Now showing items 21-40 of 2676 records
A Novel Epigenetic Drug-Eluting Balloon Angioplasty Device: Evaluation in a Large Animal Model of Neointimal Hyperplasia.
CARDIOVASCULAR DRUGS AND THERAPY - 30 Dec 2019
Drug-eluting balloon catheters (DEBc) coated with paclitaxel (PTX) have been associated with potential safety concerns. An efficacious but less toxic balloon coating may reduce these outcomes. We evaluated a novel DEBc, Epi-Solve, coated with metacept-3 (MCT-3), a member of the histone deacetylase inhibitor (HDACi) class of epigenetic agents, in a large animal model of neointimal hyperplasia (N...
Predictors of the Acute Postprandial Response to Breaking Up Prolonged Sitting.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 31 Dec 2019
To identify predictors of favourable changes to postprandial insulin and glucose levels in response to interrupting prolonged sitting time with standing or light intensity physical activity.Data were combined from four similarly designed randomised acute cross-over trials (n=129; BMI range 19.6 to 44.6kg/m2; South Asian=31.0%; dysglycaemia=27.1%). Treatments included: prolonged sitting (6.5hour...
Lancet Commission on Hypertension group position statement on the global improvement of accuracy standards for devices that measure blood pressure.
JOURNAL OF HYPERTENSION - 01 Jan 2020
: The Lancet Commission on Hypertension identified that a key action to address the worldwide burden of high blood pressure (BP) was to improve the quality of BP measurements by using BP devices that have been validated for accuracy. Currently, there are over 3000 commercially available BP devices, but many do not have published data on accuracy testing according to established scientific stand...
Hall Technique crowns and children's masseter muscle activity: a surface-electromyography pilot study.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY - 01 Jan 2020
Hall technique crowns (HTCs) alter the occlusion temporarily, potentially affecting jaw muscles, particularly the masseter -the primary jaw-closing muscle.To assess masseter muscle activity (MMA) in children treated with a unilateral HTC.In 12 children treated with a single HTC, bilateral MMA was recorded with surface electromyography (sEMG) for ten cycles of Rest-Position (RP) and Maximum-Volu...
Risk of Rapid Kidney Function Decline, All-Cause Mortality, and Major Cardiovascular Events in Nonalbuminuric Chronic Kidney Disease in Type 2 Diabetes.
DIABETES CARE - 01 Jan 2020
We aimed to investigate the rate of progression of nonalbuminuric chronic kidney disease (CKD) to end-stage kidney disease (ESKD) or death or major cardiovascular events (MACE) compared with albuminuric and nonalbuminuric phenotypes.We included 10,185 participants with type 2 diabetes enrolled in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study. Based on baseline albuminuria...
Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.
DIABETES - 01 Jan 2020
The sequelae of diabetes include microvascular complications such as diabetic kidney disease (DKD), which involves glucose-mediated renal injury associated with a disruption in mitochondrial metabolic agility, inflammation, and fibrosis. We explored the role of the innate immune complement component C5a, a potent mediator of inflammation, in the pathogenesis of DKD in clinical and experimental ...
Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl.
ANTIOXIDANTS & REDOX SIGNALING - 01 Jan 2020
Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO), known as NO resistance, occurs in many cardiovascular disease states, prominently in diabetes and especially in the presence of marked hyperglycemia. In this study, we sought to determine in moderate and severe diabetes (i) whether NO resistance also occurs in the myocardium, and (ii) whether the NO redox sibling...
Comorbidities of HIV infection: role of Nef-induced impairment of cholesterol metabolism and lipid raft functionality.
AIDS (LONDON, ENGLAND) - 01 Jan 2020
: Combination antiretroviral therapy has dramatically changed the outcome of HIV infection, turning it from a death sentence to a manageable chronic disease. However, comorbidities accompanying HIV infection, such as metabolic and cardio-vascular diseases, as well as cognitive impairment, persist despite successful virus control by combination antiretroviral therapy and pose considerable challe...
Handheld ultrasound to reduce requests for inappropriate echocardiogram (HURRIE).
ECHO RESEARCH AND PRACTICE - 01 Dec 2019
Handheld ultrasound could provide sufficient information to satisfy the clinical questions underlying 'rarely appropriate' echo requests, but there are limited data about its use as a gatekeeper to standard echocardiography. We sought to determine whether the use of handheld ultrasound could improve the appropriate use of echocardiography.A prospective study comparing handheld ultrasound strate...
Prescriber Education Interventions to Optimize Opioid Prescribing in Acute Care: A Systematic Review.
PAIN PHYSICIAN - 01 Nov 2019
Opioid medications are frequently used effectively for analgesia in acute settings, however, they are associated with dependence and addiction, and were implicated in 47,600 American fatalities in 2017. Evidence suggests that despite guidelines and professional body recommendations, acute prescribing remains highly variable. Educational interventions targeting prescribers have potential to opti...
Author Correction: Exome sequencing of Finnish isolates enhances rare-variant association power.
NATURE - 01 Nov 2019
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
Dynamic Atrial Substrate During High-Density Mapping of Paroxysmal and Persistent AF: Implications for Substrate Ablation.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Nov 2019
This study sought to determine the impact of rate and direction on left atrial (LA) substrate.The extent to which substrate mapped in sinus rhythm varies according to cycle length and direction of wave front propagation is unknown.A total of 73 consecutive patients with atrial fibrillation (AF) underwent electroanatomic LA mapping before pulmonary vein isolation using multipolar catheter during...
Cardiovascular Imaging Driven by Technical Advances Needs to be Grounded in Value.
JACC. CARDIOVASCULAR IMAGING - 01 Nov 2019
Differences in transportation and leisure physical activity by neighborhood design controlling for residential choice.
JOURNAL OF SPORT AND HEALTH SCIENCE - 01 Nov 2019
Cross-sectional studies provide useful insight about the associations between the built environment and physical activity (PA), particularly when reasons for neighborhood choice are considered. Our study analyzed the relationship between levels of weekly transportation and leisure PA among 3 neighborhood designs, statistically adjusting for sociodemographic characteristics and reasons for neigh...
Letter to the Editor.
CURRENT SPORTS MEDICINE REPORTS - 01 Nov 2019
Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl
ANTIOXIDANTS & REDOX SIGNALING - 02 Nov 2019
Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO•), known as NO• resistance, occurs in many cardiovascular disease states, prominently in diabetes and especially in the presence of marked hyperglycemia. In the current study, we sought to determine in moderate and severe diabetes 1) whether NO• resistance also occurs in myocardium, 2) whether NO• redox sibling nit...
Pooled summary of native T1 value and extracellular volume with MOLLI variant sequences in normal subjects and patients with cardiovascular disease.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 04 Nov 2019
T1 mapping by cardiac magnetic resonance (CMR) allows detection of abnormal myocardium. A number of myocardial abnormalities affects the signal captured in T1 mapping. We performed a systematic review and meta-analysis of native T1 and extracellular volume (ECV) in subjects with and without cardiac disease (1) to determine the normal ranges of T1 values and ECV by sequences as well as parameter...
Dynamics of switching, adherence, and persistence of dipeptidyl peptidase-4 inhibitors use: A nationwide cohort study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 04 Nov 2019
To characterise the patterns of switching, adherence, and persistence among adults aged ≥18 years with diabetes prescribed dipeptidyl peptidase-4 inhibitors (DPP-4is) in Australia.The analysis included 15,915 adults newly prescribed DPP-4is (sitagliptin = 9576; vildagliptin = 1130; saxagliptin = 1126; linagliptin = 3560; and alogliptin = 523). Multivariable logistic regression model was used to...
Prevalence and associations of frailty in residents of Australian aged care facilities: findings from a retrospective cohort study.
AGING CLINICAL AND EXPERIMENTAL RESEARCH - 04 Nov 2019
Studies conducted among older people have shown that frailty is a common condition associated with an array of adverse outcomes. The aims of this study were to identify the prevalence and associations of frailty in older people residing in several aged care facilities located in Queensland, Australia.The database used for this study was drawn from the Aged Care Funding Instrument (ACFI) databas...
Commonly used screening instruments to identify frailty among community-dwelling older people in a general practice (primary care) setting: a study of diagnostic test accuracy.
THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES - 05 Nov 2019
Rapid frailty screening remains problematic in primary care. The diagnostic test accuracy (DTA) of several screening instruments has not been sufficiently established. We evaluated the DTA of several screening instruments against two reference standards: Fried's Frailty Phenotype [FP] and the Adelaide Frailty Index [AFI]), a self-reported questionnaire.DTA study within three general practices i...