Publications
Now showing items 21-40 of 5325 records
Characterization of mAb104, a Monoclonal Antibody Targeting a Conformationally Exposed, Tumor-specific epitope of HER2.
MOLECULAR CANCER THERAPEUTICS - 13 May 2025
We generated a novel HER2 monoclonal antibody (mAb104) which binds to an epitope in domain II of HER2 that is conformationally exposed in tumors in response to HER2 amplification or activation but is not accessible to antibody binding in normal tissues. Consistent with other studies that evaluated antibodies targeting conformationally exposed epitopes, mAb104 lacked in vitro activity however sh...
Rationale and design of a randomised phase II multicentre crossover trial investigating a sodium-glucose co-transporter 2 inhibitor, dapagliflozin, combined with a novel continuous ketone monitor in adults with type 1 diabetes to reduce the risk of diabetic ketoacidosis: the PARTNER study.
BMJ OPEN - 06 May 2025
Sodium-glucose co-transporter inhibitors have potential glycaemic and non-glycaemic benefits in people with type 1 diabetes (T1D). However, the increased risk of diabetic ketoacidosis (DKA) limits their widespread use. We hypothesise that dapagliflozin 10 mg daily, combined with the use of continuous ketone monitoring (CKM) and education strategies to mitigate progression to DKA, will demonstra...
Healthcare Costs of Myocardial Infarction in Denmark: A Nation-Wide Registry-Based Cohort Study.
VALUE IN HEALTH REGIONAL ISSUES - 06 May 2025
Myocardial infarction (MI) is highly detrimental and healthcare intensive with a high incidence globally. This study aimed to estimate the individual healthcare costs of MI in Denmark from a public health provider perspective. In this nation-wide registry-based cohort study, individuals with incident MI between 2012 and 2016 were propensity score-matched 1:3 with non-MI controls. Excess costs w...
Oncogenic proteome of pancreatic cancer extracellular vesicles: sodium/myo-inositol cotransporter as a potential marker.
SIGNAL TRANSDUCTION AND TARGETED THERAPY - 07 May 2025
Alteration of gut microbiota associated with hypertension in children.
BMC MICROBIOLOGY - 08 May 2025
The association of disturbance in gut microbiota with hypertension (HTN) defined on three separate occasions among children and adolescents remains unclear. In this study, we aimed to compare the differences in gut microbiota composition and diversity between children with HTN and those with normal blood pressure (BP). Data and stool samples were collected from the second follow-up of a childho...
Health status in stage B heart failure from diabetic cardiomyopathy baseline results from ARISE-HF.
JOURNAL OF DIABETES AND ITS COMPLICATIONS - 25 Apr 2025
Assess the determinants of health status and its correlation with key parameters in individuals with diabetic cardiomyopathy (DbCM). In the ARISE-HF trial, the Kansas City Cardiomyopathy Questionnaire (KCCQ), cardiopulmonary exercise testing (CPET), Physical Activity Scale for the Elderly (PASE) score, echocardiographic, and laboratory assessments were performed at baseline in 691 persons with ...
Thoracic lymph collection impacts the level of endogenous macromolecules in rat biological fluids.
INTERNATIONAL JOURNAL OF PHARMACEUTICS - 26 Apr 2025
Lymph collection via insertion of a cannula into a lymphatic vessel is the most commonly used procedure to quantify the transport of pharmaceutical agents into lymph following administration to rodents. Further, lymph is derived from interstitial fluid draining specific organs and tissues such that compositional analysis of lymph collected via cannulation can provide useful information about bi...
Childhood 25-OH-vitamin D Levels Predict Early Cardiovascular Outcomes in Adulthood: The Cardiovascular Risk in Young Finns Study.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 29 Apr 2025
Comprehending the Epidemiology and Aetiology of Childhood Obesity: Integrating Life Course Approaches for Prevention and Intervention.
29 Apr 2025
Childhood obesity is defined as a medical condition characterised by abnormally high amounts of body fat relative to lean body mass, which increases the risk of adverse health outcomes among children and adolescents from birth to 18 years. The prevalence of childhood obesity, which has serious healthcare implications, is surging, together with its healthcare burden. In this review we explore th...
SpaNorm: spatially-aware normalization for spatial transcriptomics data.
GENOME BIOLOGY - 29 Apr 2025
Normalization of spatial transcriptomics data is challenging due to spatial association between region-specific library size and biology. We develop SpaNorm, the first spatially-aware normalization method that concurrently models library size effects and the underlying biology, segregates these effects, and thereby removes library size effects without removing biological information. Using 27 t...
Environmental Risk Factors Are Associated With the Natural History of Familial Dilated Cardiomyopathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 02 May 2025
Familial dilated cardiomyopathy (DCM) is characterized by marked variability in phenotypic penetrance. The extent to which this is determined by patient-specific environmental factors is unknown. A retrospective longitudinal cohort study was performed in families with DCM-causing genetic variants. Environmental factors were classified into 2 subsets based on evidence for a causal link to depres...
"It's Good. It's Really Good.": Perspectives of Older Adults, Exercise/Recreation Professionals, and Primary Care Providers on Designing a Movement Behavior Intervention Using the Staircase Approach.
JOURNAL OF AGING AND PHYSICAL ACTIVITY - 02 May 2025
Interventions targeting sedentary behavior in older adults have reported mixed success for behavior change. The previously proposed Staircase Approach offers a novel strategy to support long-term behavior change by targeting a reduction in sedentary time before progressing to increasing physical activity levels. The current study aimed to understand the perceptions of older adults, exercise/rec...
CVOT summit report 2024: new cardiovascular, kidney, and metabolic outcomes.
CARDIOVASCULAR DIABETOLOGY - 02 May 2025
The 10th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on December 5-6, 2024. This year, discussions about cardiovascular (CV) and kidney outcome trials centered on the recent findings from studies involving empagliflozin (EMPACT-MI), semaglutide (STEP-HFpEF-DM and FLOW), tirzepatide (SURMOUNT-OSA and SUMMIT), and finer...
Artificial intelligence in chronic kidney disease management: a scoping review.
THERANOSTICS - 01 Jan 2025
<b>Rationale:</b> Chronic kidney disease (CKD) is a major public health problem worldwide associated with cardiovascular disease, renal failure, and mortality. To effectively address this growing burden, innovative solutions to management are urgently required. We conducted a scoping review to identify key use cases in which artificial intelligence (AI) could be leveraged for improving manageme...
Comparing the effectiveness of calorie restriction with and without time-restricted eating on the circadian regulation of metabolism: rationale and protocol of a three-arm randomised controlled trial in adults at risk of type 2 diabetes.
NUTRITION RESEARCH (NEW YORK, N.Y.) - 27 Mar 2025
Time-restricted eating (TRE) may extend the cardiometabolic health benefits of calorie restriction (CR). However, few studies have compared its effect on the circadian regulation of glucose metabolism and the optimal time of day to initiate TRE is also unclear. This study aims to compare the effectiveness of CR with and without TRE on glucose tolerance in response to 3 identical meals consumed ...
Do physiological changes in fatty acid composition alter cellular ferroptosis susceptibility and influence cell function?
JOURNAL OF LIPID RESEARCH - 01 Apr 2025
Ferroptosis is an iron-dependent form of cell death driven by the excessive peroxidation of poly-unsaturated fatty acids (PUFAs) within membrane phospholipids. Ferroptosis is a hallmark of many diseases and preventing or inducing ferroptosis has considerable therapeutic potential. Like other forms of cell death, the pathological importance and therapeutic potential of ferroptosis is well apprec...
Nandrolone (17-Nortestosterone) And Glucose Metabolism: From Ugly Duckling To Handsome Swan.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2025
Glucosarcopenia, or sarcopenia coexisting with diabetes, is a common condition. Caused by various factors, including poor glucose control, as well as some glucoselowering therapies, sarcopenia negatively impacts quality of life and long-term health. Nandrolone, or 19- nortestosterone, is a selective anabolic receptor modulator (SARM), classified as an anabolic-androgenic steroid (AAS). A review...
Sapiopsychosocial triage in obesity care.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2025
With the increasing prevalence of obesity, a triage system is needed to prioritize access to obesity care services, as well as support efficient choice of education and counselling strategies. The sapiopsychosocial triage (SPST) system, based upon cognitive, psychological and social assessment of the person living with obesity, helps determine the style and strategy of obesity management. It ca...
The Antifibrotic Effects of Eplerenone in Hypertrophic Cardiomyopathy: A Randomized Clinical Trial.
JACC. HEART FAILURE - 03 Apr 2025
Fibrosis plays a central role in hypertrophic cardiomyopathy (HCM), contributing to symptoms via impaired systolic and diastolic function and ventricular arrhythmias. The aim of this study was to determine if eplerenone has an antifibrotic effect in nonobstructive HCM (resting left ventricular outflow tract gradient <30 mm Hg). This was a randomized, double-blind, placebo-controlled trial of ep...
Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood.
BMC MEDICINE - 14 Apr 2025
Although the associations between cord blood lipidome and neonatal birth weight are established, it remains uncertain whether sexual dimorphism in fetal fat accumulation extends to the relationship between cord blood lipid profiles and neonatal abdominal fat compartments. Understanding these relationships could provide insights into early sex-specific differences in lipid metabolism. We conduct...
