Now showing items 21-40 of 2672 records
Risk of Rapid Kidney Function Decline, All-Cause Mortality, and Major Cardiovascular Events in Nonalbuminuric Chronic Kidney Disease in Type 2 Diabetes.
DIABETES CARE - 01 Jan 2020
We aimed to investigate the rate of progression of nonalbuminuric chronic kidney disease (CKD) to end-stage kidney disease (ESKD) or death or major cardiovascular events (MACE) compared with albuminuric and nonalbuminuric phenotypes.We included 10,185 participants with type 2 diabetes enrolled in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. Based on baseline albuminuria...
Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.
DIABETES - 01 Jan 2020
The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. We explored the role of the innate immune complement component C5a, a potent mediator of inflammation, in the pathogenesis of DKD in clinical and experimental ...
Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl.
ANTIOXIDANTS & REDOX SIGNALING - 01 Jan 2020
Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO), known as NO resistance, occurs in many cardiovascular disease states, prominently in diabetes and especially in the presence of marked hyperglycemia. In this study, we sought to determine in moderate and severe diabetes (i) whether NO resistance also occurs in the myocardium, and (ii) whether the NO redox sibling...
Comorbidities of HIV infection: role of Nef-induced impairment of cholesterol metabolism and lipid raft functionality.
AIDS (LONDON, ENGLAND) - 01 Jan 2020
: Combination antiretroviral therapy has dramatically changed the outcome of HIV infection, turning it from a death sentence to a manageable chronic disease. However, comorbidities accompanying HIV infection, such as metabolic and cardio-vascular diseases, as well as cognitive impairment, persist despite successful virus control by combination antiretroviral therapy and pose considerable challe...
Handheld ultrasound to reduce requests for inappropriate echocardiogram (HURRIE).
ECHO RESEARCH AND PRACTICE - 01 Dec 2019
Handheld ultrasound could provide sufficient information to satisfy the clinical questions underlying 'rarely appropriate' echo requests, but there are limited data about its use as a gatekeeper to standard echocardiography. We sought to determine whether the use of handheld ultrasound could improve the appropriate use of echocardiography.A prospective study comparing handheld ultrasound strate...
Prescriber Education Interventions to Optimize Opioid Prescribing in Acute Care: A Systematic Review.
PAIN PHYSICIAN - 01 Nov 2019
Opioid medications are frequently used effectively for analgesia in acute settings, however, they are associated with dependence and addiction, and were implicated in 47,600 American fatalities in 2017. Evidence suggests that despite guidelines and professional body recommendations, acute prescribing remains highly variable. Educational interventions targeting prescribers have potential to opti...
Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power.
NATURE - 01 Nov 2019
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
Dynamic Atrial Substrate During High-Density Mapping of Paroxysmal and Persistent AF: Implications for Substrate Ablation.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Nov 2019
This study sought to determine the impact of rate and direction on left atrial (LA) substrate.The extent to which substrate mapped in sinus rhythm varies according to cycle length and direction of wave front propagation is unknown.A total of 73 consecutive patients with atrial fibrillation (AF) underwent electroanatomic LA mapping before pulmonary vein isolation using multipolar catheter during...
Cardiovascular Imaging Driven by Technical Advances Needs to be Grounded in Value.
JACC. CARDIOVASCULAR IMAGING - 01 Nov 2019
Differences in transportation and leisure physical activity by neighborhood design controlling for residential choice.
JOURNAL OF SPORT AND HEALTH SCIENCE - 01 Nov 2019
Cross-sectional studies provide useful insight about the associations between the built environment and physical activity (PA), particularly when reasons for neighborhood choice are considered. Our study analyzed the relationship between levels of weekly transportation and leisure PA among 3 neighborhood designs, statistically adjusting for sociodemographic characteristics and reasons for neigh...
Letter to the Editor.
CURRENT SPORTS MEDICINE REPORTS - 01 Nov 2019
Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl
ANTIOXIDANTS & REDOX SIGNALING - 02 Nov 2019
Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO•), known as NO• resistance, occurs in many cardiovascular disease states, prominently in diabetes and especially in the presence of marked hyperglycemia. In the current study, we sought to determine in moderate and severe diabetes 1) whether NO• resistance also occurs in myocardium, 2) whether NO• redox sibling nit...
Pooled summary of native T1 value and extracellular volume with MOLLI variant sequences in normal subjects and patients with cardiovascular disease.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 04 Nov 2019
T1 mapping by cardiac magnetic resonance (CMR) allows detection of abnormal myocardium. A number of myocardial abnormalities affects the signal captured in T1 mapping. We performed a systematic review and meta-analysis of native T1 and extracellular volume (ECV) in subjects with and without cardiac disease (1) to determine the normal ranges of T1 values and ECV by sequences as well as parameter...
Dynamics of switching, adherence, and persistence of dipeptidyl peptidase-4 inhibitors use: A nationwide cohort study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 04 Nov 2019
To characterise the patterns of switching, adherence, and persistence among adults aged ≥18 years with diabetes prescribed dipeptidyl peptidase-4 inhibitors (DPP-4is) in Australia.The analysis included 15,915 adults newly prescribed DPP-4is (sitagliptin = 9576; vildagliptin = 1130; saxagliptin = 1126; linagliptin = 3560; and alogliptin = 523). Multivariable logistic regression model was used to...
Prevalence and associations of frailty in residents of Australian aged care facilities: findings from a retrospective cohort study.
AGING CLINICAL AND EXPERIMENTAL RESEARCH - 04 Nov 2019
Studies conducted among older people have shown that frailty is a common condition associated with an array of adverse outcomes. The aims of this study were to identify the prevalence and associations of frailty in older people residing in several aged care facilities located in Queensland, Australia.The database used for this study was drawn from the Aged Care Funding Instrument (ACFI) databas...
Commonly used screening instruments to identify frailty among community-dwelling older people in a general practice (primary care) setting: a study of diagnostic test accuracy.
THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES - 05 Nov 2019
Rapid frailty screening remains problematic in primary care. The diagnostic test accuracy (DTA) of several screening instruments has not been sufficiently established. We evaluated the DTA of several screening instruments against two reference standards: Fried's Frailty Phenotype [FP] and the Adelaide Frailty Index [AFI]), a self-reported questionnaire.DTA study within three general practices i...
A quantitative bias analysis to estimate measurement error-related attenuation of the association between self-reported physical activity and colorectal cancer risk.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 05 Nov 2019
Self-reported physical activity is inaccurate, yet few investigators attempt to adjust for measurement error when estimating risks for health outcomes. We estimated what the association between self-reported physical activity and colorectal cancer risk would be if physical activity had been assessed using accelerometry instead.We conducted a validation study in which 235 Australian adults compl...
When does prone sleeping improve cardiorespiratory status in preterm infants in the NICU?
SLEEP - 06 Nov 2019
Preterm infants undergoing intensive care are often placed prone to improve respiratory function. Current clinical guidelines recommend preterm infants are slept supine from 32 weeks' postmenstrual age, regardless of gestational age at birth. However, respiratory function is also related to gestational and chronological ages and is affected by sleep state. We aimed to identify the optimal timin...
Dyslipidaemia prevalence and associated risk factors in the United Arab Emirates: a population-based study.
BMJ OPEN - 07 Nov 2019
To determine and describe the prevalence and pattern of dyslipidaemia and its associated risk factors among an adult Emirati population.Population-based, cross-sectional study.Adults living in the Northern Emirates.824 adult participants (51.8% men, 48.2% women, mean age 42.8±13.4 years old).Fasting blood samples were collected, blood pressure and waist circumference were measured.The overall d...
Social-ecological correlates of accelerometer-measured occupational sitting among Japanese desk-based workers.
BMC PUBLIC HEALTH - 08 Nov 2019
Although the main targets for reducing workplace sedentary behavior have been clarified, only a few studies have examined the association between social-ecological factors and workplace sedentary behavior for effective intervention. The present study aimed to examine the social-ecological factors of workplace sedentary behavior among Japanese sedentary workers.Participants were recruited via a ...