Publications
Now showing items 201-220 of 5153 records
Tailored environments for directed mesenchymal stromal cell proliferation and differentiation using decellularized extracellular matrices in conjunction with substrate modulus.
ACTA BIOMATERIALIA - 22 Aug 2024
Decellularised extracellular matrix (dECM) produced by mesenchymal stromal cells (MSCs) is a promising biomaterial for improving the ex vivo expansion of MSCs. The dECMs are often deposited on high modulus surfaces such as tissue culture plastic or glass, and subsequent differentiation assays often bias towards osteogenesis. We tested the hypothesis that dECM deposited on substrates of varying ...
Acute Neuroinflammation Alters the Transport of a Model Therapeutic Protein from the Brain into Lymph and Blood.
26 Aug 2024
The drainage of fluid and solutes along lymphatic pathways from the brain has been found to be impaired in mouse models of multiple sclerosis, Alzheimer's disease, and Parkinson's disease where neuroinflammation is present. We recently demonstrated that <sup>3</sup>H-albumin, a model therapeutic protein (∼65 kDa), undergoes preferential lymphatic transport from the brain using a cervical lymph ...
Platelets in Vascular Calcification: A Comprehensive Review of Platelet-Derived Extracellular Vesicles, Protein Interactions, Platelet Function Indices, and their Impact on Cellular Crosstalk.
SEMINARS IN THROMBOSIS AND HEMOSTASIS - 27 Aug 2024
Vascular calcification (VC) commonly accompanies the development of atherosclerosis, defined by the accumulation of calcium in the arterial wall, potentially leading to stroke and myocardial infarction. Severe and unevenly distributed calcification poses challenges for interventional procedures, elevating the risks of vascular dissection, acute vascular occlusion, restenosis, and other major ad...
Radiofrequency catheter ablation of persistent atrial fibrillation by pulmonary vein isolation with or without left atrial posterior wall isolation: long-term outcomes of the CAPLA trial.
EUROPEAN HEART JOURNAL - 31 Aug 2024
Posterior wall isolation (PWI) is commonly incorporated into catheter ablation (CA) strategies for persistent atrial fibrillation (AF) in an attempt to improve outcomes. In the CAPLA randomized study, adjunctive PWI did not improve freedom from atrial arrhythmia at 12 months compared with pulmonary vein isolation (PVI) alone. Whether additional PWI reduces arrhythmia recurrence over the longer ...
Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries.
THE LANCET. DIABETES & ENDOCRINOLOGY - 01 Sep 2024
Meat consumption could increase the risk of type 2 diabetes. However, evidence is largely based on studies of European and North American populations, with heterogeneous analysis strategies and a greater focus on red meat than on poultry. We aimed to investigate the associations of unprocessed red meat, processed meat, and poultry consumption with type 2 diabetes using data from worldwide cohor...
A new method for network bioinformatics identifies novel drug targets for mucinous ovarian carcinoma.
NAR GENOMICS AND BIOINFORMATICS - 01 Sep 2024
Mucinous ovarian carcinoma (MOC) is a subtype of ovarian cancer that is distinct from all other ovarian cancer subtypes and currently has no targeted therapies. To identify novel therapeutic targets, we developed and applied a new method of differential network analysis comparing MOC to benign mucinous tumours (in the absence of a known normal tissue of origin). This method mapped the protein-p...
Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial.
CIRCULATION - 01 Sep 2024
<b>Background:</b> Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, and health-related quality of life. The G allele of the noncoding single nucleotide polymorphism <i>RS9349379</i> enhances expression of the endothelin-1 gene (<i>EDN1</i>) in human vascular cells, potentially increasing circulating conce...
Glucofriendly couscous usage in diabetes.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Aug 2024
Couscous, a staple food of Northern Africa and the Middle East, is consumed across the world. Being carbohydrate - rich, it is often forbidden to persons with diabetes. Its social and cultural connotations, however, do not allow absolute avoidance of this dish in real life. This brief article explores various ways of preparing, serving and eating couscous, in a glucofriendly manner. The authors...
A Home for the Orphan?: Isolated Tricuspid Regurgitation as Part of HFpEF.
JACC. CARDIOVASCULAR IMAGING - 10 Aug 2024
Is public transport a promising strategy for increasing physical activity? Evidence from a study of objectively measured public transport use and physical activity.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 19 Aug 2024
Greater public transport use has been linked to higher physical activity levels. However, neither the amount of physical activity associated with each daily public transport trip performed, nor the potential total physical activity gain associated with an increase in trips/day, has been determined. Using objective measures, we aimed to quantify the association between public transport use, phys...
Community Control of Hypertension and Diabetes (CoCo-HD) program in the Indian states of Kerala and Tamil Nadu: a study protocol for a type 3 hybrid trial.
BMC PUBLIC HEALTH - 21 Aug 2024
India grapples with a formidable health challenge, with an estimated 315 million adults afflicted with hypertension and 100 million living with diabetes mellitus. Alarming statistics reveal rates for poor treatment and control of hypertension and diabetes. In response to these pressing needs, the Community Control of Hypertension and Diabetes (CoCo-HD) program aims to implement structured lifes...
Fair Allocation of GLP-1 and Dual GLP-1-GIP Receptor Agonists.
THE NEW ENGLAND JOURNAL OF MEDICINE - 22 Aug 2024
Haptoglobin phenotype and levels in type 2 diabetes and effects of fenofibrate.
JOURNAL OF DIABETES INVESTIGATION - 22 Aug 2024
In diabetes haptoglobin (Hp) 2 vs Hp 1 allelic product is associated with cardiac and renal complications. Few studies report both Hp phenotype and Hp levels. In a Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial substudy we evaluated the Hp phenotype, Hp levels, and fenofibrate effects. In 480 adults with type 2 diabetes (T2D) the Hp phenotype was assessed and the Hp level...
Initiating or switching to insulin degludec/insulin aspart in a real-world population of adults with type 2 diabetes in Australia: results from a prospective, non-interventional study.
INTERNAL MEDICINE JOURNAL - 22 Aug 2024
Insulin degludec/insulin aspart (IDegAsp) is a fixed-ratio co-formulation of insulin degludec and insulin aspart for the treatment of people with diabetes and suboptimal glycaemic control. Few real-world studies of IDegAsp treatment have been conducted. Here, we report results from the Australian cohort of the global ARISE study of real-world IDegAsp use. To investigate glycaemic control and ot...
Long-term risk of heart failure in adult cancer survivors: a systematic review and meta-analysis.
HEART (BRITISH CARDIAC SOCIETY) - 22 Aug 2024
Cancer survivors are at increased risk of heart failure (HF). While cardiotoxicity is commonly sought at the time of cancer chemotherapy, HF develops as a result of multiple 'hits' over time, and there is limited evidence regarding the frequency and causes of HF during survivorship. This systematic review sought to investigate the relationship between cardiotoxic cancer therapies and HF during ...
Piezo1 expression in neutrophils regulates shear-induced NETosis.
NATURE COMMUNICATIONS - 22 Aug 2024
Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood cells to attach to. In circulation, neutrophils are constantly exposed to hemodynamic forces such as shear stress, which in turn regulates many ...
Prognostication and Interventional Guidance Using Acceleration-Ejection Time Ratio in Undifferentiated Paradoxical Low-Flow Low-Gradient Aortic Stenosis.
JACC. CARDIOVASCULAR IMAGING - 30 Jul 2024
Studies in paradoxical low-flow low-gradient aortic stenosis (PLFAS) have demonstrated conflicting outcomes with variable survival advantage from aortic valve replacement (AVR). PLFAS is a heterogeneous composition of patients with uncertainty regarding true stenosis severity that continues to confound decision-making for AVR. The purpose of this study was to investigate the utility of the Dopp...
Definition and Validation of Prognostic Phenotypes in Moderate Aortic Stenosis.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2024
Adverse outcomes from moderate aortic stenosis (AS) may be caused by progression to severe AS or by the effects of comorbidities. In the absence of randomized trial evidence favoring aortic valve replacement (AVR) in patients with moderate AS, phenotyping patients according to risk may assist decision making. This study sought to identify and validate clusters of moderate AS that may be used to...
Use of artificial intelligence-guided echocardiography to detect cardiac dysfunction and heart valve disease in rural and remote areas: Rationale and design of the AGILE-echo trial.
AMERICAN HEART JOURNAL - 10 Aug 2024
Transthoracic echocardiography (TTE) is essential in the diagnosis of cardiovascular diseases (CVD), including but not limited to heart failure (HF) and heart valve disease (HVD). However, its dependence on expert acquisition means that its accessibility in rural areas may be limited, leading to delayed management decisions and potential missed diagnoses. Artificial intelligence-guided (AI)-TTE...
Mineralocorticoid receptors, macrophages and new mechanisms for cardiovascular disease.
MOLECULAR AND CELLULAR ENDOCRINOLOGY - 10 Aug 2024
