Publications
Now showing items 3261-3280 of 5702 records
Building an Academic-Industry Partnership to Tackle Australia's Biggest Health Burden.
HEART, LUNG & CIRCULATION - 01 Aug 2019
Cardiovascular disease (CVD) poses a highly significant health and economic burden in Australia and worldwide, with the latest global burden of disease study identifying cardiovascular disease as an "expanding threat to global health" [1]. Australian cardiovascular researchers are recognised internationally for their broad expertise spanning from fundamental molecular and cellular biology, thro...
Factors That Prevent Progression to Transcatheter Aortic Valve Implantation (TAVI).
HEART, LUNG & CIRCULATION - 01 Aug 2019
Transcatheter aortic valve implantation (TAVI) is increasingly used for intermediate- and high-risk patients with severe symptomatic aortic stenosis (AS). However, safe undertaking of the procedure may be precluded by various anatomic factors. This study sought to identify prevalence of factors that prevent progression to TAVI.TAVI candidates with severe AS undergoing workup coronary angiograph...
On-Pump Beating Heart Versus Conventional Coronary Artery Bypass Grafting Early After Myocardial Infarction: A Propensity-Score Matched Analysis From the ANZSCTS Database.
HEART, LUNG & CIRCULATION - 01 Aug 2019
Coronary artery bypass grafting (CABG) performed early after acute myocardial infarction (AMI) carries a high risk of mortality. By avoiding cardioplegic arrest and aortic cross-clamping, on-pump beating heart CABG (ONBEAT) may benefit patients requiring urgent or emergency revascularisation in the setting of AMI. We evaluated the early and long-term outcomes of ONBEAT versus conventional CABG ...
Reply to the Editor- Mediterranean diet and wine intake could improve atrial function in patients with atrial fibrillation.
HEART RHYTHM - 01 Aug 2019
Response by Climie et al to Letter Regarding Article "Individual and Neighborhood Deprivation and Carotid Stiffness: The Paris Prospective Study III".
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Aug 2019
Effects of empagliflozin treatment on cardiac function and structure in patients with type 2 diabetes: a cardiac magnetic resonance study.
INTERNAL MEDICINE JOURNAL - 01 Aug 2019
The effects of empagliflozin on cardiac structure and function are not known.To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging.Twenty patients attending a specialist diabetes service recommended for treatment with empagliflozin, and 8 control patients with T2D on ...
New insights about post-exercise albuminuria in hypertensive patients.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 01 Aug 2019
Comorbid elevated symptoms of anxiety and depression in adults with type 1 or type 2 diabetes: Results from the International Diabetes MILES Study.
JOURNAL OF DIABETES AND ITS COMPLICATIONS - 01 Aug 2019
We examined: (a) the prevalence of comorbid elevated symptoms of anxiety/depression; (b) its demographic/clinical correlates; (c) associations with self-care behaviors, by diabetes type.Cross-sectional self-report data of 6590 adults with diabetes (42% type 1; 58% type 2) from the Australian and Dutch Diabetes MILES studies were used. Elevated symptoms of anxiety/depression were defined as GAD-...
Physical activity recommendations for avoiding hypertension and its complications: try harder!
JOURNAL OF HYPERTENSION - 01 Aug 2019
Hypertension, white-coat hypertension and masked hypertension in Australia: findings from the Australian Diabetes, Obesity, and Lifestyle Study 3.
JOURNAL OF HYPERTENSION - 01 Aug 2019
The Australian Diabetes, Obesity, and Lifestyle Study is a national, population-based examination of ∼11 000 adults with a third follow-up phase at 12 years. The aim was to use ambulatory blood pressure monitoring (ABPM) in a subsample (n = 508) of the main Australian Diabetes third follow-up cohort to determine the proportion with established, masked or white-coat hypertension in city and regi...
Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice.
JOURNAL OF LIPID RESEARCH - 01 Aug 2019
Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a resultant myopathy called dysferlinopathy. Dysferlinopathy manifests postgrowth with a progressive loss of skeletal muscle function, early intramyocellular lipid accumulation, and a striking later replacement of selective muscles by adipocytes. To better understand th...
Global Longitudinal Shortening: A Positive Step Towards Reducing Confusion Surrounding Global Longitudinal Strain.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2019
Impaired Cardiac Reserve and Abnormal Vascular Load Limit Exercise Capacity in Chronic Thromboembolic Disease.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2019
This study was a comprehensive evaluation of cardiopulmonary function in patients with chronic thromboembolic (pulmonary vascular) disease (CTED) during exercise.Exertional dyspnea is frequent following pulmonary embolism, but only a minority of patients eventually develops chronic thromboembolic pulmonary hypertension (CTEPH). Better understanding of the factors that limit exercise capacity in...
Persistent Impairment in Cardiopulmonary Fitness after Breast Cancer Chemotherapy.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 01 Aug 2019
Anthracycline chemotherapy (AC) is associated with acute reductions in cardiopulmonary fitness (V˙O2peak). We sought to determine whether changes in V˙O2peak and cardiac function persisted at 12 months post-AC completion, and whether changes in cardiac function explain the heightened long-term heart failure risk.Women with breast cancer scheduled for AC (n = 28) who participated in a nonrandomi...
Exome sequencing of Finnish isolates enhances rare-variant association power.
NATURE - 01 Aug 2019
Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and in isolation following a series of bottlenecks, individuals of these populations have numerous deleterious alleles at a relatively high frequency. Here...
High-intensity interval training in chronic kidney disease: A randomized pilot study.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS - 01 Aug 2019
High-intensity interval training (HIIT) increases mitochondrial biogenesis and cardiorespiratory fitness in chronic disease populations, however has not been studied in people with chronic kidney disease (CKD). The aim of this study was to compare the feasibility, safety, and efficacy of HIIT with moderate-intensity continuous training (MICT) in people with CKD.Fourteen individuals with stage 3...
Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability.
THROMBOSIS AND HAEMOSTASIS - 01 Aug 2019
Microvesicles (MVs) are small cell-derived vesicles, which are mainly released by activated cells. They are part of a communication network delivering biomolecules, for example, inflammatory molecules, via the blood circulation to remote cells in the body. Platelet-derived MVs are known to induce vascular inflammation. Research on the mediators and mechanisms of their inflammatory effects has a...
Cardiovascular effects of caffeinated beverages.
TRENDS IN CARDIOVASCULAR MEDICINE - 01 Aug 2019
Caffeine is the world's most popular 'drug', with tea and coffee a ubiquitous part of daily life. As a psychoactive stimulant, there are potential concerns regarding adverse cardiovascular squeal. Cardiovascular conditions, encompassing hypertension, coronary artery disease, rhythm disorders and heart failure affect billions of patients worldwide. We aim to provide a patient-centered comprehens...
Reply to letter by Frey et al. regarding the article: Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar.
EUROPEAN HEART JOURNAL - 30 Jul 2019
Sex-Based Mhrt Methylation Chromatinizes MeCP2 in the Heart.
ISCIENCE - 26 Jul 2019
In the heart, primary microRNA-208b (pri-miR-208b) and Myheart (Mhrt) are long non-coding RNAs (lncRNAs) encoded by the cardiac myosin heavy chain genes. Although preclinical studies have shown that lncRNAs regulate gene expression and are protective for pathological hypertrophy, the mechanism underlying sex-based differences remains poorly understood. In this study, we examined DNA- and RNA-me...
