Publications
Now showing items 4001-4020 of 5385 records
Ratiometric two-photon fluorescent probes for mitochondrial hydrogen sulfide in living cells
J ORG CHEM - 17 Oct 2014
Hydrogen sulfide (H2S) is an important signaling molecule with diverse biological roles. Various fluorescent probes for H2S with biological application have been developed. However, two-photon ratiometric imaging of mitochondrial H2S is scarce. In this paper, we report two ratiometric two-photon probes, AcHS-1 and AcHS-2, which employ 4-amino-1,8-naphthalimide as the fluorophore and 4-azidobenz...
Automated influenza-like illness reporting-an efficient adjunct to traditional sentinel surveillance
PUBLIC HEALTH REP - 01 Jan 2001
OBJECTIVES:
We compared an electronic health record-based influenza-like illness (ILI) surveillance system with manual sentinel surveillance and virologic data to evaluate the utility of the automated system for routine ILI surveillance.
METHODS:
We obtained weekly aggregate ILI reports from the Electronic medical record Support for Public Health (ESP) disease-detection and reporting system,...
Simultaneous characterization of sympathetic and cardiac arms of the baroreflex through sequence techniques during incremental head-up tilt
FRONT PHYSIOL - 01 Jan 2016
We propose a sympathetic baroreflex (sBR) sequence method for characterizing sBR from spontaneous beat-to-beat fluctuations of muscle sympathetic nerve activity (MSNA) and diastolic arterial pressure (DAP). The method exploits a previously defined MSNA variability quantifying the fluctuations of MSNA burst rate. The method is based on the detection of MSNA and DAP sequences characterized by the...
Diabetes and risk of physical disability in adults: a systematic review and meta-analysis
LANCET DIABETES ENDOCRINOL - 22 Jan 2014
BACKGROUND
According to previous reports, the risk of disability as a result of diabetes varies from none to double. Disability is an important measure of health and an estimate of the risk of disability as a result of diabetes is crucial in view of the global diabetes epidemic. We did a systematic review and meta-analysis to estimate this risk.
METHODS
We searched Ovid, Medline, Embase, Coc...
Survival in patients with myocardial infarction complicated by out-of-hospital cardiac arrest undergoing emergency percutaneous coronary intervention
INT J CARDIOL - 21 Nov 2013
OBJECTIVES:
We sought to evaluate the clinical outcomes of patients with myocardial infarction (MI) complicated by out-of-hospital cardiac arrest (OHCA) undergoing percutaneous coronary intervention (PCI).
BACKGROUND:
Controversy remains regarding the benefit of early PCI in patients with MI complicated by OHCA.
METHODS:
We analyzed the outcomes of 88 consecutive patients presenting with M...
Multifunctional thrombin-activatable polymer capsules for specific targeting to activated platelets
ADV MATER - 16 Sep 2015
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide
ADV HEALTHC MATER - 01 Oct 2015
Nanoporous metal-phenolic particles are fabricated through the nanostructural replication of dense FeIII -TA complexes in nanoporous CaCO3 template particles. The particles have potential for the diagnostic detection of endogenous levels of H2 O2 ex vivo and in vivo by ultrasound imaging, which is based on the catalytic activity of the coordinated Fe3+ in the particles to break down H2 O2 to O2...
Boronate-phenolic network capsules with dual response to acidic pH and cis-diols
ADV HEALTHC MATER - 26 Aug 2015
Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials. The BPN capsules are stable in the presence of competing carbohydrates, but dissociate at acidic pH or in the presence of competing cis-diols at physiological pH. This engineered capsule system provides a platform for a wide range of biological and biomedical appli...
Relationship between mental health and foot pain
ARTHRITIS CARE RES - 01 Aug 2014
OBJECTIVE:
Although mental health is related to the persistence of musculoskeletal pain, our understanding of the relationship between mental health and foot pain is limited. Subsequently, we conducted a 3-year longitudinal study to examine the relationship between mental health and foot pain in a community-based population.
METHODS:
Eighty-three community-dwelling participants (mean ± S...
Association of weight gain with incident knee pain, stiffness, and functional difficulties: a longitudinal study
ARTHRITIS CARE RES - 01 Jan 2013
OBJECTIVE:
To examine the longitudinal association between significant weight change and change in knee symptoms (pain, stiffness, and function), and to determine whether the effects differ in those who are obese and those with osteoarthritis (OA).
METHODS:
Two hundred fifty subjects ranging from normal weight to obese (body mass index range 16.9-59.1 kg/m(2) ) and no significant musculoskel...
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection
FEBS LETT - 01 Oct 2017
High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in CD4+Glut1+ T cells from HIV+ subjects. TCR engagement of CD4+Glut1+ T cells from HIV+ subjects demonstrates hyperresponsive PI3K-mammalian target of rapamycin signaling. High ...
Association of diabetic macular edema and proliferative diabetic retinopathy with cardiovascular disease a systematic review and meta-analysis
JAMA OPHTHALMOL - 01 Jun 2017
Importance:
Previous studies on the relationship between diabetic retinopathy (DR) and cardiovascular disease (CVD) focused on the early stages of DR. Understanding whether patients with type 2 diabetes and severe stages of DR (diabetic macular edema [DME] and proliferative diabetic retinopathy [PDR]) have a higher risk of CVD will allow physicians to more effectively counsel patients.
Obje...
Association of neighborhood demographics with out-of-hospital cardiac arrest treatment and outcomes: where you live may matter
JAMA CARDIOL - 01 Oct 2017
Importance:
We examined whether resuscitation care and outcomes vary by the racial composition of the neighborhood where out-of-hospital cardiac arrests (OHCAs) occur.
Objective:
To evaluate the association between bystander treatments (cardiopulmonary resuscitation and automatic external defibrillation) and timing of emergency medical services personnel on OHCA outcomes according to the...
Predictive score for 30-day readmission or death in heart failure
JAMA CARDIOL - 01 Jun 2016
Readmissions shortly after heart failure (HF) are common, expensive, and usually considered preventable. However, despite the use of several interventions, rates of readmission after HF remain stable. An effective risk score might permit the targeting of resource-intensive interventions (such as disease-management programs) specifically on high-risk patients. We sought to determine the combinat...
Association of cardiometabolic multimorbidity with mortality
JAMA - 07 Jul 2015
IMPORTANCE:
The prevalence of cardiometabolic multimorbidity is increasing.
OBJECTIVE:
To estimate reductions in life expectancy associated with cardiometabolic multimorbidity.
DESIGN, SETTING, AND PARTICIPANTS:
Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689,300 particip...
Effect of vericiguat, a soluble guanylate cyclase stimulator, on natriuretic peptide levels in patients with worsening chronic heart failure and reduced ejection fraction: the SOCRATES-REDUCED randomized trial
JAMA - 01 Dec 2015
IMPORTANCE:
Worsening chronic heart failure (HF) is a major public health problem.
OBJECTIVE:
To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic HF and reduced left ventricular ejection fraction (LVEF).
DESIGN, SETTING, AND PARTICIPANTS:
Dose-finding phase 2 study that randomized 456 patients across...
Effect of finerenone on albuminuria in patients with diabetic nephropathy a randomized clinical trial
JAMA - 01 Sep 2015
IMPORTANCE:
Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with chronic kidney disease but may be underused because of a high risk of adverse events.
OBJECTIVE:
To evaluate the safety and efficacy of different oral doses of the nonsteroidal mineralocorticoid receptor antagonist finerenone, given f...
Glycated hemoglobin measurement and prediction of cardiovascular disease
JAMA - 26 Mar 2014
IMPORTANCE:
The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain.
OBJECTIVE:
To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk.
DESIGN, SETTING, AND PARTICIPANTS:
Analysis of individual-par...
Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial
JAMA - 06 Feb 2013
IMPORTANCE: Approximately one-third of patients with peripheral artery disease experience intermittent claudication, with consequent loss of quality of life.
OBJECTIVE: To determine the efficacy of ramipril for improving walking ability, patient-perceived walking performance, and quality of life in patients with claudication.
DESIGN, SETTING, AND PATIENTS: Randomized, double-blind, placebo-co...
Surgical vs conventional therapy for weight loss treatment of obstructive sleep apnea: a randomized controlled trial
JAMA - 19 Sep 2012
CONTEXT: Obstructive sleep apnea (OSA) is strongly related to obesity. Weight loss is recommended as part of the overall management plan for obese patients diagnosed with OSA.
OBJECTIVE: To determine whether surgically induced weight loss is more effective than conventional weight loss therapy in the management of OSA.
DESIGN, SETTING, AND PATIENTS: A randomized controlled trial of 60 obe...
