Publications
Now showing items 21-40 of 5702 records
Medication Use in Type 1 Diabetes and the Association with Socioeconomic Disadvantage: Analysis of a National Linked Dataset.
DIABETES TECHNOLOGY & THERAPEUTICS - 03 Oct 2025
<b><i>Objectives:</i></b> To explore trends in the receipt of commonly prescribed medications (beyond insulin) in people with type 1 diabetes in Australia, including polypharmacy, and to investigate socioeconomic disparities across these trends. <b><i>Methods:</i></b> A retrospective analysis of 68,287 people with type 1 diabetes registered on the National Diabetes Services Scheme between 2013 ...
Socioeconomic inequalities in waist circumference and its 12-year change: Moderation by neighbourhood population density.
PREVENTIVE MEDICINE REPORTS - 01 Nov 2025
Reducing socioeconomic inequalities in obesity is a public health priority. We examined whether population density, a key environmental characteristic associated with obesity, moderates the associations of area-level socioeconomic status (SES) with waist circumference and its rate of change. Data from adults in an Australian national study, collected across three waves (1999-2000, 2005-06, 2011...
Sustained Improvement in Quality of Life Following Catheter Ablation for Persistent AF Beyond 3 Years: That's No Sham.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Sep 2025
Catheter ablation (CA) is an effective treatment for atrial fibrillation (AF) that improves arrhythmia burden and quality of life (QOL). However, there are limited data on long-term QOL outcomes in patients with persistent AF (PsAF). This study sought to evaluate long-term QOL outcomes up to 3 years post-ablation for patients with PsAF in CAPLA (Catheter Ablation for Persistent Atrial Fibrillat...
Cardiac arrest and aortic dissection: A bad combination.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 16 Sep 2025
Rethinking cardiovascular prevention: cost-effective cholesterol lowering for statin-intolerant patients in Australia and the UK.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 22 Sep 2025
Approximately 1 in 11 people are intolerant to statins. There have been no studies evaluating the cost-effectiveness of early intervention for primary prevention of cardiovascular disease (CVD) with three non-statin drugs [ezetimibe, proprotein convertase subtilisin-kexin type 9 inhibitors (PCSK9i; inclisiran and evolocumab), and bempedoic acid]. We aimed to evaluate the cost-effectiveness of t...
Clarifying the cognitive mechanisms and isolated effects of plaque visualization in cardiovascular risk reduction: reply.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 22 Sep 2025
Yoga vs Regular Exercise for Atrial Fibrillation: Design of the Yoga-AF Randomized Controlled Trial.
AMERICAN HEART JOURNAL - 22 Sep 2025
Lifestyle modification is a key pillar of AF management. Yoga has beneficial effects on cardiovascular health and has shown promise as an intervention in AF. However, randomised data are absent. To determine the effect of regular yoga on AF episodes and AF burden in people with paroxysmal or persistent AF over a 12-month period. This is a randomised control trial of a yoga program in addition t...
Targeting the NLRP3 Inflammasome-Gasdermin D Axis to Combat Cardiovascular Diseases.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY - 23 Sep 2025
Cardiovascular disease remains a leading global cause of mortality, with inflammation playing a crucial role in driving its pathology. Despite advancements in cardiovascular disease management, current treatment options primarily address risk factors and symptoms rather than underlying disease mechanisms. Among the key mechanistic drivers are the NLRP3 multiprotein inflammasome complexes of the...
Actigraphy-based measures of sleep quality and duration are associated with maternal glycemia in mid-pregnancy.
SLEEP MEDICINE - 23 Sep 2025
Studies in nonpregnant populations have linked insufficient and poor-quality sleep with hyperglycemia. However, this association is not well characterized in pregnancy, mainly due to challenges with self-reported measures of sleep. In this exploratory analysis, we examined associations of actigraphy-measured sleep duration and sleep efficiency with post-challenge glucose levels in mid-pregnancy...
Methylene blue in cardiogenic shock and cardiac arrest: A systematic review.
09 Sep 2025
Cardiogenic shock and cardiac arrest are associated with high risk of mortality despite advances in resuscitation techniques and supportive care. A growing body of evidence implicates a systemic inflammatory response syndrome (SIRS) in the pathogenesis of post-arrest vasoplegia and end-organ injury. Methylene blue (MB), a nitric oxide pathway inhibitor, has shown efficacy in vasoplegic and sept...
The association of haptoglobin levels and phenotype with cardiovascular disease in Type 2 diabetes: a Fenofibrate Intervention and Event Lowering in Diabetes sub-study.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 11 Sep 2025
Haptoglobin (HP) 2-2 phenotype has been suggested as a risk factor for cardiovascular disease (CVD) and to modulate fenofibrate benefit on CVD risk in Type 2 diabetes. However, little is known as to whether HP levels modulate CVD risk and fenofibrate response. Haptoglobin phenotype and levels were determined in 8047 Fenofibrate Intervention and Event Lowering in Diabetes trial participants at b...
The cost-effectiveness of semaglutide in reducing cardiovascular risk among people with overweight and obesity and existing cardiovascular disease, but without diabetes.
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES - 12 Sep 2025
The Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity (SELECT) trial demonstrated significant reductions in cardiovascular outcomes in people with cardiovascular disease (CVD) and overweight or obesity (but without diabetes). However, the cost of the medication has raised concerns about its financial viability and accessibility within healthcare systems. This s...
A 7-year prospective analysis of sustained benefits of multicomponent risk assessment and data-driven care in patients with type 2 diabetes: The Malaysian JADE Program.
DIABETES, OBESITY & METABOLISM - 15 Sep 2025
We evaluated the sustained effects of multicomponent risk assessment and data-driven care augmented by the web-based Joint Asia Diabetes Evaluation (JADE) Platform with a built-in template to guide comprehensive assessment (CA) for risk stratification on top of usual care in patients with type 2 diabetes (T2D) from Malaysia. In 2012-2015, 1196 T2D patients participated in a 1-year JADE Program ...
Diagnostic and prognostic comparison of stress ECG, CMR and SPECT, alone and sequentially, in stable chest pain.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE - 15 Sep 2025
Exercise ECG remains widely performed in the assessment of patients with suspected cardiac chest pain. We aimed to assess the comparative diagnostic and prognostic yield of exercise ECG, single photon emission computed tomography (SPECT) and cardiovascular magnetic resonance (CMR), in a large prospective patient population. Patients recruited to CE-MARC who had exercise ECG were included and fo...
Risk-Guided Disease Management To Prevent Heart Failure In Adult Cancer Survivors of Previous Cardiotoxic Cancer Treatments: Baseline Results of the REDEEM Trial.
AMERICAN HEART JOURNAL - 16 Sep 2025
Adult cancer survivors are at increased risk of heart failure (HF) due to standard risk factors and cancer treatment-related cardiac dysfunction. However, the prevalence and treatment of subclinical/stage B heart failure (SBHF) in this population are not well defined. The REDEEM (Risk-guided Disease managEment plan to prevEnt heart failure in patients treated with previous cardiotoxic cancer tr...
Targeting the ARF6-dependent recycling pathway to alter lipid rafts and reduce inflammation.
JOURNAL OF LIPID RESEARCH - 16 Sep 2025
Partitioning of inflammatory receptors into lipid rafts is essential for their function, making lipid rafts a promising target for anti-inflammatory therapies. However, the practical application of lipid raft-targeted therapies has been limited by a lack of mechanistic understanding of their regulation. In this study, we demonstrate that targeting the Arf6-dependent recycling pathway effectivel...
Short bouts of accumulated exercise: Review and consensus statement on definition, efficacy, feasibility, practical applications, and future directions.
JOURNAL OF SPORT AND HEALTH SCIENCE - 17 Sep 2025
Insufficient physical activity and prolonged sedentary behavior have emerged as major global public health challenges. Short bouts (≤10 min) of accumulated exercise (SBAE) throughout the day may be a promising strategy to mitigate the adverse effects of prolonged sitting and promote physical activity, ultimately promoting overall health. However, previous ambiguity in defining this concept has ...
Validity and Reliability of a Self-Administered Questionnaire for 24-Hour Movement Behaviors.
JOURNAL OF EPIDEMIOLOGY - 06 Sep 2025
Brief measures of 24-hour movement behaviors are needed to easily evaluate their durations. The present study investigated the criterion validity and test-retest reliability of a brief self-report instrument to assess 24-hour movement behaviors. A paper-based self-administered questionnaire was used to assess sleep, sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-...
Biomechanic regulation of neutrophil extracellular traps in the cardiovascular system.
06 Sep 2025
Neutrophil extracellular trap (NET) formation, or NETosis, is a key innate immune response that contributes to cardiovascular diseases, including vascular inflammation, atherosclerosis, and thrombosis. In the cardiovascular system, neutrophils encounter mechanical cues such as shear stress, matrix stiffness, and cyclic stretch that influence their activation and NET release. This review examine...
Obesity-related glomerulopathy: a lesser known complication of obesity.
CURRENT OPINION IN ENDOCRINOLOGY, DIABETES, AND OBESITY - 08 Sep 2025
Obesity is a global health concern and is intricately linked to cardiovascular disease and metabolic disorders. While its causal association with chronic kidney disease (CKD) has also been recognized, this entity has not been discussed extensively. Obesity-related glomerulopathy (ORG) is pathologically a secondary form of focal segmental glomerulosclerosis (FSGS), which typically presents clini...
