Publications
Now showing items 21-40 of 4807 records
Evolocumab in metastatic castration-resistant prostate cancer: study protocol for a single-arm, phase II trial, and initial experience with use of a validated lipid biomarker to direct therapy.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY - 01 Jan 2024
Despite advances in the treatment of metastatic castration-resistant prostate cancer (mCRPC), primary and secondary resistance to current therapies remains. Elevated circulating sphingolipids are associated with poor outcomes in patients with mCRPC, including therapeutic resistance and shorter overall survival. PCPro is a clinically accessible, regulatory compliant plasma lipid biomarker of poo...
Computational modelling of valvular heart disease: haemodynamic insights and clinical implications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY - 01 Jan 2024
An aging population and an increasing incidence of cardiovascular risk factors form the basis for a global rising prevalence of valvular heart disease (VHD). Research to further our understanding of the pathophysiology of VHD is often confined to the clinical setting. However, in recent years, sophisticated computational models of the cardiovascular system have been increasingly used to investi...
Validation of the CRAVE-C scale in Chinese adults: a four-study examination of competing motivations for physical activity versus rest.
FRONTIERS IN PSYCHOLOGY - 01 Jan 2024
The study aimed to validate the Cravings for Rest and Volitional Energy Expenditure (CRAVE) scale among Chinese adults with different health conditions (healthy control, chronic illnesses, and psychiatric disorders) and skill levels (athletes vs. non-athletes). In Study 1, a confirmatory factor analysis (CFA) using the Maximum Likelihood Method (MLM) was performed on a Chinese sample of emergin...
A Physical Activity and Sitting Time Balance Index and All-Cause Mortality Risk.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE - 23 Jul 2024
Achieving a healthier balance of more time spent in physical activity (PA) and less time in sedentary behaviour is now widely advocated for achieving multiple health benefits. This study introduces a Physical Activity and Sitting Time Balance Index (PASTBI), a potential risk identification tool addressing the interplay between PA and sedentary behaviour; and aims to explore its association with...
Remote myocardial zone characteristics in type 2 diabetes patients with prior myocardial infarction and comparisons with diabetes patients with no prior infarction.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM - 01 Jan 2024
HIV-1 Nef is carried on the surface of extracellular vesicles.
01 Jul 2024
Extracellular vesicles (EVs) serve as pivotal mediators of intercellular communication in both health and disease, delivering biologically active molecules from vesicle-producing cells to recipient cells. In the context of HIV infection, EVs have been shown to carry the viral protein Nef, a key pathogenic factor associated with HIV-related co-morbidities. Despite this recognition, the specific ...
The KgA1c Paradox: Widening the spectrum.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jul 2024
The term KgA1c paradox is used to describe the unwanted rise in weight that occurs when HbA1c is controlled using conventional therapy. We highlight facets of pathophysiology, prevention, pharmacology, person centred care, and epidemiology, which correspond to the concept of KgA1c paradox. We suggest a novel index, KgA1c product [(BMI) x (HbA1c)], which can be used to evaluate efficacy of drugs...
NAFLD and MAFLD independently increase the risk of major adverse cardiovascular events (MACE): a 20-year longitudinal follow-up study from regional Australia.
HEPATOLOGY INTERNATIONAL - 15 Jul 2024
The association between fatty liver disease (FLD) and cardiovascular disease (CVD) in an Australian context has yet to be defined. The primary aim of this study was to investigate the association between FLD and 3-point major adverse cardiovascular events (MACE). This was a longitudinal follow-up study of a randomly sampled adult cohort from regional Australia between 2001 and 2003. Baseline co...
Maternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring.
CIRCULATION RESEARCH - 17 Jul 2024
Apicolateral bulge: A potential mimic of arrhythmogenic right ventricular cardiomyopathy in a professional athlete-A case report and literature review.
JOURNAL OF CLINICAL ULTRASOUND : JCU - 17 Jul 2024
Soccer is the most popular sport in the world, with over 265 million active players and approximately 0.05% professional players worldwide. The Fédération Internationale de Football Association (FIFA) has made preparticipation screening recommendations which involve electrocardiography and echocardiography being performed prior to international competition. The aim of preparticipation cardiovas...
Early Use of Aspirin for Coronary Allograft Prophylaxis in Heart Transplant Recipients.
TRANSPLANTATION - 18 Jul 2024
Coronary allograft vasculopathy (CAV) remains a significant cause of morbidity and mortality after heart transplantation. The use of aspirin for CAV prophylaxis has recently garnered interest as a possible therapeutic adjunct in this setting. This 2-center retrospective cohort study included 372 patients who underwent heart transplantation between January 2009 and March 2018 and were stratified...
Clinical Significance of Exercise Pulmonary Hypertension With a Negative Diastolic Stress Test for Suspected Heart Failure With Preserved Ejection Fraction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 19 Jul 2024
Half of patients with heart failure with preserved ejection fraction (HFpEF) remain undiagnosed by resting evaluation alone. Therefore, exercise testing is proposed. The diastolic stress test (DST), however, has limited sensitivity. We aimed to determine the clinical significance of adding the mean pulmonary artery pressure over cardiac output (mPAP/CO) slope to the DST in suspected HFpEF. In t...
Integrated image-based deep learning and language models for primary diabetes care.
NATURE MEDICINE - 19 Jul 2024
Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary care physicians (PCPs), particularly in low-resource settings. Here, to bridge the gaps, we developed an integrated image-language system (DeepDR-LLM), combining a large language model (LLM module) and image-based deep learning (DeepDR-Transformer), to pro...
piscesCSM: prediction of anticancer synergistic drug combinations.
JOURNAL OF CHEMINFORMATICS - 19 Jul 2024
While drug combination therapies are of great importance, particularly in cancer treatment, identifying novel synergistic drug combinations has been a challenging venture. Computational methods have emerged in this context as a promising tool for prioritizing drug combinations for further evaluation, though they have presented limited performance, utility, and interpretability. Here, we propose...
Aptasensors and Advancement in Molecular Recognition Technology
ADVANCED MATERIALS TECHNOLOGIES - 02 Jul 2024
Synthetic oligonucleic acids known as aptamers exhibit remarkable selectivity and affinity for target recognition and binding. Selected via an iterative process known as “selective evolution of ligands by exponential enrichment” (SELEX), aptamers fold into defined 3D conformations to interact with their targets. The incorporation of aptamers as recognition elements has driven notable progress i...
PVC Triggers in Early Repolarization Syndrome: A New Wave of Knowledge.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jan 2024
Predictors of pacemaker requirement in patients receiving implantable loop recorders for unexplained syncope: A systematic review and meta-analysis.
HEART RHYTHM - 18 Mar 2024
Implantable loop recorders (ILRs) are increasingly used to evaluate patients with unexplained syncope. Identification of all predictors of bradycardic syncope and consequent permanent pacemaker (PPM) insertion is of substantial clinical interest as patients in the highest risk category may benefit from upfront pacemaker insertion. We performed a systematic review and meta-analysis to identify r...
C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation.
JOURNAL OF ADVANCED RESEARCH - 09 Jul 2024
Despite recent substantial progress in vascularized composite allotransplantation (VCA), such as face transplantations, short- and long-term allograft survival is severely limited by allograft rejection. The acute-phase response, directly after allogeneic transplantation, represents an immune-inflammatory reaction to ischemia/reperfusion and acts as an early initiator of graft rejection. Acute-...
Mechanical dyssynchrony as a selection criterion for cardiac resynchronization therapy: Design of the AMEND-CRT trial.
ESC HEART FAILURE - 10 Jul 2024
One third of patients do not improve after cardiac resynchronization therapy (CRT). Septal flash (SF) and apical rocking (ApRock) are deformation patterns observed on echocardiography in most patients eligible for CRT. These markers of mechanical dyssynchrony have been associated to improved outcome after CRT in observational studies and may be useful to better select patients. The aim of this ...
The effect of ambient temperatures on hospital admissions for kidney diseases in Central Australia.
ENVIRONMENTAL RESEARCH - 29 Jun 2024
This study aimed to quantify risk of hospitalisations for kidney diseases related to ambient temperature in Central Australia, Northern Territory (NT). Daily hospitalisation data were extracted for Alice Springs Hospital, Central Australia, 2010-2021. The association between daily mean temperature and daily hospital admissions for total kidney and specific kidney conditions was assessed using a...
