Publications
Now showing items 21-40 of 5596 records
First in Human Feasibility Study of an Insulin Patch Pump Combined With CGM-Insulin Delivery Cannula.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY - 09 Apr 2026
Combining a patch pump (PP) with a single-insertion glucose-sensing cannula (continuous glucose monitor with an insulin set [CGM-IS]) may reduce user burden compared with tethered insulin pumps or multiple daily injections. We aimed to determine feasibility of a combined device. This feasibility study evaluated a PP with a CGM-IS (PP-CGM-IS) with manual bolus insulin dosing in T1D adults with i...
The nationwide prevalence of anaemia and the associated factors in the general adult population in Malaysia.
BMC PUBLIC HEALTH - 07 Apr 2026
Author Correction: Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans.
COMMUNICATIONS MEDICINE - 06 Apr 2026
Plasma lipid trajectories improve prediction of future Alzheimer's disease.
JOURNAL OF ALZHEIMER'S DISEASE : JAD - 06 Apr 2026
BackgroundEarly identification of individuals at elevated risk for Alzheimer's disease (AD) is critical for prevention. Blood-based biomarkers offer scalable alternatives to cerebrospinal fluid and imaging, but the prognostic value of longitudinal plasma lipid trajectories remains unclear.ObjectiveTo evaluate whether multi-year plasma lipid trajectories improve prediction of AD conversion beyon...
Deprescribing in Older People: A Clinical Practice Guideline Summary.
THE MEDICAL JOURNAL OF AUSTRALIA - 01 Apr 2026
Older people face higher risks of medicine-related harm due to polypharmacy and the use of potentially inappropriate medicines. Current treatment guidelines rarely specify when to stop medicines, leading to medicines often being continued indefinitely without a clear deprescribing plan. While deprescribing guidelines exist for some medicine classes, limited guidance is a major barrier to depres...
sAlpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2026
The incidence and prevalence of heart failure (HF) with preserved ejection fraction (HFpEF) continue to rise, yet evidence-based therapy remains limited. Due to the complexity of HFpEF pathology, traditional HF medication has shown inconsistent efficacy in improving clinical outcomes and reducing morbidity. Therefore, highlighting the urgent need for novel interventions. The αlpha-7 nicotinic a...
Comparing dementia prevalence in Australians with and without diabetes across sociodemographic groups: Findings from the 2021 national census.
JOURNAL OF ALZHEIMER'S DISEASE : JAD - 17 Apr 2026
BackgroundDiabetes is a recognized risk factor for dementia, but its impact on dementia burden across sociodemographic groups in Australia is not well characterized.ObjectiveTo compare prevalence of dementia among Australians with and without diabetes and examine variation across key sociodemographic factors.MethodsWe conducted a cross-sectional analysis of the 2021 Australian national census a...
Uncovering shared and tissue-specific molecular adaptations to intermittent fasting in liver, brain, and muscle.
ELIFE - 17 Apr 2026
Intermittent fasting (IF) has emerged as a powerful dietary intervention with profound metabolic benefits, yet the tissue-specific molecular mechanisms underlying these effects remain poorly understood. In this study, we employed comprehensive proteomics and transcriptomics analysis to investigate the systemic and organ-specific adaptations to IF in male C57BL/6 mice. Following a 16 hr daily fa...
Ultra-mild bisulphite sequencing for DNA methylation analysis from low-input clinical specimens.
CLINICAL EPIGENETICS - 16 Apr 2026
In a recent paper published in Nature Communications, Dai and colleagues offer a practical re-engineering of a workhorse: ultra-mild bisulphite sequencing (UMBS-seq), which re-tunes classical bisulphite conversion so that fragmented, low-input clinical DNA can yield methylomes that are not merely usable, but technically reliable. In this commentary, we set the advance in its proper frame-less a...
Waist-to-Height Ratio Is Associated With the Risk of Coronary Artery Disease in Type 1 Diabetes: A 19-Year Cohort Study.
DIABETES CARE - 14 Apr 2026
Obesity, kidney disease, and coronary artery disease (CAD) are interconnected. Here, the relationship between central obesity and CAD across albuminuria categories in type 1 diabetes was investigated. Data on 4,349 individuals without prior CAD from the Finnish Diabetic Nephropathy Study were analyzed. Central obesity was defined as waist-to-height ratio (WHtR) ≥0.5. Outcomes included acute myo...
Exercise effects on lean body mass, muscle strength and functional performance in patients with metastatic breast cancer: the randomized controlled PREFERABLE-EFFECT study.
BREAST CANCER RESEARCH : BCR - 13 Apr 2026
Beyond CABG vs. PCI: Contemporary and Future Coronary Revascularisation from Historical Evolution to Artificial Intelligence, Robotics, and Hybrid Strategies.
JOURNAL OF CLINICAL MEDICINE - 01 Apr 2026
Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are the two dominant revascularisation strategies for obstructive coronary artery disease, yet their relative roles continue to shift because they address coronary pathophysiology differently with ever-evolving techniques. PCI has advanced through iterative improvements, including balloon angioplasty, bare-metal...
Current evidence for diagnosis and management of cardiac vasculitis.
HEART (BRITISH CARDIAC SOCIETY) - 20 Apr 2026
Cardiac vasculitis represents a heterogeneous group of immune-mediated disorders that can involve the coronary vessels, myocardium, valvular apparatus and pericardial tissues. Despite its rarity, cardiac vasculitis may result in significant clinical sequelae such as acute coronary syndrome, heart failure, cardiac arrhythmias and pericarditis. Diagnosis is challenging because symptoms are often ...
Risk Prediction in Cardio-Oncology: Conceptual and Methodological Considerations: JACC: CardioOncology State-of-the-Art Review.
JACC. CARDIOONCOLOGY - 01 Apr 2026
Risk prediction models can guide prevention, monitoring, and treatment decisions in cardio-oncology, but their development requires careful attention to methodological challenges unique to cardiovascular disease arising in the context of cancer. In this state-of-the-art review, the authors use case scenarios to illustrate how prediction objectives, index dates, and time horizons must align with...
Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY PLUS - 01 Jun 2026
Ischemic heart disease remains the leading cause of morbidity and mortality worldwide. While current therapies prolong survival, they do not address underlying tissue damage. Messenger RNA (mRNA)-based therapies offer a promising alternative for repair and regeneration. However, targeted and effective delivery to the injured heart remains challenging. Lipid nanoparticles (LNPs) have emerged as ...
Artificial intelligence-powered virtual standardized patients in teaching history-taking skills to medical students: a randomized controlled trial.
BMC MEDICAL EDUCATION - 30 Apr 2026
Correction: Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2026
[This corrects the article DOI: 10.3389/fphar.2026.1756039.].
Prothrombotic genetic variants and cancer-associated venous thromboembolism: defining thrombotic risk across tumor types.
HAEMATOLOGICA - 07 May 2026
Cancer-associated venous thromboembolism (CAT) is a major cause of mortality in cancer patients. Prothrombotic genetic variants increase venous thromboembolism risk in the general population, but contribution to CAT remains unclear, particularly within different tumor types. We sought to determine whether the presence of thrombophilic variants influence relative and absolute CAT risk, and may b...
LIPID MAPS: Powering discovery in lipidomics.
SCIENCE SIGNALING - 05 May 2026
As lipidomics approaches its 25th anniversary, we explore how lipid research has matured over the years while highlighting emerging innovations that are expanding our ability to study these diverse, life-critical biomolecules. In particular, we showcase the community-driven, open-access databases, software, and educational resources made freely available through the ELIXIR Core Data Resource LI...
Unlocking the potential of light-intensity physical activity for public health: a call to action for research.
BRITISH JOURNAL OF SPORTS MEDICINE - 04 May 2026
