Publications
Now showing items 2081-2100 of 5325 records
Multiday cycles of heart rate are associated with seizure likelihood: An observational cohort study.
EBIOMEDICINE - 01 Oct 2021
Circadian and multiday rhythms are found across many biological systems, including cardiology, endocrinology, neurology, and immunology. In people with epilepsy, epileptic brain activity and seizure occurrence have been found to follow circadian, weekly, and monthly rhythms. Understanding the relationship between these cycles of brain excitability and other physiological systems can provide new...
Overcoming enzalutamide resistance in metastatic prostate cancer by targeting sphingosine kinase.
EBIOMEDICINE - 01 Oct 2021
Intrinsic resistance to androgen receptor signalling inhibitors (ARSI) occurs in 20-30% of men with metastatic castration-resistant prostate cancer (mCRPC). Ceramide metabolism may have a role in ARSI resistance. Our study's aim is to investigate the association of the ceramide-sphingosine-1-phosphate (ceramide-S1P) signalling axis with ARSI resistance in mCRPC.Lipidomic analysis (∼700 lipids) ...
The mutation G133D on Leishmania guyanensis AQP1 is highly destabilizing as revealed by molecular modeling and hypo-osmotic shock assay.
BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES - 01 Oct 2021
The Leishmania aquaglyceroporin 1 (AQP1) plays an important role in osmoregulation and antimony (Sb) uptake, being determinant for resistance to antimony. We have previously demonstrated that G133D mutation on L. guyanensis AQP1 (LgAQP1) leads to reduced Sb uptake. Here, we investigated the effects of G133D mutation on LgAQP1 structure, associated with Sb uptake and alterations in osmoregulatio...
Impact of a coronary artery calcium-guided statin treatment protocol on cardiovascular risk at 12 months: Results from a pragmatic, randomised controlled trial.
ATHEROSCLEROSIS - 01 Oct 2021
Coronary artery calcium (CAC) may encourage patients to adhere to primary prevention recommendations. This study sought to evaluate the benefit of a CAC-guided risk-management protocol in those with a family history of premature coronary artery disease (FHCAD).In this Australian multi-centre, randomized controlled trial (Coronary Artery Calcium score: Use to Guide management of Hereditary Coron...
Multi-targeted H/F MRI unmasks specific danger patterns for emerging cardiovascular disorders.1
NATURE COMMUNICATIONS - 06 Oct 2021
Prediction of the transition from stable to acute coronary syndromes driven by vascular inflammation, thrombosis with subsequent microembolization, and vessel occlusion leading to irreversible myocardial damage is still an unsolved problem. Here, we introduce a multi-targeted and multi-color nanotracer platform technology that simultaneously visualizes evolving danger patterns in the developmen...
Bone Morphogenetic Protein 7 Gene Delivery Improves Cardiac Structure and Function in a Murine Model of Diabetic Cardiomyopathy.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2021
Diabetes is a major contributor to the increasing burden of heart failure prevalence globally, at least in part due to a disease process termed diabetic cardiomyopathy. Diabetic cardiomyopathy is characterised by cardiac structural changes that are caused by chronic exposure to the diabetic milieu. These structural changes are a major cause of left ventricular (LV) wall stiffness and the develo...
Type 2 diabetes after a pregnancy with gestational diabetes among first nations women in Australia: The PANDORA study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 13 Oct 2021
To determine among First Nations and Europid pregnant women the cumulative incidence and predictors of postpartum type 2 diabetes and prediabetes and describe postpartum cardiovascular disease (CVD) risk profiles.PANDORA is a prospective longitudinal cohort of women recruited in pregnancy. Ethnic-specific rates of postpartum type 2 diabetes and prediabetes were reported for women with diabetes ...
Effects of lignocaine vs. opioids on antiplatelet activity of ticagrelor: the LOCAL trial.
EUROPEAN HEART JOURNAL - 14 Oct 2021
We assessed the impact of intravenous fentanyl and lignocaine on the pharmacokinetics and pharmacodynamics of ticagrelor in patients with unstable angina and non-ST-elevation myocardial infarction and their procedural analgesic efficacy and safety.Seventy patients undergoing coronary angiography with ticagrelor loading were included in the pharmacokinetic and pharmacodynamic analyses of this ra...
A novel deep intronic variant strongly associates with Alkaptonuria.
NPJ GENOMIC MEDICINE - 22 Oct 2021
Alkaptonuria is a rare autosomal recessive inherited disorder of tyrosine metabolism, which causes ochronosis, arthropathy, cardiac valvular calcification, and urolithiasis. The epidemiology of alkaptonuria in East Asia is not clear. In this study, patients diagnosed with alkaptonuria from January 2010 to June 2020 were reviewed. Their clinical and molecular features were further compared with ...
A RE-AIM evaluation in early adopters to iteratively improve the online BeUpstanding™ program supporting workers to sit less and move more.
BMC PUBLIC HEALTH - 22 Oct 2021
The web-based BeUpstanding program supports desk workers to sit less and move more. Successfully translated from a research-delivered intervention, BeUpstanding has gone through iterative development and evaluation phases in preparation for wide-scale implementation. In the third planned "early-adopters" phase (01/09/2017-11/06/2019), the program was made freely-available online. An integrated ...
Absolute risk assessment for guiding cardiovascular risk management in a chest pain clinic.
THE MEDICAL JOURNAL OF AUSTRALIA - 15 Nov 2021
Screening of first-degree relatives of patients with bicuspid aortic valve: a counsel of perfection?
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES - 28 Oct 2021
Sudden cardiac death related to physical exercise in the young: a nationwide cohort study of Australia.
INTERNAL MEDICINE JOURNAL - 31 Oct 2021
Sudden cardiac death (SCD) during physical exercise is devastating. We aimed to evaluate causes and circumstances of exercise-related SCD in the young in Australia.We reviewed the National Coronial Information System database for deaths in Australia relating to cardiovascular disease in cases aged 10-35 years between 2000-2016. Included cases had undertaken physical exercise at time of event. W...
Daylight savings time transitions and risk of out-of-hospital cardiac arrest: An interrupted time series analysis.
RESUSCITATION - 01 Nov 2021
Many studies have reported increases in the risk of acute cardiovascular events following daylight savings time (DST) transitions. We sought to investigate the effect of DST transition on the incidence of out-of-hospital cardiac arrest (OHCA).Between January 2000 and December 2020, we performed an interrupted time series analysis of the daily number of OHCA cases of medical aetiology from the V...
Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy.
NEUROBIOLOGY OF DISEASE - 01 Nov 2021
This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilepticus (post-KA SE) model of chronic acquired temporal lobe epilepsy (TLE), specifically to examine for changes between the pre-epileptic, early epileptogenesis and the chronic epilepsy stages. We also aimed to examine whether any changes related to the seizure frequency in indiv...
Maximal Wall Thickness Measurement in Hypertrophic Cardiomyopathy: Biomarker Variability and its Impact on Clinical Care.
JACC. CARDIOVASCULAR IMAGING - 01 Nov 2021
The aim of this study was to define the variability of maximal wall thickness (MWT) measurements across modalities and predict its impact on care in patients with hypertrophic cardiomyopathy (HCM).Left ventricular MWT measured by echocardiography or cardiovascular magnetic resonance (CMR) contributes to the diagnosis of HCM, stratifies risk, and guides key decisions, including whether to place ...
The Impact of Measurement Variability on the Ability of Cardiovascular Imaging to Attain Biomarker Status.
JACC. CARDIOVASCULAR IMAGING - 01 Nov 2021
Efficient computation of Faith's phylogenetic diversity with applications in characterizing microbiomes.
01 Nov 2021
The number of publicly available microbiome samples is continually growing. As data set size increases, bottlenecks arise in standard analytical pipelines. Faith's phylogenetic diversity (Faith's PD) is a highly utilized phylogenetic alpha diversity metric that has thus far failed to effectively scale to trees with millions of vertices. Stacked Faith's phylogenetic diversity (SFPhD) enables cal...
Paul Zimmet: A Voice for Diabetes.
DIABETES CARE - 01 Nov 2021
Association of traditional risk factors with carotid intima-media thickness and carotid plaque in asymptomatic individuals with a family history of premature cardiovascular disease.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 03 Nov 2021
The use of imaging to detect subclinical atherosclerosis helps to inform decision-making in people classified as having intermediate risk for cardiovascular disease (CVD). This study sought to use carotid plaque as an alternative to carotid intima media thickness (cIMT). Carotid ultrasound for assessment of cIMT and plaque was obtained in 1031 people (53 years, 61% female) with a family history...
