Publications
By Year
Now showing items 21-40 of 2514 records
Should we screen for frailty in primary care settings? A fresh perspective on the frailty evidence base: A narrative review.
Rachel C Ambagtsheer; Justin J Beilby; Renuka Visvanathan; Elsa Dent; Solomon Yu; Annette J Braunack-Mayer
PREVENTIVE MEDICINE - 01 Feb 2019
With older adults living longer, health service providers have increasingly turned their attention towards frailty and its significant consequences for health and well-being. Consequently, frailty screening has gained momentum as a possible health policy answer to the question of what can be done to prevent frailty's onset and progression. However, who should be screened for frailty, where and ...
Sympathetic Nervous System Activation and Its Modulation: Role in Atrial Fibrillation.
Revathy Carnagarin; Marcio G Kiuchi; Jan K Ho; Vance B Matthews; Markus P Schlaich
FRONTIERS IN NEUROSCIENCE - 01 Jan 2018
The autonomic nervous system (ANS) has a significant influence on the structural integrity and electrical conductivity of the atria. Aberrant activation of the sympathetic nervous system can induce heterogeneous changes with arrhythmogenic potential which can result in atrial tachycardia, atrial tachyarrhythmias and atrial fibrillation (AF). Methods to modulate autonomic activity primarily thro...
Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O Sensitive Voltage-Gated K Channels.2
Fenling Fan; Hua Tian; Jie Geng; Jizhao Deng; Ya Liu; Chunyan Chen; Songlin Zhang; Yushun Zhang; Jie Li; Hongyan Tian; Anthony M Dart; Yuliang Zou
FRONTIERS IN PHARMACOLOGY - 01 Jan 2018
The purpose of this study is to elucidate mechanism(s) by which the orally active PGI2 analog, Beraprost (BPS), ameliorates pulmonary hypertension (PH). Prostaglandins are an important treatment for PH. Mechanisms of their action are not fully elucidated in relation to receptor subtype and effects on O sensitive Kv channels. Distal (3rd order and beyond) pulmonary arteries from chronically hyp...
High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors.
Kevin Huynh; Christopher K Barlow; Kaushala S Jayawardana; Jacquelyn M Weir; Natalie A Mellett; Michelle Cinel; Dianna J Magliano; Jonathan E Shaw; Brian G Drew; Peter J Meikle
CELL CHEMICAL BIOLOGY - 17 Jan 2019
High-throughput targeted lipid profiling with liquid chromatography-mass spectrometry (LC-MS) has been used extensively to identify associations between plasma lipid species and disease states. Such methods, used to characterize larger clinical cohorts, often suffer from an inability to differentiate isomeric forms of glycerophospholipids that are typically reported as the sum fatty acid carbon...
Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.
Amanda E Brandon; Bing M Liao; Barbara Diakanastasis; Benjamin L Parker; Katy Raddatz; Sophie A McManus; Liam O'Reilly; Erica Kimber; A Gabrielle van der Kraan; Dale Hancock; Darren C Henstridge; Peter J Meikle; Gregory J Cooney; David E James; Saskia Reibe; Mark A Febbraio; Trevor J Biden; Carsten Schmitz-Peiffer
CELL METABOLISM - 08 Jan 2019
Protein kinase C epsilon (PKCɛ) activation in the liver is proposed to inhibit insulin action through phosphorylation of the insulin receptor. Here, however, we demonstrated that global, but not liver-specific, deletion of PKCɛ in mice protected against diet-induced glucose intolerance and insulin resistance. Furthermore, PKCɛ-dependent alterations in insulin receptor phosphorylation were not d...
Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis.
Raelene J Pickering; Christos Tikellis; Carlos J Rosado; Despina Tsorotes; Alexandra Dimitropoulos; Monique Smith; Olivier Huet; Ruth M Seeber; Rekhati Abhayawardana; Elizabeth Km Johnstone; Jonathan Golledge; Yutang Wang; Karin A Jandeleit-Dahm; Mark E Cooper; Kevin Dg Pfleger; Merlin C Thomas
THE JOURNAL OF CLINICAL INVESTIGATION - 02 Jan 2019
Activation of the type 1 angiotensin II receptor (AT1) triggers proinflammatory signaling through pathways independent of classical Gq signaling that regulate vascular homeostasis. Here, we report that the AT1 receptor preformed a heteromeric complex with the receptor for advanced glycation endproducts (RAGE). Activation of the AT1 receptor by angiotensin II (Ang II) triggered transactivation o...
Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling.
My-Nhan Nguyen; Mark Ziemann; Helen Kiriazis; Yidan Su; Zara Thomas; Qun Lu; Daniel G Donner; Wei-Bo Zhao; Haloom Rafehi; Junichi Sadoshima; Julie R McMullen; Assam El-Osta; Xiao-Jun Du
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Jan 2019
Dilated cardiomyopathy (DCM) is a major cause of heart failure without effective therapy. Fibrogenesis plays a key role in the development of DCM, but little is known of the expression of the profibrotic factor galectin-3 (Gal-3) and its role in DCM pathophysiology. In a mouse DCM model with transgenic (TG) overexpression of mammalian sterile 20-like kinase 1 (Mst1), we studied Gal-3 expression...
Comparison of short-term clinical outcomes of proximal versus nonproximal lesion location in patients treated with primary percutaneous coronary intervention for ST-elevation myocardial infarction: The PROXIMITI study.
Samer Noaman; Cheng Yee Goh; Sara Vogrin; Angela L Brennan; Nick Andrianopoulos; Diem T Dinh; Jeffrey Lefkovits; Christopher M Reid; Antony Walton; Omar Al-Mukhtar; Sinjini Biswas; Dion Stub; Stephen J Duffy; Nicholas Cox; William Chan
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS - 01 Jan 2019
The objective of this study was to investigate the association of proximal and nonproximal location of culprit coronary lesions with clinical outcomes of patients presenting with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI).Proximal culprit lesion location in patients presenting with STEMI is associated with increased mortality when comp...
Impact of Socioeconomic Status on Clinical Outcomes in Patients With ST-Segment-Elevation Myocardial Infarction.
Sinjini Biswas; Nick Andrianopoulos; Stephen J Duffy; Jeffrey Lefkovits; Angela Brennan; Antony Walton; William Chan; Samer Noaman; James A Shaw; Andrew Ajani; David J Clark; Melanie Freeman; Chin Hiew; Ernesto Oqueli; Christopher M Reid; Dion Stub
CIRCULATION. CARDIOVASCULAR QUALITY AND OUTCOMES - 01 Jan 2019
Low socioeconomic status (SES) has been previously shown to be associated with worse cardiovascular outcomes. However, unlike in Australia, many of these studies have been performed in countries without universal healthcare where SES may be expected to have a greater impact on care and outcomes. We sought to determine whether there is an association between SES and baseline characteristics, cli...
Serum amyloid A does not affect high-density lipoprotein cholesterol measurement by a homogeneous assay.
Megumi Sato; Ryunosuke Ohkawa; Hann Low; Madoka Nishimori; Shigeo Okubo; Akira Yoshimoto; Kouji Yano; Takahiro Kameda; Yutaka Yatomi; Minoru Tozuka
CLINICAL BIOCHEMISTRY - 01 Jan 2019
Serum amyloid A (SAA), which is one of the acute phase proteins, alters the structure of HDL by associating with it during circulation. We focused on whether SAA influences the values of HDL-cholesterol (HDL-C) measurements when using a homogeneous assay.HDLs were isolated by ultracentrifugation from serum samples of 248 patients that were stratified into three groups based on their serum SAA c...
Recommendations for participation in competitive and leisure time sport in athletes with cardiomyopathies, myocarditis, and pericarditis: position statement of the Sport Cardiology Section of the European Association of Preventive Cardiology (EAPC).
Antonio Pelliccia; Erik Ekker Solberg; Michael Papadakis; Paolo Emilio Adami; Alessandro Biffi; Stefano Caselli; Andrè La Gerche; Josef Niebauer; Axel Pressler; Christian M Schmied; Luis Serratosa; Martin Halle; Frank Van Buuren; Mats Borjesson; Francois Carrè; Nicole M Panhuyzen-Goedkoop; Hein Heidbuchel; Iacopo Olivotto; Domenico Corrado; Gianfranco Sinagra; Sanjay Sharma
EUROPEAN HEART JOURNAL - 01 Jan 2019
Myocardial diseases are associated with an increased risk of potentially fatal cardiac arrhythmias and sudden cardiac death/cardiac arrest during exercise, including hypertrophic cardiomyopathy, dilated cardiomyopathy, left ventricular non-compaction, arrhythmogenic cardiomyopathy, and myo-pericarditis. Practicing cardiologists and sport physicians are required to identify high-risk individuals...
Recommendations for participation in leisure time or competitive sports in athletes-patients with coronary artery disease: a position statement from the Sports Cardiology Section of the European Association of Preventive Cardiology (EAPC).
Mats Borjesson; Mikael Dellborg; Josef Niebauer; Andre LaGerche; Christian Schmied; Erik E Solberg; Martin Halle; Emilio Adami; Alessandro Biffi; Francois Carré; Stefano Caselli; Michael Papadakis; Axel Pressler; Hanne Rasmusen; Luis Serratosa; Sanjay Sharma; Frank van Buuren; Antonio Pelliccia
EUROPEAN HEART JOURNAL - 01 Jan 2019
Sudden Death and Ventricular Arrhythmias in Athletes: Screening, De-Training and the Role of Catheter Ablation.
M Darragh Flannery; André La Gerche
HEART, LUNG & CIRCULATION - 01 Jan 2019
Athletes enjoy excellent health outcomes including greater longevity relative to non-athletic counterparts. Paradoxically, however, endurance athletic conditioning is associated with an increase in some arrhythmias. This review discusses the potential mechanisms for this paradox and strategies enabling early identification of potentially serious pathologies. Screening remains contentious due to...
Regression to the mean of repeated ambulatory blood pressure monitoring in five studies.
Myles N Moore; Emily R Atkins; Abdul Salam; Michele L Callisaya; James L Hare; Thomas H Marwick; Mark R Nelson; Leah Wright; James E Sharman; Anthony Rodgers
JOURNAL OF HYPERTENSION - 01 Jan 2019
To estimate the size of regression to the mean with ambulatory blood pressure (ABP) measurement.Participants from five studies who had repeated blood pressure (BP) measurements using office and ambulatory devices were included. Regression to the mean was calculated following participants being grouped by baseline BP categories. Regression dilution ratio was calculated for groups defined by each...
The impact of 2 years of high-intensity exercise training on a model of integrated cardiovascular regulation.
Michinari Hieda; Erin J Howden; Satyam Sarma; William Cornwell; Justin S Lawley; Takashi Tarumi; Dean Palmer; Mitchel Samels; Braden Everding; Sheryl Livingston; Qi Fu; Rong Zhang; Benjamin D Levine
THE JOURNAL OF PHYSIOLOGY - 01 Jan 2019
Heart rate variability, a common and easily measured index of cardiovascular dynamics, is the output variable of complicated cardiovascular and respiratory control systems. Both neural and non-neural control mechanisms may contribute to changes in heart rate variability. We previously developed an innovative method using transfer function analysis to assess the effect of prolonged exercise trai...
Lower body negative pressure to safely reduce intracranial pressure.
Lonnie G Petersen; Justin S Lawley; Alexander Lilja-Cyron; Johan C G Petersen; Erin J Howden; Satyam Sarma; William K Cornwell; Rong Zhang; Louis A Whitworth; Michael A Williams; Marianne Juhler; Benjamin D Levine
THE JOURNAL OF PHYSIOLOGY - 01 Jan 2019
During long-term missions, some astronauts experience structural and functional changes of the eyes and brain which resemble signs/symptoms experienced by patients with intracranial hypertension. Weightlessness prevents the normal cerebral volume and pressure 'unloading' associated with upright postures on Earth, which may be part of the cerebral and ocular pathophysiology. By placing the lower...
Distribution and Prognostic Significance of Left Ventricular Global Longitudinal Strain in Asymptomatic Significant Aortic Stenosis: An Individual Participant Data Meta-Analysis.
Julien Magne; Bernard Cosyns; Bogdan A Popescu; Helle G Carstensen; Jordi Dahl; Milind Y Desai; Leighton Kearney; Patrizio Lancellotti; Thomas H Marwick; Kimi Sato; Masaaki Takeuchi; Concetta Zito; Anne-Claire Casalta; Dania Mohty; Luc Piérard; Gilbert Habib; Erwan Donal
JACC. CARDIOVASCULAR IMAGING - 01 Jan 2019
In this individual participant data meta-analysis on left ventricular global longitudinal strain (LVGLS), our objective was to: 1) describe its distribution; 2) identify the most predictive cutoff values; and 3) assess its impact on mortality in asymptomatic patients with significant aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF).The evidence supporting the prognos...
Assessment of Subclinical Left Ventricular Dysfunction in Aortic Stenosis.
Jordi S Dahl; Julien Magne; Patricia A Pellikka; Erwan Donal; Thomas H Marwick
JACC. CARDIOVASCULAR IMAGING - 01 Jan 2019
Left ventricular (LV) systolic dysfunction is an adverse consequence of the pressure overload of severe aortic stenosis (AS). The enlargement of the interstitial space with reactive fibrosis and subsequently with replacement fibrosis and cell death has been suggested to be the main driver of the transition to symptoms, heart failure, and adverse cardiovascular events even after aortic valve rep...
Built environment and cardio-metabolic health: systematic review and meta-analysis of longitudinal studies.
M Chandrabose; J N Rachele; L Gunn; A Kavanagh; N Owen; G Turrell; B Giles-Corti; T Sugiyama
OBESITY REVIEWS : AN OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF OBESITY - 01 Jan 2019
Built environment attributes may be related to cardio-metabolic diseases (e.g. type 2 diabetes, heart disease and stroke) and their risk factors, potentially by influencing residents' physical activity. However, existing literature reviews on the built environment and health for the most part focus on obesity as the outcome and rely on cross-sectional studies. This systematic review synthesized...
Nutritional Deficiencies in Severe Obesity: a Multiethnic Asian Cohort.
Phong Ching Lee; Sonali Ganguly; John B Dixon; Hong Chang Tan; Chin Hong Lim; Kwang Wei Tham
OBESITY SURGERY - 01 Jan 2019
Micronutrient deficiencies are highly prevalent in patients seeking metabolic-bariatric surgery (MBS), although literature remains scant in Asia. In this study, we assess the prevalence of nutritional deficiencies in patients with clinically severe obesity in Singapore and examine factors associated with the deficiencies.This is a prospective, observational study of 577 consecutive patients sch...
Show more...