Publications
Now showing items 3161-3180 of 5325 records
Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2019
Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE) mice. Male ApoE mice received vehicle (control), low-level lipopolysaccharide (LPS), or recombinant human SAA by . injection every third day for 2 weeks. Heart, ao...
Trends in Incidence of ESKD in People With Type 1 and Type 2 Diabetes in Australia, 2002-2013.
AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION - 01 Mar 2019
The number of people with diabetes and end-stage kidney disease (ESKD) is increasing worldwide, but it is unknown whether this indicates an increasing risk for ESKD in people with diabetes. We examined temporal trends in the incidence of ESKD within the Australian population with diabetes from 2002 to 2013.Follow-up study using a national health care services registry.Registrants with type 1 or...
Muscle sympathetic nerve activity and hemodynamic responses to venous distension: does sex play a role?
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Mar 2019
Peripheral venous distension mechanically stimulates type III/IV sensory fibers in veins and evokes pressor and sympathoexcitatory reflex responses in humans. As young women have reduced venous compliance and impaired sympathetic transduction, we tested the hypothesis that pressor and sympathoexcitatory responses to venous distension may be attenuated in women compared with men. Mean arterial p...
Lipidomic profiling reveals early-stage metabolic dysfunction in overweight or obese humans.
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS - 01 Mar 2019
Advances in mass spectrometry and lipidomics techniques are providing new insights into the role of lipid metabolism in obesity-related diseases. However, human lipidomic studies have been inconsistent, owing to the use of indirect proxy measures of metabolic outcomes and relatively limited coverage of the lipidome. Here, we employed comprehensive lipid profiling and gold-standard metabolic mea...
Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis.
HAEMATOLOGICA - 01 Mar 2019
Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated blood pressure. We aimed to determine how the sympathetic nervous system direct...
Comparison of Magnetic Resonance Analysis of Myocardial Scarring With Biomarker Release Following S-T Elevation Myocardial Infarction.
HEART, LUNG & CIRCULATION - 01 Mar 2019
Late gadolinium enhancement (LGE) with cardiac magnetic resonance (CMR) is commonly assumed to represent myocardial fibrosis; however, comparative human histological data are limited, and there is no consensus on the most accurate method for LGE quantitation. We evaluated the relationship between CMR assessment of regional fibrosis and infarct size assessment using serial biomarkers after ST el...
Renal nerves contribute to hypertension in Schlager BPH/2J mice.
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 01 Mar 2019
Schlager mice (BPH/2J) are hypertensive due to a greater contribution of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS). The kidneys of BPH/2J are hyper-innervated suggesting renal nerves may contribute to the hypertension. We therefore determined the effect of bilateral renal denervation (RD) on hypertension in BPH/2J. Mean arterial pressure (MAP) was measured by radio...
Bariatric Surgery Worldwide: Baseline Demographic Description and One-Year Outcomes from the Fourth IFSO Global Registry Report 2018.
OBESITY SURGERY - 01 Mar 2019
Since 2014, the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) has produced an annual report of all bariatric surgery submitted to the Global Registry. We describe baseline demographics of international practice from the 4th report.The IFSO Global Registry amalgamated data from 51 different countries, 14 of which provided data from their national registries. ...
CXCR4 Antagonism Reduces Cardiac Fibrosis and Improves Cardiac Performance in Dilated Cardiomyopathy.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2019
Myocardial fibrosis is a key pathologic finding in the failing heart and is implicated as a cause of increased ventricular stiffness and susceptibility to ventricular arrhythmia. Neurohormonal mediators such as aldosterone and angiotensin II are known to cause fibrosis in experimental models, however, clinical evidence for the reversal of fibrosis with relevant antagonists is limited. Recent st...
Comparative analysis reveals a role for TGF-β in shaping the residency-related transcriptional signature in tissue-resident memory CD8+ T cells.
PLOS ONE - 01 Jan 2019
Tissue-resident CD8+ memory T (TRM) cells are immune cells that permanently reside at tissue sites where they play an important role in providing rapid protection against reinfection. They are not only phenotypically and functionally distinct from their circulating memory counterparts, but also exhibit a unique transcriptional profile. To date, the local tissue signals required for their develo...
A Multi-Center Comparison of O Trainability Between Interval Training and Moderate Intensity Continuous Training.2peak
FRONTIERS IN PHYSIOLOGY - 01 Jan 2019
There is heterogeneity in the observed O response to similar exercise training, and different exercise approaches produce variable degrees of exercise response (trainability). The aim of this study was to combine data from different laboratories to compare O trainability between various volumes of interval training and Moderate Intensity Continuous Training (MICT). For interval training, volume...
Relation of Alcohol Consumption to Left Ventricular Fibrosis Using Cardiac Magnetic Resonance Imaging.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Feb 2019
Light-to-moderate regular alcohol consumption has been associated with reduced mortality, heart failure, and sudden death, with a well described "U-shaped" relationship. We sought to determine whether markers of diffuse ventricular fibrosis as assessed by cardiac magnetic resonance imaging (CMR) T mapping differ between nondrinkers and regular drinkers. We prospectively recruited 165 participan...
Cardiovascular and other competing causes of death among patients with cancer from 2006 to 2015: An Australian population-based study.
CANCER - 01 Feb 2019
With improved cancer survivorship, cardiovascular disease (CVD) and other noncancer events compete with cancer as the underlying cause of death, but the risks of mortality in competing-risk settings have not been well characterized.The authors identified 21,637 individuals who had a first cancer registered between 2006 and 2013, with follow-up to 2015, in the Australian population-based Tasmani...
Long-term blood pressure trajectories and incident atrial fibrillation in women and men: the Tromsø Study.
EUROPEAN HEART JOURNAL - 21 Apr 2020
To explore sex-specific associations between long-term individual blood pressure (BP) patterns and risk of incident atrial fibrillation (AF) in the general population.Blood pressure was measured in 8376 women and 7670 men who attended at least two of the three population-based Tromsø Study surveys conducted in 1986-87, 1994-95, and 2001. Participants were followed for incident AF throughout 201...
Misclassification of cricket in the American College of Cardiology (ACC) Task Force classification of sports.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Apr 2020
Gender equity within medical specialties of Australia and New Zealand: cardiology's outlier status.
INTERNAL MEDICINE JOURNAL - 01 Apr 2020
Gender disparity remains a prominent medical workforce issue, extending beyond surgical specialties with low proportions of female doctors.To examine female representation within Australia and New Zealand (NZ) among physician specialties and certain comparator surgical specialties with a focus on cardiology as an outlier of workforce gender equality.Data of practising medical specialists, new c...
Increased Incidence of Noise in the Tendril Pacemaker Lead Detected via Remote Monitoring.
HEART, LUNG & CIRCULATION - 01 Jun 2020
Prior studies suggest increased rates of noise on the Tendril (St Jude Medical/Abbott, St. Paul, MN, USA) pacemaker lead. We aim to assess the incidence of lead noise in the Tendril and 5076 (Medtronic PLC, Minneapolis, MN, USA) pacemaker leads in our cohort and in the process assess the utility of remote monitoring for identifying lead malfunction.Deidentified, multi-centre, prospectively coll...
The Impact of Out-of-Hours Presentation on Clinical Outcomes in ST-Elevation Myocardial Infarction.
HEART, LUNG & CIRCULATION - 01 Jun 2020
Systems of care have been established to ensure patients with ST-elevation myocardial infarction (STEMI) get timely access to primary percutaneous coronary intervention (PPCI). In this study, we evaluated whether patients undergoing PPCI both in-hours and out-of-hours experience similar care and clinical outcomes.Of 9,865 patients who underwent PCI for STEMI from 2005 to 2016 and were enrolled ...
Cross-sectional and prospective relationships of passive and mentally active sedentary behaviours and physical activity with depression.
THE BRITISH JOURNAL OF PSYCHIATRY : THE JOURNAL OF MENTAL SCIENCE - 01 Aug 2020
Sedentary behaviour can be associated with poor mental health, but it remains unclear whether all types of sedentary behaviour have equivalent detrimental effects.To model the potential impact on depression of replacing passive with mentally active sedentary behaviours and with light and moderate-to-vigorous physical activity. An additional aim was to explore these relationships by self-report ...
Levels and determinants of perceived health risk from solid wastes among communities living near to dumpsites in Kenya.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH - 01 Aug 2020
Many countries in sub-Saharan Africa have poor solid waste management systems, putting people living near dumpsites at higher risk of disease infections. Good risk perception could enhance individual- and community-level protection and prevention efforts. The objective of this study was to examine the levels and determinants of perceived health risk associated with exposure to solid waste dumps...
