Cardiovascular disease (CVD) poses a highly significant health and economic burden in Australia and worldwide, with the latest global burden of disease study identifying cardiovascular disease as an "expanding threat to global health" [1]. Australian cardiovascular researchers are recognised internationally for their broad expertise spanning from fundamental molecular and cellular biology, through innovative bioengineering approaches, patient-focussed clinical trials, and impactful community interventions for improved public health. However, funding challenges have resulted in a fragmented research sector struggling to survive, let alone work together as an effective national team with strategic leadership and collaboration. The Australian Cardiovascular Alliance have successfully advocated for a federally supported Mission for Cardiovascular Helath ($220 Million). A key element of success in their goal of enhancing the CV health of Austrlaians, is partnering with industry.