Publications
Now showing items 21-40 of 5118 records
Left ventricular size and heart failure: A cardiac MRI assessment of 38,129 individuals from the UK Biobank.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 26 Oct 2024
Previous studies suggest that prevalent heart failure (HF) differs based on left ventricular ejection fraction (LVEF) and left ventricular (LV) chamber size. Furthermore, the prevalence of HF with preserved ejection fraction (HFpEF) is often considered approaching, or exceeding that of HF with reduced ejection fraction in the community. The aim of this study was to evaluate prevalent and incide...
Left Ventricular Summit Arrhythmias: State-of-the-Art Review of Anatomy, Mapping, and Ablation Strategies.
JACC. CLINICAL ELECTROPHYSIOLOGY - 22 Oct 2024
The left ventricular summit (LVS) is the most common site of epicardial arrhythmias. Ablation of LVS arrhythmias continue to pose a challenge to the electrophysiologist because of its complex and intimate anatomical location. In this review, we undertake a detailed examination of the intricate anatomy of the LVS alongside a comprehensive synthesis of mapping and ablation strategies used to trea...
Outcomes After Percutaneous Coronary Intervention in Patients with Prior Coronary Artery Bypass Grafting.
THE AMERICAN JOURNAL OF CARDIOLOGY - 27 Oct 2024
In patients with prior CABG requiring subsequent PCI there is uncertainty whether bypass grafts or native coronary arteries should be targeted. We analysed data from 2,764 patients with prior CABG in the Melbourne Interventional Group registry (2005-2018), divided into two groups: those undergoing PCI to a native vessel (n=1,928) and those with PCI to a graft vessel (n=836).Patients with a graf...
Acute Inhibition of Drp1 Mitigates Adverse Cardiac Remodelling following Chronic Reperfused Myocardial Infarction.
CARDIOVASCULAR DRUGS AND THERAPY - 21 Oct 2024
Behavioral and Psychosocial Dynamics in Diabetes Management: A Path Analysis to Examine the Influence of Acculturation in Arab Immigrant Communities.
21 Oct 2024
Type 2 diabetes mellitus (T2DM) prevalence is rising globally. Arab immigrants with T2DM, one of the least studied ethnic minorities, have a higher diabetes prevalence and more prominent management-related challenges compared with mainstream host societies. Acculturation's impact on self-care activities and diabetes distress (DD) is understudied globally. To examine how acculturation affects se...
Validation of serum non-invasive tests of liver fibrosis as prognostic markers of clinical outcomes in people with fatty liver disease in Australia.
24 Oct 2024
The validity of non-invasive tests (NITs) of liver fibrosis for the prediction of liver and mortality outcomes in an Australian cohort is unknown. We aimed to verify the utility of available NITs to predict overall and cause-specific mortality and major adverse liver outcome (MALO). This was an analysis from the Crossroads 1 clinic sub-study of a randomly sampled adult cohort from regional Aust...
Predictors in Youth of Adult Cardiovascular Events.
PEDIATRICS - 14 Oct 2024
Childhood risk factors are associated with cardiovascular events in adulthood. We compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a model that additionally included lipids to predict cardiovascular events in adulthood. The study comprised 11 550 participants from 7 longitudinal cohort studies in the United States, Australia, and Finland with...
Myocardial extracellular volume measurement using cardiac computed tomography.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 14 Oct 2024
Myocardial fibrosis is a common endpoint of many cardiac diseases and increasingly recognized as a predictor of heart failure, arrhythmia, and death. Recent studies have utilised cardiac computed tomography (CT) scans with delayed phase imaging to quantify diffuse fibrosis of the myocardium. CT extracellular volume (CT-ECV) measurement correlates well with CMR and histological myocardial fibros...
The mitral to aortic/pulmonary velocity-time integral ratio is a simple, feasible and accurate discriminator for echocardiographic evaluation of severe isolated mitral regurgitation.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 17 Oct 2024
Echocardiographic quantification of mitral regurgitation (MR) remains challenging, requiring dedicated image acquisition, and is limited by potential error from geometric assumptions of annular dimensions. Volume is a product of area and flow and assuming proportional mitral/aortic areas, an increased mitral-inflow volume compared to LV/RV-outflow semi-quantitatively represents greater MR regur...
Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Eligibility and Prescription Rates in Patients Presenting With Recurrent Acute Coronary Syndromes.
HEART, LUNG & CIRCULATION - 17 Oct 2024
Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are novel medications for reducing low-density lipoprotein cholesterol (LDL-C) levels. In 2020, the Australian Pharmaceutical Benefits Scheme (PBS) began subsidising PCSK9 inhibitors for secondary prevention of cardiovascular disease in patients with LDL-C >2.6 mmol/L despite statin and ezetimibe therapy. This criterion was expand...
Urinary metabolomics provide insights into coronary artery disease in individuals with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY - 26 Nov 2024
Type 1 diabetes increases the risk of coronary artery disease (CAD). High-throughput metabolomics may be utilized to identify metabolites associated with disease, thus, providing insight into disease pathophysiology, and serving as predictive markers in clinical practice. Urine is less tightly regulated than blood, and therefore, may enable earlier discovery of disease-associated markers. We st...
Polygenic Prediction of Recurrent Events After Early-Onset Myocardial Infarction.
CIRCULATION. GENOMIC AND PRECISION MEDICINE - 29 Nov 2024
Myocardial infarction (MI) is a complex disease caused by both lifestyle and genetic factors. This study aims to investigate the predictive value of genetic risk, in addition to traditional cardiovascular risk factors, for recurrent events following early-onset MI. The Italian Genetic Study of Early-Onset Myocardial Infarction is a cohort study enrolling patients with MI before 45 years. Monoge...
Bioavailable testosterone and androgen receptor activation, but not total testosterone, are associated with muscle mass and strength in females.
THE JOURNAL OF PHYSIOLOGY - 11 Oct 2024
Testosterone, the major androgen, influences the reproductive and non-reproductive systems in males and females via binding to the androgen receptor (AR). Both circulating endogenous testosterone and muscle AR protein content are positively associated with muscle mass and strength in males, but there is no such evidence in females. Here, we tested whether circulating testosterone levels were as...
Epigenomic biomarkers of cardiometabolic disease: How far are we from daily practice?
CARDIOVASCULAR DIABETOLOGY - 07 Nov 2024
Determining whether someone has cardiometabolic disease (CMD), especially in the early stages, can be complicated. Risk stratification ordinarily depends on an extended process relying on medical history that typically considers blood pressure, cholesterol, smoking and diabetes status. Physicians have long relied on these key patient characteristics to assess CMD risk. However, these widely use...
Obesity Associated Reproductive and Sexual Syndrome(OARS) in Men.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Nov 2024
Obesity, which has emerged as a major global public health challenge, is associated with myriad medical and multisystemic complications. Obesity impacts the male reproductive and sexual function in multiple ways as well. However, perhaps because of the focus on cardiovascular and metabolic health, the gonadal aspects of obesity medicine have not been given due attention. We propose the term OAR...
Somnometabolic Syndrome Revisited.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Nov 2024
The term somnometabolic syndrome has been used to describe a condition where obstructive sleep apnoea coexists with one or more components of metabolic syndrome. We propose a wider definition, stating that somnometabolic syndrome refers to the multifaceted, bidirectional relationship between sleep and metabolic health, including vascular health. This also includes the association of sleep with ...
Physio-Friendly Remission-Facilitating Pharmacotherapy (PRP) in Type 2 Diabetes.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Nov 2024
This brief communication describes the concept of physiofriendly pharmacotherapy for type 2 diabetes mellitus. Physio-friendly therapy is defined as that which restores metabolic, including glycaemic and weight homoeostasis, to near normal levels. Drugs such as glucagon like peptide 1 receptor agonists (GLP1RA), sodium glucose cotransporter- 2 inhibitors (SGLT2i), and alfa glucosidase inhibitor...
Lipoxin A<sub>4</sub> improves cardiac remodeling and function in diabetes-associated cardiac dysfunction.
CARDIOVASCULAR DIABETOLOGY - 20 Nov 2024
Diabetic heart disease may eventually lead to heart failure, a leading cause of mortality in diabetic individuals. The lack of effective treatments for diabetes-induced heart failure may result from a failure to address the underlying pathological processes, including chronic, low-grade inflammation. Previous studies have reported that lipoxin A<sub>4</sub> (LXA<sub>4</sub>), known to promote r...
Low-Density Lipoprotein Cholesterol Level Distributions Across Different Ages: Implications for Screening Children for Severe and Familial Hypercholesterolemia.
CIRCULATION - 19 Nov 2024
Low breast density is associated with epicardial adipose tissue volume and coronary artery disease.
CLINICAL IMAGING - 17 Nov 2024
Epicardial adipose tissue volume (EATv), is well correlated with coronary artery disease (CAD), however not reported clinically. Breast density, measured on mammography, has shown promise as a reflector of cardiometabolic risk, with less dense breasts indicating greater proportion of adipose tissue. We aimed to evaluate the association between breast density, EATv and CAD. Retrospective, cross-...
