Publications
Now showing items 761-780 of 4875 records
Genetically personalised organ-specific metabolic models in health and disease.
NATURE COMMUNICATIONS - 29 Nov 2022
Understanding how genetic variants influence disease risk and complex traits (variant-to-function) is one of the major challenges in human genetics. Here we present a model-driven framework to leverage human genome-scale metabolic networks to define how genetic variants affect biochemical reaction fluxes across major human tissues, including skeletal muscle, adipose, liver, brain and heart. As ...
Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons.
ESC HEART FAILURE - 01 Dec 2022
Prescribed opioids are commonly used in the older community-dwelling population for the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use.A post hoc analysis of...
Of Mice and Man: The Unwinding of CLEC-2 as an Antithrombotic Target?
THROMBOSIS AND HAEMOSTASIS - 01 Dec 2022
Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 01 Dec 2022
The neural pathways in which the brain regulates the cardiovascular system is via sympathetic and parasympathetic control of the heart and sympathetic control of the systemic vasculature. Various cortical and sub-cortical sites are involved, but how these critical brain regions for cardiovascular control are altered in healthy aging and other risk conditions that may contribute to cardiovascula...
: A Web Server for Predicting Cardiotoxicity of Small Molecules.cardioToxCSM
JOURNAL OF CHEMICAL INFORMATION AND MODELING - 24 Oct 2022
The design of novel, safe, and effective drugs to treat human diseases is a challenging venture, with toxicity being one of the main sources of attrition at later stages of development. Failure due to toxicity incurs a significant increase in costs and time to market, with multiple drugs being withdrawn from the market due to their adverse effects. Cardiotoxicity, for instance, was responsible ...
Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.
MICROBIOLOGY SPECTRUM - 26 Oct 2022
With increasing emergence of antimicrobial resistant bacteria (ARB) and the risk this poses to public health, there are growing concerns regarding water pollution contributing to the spread of antimicrobial resistance (AMR) through inadequate amenities and the rapid rate of urbanization. In this study, the impact of different anthropogenic factors on the prevalence of AMR in the urban water cyc...
APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.
ALZHEIMER'S & DEMENTIA : THE JOURNAL OF THE ALZHEIMER'S ASSOCIATION - 01 Nov 2022
The apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood.We performed lipidomic analysis on three independent cohorts (the Australian Imaging, Biomarkers and Lifestyle [AIBL] flagship study, n = 1087; the Alzheimer's Disease Neuro...
How Dietary Fibre, Acting via the Gut Microbiome, Lowers Blood Pressure.
CURRENT HYPERTENSION REPORTS - 01 Nov 2022
To discuss the interplay behind how a high-fibre diet leads to lower blood pressure (BP) via the gut microbiome.Compelling evidence from meta-analyses support dietary fibre prevents the development of cardiovascular disease and reduces BP. This relation is due to gut microbial metabolites, called short-chain fatty acids (SCFAs), derived from fibre fermentation. The SCFAs acetate, propionate and...
Stroke genetics informs drug discovery and risk prediction across ancestries.
NATURE - 01 Nov 2022
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (6...
kinCSM: Using graph-based signatures to predict small molecule CDK2 inhibitors.
PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY - 01 Nov 2022
Protein phosphorylation acts as an essential on/off switch in many cellular signaling pathways. This has led to ongoing interest in targeting kinases for therapeutic intervention. Computer-aided drug discovery has been proven a useful and cost-effective approach for facilitating prioritization and enrichment of screening libraries, but limited effort has been devoted providing insights on what ...
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
MICROBIAL GENOMICS - 01 Nov 2022
is a leading cause of bacterial meningitis in South-East Asia, with frequent zoonotic transfer to humans associated with close contact with pigs. A small number of invasive lineages are responsible for endemic infection in the swine industry, causing considerable global economic losses. A lack of surveillance and a rising trend in clinical treatment failure has raised concerns of growing antimi...
The Cost-Effectiveness of the SMART Work & Life Intervention for Reducing Sitting Time.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 11 Nov 2022
Sedentary behaviours continue to increase and are associated with heightened risks of morbidity and mortality. We assessed the cost-effectiveness of SMART Work & Life (SWAL), an intervention designed to reduce sitting time inside and outside of work, both with (SWAL-desk) and without (SWAL-only) a height-adjustable workstation compared to usual practice (control) for UK office workers. Health o...
Impact of within-visit systolic blood pressure change patterns on blood pressure classification: the Cardiovascular Risk in Young Finns Study.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 15 Nov 2022
Most international guidelines recommend that repeat blood pressure (BP) readings are required for BP classification. Two international guidelines diverge from this by recommending that no further BP measurements are required if the first clinic BP is below a hypertension threshold. The extent to which within-visit BP variability patterns change over time, and whether this could impact BP classi...
Prevalence of waterpipe smoking and its associated factors among adolescents aged 12-16 years in 73 countries/territories.
FRONTIERS IN PUBLIC HEALTH - 01 Jan 2022
To describe the recent prevalence of, and trends in, waterpipe smoking and to examine its associated factors among adolescents aged 12-16 years in 73 countries/territories (hereafter "countries").Data from 72 countries that had conducted a Global Youth Tobacco Survey (GYTS) in 2010-2019 and from the National Youth Tobacco Survey in the United States in 2019 were used to assess the recent preval...
Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 18 Nov 2022
Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to repair injured cardiac tissues and regulate pathological fibrosis. However, scalable generation of stem cells and derived EVs for clinical utility remains a huge technical challenge. Here, we report a rapid size-based extrusion strategy to generate EV-like membranous nanovesicles (NVs) from easily sourc...
Long term all-cause and cardiovascular disease mortality among women who undergo fertility treatment.
THE MEDICAL JOURNAL OF AUSTRALIA - 21 Nov 2022
To compare age-adjusted all-cause and CVD mortality, relative to the general female population, for women registered for fertility treatment who received it and those who did not.Prospective cohort study; analysis of Monash IVF clinical registries data, 1975-2018, linked with National Death Index mortality data.All women who registered for fertility treatment at Monash IVF (Melbourne, Victoria)...
Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2022
Cardiac fibrosis is central to heart failure (HF), especially HF with preserved ejection fraction (HFpEF), often caused by hypertension. Despite fibrosis causing diastolic dysfunction and impaired electrical conduction, responsible for arrhythmia-induced sudden cardiac death, the mechanisms are poorly defined and effective therapies are lacking. Here we show that crosstalk between cardiac cytot...
The Importance of Research on Occupational Sedentary Behaviour and Activity Right Now.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 28 Nov 2022
The workplace has been identified as a key setting for public health interventions to 'promote and maintain the highest degree of physical, mental and social well-being of workers in all occupations' by the World Health Organisation [...].
Proportion and trend in the age of cigarette smoking initiation among adolescent smoking experiencers aged 13-15 years in 148 countries/territories.
FRONTIERS IN PUBLIC HEALTH - 01 Jan 2022
Limited studies have assessed the recent proportion and trend in the age of cigarette smoking initiation among adolescent smoking experiencers globally. We aimed to assess the recent global proportion, associated factors and the long-term trend of the initiated age of cigarette smoking among adolescent smoking experiencers.We used data from the most recent Global Youth Tobacco Survey on 99,728 ...
Quantification and Selective Use of Multimodality Imaging in the Assessment of Valvular Regurgitation.
JACC. CARDIOVASCULAR IMAGING - 01 May 2022
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