Publications
Now showing items 201-220 of 5702 records
Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 09 Dec 2025
To understand the biological function of genomic regions, vast molecular data have been generated to annotate mammalian genomes. However, how to effectively use such extensive information to improve the mapping and prediction of complex traits, including those that respond to climate change, remains unresolved. Here, we apply a Bayesian framework to estimate a Functional-And-Evolutionary Multi-...
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma.
NATURE CELL BIOLOGY - 28 Nov 2025
Extracellular vesicles (EVs) are an essential signalling entity in human plasma implicated in health and disease. Still, their core protein and lipid componentry, which lie at the centre of EV form and function, remain poorly defined. Here we performed high-resolution density gradient fractionation of over 140 human plasma samples to isolate circulating EVs, and systematically constructed their...
Pre-storage leucoreduction of platelet concentrates reduced biological response modifier concentrations and TRALI incidence in an in vivo sheep model.
SCIENTIFIC REPORTS - 26 Nov 2025
Transfusion-related acute lung injury (TRALI) is a potentially fatal transfusion reaction. It can be caused by the transfusion of proteins, lipids, and extracellular vesicles that accumulate in blood components during routine storage and are collectively referred to as biological response modifiers (BRMs). It has been suggested that leucoreduction might reduce TRALI risk by limiting the accumul...
Stimulation at the frontal cortex influences the exercise activity and skeletal muscle status in senescence-accelerating mice.
NPJ AGING - 25 Nov 2025
Senescence-associated frailty and sarcopenia are global challenges. We here investigated neuronal activity and skeletal muscle biology in senescence-accelerated mouse prone 8 (SAMP8) mice with scalp acupuncture stimulation (SAPS). Excise activity was assessed using rotarod test in the three groups: SAMP8 mice receiving SAPS (SP8-Ap), SAMP8 controls (SP8-C), and senescence-accelerated mouse resi...
Depression as a moderator and mediator of functional status in patients with Long COVID: a cross-sectional and longitudinal observational study from the PERCEIVE cohort in Australia.
BMJ OPEN - 21 Nov 2025
In patients with post-acute sequelae of COVID-19 (PASC), depression has been associated with symptom severity, the duration since infection and ongoing functional impairment. However, the interconnections between these factors remain inadequately understood. This study aimed to explore the roles of depressive symptoms in moderating and mediating the relationships between post-COVID-19 condition...
Rethinking diabetes care for Indigenous Australians: the need for Indigenous-codesigned and led diabetes models of care.
THE MEDICAL JOURNAL OF AUSTRALIA - 17 Nov 2025
Automated Insulin Delivery Beyond Glycemic Outcomes: Endpoints and Evidence.
DIABETES TECHNOLOGY & THERAPEUTICS - 14 Nov 2025
Automated insulin delivery (AID) systems have been shown to be an effective therapeutic option for people with type 1 diabetes and, more recently, for people with type 2 diabetes. To date, the benefit of AID systems has been primarily assessed by glycemic parameters and has been shown to optimize glucose control for people living with diabetes. However, it is increasingly recognized that diabet...
Living arrangements and associations with well-being among older adults in China: a national population-based study.
BMC GERIATRICS - 28 Nov 2025
Special Issue "New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 3rd Edition".
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 29 Oct 2025
Cardiovascular disease (CVD) encompasses a broad spectrum of conditions affecting the heart and blood vessels [...].
High Salt Intake and Atherosclerosis Progression-Not Only via Blood Pressure: A Narrative Review.
NUTRIENTS - 03 Nov 2025
Excessive dietary salt intake remains a critical and underestimated global health concern, strongly associated with increased cardiovascular disease risk. While the relationship between salt and arterial hypertension is well established, accumulating evidence highlights additional, blood pressure-independent mechanisms linking high salt intake with the progression of atherosclerosis. Beyond its...
Ceramide as a Biomarker for HFpEF in Women: Menopause, Aging, and Pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 06 Nov 2025
Heart failure with preserved ejection fraction (HFpEF) currently accounts for half of the heart failure (HF) cases world-wide, affecting nearly 32 million people. HFpEF has a skewed prevalence toward females and those older than 65 years old. The pathophysiology of HFpEF is suggestive of a conglomerate of inflammatory, hypertensive, as well as metabolic dysfunction, giving rise to the syndrome....
A Novel Digital Platform to Support Child and Family Mental Health in Australia (Child and Family eHub): Protocol for a Mixed Methods Evaluation.
13 Nov 2025
Child mental health disorders are a significant Australian public health issue with high prevalence rates compounded by inequitably higher rates for those living in families with lower income, lower levels of parental education, and higher levels of unemployment. Prevention and early intervention approaches are critical to address problems early. When caregivers seek information and services to...
Effect of GLP-1 receptor agonists on body composition.
CURRENT OPINION IN ENDOCRINOLOGY, DIABETES, AND OBESITY - 13 Oct 2025
Obesity is present in up to 85% of individuals with type 2 diabetes mellitus (T2DM) and poses a major therapeutic challenge. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for T2DM, are now widely used for obesity management and increasingly recognized for their impact on body composition beyond weight reduction. This review summarizes evidence on the effects of GLP-1...
The protective effect of breastfeeding on infant inflammation: a mediation analysis of the plasma lipidome and metabolome.
BMC MEDICINE - 08 Oct 2025
Inflammation has long-term health impacts across the life course. Breastfeeding substantially reduces inflammation risk, but key pathways, including the extent that this is due to protection against early life infection, are poorly understood. We aimed to investigate the relationships between breastfeeding, inflammation, and infection burden, and to determine the extent to which metabolomic and...
Clinical relevance of extracellular vesicles in cancer - therapeutic and diagnostic potential.
NATURE REVIEWS. CLINICAL ONCOLOGY - 08 Oct 2025
Extracellular vesicles (EVs) encompass a multitude of lipid bilayer-delimited particles, of which exosomes are the most widely studied. Bidirectional cell-cell communications via EVs have a pivotal role in the physiology of multicellular organisms. EVs carry biological cargoes (including proteins, RNA, DNA, lipids and metabolites) capable of mediating a range of pleiotropic cellular functions. ...
Joslin Kidney Panel of Circulating Proteins: A Tool for ESKD Risk Discrimination and Individualized Diabetic Kidney Disease Treatment.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : CJASN - 10 Oct 2025
To facilitate personalized treatment of diabetic kidney disease (DKD), we developed the Joslin Kidney Panel (JKP) of 21 circulating proteins associated with progression to end-stage kidney disease (ESKD). Prognostic models using baseline concentrations of JKP proteins in circulation and clinical markers were then developed to stratify individuals according to ESKD risk and according to response...
Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids.
TRANSLATIONAL PSYCHIATRY - 10 Oct 2025
Autism Spectrum Disorder (ASD) affects 1 percent of the world's population with an increased prevalence of 178 percent since 2000. Although altered synaptic function putatively accounts for many of the abnormalities seen in ASD, the specific molecular mechanisms underlying this disorder remain poorly defined. A growing body of evidence suggests that extracellular vesicles (EVs), specifically ex...
Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner.
NATURE COMMUNICATIONS - 11 Oct 2025
Given that the SARS-CoV-2 virus, and the COVID-19 pandemic, constitutes a major environmental challenge faced by billions of people worldwide, we investigated whether paternal pre-conceptual SARS-CoV-2 infection has impacts on sperm RNA content, and intergenerational (F1) and transgenerational (F2) effects on offspring phenotypes. Using an established mouse-adapted SARS-CoV-2 (P21) preclinical ...
When Microbes Meet Androgens: A Sex-Specific Path to Hypertension.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Nov 2025
The Around the Clock Terminology Consortium: A Global Consensus on Terminology to Discuss the 24-Hour Cycle of Physical Activity, Sedentary Behavior, and Sleep.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 11 Oct 2025
