Now showing items 21-40 of 2838 records
EasyVS: a user friendly web based tool for molecule library selection and structure-based virtual screening.
BIOINFORMATICS (OXFORD, ENGLAND) - 12 May 2020
EasyVS is a web-based platform built to simplify molecule library selection and virtual screening. With an intuitive interface, the tool allows users to go from selecting a protein target with a known structure and tailoring a purchasable molecule library to performing and visualising docking in a few clicks. Our system also allows users to filter screening libraries based on molecule propertie...
Reducing sitting at work: process evaluation of the SMArT Work (Stand More At Work) intervention.
TRIALS - 13 May 2020
Office-based workers accumulate high amounts of sitting time. Stand More At Work (SMArT Work) aimed to reduce occupational sitting time and a cluster randomised controlled trial demonstrated it was successful in achieving this aim. The purpose of this paper is to present the process evaluation of the SMArT Work intervention.Questionnaire data were collected from intervention participants at 6 m...
Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice.
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 19 May 2020
BPH/2J mice are a genetic model of hypertension with overactivity of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). BPH/2J display higher renal renin mRNA and low levels of its negative regulator microRNA-181a (miR-181a). We hypothesise that high renal SNS activity may reduce miR-181a expression, which contributes to elevated RAS activity and hypertension in BPH/2J. Ou...
Reply: Possible impact of membrane ACE2 expression on COVID-19 infection.
JOURNAL OF HYPERTENSION - 01 Jun 2020
2020 International Society of Hypertension Global Hypertension Practice Guidelines.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2020
Remnant lipoproteins: are they equal to or more atherogenic than LDL?
CURRENT OPINION IN LIPIDOLOGY - 01 Jun 2020
To critically appraise new insights into the biology of remnant lipoproteins and their putative role in the pathophysiology of atherosclerotic cardiovascular disease, and to compare the atherogenicity of remnant particles with that of low-density lipoproteins (LDL).New in-vivo stable isotope tracer studies of the kinetics of apoB48 and apoB100-containing lipoproteins in postprandial conditions ...
Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 01 Jul 2020
Cardiorenal syndrome (CRS) is a major health burden worldwide in need of novel therapies, as current treatments remain suboptimal. The present study assessed the therapeutic potential of apoptosis signal-regulating kinase 1 (ASK1) inhibition in a rat model of CRS.Adult male Sprague-Dawley rats underwent surgery for myocardial infarction (MI) (week 0) followed by 5/6 subtotal nephrectomy (STNx) ...
Association Between Physical Activity, Exercise Capacity and Risk of Arrhythmias: Evidence from the UK Biobank Cohort
EUROPEAN HEART JOURNAL - 01 Jan 2019
Epub ahead of print
Cardiac arrest and sudden cardiac death registries: a systematic review of global coverage.
OPEN HEART - 01 Jan 2020
Sudden cardiac death (SCD) is a major global health problem, accounting for up to 20% of deaths in Western societies. Clinical quality registries have been shown in a range of disease conditions to improve clinical management, reduce variation in care and improve outcomes.To identify existing cardiac arrest (CA) and SCD registries, characterising global coverage and methods of data capture and ...
Mechanisms of Chronotropic Incompetence in Heart Failure With Preserved Ejection Fraction.
CIRCULATION. HEART FAILURE - 01 Mar 2020
Chronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and is associated with impaired aerobic capacity. We investigated the integrity of cardiac β-receptor responsiveness, an important mechanism involved in exertional increases in HR, in HFpEF and control subjects.Thirteen carefully screened patients with HFpEF and 13 senior controls underwent exercise te...
Fat Therapeutics: The Clinical Capacity of Adipose-Derived Stem Cells and Exosomes for Human Disease and Tissue Regeneration.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2020
Fat grafting is a well-established surgical technique used in plastic surgery to restore deficient tissue, and more recently, for its putative regenerative properties. Despite more frequent use of fat grafting, however, a scientific understanding of the mechanisms underlying either survival or remedial benefits of grafted fat remain lacking. Clinical use of fat grafts for breast reconstruction ...
Can angiotensin receptor-blocking drugs perhaps be harmful in the COVID-19 pandemic?
JOURNAL OF HYPERTENSION - 11 Mar 2020
Optimal Mechanical Unloading in Left Ventricular Assist Device Recipients Relates to Progressive Up-Titration in Pump Speed.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 12 Mar 2020
Left ventricular (LV) assist devices (LVADs) are known to elicit reverse remodeling by mechanically unloading the left ventricle. Current guidelines target a reduction in LV end-diastolic diameter (LVEDD) of 15% compared with pre-LVAD dimensions; however, there is significant heterogeneity in the degree of unloading achieved. We sought to investigate factors associated with mechanical unloading...
Helical flow: A means to identify unstable plaques and a new direction for the design of vascular grafts and stents.
ATHEROSCLEROSIS - 12 Mar 2020
Evaluation of elevated heart rate as a sympathetic nervous system biomarker in essential hypertension.
JOURNAL OF HYPERTENSION - 13 Mar 2020
There is a need for an easily accessible biomarker of sympathetic nervous activation in essential hypertension, but none exists. Heart rate (HR) has been suggested, but requires validation, now doubly important as an elevated HR in hypertension has emerged as an independent cardiovascular risk factor.Isotope dilution methodology was used to measure total and regional noradrenaline spillover and...
Effects of a lifestyle intervention on cardiovascular risk among high-risk individuals for diabetes in a low- and middle-income setting: Secondary analysis of the Kerala Diabetes Prevention Program.
PREVENTIVE MEDICINE - 16 Mar 2020
We aimed to examine whether a lifestyle intervention was effective in reducing cardiovascular disease (CVD) risk in individuals at high-risk of developing diabetes in a low- and middle-income setting. The Kerala Diabetes Prevention Program was evaluated by a cluster-randomized controlled trial (2013-2016) of 1007 individuals (aged 30-60 years) at high-risk for diabetes (Indian Diabetes Risk Sco...
Site qualification and clinical interpretation standards for Tc-SPECT perfusion imaging in a multi-center study of MITNEC (Medical Imaging Trials Network of Canada).99m
JOURNAL OF NUCLEAR CARDIOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY - 17 Mar 2020
Qualification and interpretation standards are essential for establishing Tc-SPECT MPI accuracy vs. alternative modalities.99mRest-stress Tc-SPECT phantom scans were acquired on 35 cameras. LV defects were quantified with summed stress (SSS) and difference scores (SDS) at 2 core labs. SDS ≥ 2 in the right coronary artery (RCA) was the qualifying standard. Twenty rest (R)-stress (S) patient imag...
Left ventricular remodelling in elite and sub-elite road cyclists.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS - 18 Mar 2020
Marked adaptation of left ventricular (LV) structure in endurance athletes is well established. However, previous investigations of functional and mechanical adaptation have been contradictory. A lack of clarity in subjects' athletic performance level may have contributed to these disparate findings. This study aimed to describe structural, functional and mechanical characteristics of the cycli...
International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health.
BMJ OPEN - 18 Mar 2020
Numerous studies have found associations between characteristics of urban environments and risk factors for dementia and cognitive decline, such as physical inactivity and obesity. However, the contribution of urban environments to brain and cognitive health has been seldom examined directly. This cohort study investigates the extent to which and how a wide range of characteristics of urban env...
Lipid rafts as a therapeutic target.
JOURNAL OF LIPID RESEARCH - 23 Mar 2020
Lipid rafts regulate the initiation of cellular metabolic and signaling pathways by organizing the pathway components in ordered microdomains on the cell surface. Cellular responses regulated by lipid rafts range from physiological to pathological, and the success of a therapeutic approach targeting "pathological" lipid rafts depends on the ability of a remedial agent to recognize them and disr...