Publications
Now showing items 4001-4020 of 5702 records
Prospective Associations of Local Destinations and Routes With Middle-to-Older Aged Adults' Walking.
THE GERONTOLOGIST - 18 Jan 2018
To examine prospective associations of perceived attributes of local destinations and routes with middle-to-older aged adults' 4-year changes in walking for transport (WT) and walking for recreation (WR).Data were collected from adults aged 50-64 years old, living in Adelaide, Australia. Participants (N = 454) reported weekly frequency of WT and WR at baseline (2003-2004) and follow-up (2007-20...
Vascular dysfunction in the stroke-prone spontaneously hypertensive rat is dependent on constrictor prostanoid activity and Y chromosome lineage.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 16 Jan 2018
Vascular dysfunction is a hallmark of hypertension and the strongest risk factor to date for coronary artery disease. As Y chromosome lineage has emerged as one of the strongest genetic predictors of cardiovascular disease risk to date, we investigated if Y chromosome lineage modulated this important facet in the stroke-prone spontaneously hypertensive rat (SHRSP) using consomic strains. Here, ...
Associations of alcohol intake, smoking, physical activity and obesity with survival following colorectal cancer diagnosis by stage, anatomic site and tumor molecular subtype.
INTERNATIONAL JOURNAL OF CANCER - 15 Jan 2018
The influence of lifestyle factors on survival following a diagnosis of colorectal cancer (CRC) is not well established. We examined associations between lifestyle factors measured before diagnosis and CRC survival. The Melbourne Collaborative Cohort Study collected data on alcohol intake, cigarette smoking and physical activity, and body measurements at baseline (1990-1994) and wave 2 (2003-20...
Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?
ANTIOXIDANTS (BASEL, SWITZERLAND) - 12 Jan 2018
Vitamins E, A, D and K comprise the class of lipid-soluble vitamins. For vitamins A and D, a metabolic conversion of precursors to active metabolites has already been described. During the metabolism of vitamin E, the long-chain metabolites (LCMs) 13'-hydroxychromanol (13'-OH) and 13'-carboxychromanol (13'-COOH) are formed by oxidative modification of the side-chain. The occurrence of these met...
MELODI: Mining Enriched Literature Objects to Derive Intermediates.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 12 Jan 2018
The scientific literature contains a wealth of information from different fields on potential disease mechanisms. However, identifying and prioritizing mechanisms for further analytical evaluation presents enormous challenges in terms of the quantity and diversity of published research. The application of data mining approaches to the literature offers the potential to identify and prioritize m...
Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.
CELL METABOLISM - 09 Jan 2018
Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged in extracellular vesicles (EVs), we employed quantitative proteomic techniques to characterize the exercise-induced secretion of EV-contained proteins. Following ...
Assessment of Fetal Kidney Growth and Birth Weight in an Indigenous Australian Cohort.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2017
Indigenous Australians experience higher rates of renal disease and hypertension than non-Indigenous Australians. Low birth weight is recognized as a contributing factor in chronic disease and has been shown to increase the risk of renal failure in adulthood. A smaller kidney volume with fewer nephrons places an individual at risk of hypertension and renal failure. Indigenous Australians have f...
Hospitalisation in Patients With Heart Failure With Preserved Ejection Fraction.
CLINICAL MEDICINE INSIGHTS. CARDIOLOGY - 01 Jan 2018
Heart failure is highly prevalent with more than 50% of cases being patients with a preserved ejection fraction (HFPEF), a figure that is projected to increase due to the changing risk factor landscape, in particular the ageing population. Overall mortality is similar to patients with heart failure with reduced ejection fraction (HFREF), as are the rates of hospitalisation. Patients with HFPEF ...
A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury.
EUROPEAN HEART JOURNAL - 07 Jan 2018
CD39 is a cell membrane NTPase with anti-inflammatory and anti-platelet effects. However, its clinical use is limited by its bleeding side effect. With the goal of harnessing its therapeutic potential while avoiding haemostatic problems, we designed a fusion protein consisting of the extracellular domain of CD39 and a single-chain antibody (Targ-CD39) that specifically binds to activated glycop...
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation.
CIRCULATION RESEARCH - 05 Jan 2018
Human cardiac mesenchymal cells (CMSCs) are a therapeutically relevant primary cell population. Diabetes mellitus compromises CMSC function as consequence of metabolic alterations and incorporation of stable epigenetic changes.To investigate the role of α-ketoglutarate (αKG) in the epimetabolic control of DNA demethylation in CMSCs.Quantitative global analysis, methylated and hydroxymethylated ...
Does sympathetic dysfunction occur before denervation in pure autonomic failure?
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 16 Jan 2018
Pure autonomic failure (PAF) is a rare sporadic disorder characterized by autonomic failure in the absence of a movement disorder or dementia and is associated with very low plasma norepinephrine (NE) levels-suggesting widespread sympathetic denervation, however due to its rarity the pathology remains poorly elucidated. We sought to correlate clinical and neurochemical findings with sympathetic...
Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction.
ISLETS - 02 Jan 2018
The contribution of environmental factors to pancreatic islet damage in type 1 diabetes remains poorly understood. In this study, we crossed mice susceptible to type 1 diabetes, where parental male (CD8 T cells specific for IGRP; NOD8.3) and female (NOD/ShiLt) mice were randomized to a diet either low or high in AGE content and maintained on this diet throughout pregnancy and lactation. After w...
Genome-Wide Association Studies and Risk Scores for Coronary Artery Disease: Sex Biases.
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY - 01 Jan 2018
Phenotypic sex differences in coronary artery disease (CAD) and its risk factors have been apparent for many decades in basic and clinical research; however, whether these are also present at the gene level and thus influence genome-wide association and genetic risk prediction studies has often been ignored. From fundamental and medical standpoints, this is critically important to assess in ord...
Wearable Technology and Physical Activity in Chronic Disease: Opportunities and Challenges.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE - 01 Jan 2018
Physical Activity and Sedentary Behavior Subsequent to Serious Orthopedic Injury: A Systematic Review.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION - 01 Jan 2018
To systematically review and synthesize the evidence on physical activity and sedentary behavior after serious orthopedic injury.Eight electronic databases and reference lists of relevant articles were searched from inception to March 2016.Studies on physical activity and sedentary behavior measured objectively or via self-report among patients with a serious orthopedic injury (acute bone or so...
A comparison of two malnutrition screening tools in acute medical inpatients and validation of a screening tool among adult Indigenous Australian patients.
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION - 01 Jan 2018
The objectives of this study were to identify and validate a screening tool to detect malnutrition among Indigenous and non-Indigenous Australian patients.This study included medical patients admitted into three regional hospitals in Australia. A literature review was undertaken of current screening tools before the Malnutrition Screening Tool (MST) and the newly developed Adult Nutrition Tool ...
A Functional Kinase Short Interfering Ribonucleic Acid Screen Using Protease-Activated Receptor 2-Dependent Opening of Transient Receptor Potential Vanilloid-4.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES - 01 Jan 2018
Protease-activated receptor 2 (PAR) is a proinflammatory G-protein coupled receptor (GPCR) that is activated by inflammatory proteases, and its activation initiates signaling pathways that modulate the nonselective cation channel transient receptor potential vanilloid-4 (TRPV4). PAR-dependent opening of TRPV4 has been attributed to kinase activation, but the identity of the responsible enzymes ...
Objective Metabolomics Research.
CLINICAL CHEMISTRY - 01 Jan 2018
Study design and methods for the ACTIVity And TEchnology (ACTIVATE) trial.
CONTEMPORARY CLINICAL TRIALS - 01 Jan 2018
Physical activity is positively associated with survival and quality of life among breast cancer survivors. Despite these benefits, the majority of breast cancer survivors are insufficiently active. The potential health benefits of reducing sedentary behaviour (sitting time) in this population have not been extensively investigated. The ACTIVATE Trial will evaluate the efficacy of an interventi...
Long-term Trends in Antidiabetes Drug Usage in the U.S.: Real-world Evidence in Patients Newly Diagnosed With Type 2 Diabetes.
DIABETES CARE - 01 Jan 2018
To explore temporal trends in antidiabetes drug (ADD) prescribing and intensification patterns, along with glycemic levels and comorbidities, and possible benefits of novel ADDs in delaying the need for insulin initiation in patients diagnosed with type 2 diabetes.Patients with type 2 diabetes aged 18-80 years, who initiated any ADD, were selected ( = 1,023,340) from the U.S. Centricity Electro...
