Athletes are predisposed to atrial arrhythmias but the association between intense endurance exercise training, ventricular arrhythmias (VAs) and sudden cardiac death is less well established. Thus, it is unclear whether the 'athlete's heart' promotes specific arrhythmias or whether it represents a more general pro-arrhythmogenic phenotype. Whilst direct causality has not been established, it a...

The optimal revascularization strategy in patients with ischaemic cardiomyopathy remains unclear with no contemporary randomized trial data to guide clinical practice. This study aims to assess long-term survival in patients with severe ischaemic cardiomyopathy revascularized by either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI). Using the Australian and N...

Alzheimer's disease (AD) pathogenesis involves dysregulation in diverse biochemical processes. Nevertheless, plasma tau phosphorylated at threonine 181 (P-tau181), a recognised AD biomarker, has been described to reflect early-stage cortical amyloid-β (Aβ) deposition in cognitively normal (CN) adults. Therefore, identifying changes in plasma metabolites associated with plasma P-tau181 at the pr...

Understanding the impact of environmental exposures on disease incidence is important for environmental guidelines, health services management, and advising patients. We aimed to assess the relationship between daily mean temperature and common pollutants with atrial fibrillation (AF) presentations to emergency departments (EDs). The study included consecutive adult patients presenting with AF ...

In this opinion piece, we introduce the concept of ergonomic endocrinology. Ergonomic endocrinology is defined as the bidirectional and multifaceted relationship between endocrine health and dysfunction on one hand, and ergonomic design and engineering on the other. We describe the various domains of ergonomic endocrinology, using the classification rubric of physical, cognitive and organizatio...

This conceptual paper defines and describes pragmatic person centred care as an enhanced and expanded version of the construct of person centred care (PCC). Pragmatic person centred care is defined as health care that is respectful of, and responsive to the person's preferences, needs and values, while being reflective of available resource, reserves, and restrictions, regulating and balancing ...

Kwashiorkor is a form of protein energy malnutrition, while obesity usually occurs due to overnutrition. These syndromes, therefore, are considered to be poles apart. However, there are many similarities between the two conditions. Both are forms of malnutrition, and have common features in causation, clinical presentation, comorbidities and complications, as well as strategies for management. ...

Despite evidence of the short-term benefits of multicomponent primary care-based interventions, their long-term effects are unproven. To evaluate the long-term outcomes of a system-integrated technology-enabled model of care (SINEMA intervention) for stroke management for systolic blood pressure (BP) and other outcomes among patients with stroke in China. This long-term follow-up included commu...

Cardiology training in the UK is facing significant challenges due to a range of factors. Recent curriculum changes have further compounded this issue and significantly risk the ability to produce adequately trained consultants capable of managing patients with increasingly complex cardiovascular disease. The introduction of mandatory dual accreditation in general internal medicine (GIM) alongs...

The sympathetic nervous system (SNS) is essential for the body's immediate response to stress, initiating physiological changes that can be measured through sympathetic nerve activity (SNA). While microneurography (MNG) is the gold standard for direct SNA measurement, its invasive nature limits its practical use in clinical settings. This study investigates the use of multi-wavelength photoplet...

Controversy remains whether the mortality risk in people with fatty liver disease (FLD) including metabolic-(dysfunction) associated steatotic liver disease (MASLD) and metabolic-(dysfunction) associated fatty liver disease (MAFLD) is higher than observed in those without FLD. We aimed to determine the mortality rate and mortality rate ratio (MRR) for these FLDs. The study population was a rand...

The aim of this prospective cohort study was to investigate the associations between changes in cardiorespiratory fitness (CRF) and the risk of colorectal and prostate cancer in men. Data from men who completed a health assessment both in military conscription in youth and an occupational health profile assessment (HPA) later in life were used. CRF was assessed as estimated V̇O_2max, ...

To investigate the associations between psychological well-being, measured with the Postnatal Well-being in Transition (PostTrans) Questionnaire, and diabetes distress among mothers with type 1 or type 2 diabetes. Eighty-two postnatal women completed a cross-sectional survey. The survey included the Diabetes Distress Scale, and the PostTrans Questionnaire to assess the psychosocial well-being o...

Current Australian cardiovascular disease (CVD) prevention guidelines calculate 5-year CVD risk and recommend treatment when risk crosses specific thresholds. This may leave risk factors untreated for people with a low short-term (i.e. 5 years), but high long-term (i.e. lifetime), risk of CVD. We aimed to evaluate the cost effectiveness of intervention for risk factor control at age 40 years (r...