Publications
Now showing items 21-40 of 5027 records
Corrigendum to 'The effect of ambient temperatures on hospital admissions for kidney diseases in Central Australia' [Environ. Res. 259 (2024) 119502].
ENVIRONMENTAL RESEARCH - 14 Oct 2024
Investigation of RNA-binding protein NOVA1 in silico: Comparison of the modern human V197 with the archaic I197 variant present in Neanderthals.
COMPUTERS IN BIOLOGY AND MEDICINE - 15 Oct 2024
By comparing the high-coverage archaic genome sequences to those of modern humans, specific genetic differences have been identified. For example, a human-specific substitution has been found in neuro-oncological ventral antigen 1 (NOVA1) - an RNA-binding protein that regulates the alternative splicing of neuronal pre-mRNA. The amino acid substitution results in an isoleucine-to-valine change a...
Intestinal Lymphatic Biology, Drug Delivery, and Therapeutics: Current Status and Future Directions.
PHARMACOLOGICAL REVIEWS - 16 Oct 2024
Historically, the intestinal lymphatics were considered passive conduits for fluids, immune cells, dietary lipids, lipid soluble vitamins, and lipophilic drugs. Studies of intestinal lymphatic drug delivery in the late 20th century focused primarily on the drugs' physicochemical properties, especially high lipophilicity, that resulted in intestinal lymphatic transport. More recent discoveries h...
Genome-wide association testing beyond SNPs.
NATURE REVIEWS. GENETICS - 07 Oct 2024
Decades of genetic association testing in human cohorts have provided important insights into the genetic architecture and biological underpinnings of complex traits and diseases. However, for certain traits, genome-wide association studies (GWAS) for common SNPs are approaching signal saturation, which underscores the need to explore other types of genetic variation to understand the genetic b...
New frontiers for exercise training: evidence of cardiovascular benefit for titin-induced dilated cardiomyopathy.
HEART (BRITISH CARDIAC SOCIETY) - 07 Oct 2024
Atrial Mechanics, Atrial Cardiomyopathy and Impact of Atrial Interventions.
JOURNAL OF CARDIAC FAILURE - 01 Oct 2024
Our comprehension of atrial mechanics, atrial cardiomyopathy and their clinical implications across various cardiovascular conditions has advanced significantly. Atrial interventions can have differing effects on atrial mechanics. With the rapid increase in the use of atrial interventions, it is crucial for investigators and clinicians to acknowledge the potential adverse effects of these inter...
Automated Breast Arterial Calcification Score Is Associated With Cardiovascular Outcomes and Mortality.
01 Nov 2024
Breast arterial calcification (BAC) on mammograms has emerged as a biomarker of women's cardiovascular disease (CVD) risk, but there is a lack of quantification tools and clinical outcomes studies. This study assessed the association of BAC (both presence and quantity) with CVD outcomes. This single-center, retrospective study included women with a screening mammogram from 2007 to 2016. BAC was...
Shear-Sensing by C-Reactive Protein: Linking Aortic Stenosis and Inflammation.
CIRCULATION RESEARCH - 18 Oct 2024
CRP (C-reactive protein) is a prototypical acute phase reactant. Upon dissociation of the pentameric isoform (pCRP [pentameric CRP]) into its monomeric subunits (mCRP [monomeric CRP]), it exhibits prothrombotic and proinflammatory activity. Pathophysiological shear rates as observed in aortic valve stenosis (AS) can influence protein conformation and function as observed with vWF (von Willebran...
Comparison of heart failure risk assessment tools among cancer survivors.
CARDIO-ONCOLOGY (LONDON, ENGLAND) - 11 Oct 2024
Cancer survivors have an increased risk of incident heart failure (HF) attributable to shared risk factors and cancer treatment-induced cardiac dysfunction. Selection for HF screening depends on risk assessment, but the optimal means of assessing risk is undefined. We undertook a comparison of HF risk calculators among survivors. In this study from the UK Biobank, cancer and HF diagnoses were d...
Prehospital factors predicting mortality in patients with shock: state-wide linkage study.
OPEN HEART - 30 Sep 2024
Patients with shock treated by emergency medical services (EMS) have high morbidity and mortality. Knowledge of prehospital factors predicting outcomes in patients with shock remains limited. We aimed to describe the prehospital predictors of mortality in patients with non-traumatic shock transported to hospital by EMS. This is a retrospective cohort study of consecutive ambulance attendances f...
Detection of sedentary time and bouts using consumer-grade wrist-worn devices: a hidden semi-Markov model.
30 Sep 2024
Wrist-worn data from commercially available devices has potential to characterize sedentary time for research and for clinical and public health applications. We propose a model that utilizes heart rate in addition to step count data to estimate the proportion of time spent being sedentary and the usual length of sedentary bouts. We developed and trained two Hidden semi-Markov models, STEPHEN (...
National implementation trial of BeUpstanding™: an online initiative for workers to sit less and move more.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 30 Sep 2024
The online BeUpstanding™ program is an eight-week workplace-delivered intervention for desk-based workers to raise awareness of the benefits of sitting less and moving more and build a supportive culture for change. A workplace representative (the "champion") delivers the program, which includes a workshop where teams collectively choose their sit less/move more strategies. A toolkit provides t...
AlzDiscovery: A computational tool to identify Alzheimer's disease-causing missense mutations using protein structure information.
PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY - 01 Oct 2024
Alzheimer's disease (AD) is one of the most common forms of dementia and neurodegenerative diseases, characterized by the formation of neuritic plaques and neurofibrillary tangles. Many different proteins participate in this complicated pathogenic mechanism, and missense mutations can alter the folding and functions of these proteins, significantly increasing the risk of AD. However, many metho...
Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
THE LANCET. NEUROLOGY - 01 Oct 2024
Up-to-date estimates of stroke burden and attributable risks and their trends at global, regional, and national levels are essential for evidence-based health care, prevention, and resource allocation planning. We aimed to provide such estimates for the period 1990-2021. We estimated incidence, prevalence, death, and disability-adjusted life-year (DALY) counts and age-standardised rates per 100...
Relationship Between Renin, Aldosterone, Aldosterone-to-Renin Ratio and Arterial Stiffness and Left Ventricular Mass Index in Young Adults.
CIRCULATION - 01 Oct 2024
Primary aldosteronism, characterized by renin-independent aldosterone production, is associated with adverse cardiovascular remodeling and outcomes. Elevated cardiovascular risk is observed even in subclinical forms of primary aldosteronism according to studies conducted primarily in middle-aged and elderly populations. This study aimed to assess whether early changes in primary aldosteronism b...
Changes in the incidence of type 2 diabetes in Australia, 2005-2019, overall and by socio-demographic characteristics: a population-based study.
THE MEDICAL JOURNAL OF AUSTRALIA - 01 Oct 2024
To estimate changes in the incidence of clinically diagnosed type 2 diabetes in Australia, overall and by age, sex, socio-economic disadvantage, geographic remoteness, and country of birth. Population-based study; analysis of National Diabetes Services Scheme (NDSS) data (age-period-cohort models). Data were extracted for incident cases of type 2 diabetes, 1 January 2005 to 31 December 2019, in...
Hepatic Retinol Dehydrogenase 11 Dampens Stress Associated with the Maintenance of Cellular Cholesterol Levels.
MOLECULAR METABOLISM - 01 Oct 2024
Dysregulation of hepatic cholesterol metabolism can contribute to elevated circulating cholesterol levels, which is a significant risk factor for cardiovascular disease. Cholesterol homeostasis in mammalian cells is tightly regulated by an integrated network of transcriptional and post-transcriptional signalling pathways. Whilst prior studies have identified many of the central regulators of th...
Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021.
THE LANCET. PUBLIC HEALTH - 01 Oct 2024
Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been proposed to achieve tobacco-free generations, none have been implemented to date....
Does insulin pump therapy offer benefits for behaviour, mood, cognition and HbA1c in children and adolescents with type 1 diabetes? A randomised controlled trial with observational follow-up.
ARCHIVES OF DISEASE IN CHILDHOOD - 25 Sep 2024
Improved behaviour, mood, cognition and HbA1c have been reported with short-term use of continuous subcutaneous insulin infusion (CSII) in youth with type 1 diabetes (T1D). We sought to re-examine these findings in a randomised controlled trial (RCT), with longitudinal follow-up. RCT of youth aged 7-15 years with T1D, at two tertiary paediatric centres. Participants were randomised to commence ...
The Digital Divide: Examining the Associations Between Mobile Health Services Use, Health Literacy, Self-Efficacy, and Social Adaptation Among Older Adults in China.
STUDIES IN HEALTH TECHNOLOGY AND INFORMATICS - 24 Sep 2024
Despite mobile health services becoming a vital tool for improving accessibility and connectivity for older people, there is limited understanding of how they use mHealth services in China. This research hoped to determine the use of health services, health literacy, self-efficacy, and social adaptation among over 60-year-old people in China. Results showed that 48% of participants used mHealth...
