans. Poor placentation in the first trimester of pregnancy is widely accepted to be an underlying cause of preeclampsia. Galectin-7 is abnormally elevated in chorionic villous samples and serum from women that subsequently develop pre-term preeclampsia. Administration of exogenous galectin-7 to pregnant mice causes preeclamps...
Modulation of Plasma Lipidomic Profiles in Metastatic Castration-Resistant Prostate Cancer by Simvastatin.
Blossom Mak; Hui-Ming Lin; Thy Duong; Kate L Mahon; Anthony M Joshua; Martin R Stockler; Howard Gurney; Francis Parnis; Alison Zhang; Tahlia Scheinberg; Gary Wittert; Lisa M Butler; David Sullivan; Andrew J Hoy; Peter J Meikle; Lisa G Horvath
CANCERS - 30 Sep 2022
Elevated circulating sphingolipids are associated with shorter overall survival and therapeutic resistance in metastatic castration-resistant prostate cancer (mCRPC), suggesting that perturbations in sphingolipid metabolism promotes prostate cancer growth. This study assessed whether addition of simvastatin to standard treatment for mCRPC can modify a poor prognostic circulating lipidomic profi...
Daytime napping and cardiovascular risk factors, cardiovascular disease, and mortality: A systematic review.
Jiahong Sun; Chuanwei Ma; Min Zhao; Costan G Magnussen; Bo Xi
SLEEP MEDICINE REVIEWS - 01 Oct 2022
Associations between night sleep duration and cardiovascular risk factors in adults have been well documented. However, the associations for daytime napping remain unclear. In this review, six databases were searched for eligible publications to April 8, 2022. A total of 11 articles were identified for umbrella review on the association of daytime napping with diabetes, metabolic syndrome (MetS...
Factors predicting cardiac arrest in acute coronary syndrome patients under 50: A state-wide angiographic and forensic evaluation of outcomes.
Elizabeth D Paratz; Alexander van Heusden; Karen Smith; Angela Brennan; Diem Dinh; Jocasta Ball; Jeff Lefkovits; David M Kaye; Stephen J Nicholls; Andreas Pflaumer; Andre La Gerche; Dion Stub;
RESUSCITATION - 01 Oct 2022
An uncertain proportion of patients with acute coronary syndrome (ACS) also experience out-of-hospital cardiac arrest (OHCA). Predictors of OHCA in ACS remain unclear and vulnerable to selection bias as pre-hospital deceased patients are usually not included.Data on patients aged 18-50 years from a percutaneous coronary intervention (PCI) and OHCA registry were combined to identify all patients...
Assessing and addressing diabetes distress among adults with type 2 diabetes: An online survey of Australian general practitioners.
Rita McMorrow; Barbara Hunter; Christel Hendrieckx; Jane Speight; Jon Emery; Jo-Anne Manski-Nankervis
PRIMARY CARE DIABETES - 01 Oct 2022
Diabetes distress is experienced by up to 36% of adults with type 2 diabetes. Australian type 2 diabetes guidelines recommend annual assessment of diabetes distress in general practice. This study explores general practitioners' knowledge, current practice, and factors influencing implementation of guidelines, including Person Reported Outcome Measure (PROM) use.A cross-sectional online survey ...
Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study.
Gabriel A Gregory; Thomas I G Robinson; Sarah E Linklater; Fei Wang; Stephen Colagiuri; Carine de Beaufort; Kim C Donaghue; ; Dianna J Magliano; Jayanthi Maniam; Trevor J Orchard; Priyanka Rai; Graham D Ogle
THE LANCET. DIABETES & ENDOCRINOLOGY - 01 Oct 2022
Accurate data on type 1 diabetes prevalence, incidence, associated mortality and life expectancy are crucial to inform public health policy, but these data are scarce. We therefore developed a model based on available data to estimate these values for 201 countries for the year 2021 and estimate the projected prevalent cases in 2040.We fitted a discrete-time illness-death model (Markov model) t...
Incidence and Predictors of Eosinophilic Myocardial Hypersensitivity in Patients Receiving Home Dobutamine.
Misha Dagan; Malanka Lankaputhra; Timothy Yeung; Su Ling Tee; Illona Bader; Kellie Easton; Ashlee Linton; Catriona McLean; Andrew Taylor; Peter Bergin; David M Kaye; Angeline Leet; James L Hare; Hitesh C Patel
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY - 01 Oct 2022
We sought to examine incidence and predictors of eosinophilic myocardial hypersensitivity (EMH) in a cohort of patients in the home inotrope program of a quaternary cardiac transplant center. Patients on home inotropes with progression to heart transplantation or ventricular assist device (VAD) between January 2000 and May 2020 were included. EMH was diagnosed by the presence of an interstitial...
The clinical implications of left ventricular diastolic dysfunction in systemic sclerosis.
Laura Ross; Shreeya Patel; Wendy Stevens; Andrew Burns; David Prior; Andre La Gerche; Mandana Nikpour
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY - 01 Oct 2022
We sought to quantify the burden of left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF) in systemic sclerosis (SSc) and assess the progression of LVDD over time and its prognostic importance.Two-hundred and twenty-five participants enrolled in the Australian Scleroderma Cohort Study were included and LVDD was assessed according to 2016 ASE/EA...
Effect of progressive resistance training with weight loss compared with weight loss alone on the fatty liver index in older adults with type 2 diabetes: secondary analysis of a 12-month randomized controlled trial.
Christine L Freer; Elena S George; Sze-Yen Tan; Gavin Abbott; David W Dunstan; Robin M Daly
BMJ OPEN DIABETES RESEARCH & CARE - 01 Oct 2022
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent (~75%) in people with type 2 diabetes (T2D). Since exercise and weight loss (WL) are recommended for the management of both NAFLD and T2D, this study examined whether progressive resistance training (PRT) plus WL could lead to greater improvements in the fatty liver index (FLI), an indicator of NAFLD, compared with WL alone in older ...
In Vivo Inhibition of miR-34a Modestly Limits Cardiac Enlargement and Fibrosis in a Mouse Model with Established Type 1 Diabetes-Induced Cardiomyopathy, but Does Not Improve Diastolic Function.
Bianca C Bernardo; Gunes S Yildiz; Helen Kiriazis; Claudia A Harmawan; Celeste M K Tai; Rebecca H Ritchie; Julie R McMullen
03 Oct 2022
MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology, and we previously reported that inhibition of miR-34a in vivo provided protection in a setting of pressure overload-induced pathological cardiac hypertrophy and dilated cardiomyopathy. Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes. However, the thera...
Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians.
Jean-Sebastien Gounot; Minghao Chia; Denis Bertrand; Woei-Yuh Saw; Aarthi Ravikrishnan; Adrian Low; Yichen Ding; Amanda Hui Qi Ng; Linda Wei Lin Tan; Yik-Ying Teo; Henning Seedorf; Niranjan Nagarajan
NATURE COMMUNICATIONS - 13 Oct 2022
Despite extensive efforts to address it, the vastness of uncharacterized 'dark matter' microbial genetic diversity can impact short-read sequencing based metagenomic studies. Population-specific biases in genomic reference databases can further compound this problem. Leveraging advances in hybrid assembly (using short and long reads) and Hi-C technologies in a cross-sectional survey, we deeply ...
In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications.
Ahmed Refaat; May Lin Yap; Geoffrey Pietersz; Aidan Patrick Garing Walsh; Johannes Zeller; Blanca Del Rosal; Xiaowei Wang; Karlheinz Peter
JOURNAL OF NANOBIOTECHNOLOGY - 15 Oct 2022
Advances in diagnostic imaging have provided unprecedented opportunities to detect diseases at early stages and with high reliability. Diagnostic imaging is also crucial to monitoring the progress or remission of disease and thus is often the central basis of therapeutic decision-making. Currently, several diagnostic imaging modalities (computed tomography, magnetic resonance imaging, and posit...
People with type 2 diabetes' experiences of emotional support in Australian general practice: a qualitative study.
Rita McMorrow; Barbara Hunter; Nana Folmann Hempler; Kaleswari Somasundaram; Jon Emery; Jo-Anne Manski-Nankervis
BJGP OPEN - 19 Oct 2022
Diabetes distress, experienced by up to 40% of people with type 2 diabetes (T2D), is the negative emotional response to the burden of living with and managing diabetes. It is associated with suboptimal glycaemia and diabetes self-management. Research indicates that people with diabetes do not recall being asked about emotional distress by healthcare professionals.To explore the experiences, nee...
Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic health.
Elena Lo Presti; Domenico Nuzzo; Wael Al Mahmeed; Khalid Al-Rasadi; Kamila Al-Alawi; Maciej Banach; Yajnavalka Banerjee; Antonio Ceriello; Mustafa Cesur; Francesco Cosentino; Alberto Firenze; Massimo Galia; Su-Yen Goh; Andrej Janez; Sanjay Kalra; Nitin Kapoor; Peter Kempler; Nader Lessan; Paulo Lotufo; Nikolaos Papanas; Ali A Rizvi; Amirhossein Sahebkar; Raul D Santos; Anca P Stoian; Peter P Toth; Vijay Viswanathan; Manfredi Rizzo;
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE - 01 Dec 2022
Obesity, type 2 diabetes (T2DM), hypertension (HTN), and Cardiovascular Disease (CVD) often cluster together as "Cardiometabolic Disease" (CMD). Just under 50% of patients with CMD increased the risk of morbidity and mortality right from the beginning of the COVID-19 pandemic as it has been reported in most countries affected by the SARS-CoV2 virus. One of the pathophysiological hallmarks of CO...
GASS-Metal: identifying metal-binding sites on protein structures using genetic algorithms.
Vinícius A Paiva; Murillo V Mendonça; Sabrina A Silveira; David B Ascher; Douglas E V Pires; Sandro C Izidoro
BRIEFINGS IN BIOINFORMATICS - 20 Sep 2022
Metals are present in >30% of proteins found in nature and assist them to perform important biological functions, including storage, transport, signal transduction and enzymatic activity. Traditional and experimental techniques for metal-binding site prediction are usually costly and time-consuming, making computational tools that can assist in these predictions of significant importance. Here ...
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