Publications
Now showing items 21-40 of 5385 records
Association of Cross-life-cycle Body Size and Genetic Risk With Cardio-renal-metabolic Conditions in Adulthood evidence from a prospective cohort study.
INTERNATIONAL JOURNAL OF SURGERY (LONDON, ENGLAND) - 04 Jun 2025
The aim of this study was to investigate the longitudinal associations between the body size trajectory and the cardio-renal-metabolic (CRM) conditions in adulthood, and evaluate the joint association between body size trajectory and polygenic risk scores (PRS) of CRM conditions. This prospective cohort study included 441,470 UK Biobank participants aged 40 to 70 years, recruited between March ...
Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy.
NATURE - 04 Jun 2025
Microangiopathy is a major complication of SARS-CoV-2 infection and contributes to the acute and chronic complications of the disease<sup>1</sup>. Endotheliopathy and dysregulated blood coagulation are prominent in COVID-19 and are considered to be major causes of microvascular obstruction<sup>1,2</sup>. Here we demonstrate extensive endothelial cell (EC) death in the microvasculature of COVID-...
Effects of live-remote exercise on quality of life and other health-related outcomes in cancer survivors: a randomised controlled trial.
JOURNAL OF CANCER SURVIVORSHIP : RESEARCH AND PRACTICE - 05 Jun 2025
Exercise following cancer treatment has been shown to improve health-related quality of life (HRQoL) and other important health outcomes, yet barriers to participation prevent many cancer survivors from exercising according to recommendations. Live-remote exercise methods could improve accessibility; however, evidence on their efficacy is limited. The EX-MED Cancer Sweden randomised controlled ...
The presence or absence of standard modifiable cardiovascular risk factors in patients with myocardial infarction impacts long-term but not 30-day mortality: a UK Biobank prospective cohort study.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 06 Jun 2025
Prior studies reported higher early mortality after acute myocardial infarction (MI) in patients without standard modifiable cardiovascular risk factors (SMuRFs), warranting further validation. We aimed to evaluate whether SMuRF-absence is associated with increased 30-day cardiovascular mortality following MI. We conducted a population-based cohort study using UK Biobank data (n = 487 177). Inc...
One Size Does Not Fit All: The Need for Sex-Specific Precision Medicine in Diabetes Technology.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY - 25 May 2025
Incorporating sex-specific factors in diabetes research and treatment is essential for advancing precision medicine. There are critical gaps in understanding and applying sex-related differences. Female-specific diabetes pathophysiology manifests in three major areas: life cycle phases (including puberty, pregnancy, and menopause), lifestyle factors (such as responses to nutrition and physical ...
The hotter and shorter the better? Strategy comparison for atrial fibrillation ablation using high power short duration settings.
INDIAN PACING AND ELECTROPHYSIOLOGY JOURNAL - 26 May 2025
Diabetes advocacy in the Asia-Pacific region.
JOURNAL OF DIABETES INVESTIGATION - 27 May 2025
Living with diabetes is challenging. From diagnosis, one has to deal with lifelong management of glycemia and other factors. Misunderstandings about diabetes persist. People with diabetes (PWD) are sometimes misperceived as having brought diabetes upon themself, being incapable of self-management, maintaining a healthy lifestyle, or appropriate dietary habits, among other negative attributes. A...
Postpartum administration of eplerenone to mitigate vascular dysfunction in mice following a preeclampsia-like pregnancy.
SCIENTIFIC REPORTS - 27 May 2025
Preeclampsia is a severe pregnancy complication associated with substantial injury to systemic vasculature, major organs, and the feto-placental unit, with an approximate mortality rate of 76,000 pregnant women and 500,000 babies each year. Preeclampsia results in up to five-fold increased risk of cardiovascular disease. There is currently no cure and limited treatment options for preeclampsia ...
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration.
CELL REPORTS - 28 May 2025
We investigated the molecular mechanisms of exercise adaptations in human muscle by integrating genome, methylome, transcriptome, and proteome data from over 1,000 participants (2,340 muscle samples). We identified distinctive signatures associated with maximal oxygen consumption (VO<sub>2max</sub>), and multi-omics integration uncovered five key genes as robust exercise markers across layers, ...
Effects of dapagliflozin on the progression of left ventricular dysfunction in type 2 diabetes mellitus: a randomized controlled trial.
CARDIOVASCULAR DIABETOLOGY - 30 May 2025
Targeting SETD7 Rescues Diabetes-Induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin-3G.
DIABETES - 01 Jun 2025
Revascularization strategies failed to improve outcome in patients with diabetes with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study investigates the role of chromatin remodelling in modulating angiogenesis in diabetes. RNA sequencing (RNA-seq), and angiogenic assays (cell migration and tube f...
Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging.
JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE - 01 Jun 2025
To date, most research investigating the influence of circulating sex hormones on ageing female skeletal muscle has been cross-sectional and focused only on dichotomised young and old, or pre- versus post-menopausal groups. This excludes an important transitional period from high to low circulating oestrogen. Using secondary data from the Baltimore Longitudinal Study of Aging, this study aimed ...
Association of the circulating lipid panel, PCPro, with clinical outcomes in metastatic hormone-sensitive prostate cancer: post-hoc analysis of the ENZAMET Phase 3 randomised trial (ANZUP 1304).
ANNALS OF ONCOLOGY : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY - 20 May 2025
Enzalutamide significantly improves overall survival (OS) of patients with metastatic hormone- sensitive prostate cancer (mHSPC). However, ∼10% of patients will die within 2 years. PCPro is a plasma lipid panel associated with decreased OS in metastatic castration-resistant prostate cancer. In this study, we assessed the association between PCPro and clinical outcomes in mHSPC by performing a p...
Metabolically healthy abdominal obesity is associated with higher odds of left ventricular geometric remodeling in children: Evidence from two school-based studies in China.
INTERNATIONAL JOURNAL OF OBESITY (2005) - 22 May 2025
The association between metabolically healthy abdominal obesity (MHO) and subclinical cardiovascular outcomes in the general pediatric population remains largely unexplored. We aimed to investigate the relationship of MHO with left ventricular geometric (LVG) remodeling in Chinese children. Data were obtained from two school-based cross-sectional studies in China, involving 2866 children aged 6...
Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure.
CIRCULATION RESEARCH - 23 May 2025
Heart failure is a global health issue with significant mortality and morbidity. There is increasing evidence that alterations in the gastrointestinal microbiome, gut epithelial permeability, and gastrointestinal disorders contribute to heart failure progression through various pathways, including systemic inflammation, metabolic dysregulation, and modulation of cardiac function. Moreover, seve...
Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021.
JAMA NEUROLOGY - 23 May 2025
Nontraumatic subarachnoid hemorrhage (SAH) represents the third most common stroke type with unique etiologies, risk factors, diagnostics, and treatments. Nevertheless, epidemiological studies often cluster SAH with other stroke types leaving its distinct burden estimates obscure. To estimate the worldwide burden of SAH. Based on the repeated cross-sectional Global Burden of Disease (GBD) 2021 ...
Restoring balance with recombinant interleukin-37: hope for halting chronic inflammation in calcific aortic valve disease.
CARDIOVASCULAR RESEARCH - 29 Apr 2025
Relationship between sRAGE and obesity in individuals with type 1 diabetes during a median follow-up of 6.3 years.
DIABETOLOGIA - 29 Apr 2025
Soluble receptor for advanced glycation end products (sRAGE) has been inversely linked to obesity, which is defined by excess of total body fat. However, body fat accumulation is also relevant for health. In this study, we investigated associations between sRAGE and obesity in individuals with type 1 diabetes over 6.3 years of follow-up. The study included 3886 adults with type 1 diabetes from ...
Risk of ischemic stroke in sinus node dysfunction with and without atrial fibrillation: evidence for the presence of a left atrial myopathy in patients with isolated sinus node dysfunction - an analysis of the UK Biobank.
HEART RHYTHM - 30 Apr 2025
Emerging evidence indicates sinus node dysfunction (SND) may be an important marker of a biatrial myopathy. However, the relative risk of ischemic stroke in isolated SND has not been clearly delineated in comparative prospective studies. This study examined the association between SND (with and without concomitant atrial fibrillation [AF]) and ischemic stroke (IS) in the United Kingdom Biobank ...
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis.
09 Apr 2025
Prolonged exposure to a high-fat diet (HFD) exacerbates intestinal disease pathology, yet the early events preceding the development of gut inflammation remain poorly understood. Here, we show that within 48 h, HFD impairs intestinal group 3 innate lymphoid cells (ILC3s) and their capacity to produce interleukin-22 (IL-22), critical for maintaining gut homeostasis. This loss of function was ass...
