Publications
Now showing items 441-460 of 5027 records
Assessing atrial myopathy with cardiac magnetic resonance imaging in embolic stroke of undetermined source.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 15 Oct 2023
Left atrial myopathy has been implicated in atrial fibrillation (AF)-related stroke and embolic stroke of undetermined source (ESUS).To use advanced cardiac magnetic resonance (CMR) imaging techniques, including left atrial (LA) strain and 4D flow CMR, to identify atrial myopathy in patients with ESUS.20 patients with ESUS and no AF or other cause for stroke, and 20 age and sex-matched controls...
Coronary Artery Disease Risk Prediction in Patients With Severe Aortic Stenosis: Development and Validation of the Aortic Stenosis-Coronary Artery Disease (AS-CAD) Score.
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Oct 2023
Patients at a low risk of coronary artery disease (CAD) could be triaged to noninvasive coronary computed tomography angiogram instead of invasive coronary angiography, reducing health care costs and patient morbidity. Therefore, we aimed to develop a CAD risk prediction score to identify those who underwent transcatheter aortic valve implantation (TAVI) at a low risk of CAD. We enrolled 1,782 ...
Mechanical Wave Speeds in Healthy and Pathologic Hearts: Depends on Where and When You Look.
JACC. CARDIOVASCULAR IMAGING - 05 Oct 2023
Hospital admissions among people with diabetes: a systematic review.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 09 Oct 2023
To describe the reasons for hospital admission among people with diabetes.We searched Emcare, Embase, Medline, and Google Scholar databases for population-based studies describing the causes of hospitalisation among people with diabetes. We included articles published in English from 1980 to 2022. For each study, we determined the most frequent reasons for admission. Studies were assessed for q...
Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.
PROTEOMICS - 03 Oct 2023
The integration of robust single-pot, solid-phase-enhanced sample preparation with powerful liquid chromatography-tandem mass spectrometry (LC-MS/MS) is routinely used to define the extracellular vesicle (EV) proteome landscape and underlying biology. However, EV proteome studies are often limited by sample availability, requiring upscaling cell cultures or larger volumes of biofluids to genera...
The challenge of risk stratification in hypertrophic cardiomyopathy: Clinical, genetic and imaging insights from a quaternary referral centre.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 04 Oct 2023
Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy and may result in sudden cardiac death (SCD). Clinical risk stratification scores are utilised to estimate SCD risk and determine potential utility of a primary prevention implantable cardioverter defibrillator (ICD).Patients with a confirmed diagnosis of HCM from a quaternary HCM service were defined according to clinica...
Mentally-passive sedentary behavior and incident depression: Mediation by inflammatory markers.
JOURNAL OF AFFECTIVE DISORDERS - 15 Oct 2023
Sedentary behavior (SB; time spent sitting, as distinct from lack of exercise or physical activity) is associated with depression, yet little is known about the relationship between different types of SB (e.g., mentally-passive versus mentally-active) with depression and potential biological mediators of these associations.We used cohort data from the 1958 National Child Development Study (n = ...
Phenotyping patients with aortic stenosis using cluster analysis to determine mortality and suitability for transcatheter aortic valve replacement
EUROPEAN HEART JOURNAL - 03 Oct 2023
Current classification of aortic stenosis (AS) is based on guideline-recommended echocardiographic criteria. Heterogeneity of patients with AS is increasingly recognised. Clinical and demographic factors in addition to echocardiographic parameters can determine those who may derive the greatest benefit from transcatheter aortic valvular replacement (TAVR) and influence patient outcomes.
Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk.
NATURE GENETICS - 01 Nov 2023
The analysis of longitudinal data from electronic health records (EHRs) has the potential to improve clinical diagnoses and enable personalized medicine, motivating efforts to identify disease subtypes from patient comorbidity information. Here we introduce an age-dependent topic modeling (ATM) method that provides a low-rank representation of longitudinal records of hundreds of distinct diseas...
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 26 Sep 2023
Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary atherosclerosis despite no SMuRFs. SMuRFless patients presenting with myocardial infarction have been observed to have an unexpected higher early mortality compa...
Prevalence of illicit drug use in young patients with sudden cardiac death.
HEART RHYTHM - 01 Oct 2023
Illicit drug use may accelerate coronary disease and cardiac hypertrophy or stimulate arrhythmias. Rates of illicit drug use in young patients with sudden cardiac death (SCD) are uncertain.The purpose of this study was to identify rates of illicit drug use in young patients with SCD.A prospective statewide registry identified out-of-hospital patients with cardiac arrest aged 18-50 years from Ap...
New-onset atrial fibrillation prediction: the HARMS2-AF risk score.
EUROPEAN HEART JOURNAL - 21 Sep 2023
Lifestyle risk factors are a modifiable target in atrial fibrillation (AF) management. The relative contribution of individual lifestyle risk factors to AF development has not been described. Development and validation of an AF lifestyle risk score to identify individuals at risk of AF in the general population are the aims of the study.The UK Biobank (UKB) and Framingham Heart Study (FHS) are ...
Circulating epigenomic biomarkers correspond with kidney disease susceptibility in high-risk populations with type 2 diabetes mellitus.
DIABETES RESEARCH AND CLINICAL PRACTICE - 24 Sep 2023
To investigate epigenomic indices of diabetic kidney disease (DKD) susceptibility among high-risk populations with type 2 diabetes mellitus.KDIGO (Kidney Disease: Improving Global Outcomes) clinical guidelines were used to classify people living with or without DKD. Differential gene methylation of DKD was then assessed in a discovery Aboriginal Diabetes Study cohort (PROPHECY, 89 people) and a...
Phenotyping heart failure by genetics and associated conditions.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 26 Sep 2023
Heart failure is a highly heterogeneous disease, and genetic testing may allow phenotypic distinctions that are incremental to those obtainable from imaging. Advances in genetic testing have allowed for the identification of deleterious variants in patients with specific heart failure phenotypes (dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and hypertrophic cardiomyo...
Multidisciplinary team discussion: the emerging gold standard for management of cardiopulmonary complications of connective tissue disease.
INTERNAL MEDICINE JOURNAL - 29 Sep 2023
Cardiopulmonary complications of connective tissue diseases (CTDs), particularly pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD), are major determinants of morbidity and mortality. Multidisciplinary meetings may improve diagnostic accuracy and optimise treatment. We review the literature regarding multidisciplinary meetings in CTD-ILD and PAH and describe our tertiary ...
Physiology of sedentary behavior.
PHYSIOLOGICAL REVIEWS - 01 Oct 2023
Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or reclining posture. Evidence relevant to understanding the physiology of SB can be derived from studies employing several experimental models: bed rest, immobilization, reduced step count, and reducing/interrupting prolonged SB. We examine the relevant physiological evidence relating to body weight and ene...
Cost-effectiveness of screening for primary aldosteronism in hypertensive patients in Australia: a Markov modelling analysis.
JOURNAL OF HYPERTENSION - 01 Oct 2023
Primary aldosteronism affects 3-14% of hypertensive patients in the primary care setting and up to 30% in the hypertensive referral units. Although primary aldosteronism screening is recommended in patients with treatment-resistant hypertension, diagnosis at an earlier stage of disease may prevent end-organ damage and optimize patient outcomes.A Markov model was used to estimate the cost-effect...
Influence of exercise training on the left atrium: implications for atrial fibrillation, heart failure, and stroke.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Oct 2023
The left atrium (LA) plays a critical role in receiving pulmonary venous return and modulating left ventricular (LV) filling. With the onset of exercise, LA function contributes to the augmentation in stroke volume. Due to the growing focus on atrial imaging, there is now evidence that structural remodeling and dysfunction of the LA is associated with adverse outcomes including incident cardiov...
Effect of Concomitant Cardiac Arrest on Outcomes in Patients With Acute Coronary Syndrome-Related Cardiogenic Shock.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Oct 2023
Patients with acute coronary syndrome (ACS)-related cardiogenic shock (CS) with or without concomitant CA may have disparate prognoses. We compared clinical characteristics and outcomes of patients with CS secondary to ACS with and without cardiac arrest (CA). Between 2014 and 2020, 1,573 patients with ACS-related CS with or without CA who underwent percutaneous coronary intervention enrolled i...
Left Ventricular End-Diastolic Pressure for the Prediction of Contrast-Induced Nephropathy and Clinical Outcomes in Patients With ST-Elevation Myocardial Infarction Who Underwent Primary Percutaneous Intervention (the ELEVATE Study).
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Sep 2023
Contrast-induced nephropathy (CIN) is an important complication of percutaneous coronary intervention (PCI). We investigated whether left ventricular end-diastolic pressure (LVEDP) in patients who underwent PCI might be additive to current risk stratification of CIN. Data from consecutive patients who underwent primary PCI for ST-elevation myocardial infarction between 2013 and 2018 at Western ...
