Publications
Now showing items 3921-3940 of 5385 records
Frequent and intensive physical activity reduces risk of cardiovascular events in type 1 diabetes
DIABETOLOGIA - 01 Mar 2017
AIMS/HYPOTHESIS:
Cardiovascular disease (CVD) is the most common cause of premature death and disability among patients with type 1 diabetes. Diabetic nephropathy accounts for the increased cardiovascular morbidity and mortality of these patients. We recently showed that the intensity of exercise predicts the incidence and progression of diabetic nephropathy in patients with type 1 diabetes....
Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control
DIABETOLOGIA - 01 Mar 2017
AIMS/HYPOTHESIS:
We aimed to examine the effect of interrupting 7 h prolonged sitting with brief bouts of walking or resistance activities on 22 h glucose homeostasis (including nocturnal-to-following morning hyperglycaemia) in adults with type 2 diabetes.
METHODS:
This study is an extension of a previously published randomised crossover trial, which included 24 inactive overweight/obese...
The effect of sodium glucose cotransporter 2 inhibition with empagliflozin on microalbuminuria and macroalbuminuria in patients with type 2 diabetes
DIABETOLOGIA - 01 Sep 2016
AIMS/HYPOTHESIS:
Sodium glucose cotransporter 2 (SGLT2) inhibition lowers HbA1c, systolic BP (SBP) and weight in patients with type 2 diabetes and reduces renal hyperfiltration associated with type 1 diabetes, suggesting decreased intraglomerular hypertension. As lowering HbA1c, SBP, weight and intraglomerular pressure is associated with anti-albuminuric effects in diabetes, we hypothesised ...
Insulin pump basal adjustment for exercise in type 1 diabetes: a randomised crossover study
DIABETOLOGIA - 01 Aug 2016
AIMS/HYPOTHESIS:
The aim of this study was to investigate the effects of exercise, vs rest, on circulating insulin and glucose, following pre-exercise insulin pump basal rate reduction.
METHODS:
This was an open-label, two-stage randomised crossover study of 14 adults (seven women, seven men) with type 1 diabetes established on insulin pump therapy. In each stage, participants fasted and...
The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis
DIABETOLOGIA - 01 Aug 2016
AIMS/HYPOTHESIS:
Angiotensin II is well-recognised to be a key mediator in driving the pathological events of diabetes-associated atherosclerosis via signalling through its angiotensin II type 1 receptor (AT1R) subtype. However, its actions via the angiotensin II type 2 receptor (AT2R) subtype are still poorly understood. This study is the first to investigate the role of the novel selective...
Burden of diabetes in Australia: life expectancy and disability-free life expectancy in adults with diabetes
DIABETOLOGIA - 01 Jul 2016
AIMS/HYPOTHESIS:
The aim of this work was to estimate the life expectancy (LE) and disability-free life expectancy (DFLE) for adults with and without diabetes.
METHODS:
The Chiang method and the adapted Sullivan method were used to estimate LE and DFLE by age and sex. Mortality data in 2011 were available from the National Diabetes Services Scheme for diabetes and from standard national ...
Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals
DIABETOLOGIA - 01 May 2016
AIMS/HYPOTHESIS:
An excess cancer incidence of 20-25% has been identified among persons with diabetes, most of whom have type 2 diabetes. We aimed to describe the association between type 1 diabetes and cancer incidence.
METHODS:
Persons with type 1 diabetes were identified from five nationwide diabetes registers: Australia (2000-2008), Denmark (1995-2014), Finland (1972-2012), Scotland ...
Life expectancy of type 1 diabetic patients during 1997-2010: a national Australian registry-based cohort study
DIABETOLOGIA - 01 Jun 2016
AIMS/HYPOTHESIS:
There is limited information about the impact of type 1 diabetes on life expectancy in a contemporary population. We examined the life expectancy of type 1 diabetic patients and explored the contribution of mortality at different ages and of different causes of death to years of life lost (YLL) compared with the general population.
METHODS:
We derived mortality rates of ...
Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes
DIABETOLOGIA - 01 Mar 2016
AIMS/HYPOTHESIS:
The aim of this study was to evaluate the relationship among age at onset of diabetes, age at onset of menarche and risk of diabetic nephropathy and laser-treated retinopathy in type 1 diabetes.
METHODS:
Data related to age at menarche were collected through questionnaires and were available for 1,304 women who participated in the Finnish Diabetic Nephropathy Study (Finn...
Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy
DIABETOLOGIA - 01 Feb 2016
AIMS/HYPOTHESIS:
Changes in podocyte morphology and function are associated with albuminuria and progression of diabetic nephropathy. NADPH oxidase 4 (NOX4) is the main source of reactive oxygen species (ROS) in the kidney and Nox4 is upregulated in podocytes in response to high glucose. We assessed the role of NOX4-derived ROS in podocytes in vivo in a model of diabetic nephropathy using a ...
Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis
DIABETOLOGIA - 01 Nov 2015
AIMS/HYPOTHESIS:
The calibre of the retinal vessels has been linked to diabetes mellitus but studies have not shown consistent results. We conducted a participant-level meta-analysis to evaluate the association between retinal arteriolar and venular calibre and diabetes.
METHODS:
We performed a systematic review on MEDLINE and EMBASE for articles published up to December 2014. We identified ...
The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics
DIABETOLOGIA - 01 Jul 2015
AIMS/HYPOTHESIS:
The risk of developing diabetes is greater for women with previous gestational diabetes mellitus (GDM). In the general population, plasma lipidomic analysis can identify individuals at risk of developing type 2 diabetes. The aim of this study was to determine whether circulating lipid levels 12 weeks following a GDM pregnancy were associated with an increased risk of developin...
Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity
DIABETOLOGIA - 01 May 2015
AIMS/HYPOTHESIS:
Brown adipose tissue (BAT) activation increases energy expenditure and may have therapeutic potential to combat obesity. The primary activating and adaptive signal for BAT is via β-adrenergic signalling. We previously demonstrated that human BAT is acutely responsive to oral administration of the sympathomimetic, ephedrine. Here we aimed to determine whether adaptive thermogen...
Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study
DIABETOLOGIA - 01 May 2015
AIMS/HYPOTHESIS:
The aim of this study was to assess how physical activity predicts the development and progression of diabetic nephropathy in patients with type 1 diabetes.
METHODS:
This prospective study (follow-up time 6.4 ± 3.1 years) included 1,390 patients (48.5% men, mean age 37.0 ± 12.4 years, duration of diabetes 20.4 ± 12.3 years) participating in the nationwide multicentre Fin...
Impact of age, age at diagnosis and duration of diabetes on the risk of macrovascular and microvascular complications and death in type 2 diabetes
DIABETOLOGIA - 01 Dec 2014
AIMS/HYPOTHESIS:
Data are inconsistent regarding the associations between age, age at diagnosis of diabetes, diabetes duration and subsequent vascular complications.
METHODS:
The associations between age (or age at diagnosis), diabetes duration and major macrovascular events, all-cause death and major microvascular events were examined in 11,140 patients with type 2 diabetes randomly allocat...
Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes
DIABETOLOGIA - 01 Sep 2014
AIMS/HYPOTHESIS:
The AGEs and the receptor for AGEs (RAGE) are known contributors to diabetic complications. RAGE also has a physiological role in innate and adaptive immunity and is expressed on immune cells. The aim of this study was to determine whether deletion of RAGE from bone-marrow-derived cells influences the pathogenesis of experimental diabetic nephropathy.
METHODS:
Groups (n = 8/...
Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes
DIABETOLOGIA - 01 Sep 2014
AIMS/HYPOTHESIS:
Latent autoimmune diabetes in adults (LADA) is phenotypically a hybrid of type 1 and type 2 diabetes. Genetically LADA is poorly characterised but does share genetic predisposition with type 1 diabetes. We aimed to improve the genetic characterisation of LADA and hypothesised that type 2 diabetes-associated gene variants also predispose to LADA, and that the associations wou...
Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification
DIABETOLOGIA - 01 Aug 2014
AIMS/HYPOTHESIS:
Diabetic nephropathy is a major diabetic complication, and diabetes is the leading cause of end-stage renal disease (ESRD). Family studies suggest a hereditary component for diabetic nephropathy. However, only a few genes have been associated with diabetic nephropathy or ESRD in diabetic patients. Our aim was to detect novel genetic variants associated with diabetic nephropa...
Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes
DIABETOLOGIA - 01 Jun 2014
AIMS/HYPOTHESIS:
An abnormal urinary albumin excretion rate (AER) is often the first clinically detectable manifestation of diabetic nephropathy. Our aim was to estimate the heritability and to detect genetic variation associated with elevated AER in patients with type 1 diabetes.
METHODS:
The discovery phase genome-wide association study (GWAS) included 1,925 patients with type 1 diabet...
Laparoscopic adjustable gastric banding and progression from impaired fasting glucose to diabetes
DIABETOLOGIA - 01 Mar 2014
AIMS/HYPOTHESIS:
Obesity and dysglycaemia are major risk factors for type 2 diabetes. We determined if obese people undergoing laparoscopic adjustable gastric banding (LAGB) had a reduced risk of progressing from impaired fasting glucose (IFG) to diabetes.
METHODS:
This was a retrospective cohort study of obese people with IFG who underwent LAGB. Weight and diabetes outcomes after a minimum ...
