Publications
Now showing items 201-220 of 4599 records
Assessing the Impact of Colchicine on Coronary Plaque Phenotype After Myocardial Infarction with Optical Coherence Tomography: Rationale and Design of the COCOMO-ACS Study.
CARDIOVASCULAR DRUGS AND THERAPY - 01 Dec 2022
Recurrent event rates after myocardial infarction (MI) remain unacceptably high, in part because of the continued growth and destabilization of residual coronary atherosclerotic plaques, which may occur despite lipid-lowering therapy. Inflammation is an important contributor to this ongoing risk. Recent studies have shown that the broad-acting anti-inflammatory agent, colchicine, may reduce adv...
Early offering transcatheter aortic valve replacement to patients with moderate aortic stenosis: quantifying costs and benefits - a Markov model-based simulation study.
BMJ OPEN - 22 Nov 2023
Aortic stenosis (AS) is one of the most common acquired cardiac valvular diseases. The success of transcatheter aortic valve implantation (TAVI) for severe AS has led to increasing interest in its use to earlier disease-moderate AS (MAS).Model-based study using a Markov microsimulation technique to evaluate the long-term costs and benefits associated with 'early' TAVI. Key data inputs were sour...
Health economics of detection and treatment of children with familial hypercholesterolemia: to screen or not to screen is no longer the question.
CURRENT OPINION IN ENDOCRINOLOGY, DIABETES, AND OBESITY - 21 Nov 2023
Heterozygous familial hypercholesterolemia (HeFH) is one of the most common monogenic disorders and is safely treatable with lipid-lowering medication. However, most individuals with HeFH remain untreated and undetected, especially in paediatric populations where the potential for long-term therapeutic benefit is higher. Here, we review the recent literature on health economic outcomes for the ...
Modelling the replacement of red and processed meat with plant-based alternatives and the estimated effect on insulin sensitivity in a cohort of Australian adults.
THE BRITISH JOURNAL OF NUTRITION - 20 Nov 2023
Dietary guidelines are increasingly promoting mostly plant-based diets, limits on red meat consumption, and plant-based sources of protein for health and environmental reasons. It is unclear how the resulting food substitutions associate with insulin resistance, a risk factor for type 2 diabetes. We modelled the replacement of red and processed meat with plant-based alternatives and the estimat...
Graft-Host Interaction and Its Effect on Wound Repair Using Mouse Models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 13 Nov 2023
Autologous skin grafting has been commonly used in clinics for decades to close large wounds, yet the cellular and molecular interactions between the wound bed and the graft that mediates the wound repair are not fully understood. The aim of this study was to better understand the molecular changes in the wound triggered by autologous and synthetic grafting. Defining the wound changes at the mo...
Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation in Persistent AF-Reply.
JAMA - 23 May 2023
New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 23 Nov 2022
The status of lipoprotein (a) [Lp(a)] as a cardiovascular risk factor has been resurrected by advances in genetics. Mendelian randomization studies show a causal link of Lp(a) with coronary artery disease (CAD), peripheral artery disease (PAD), and calcific aortic valve stenosis (CAVS). The genetics of Lp(a) is complex and extends beyond the kringle-IV type 2, as it is also dependent on ancestr...
Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 03 Nov 2023
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are i...
The impact of COVID-19 pandemic on out-of-hospital cardiac arrest: an individual patient data meta-analysis.
RESUSCITATION - 10 Nov 2023
Prior studies have reported increased out-of-hospital cardiac arrests (OHCA) incidence and lower survival during the COVID-19 pandemic. We evaluated how the COVID-19 pandemic affected OHCA incidence, bystander CPR rate and patients' outcomes, accounting for regional COVID-19 incidence and OHCA characteristics.individual patient data meta-analysis of studies which provided a comparison of OHCA i...
A repository of COVID-19 related molecular dynamics simulations and utilisation in the context of nsp10-nsp16 antivirals.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING - 10 Nov 2023
The coronavirus disease 2019 (COVID-19) pandemic highlighted the importance of establishing systems and infrastructure to develop vaccines, antiviral drugs, and therapeutic antibodies against emerging pathogens. Typical drug discovery processes involve targeting suitable proteins to effect pathogen replication or to attenuate host responses, by examining either large chemical databases or prote...
γH2AX in mouse embryonic stem cells: Distribution during differentiation and following γ-irradiation.
CELLS & DEVELOPMENT - 11 Nov 2023
Phosphorylated histone H2AX (γH2AX) represents a sensitive molecular marker of DNA double-strand breaks (DSBs) and is implicated in stem cell biology. We established a model of mouse embryonic stem cell (mESC) differentiation and examined the dynamics of γH2AX foci during the process. Our results revealed high numbers of γH2AX foci in undifferentiated mESCs, decreasing as the cells differentiat...
Establishing international optimal cut-offs of waist-to-height ratio for predicting cardiometabolic risk in children and adolescents aged 6-18 years.
BMC MEDICINE - 15 Nov 2023
Waist-to-height ratio (WHtR) has been proposed as a simple and effective screening tool for assessing central obesity and cardiometabolic risk in both adult and pediatric populations. However, evidence suggests that the use of a uniform WHtR cut-off of 0.50 may not be universally optimal for pediatric populations globally. We aimed to determine the optimal cut-offs of WHtR in children and adole...
Aspects of Program Engagement in an Online Physical Activity Intervention and Baseline Predictors of Engagement.
AMERICAN JOURNAL OF HEALTH PROMOTION : AJHP - 01 Nov 2023
Participant engagement in an online physical activity (PA) intervention is described and baseline factors related to engagement are identified.Longitudinal Study Within Randomized Controlled Trial.Online/Internet.Primary care patients (21-70 years).ActiveGOALS was a 3-month, self-directed online PA intervention (15 total lessons, remote coaching support, and a body-worn step-counter).Engagement...
Highly active nisin coated polycaprolactone electrospun fibers against both Staphylococcus aureus and Pseudomonas aeruginosa.
BIOMATERIALS ADVANCES - 01 Nov 2023
In this study, a wound dressing of electrospun polycaprolactone (PCL) fibers incorporating the antimicrobial peptide (AMP) nisin was fabricated. Nisin was physically adsorbed to the PCL fibers and tested for antibacterial activity against both Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa). The PCL fibers had an average diameter of 1.16 μm ± 0.42 μm and no signific...
Circular-SWAT for deep learning based diagnostic classification of Alzheimer's disease: application to metabolome data.
EBIOMEDICINE - 01 Nov 2023
Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. This study introduces the Circular-Sliding Window Association Test (c-SWAT) to improve the classification accuracy in predicting AD using serum-based meta...
Poor sleep and shift work associate with increased blood pressure and inflammation in UK Biobank participants.
NATURE COMMUNICATIONS - 04 Nov 2023
Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biobank cohort, we evaluate the association between circadian rhythm-disrupting behaviours, blood pressure (SBP, DBP) and inflammatory markers in >350,000 adult...
Top-down control of vestibular inputs by the dorsolateral prefrontal cortex.
EXPERIMENTAL BRAIN RESEARCH - 01 Dec 2023
The vestibular apparatus provides spatial information on the position of the head in space and with respect to gravity. Low-frequency sinusoidal galvanic vestibular stimulation (sGVS), a means of selectively changing the firing of vestibular afferents, induces a frequency-dependent perception of sway and, in some individuals, induces nausea. Given that vestibular afferents project to the insula...
Multiple Myeloma-Derived Circulating Extracellular Vesicles Affect Normal Human Stromal Cell Behaviour and Promote Tumor Progression: A Multi-Omic Approach
BLOOD - 15 Nov 2022
Extracellular vesicles (EVs) are secreted in the extracellular space, can travel through the blood stream and are transferred to target (stromal) cells. This makes EVs an important means of cell-to-cell communication both at local and distant sites (metastasis). EVs can reprogram signalling pathways in stromal cells promoting the formation of a supportive tumour microenvironment (TME) and pre-m...
Diverse strategies are needed to support physical activity engagement in women who have had breast cancer.
SUPPORTIVE CARE IN CANCER : OFFICIAL JOURNAL OF THE MULTINATIONAL ASSOCIATION OF SUPPORTIVE CARE IN CANCER - 21 Oct 2023
Physical activity can improve health in people living with and beyond breast cancer; however, how to best support physical activity participation in this population is unclear. This qualitative study sought to identify important physical activity program components for breast cancer.Women with previous breast cancer (n = 11) and allied health professionals (n = 7) participated in one-on-one sem...
Trends in the Incidence of End-Stage Kidney Disease in Type 1 and Type 2 Diabetes in Australia, 2010-2019.
AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION - 01 Nov 2023
Trends in end-stage kidney disease (ESKD) among people with diabetes may inform clinical management and public health strategies. We estimated trends in the incidence of ESKD among people with type 1 and type 2 diabetes in Australia from 2010-2019 and evaluated their associated factors.Cohort study.71,700 people with type 1 and 1,112,690 people with type 2 diabetes registered on the Australian ...
