Now showing items 21-40 of 2599 records
Lipid Rafts and Pathogens: The Art of Deception and Exploitation.
JOURNAL OF LIPID RESEARCH - 15 Oct 2019
Lipid rafts-solid regions of the plasma membrane enriched in cholesterol and glycosphingolipids-are essential parts of a cell. Functionally, lipid rafts present a platform that facilitates interaction of cells with the outside world. However, the unique properties of lipid rafts required to fulfill this function at the same time make them susceptible to exploitation by pathogens. Many steps of ...
Poor Long-Term Survival in Patients With Moderate Aortic Stenosis.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 15 Oct 2019
Historical data suggesting poor survival in patients with aortic stenosis (AS) who do not undergo treatment are largely confined to patients with severe AS.This study sought to determine the prognostic impact of all levels of native valvular AS.Severity of AS was characterized by convention and by statistical distribution in 122,809 male patients (mean age 61 ± 17 years) and 118,494 female pati...
Association of Perceived Built Environment Attributes with Objectively Measured Physical Activity in Community-Dwelling Ambulatory Patients with Stroke.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 15 Oct 2019
There is little evidence on how perceptions of the built environment may influence physical activity among post-stroke patients. This study aimed to explore the associations between perceived built environment attributes and objectively measured physical activity outcomes in community-dwelling ambulatory patients with stroke. This cross-sectional study recruited patients who could walk outside ...
Neighborhood walkability and 12-year changes in cardio-metabolic risk: the mediating role of physical activity.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 15 Oct 2019
Living in walkable neighborhoods may provide long-term cardio-metabolic health benefits to residents. Little empirical research has examined the behavioral mechanisms in this relationship. In this longitudinal study, we examined the potential mediating role of physical activity (baseline and 12-year change) in the relationships of neighborhood walkability with 12-year changes in cardio-metaboli...
Systems biology and big data in asthma and allergy - recent discoveries and emerging challenges.
THE EUROPEAN RESPIRATORY JOURNAL - 16 Oct 2019
Asthma is a common condition caused by immune and respiratory dysfunction, and it is often linked to allergy. A systems perspective may prove helpful in unravelling the complexity of asthma and allergy. Our aim is to give an overview of systems biology approaches used in allergy and asthma research. Specifically, we describe recent "omic"-level findings, and examine how these findings have been...
Comparison of 3D echocardiographic-derived indices using fully automatic left ventricular endocardial tracing (heart model) and semiautomatic tracing (3DQ-ADV).
ECHOCARDIOGRAPHY (MOUNT KISCO, N.Y.) - 17 Oct 2019
The availability of a true 3D dataset provides an opportunity for automation of left ventricular (LV) and left atrial (LA) measurements. Although manual and automated measurements of 3D volumes are known to correlate, the variance is an important parameter for the individual patient. The reasons for discrepancies remain unexplained. We hence aim to explain the disagreement between automated and...
Complement C5a Induces Renal Injury in Diabetic Kidney Disease Via Disruption in Mitochondrial Metabolic Agility.
DIABETES - 17 Oct 2019
The sequelae of diabetes mellitus include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury that is associated with a disruption in mitochondrial metabolic agility, inflammation and fibrosis. We explored the role of the innate immune complement component C5a, a potent mediator of inflammation, in the pathogenesis of DKD in clinical a...
Mechanisms Responsible for Genetic Hypertension in Schlager BPH/2 Mice.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2019
It has been 45 years since Gunther Schlager used a cross breeding program in mice to develop inbred strains with high, normal, and low blood pressure (BPH/2, BPN/3, and BPL/1 respectively). Thus, it is timely to gather together the studies that have characterized and explored the mechanisms associated with the hypertension to take stock of exactly what is known and what remains to be determined...
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context.
NATURE COMMUNICATIONS - 21 Oct 2019
Genetic studies of metabolites have identified thousands of variants, many of which are associated with downstream metabolic and obesogenic disorders. However, these studies have relied on univariate analyses, reducing power and limiting context-specific understanding. Here we aim to provide an integrated perspective of the genetic basis of metabolites by leveraging the Finnish Metabolic Syndro...
Association between HTLV-1 infection and adverse health outcomes: a systematic review and meta-analysis of epidemiological studies.
THE LANCET. INFECTIOUS DISEASES - 21 Oct 2019
Human T-cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus that causes a lifelong infection. Several diseases, including an aggressive form of leukaemia, have been designated as associated with HTLV-1, whereby having HTLV-1 is a necessary condition for diagnosis. Beyond these diseases, there is uncertainty about other health effects of HTLV-1. We aimed to synthesise evidence from epi...
Associations of built environment and proximity of food outlets with weight status: Analysis from 14 cities in 10 countries.
PREVENTIVE MEDICINE - 22 Oct 2019
The study aimed to examine associations of neighborhood built environments and proximity of food outlets (BE measures) with body weight status using pooled data from an international study (IPEN Adult). Objective BE measures were calculated using geographic information systems for 10,008 participants (4463 male, 45%) aged 16-66 years in 14 cities. Participants self-reported proximity to three t...
Atrial fibrillation in athletes: different but the same?
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 22 Oct 2019
With our powers combined: Does the pooled analysis of existing randomized data regarding treatment of atrial fibrillation in heart failure settle the case for catheter ablation?
EUROPEAN HEART JOURNAL - 22 Oct 2019
Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality.
PLOS ONE - 01 Jan 2019
GlycA is a nuclear magnetic resonance (NMR) spectroscopy biomarker that predicts risk of disease from myriad causes. It is heterogeneous; arising from five circulating glycoproteins with dynamic concentrations: alpha-1 antitrypsin (AAT), alpha-1-acid glycoprotein (AGP), haptoglobin (HP), transferrin (TF), and alpha-1-antichymotrypsin (AACT). The contributions of each glycoprotein to the disease...
Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS.
PLOS ONE - 01 Jan 2019
Platelets are key components in atherogenesis and determine the course of its clinical sequelae acute coronary syndrome (ACS). Components of the innate immune system-the superfamily of TLR receptors-are present in platelets and represent a link between atherothrombosis and inflammation. We hypothesize that alteration in platelet TLR mRNA expression is a result of inflammation driving coronary a...
Pulmonary vascular remodelling in athletes: an anti-concept to be proved.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 24 Oct 2019
Impact of follow-up time and analytical approaches to account for reverse causality on the association between physical activity and health outcomes in UK Biobank.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 25 Oct 2019
The advent of very large cohort studies (n > 500 000) has given rise to prospective analyses of health outcomes being undertaken after short (<4 years) follow-up periods. However, these studies are potentially at risk of reverse causality bias. We investigated differences in the associations between self-reported physical activity and all-cause and cardiovascular disease (CVD) mortality, and in...
The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.
CARDIOVASCULAR DRUGS AND THERAPY - 25 Oct 2019
Methylglyoxal, a by-product of glycolysis and a precursor in the formation of advanced glycation end-products, is significantly elevated in the diabetic myocardium. Therefore, we sought to investigate the mitochondria-targeted methylglyoxal scavenger, MitoGamide, in an experimental model of spontaneous diabetic cardiomyopathy.Male 6-week-old Akita or wild type mice received daily oral gavage of...
Associations of sedentary and physically-active behaviors with cognitive-function decline in community-dwelling older adults: compositional data analysis from the NEIGE study.
JOURNAL OF EPIDEMIOLOGY - 26 Oct 2019
Physical activity can help to protect against cognitive decline in older adults. However, little is known about the potential combined relationships of time spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with indices of cognitive health. We examined the cross-sectional associations of objectively-determined sedentary ...
Passive versus Mentally Active Sedentary Behaviors and Depression.
EXERCISE AND SPORT SCIENCES REVIEWS - 26 Oct 2019
Detrimental associations of sedentary behaviors with depression have been identified, but findings are inconsistent. We propose a novel approach to the classification and analysis of sedentary behaviors, which differentiates between those that are passive (e.g., TV viewing) and mentally active (e.g., reading). Available evidence is summarized, and research questions relating to measurement, cau...