Publications
Now showing items 1921-1940 of 5702 records
Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance.
MOLECULAR NEUROBIOLOGY - 01 Feb 2022
HIV-associated neurocognitive disorders (HAND) is a term used to describe a variety of neurological impairments observed in HIV-infected individuals. The pathogenic mechanisms of HAND and of its connection to HIV infection remain unknown, but one of the considered hypotheses suggests that HIV infection accelerates the development of Alzheimer's disease. Previous studies suggested that HIV-1 Nef...
A Combined Echocardiography Approach for the Diagnosis of Cancer Therapy-Related Cardiac Dysfunction in Women With Early-Stage Breast Cancer.
JAMA CARDIOLOGY - 01 Mar 2022
Diagnosis of cancer therapy-related cardiac dysfunction (CTRCD) remains a challenge. Cardiovascular magnetic resonance (CMR) provides accurate measurement of left ventricular ejection fraction (LVEF), but access to repeated scans is limited.To develop a diagnostic model for CTRCD using echocardiographic LVEF and strain and biomarkers, with CMR as the reference standard.In this prospective cohor...
Protein phosphatase 2A in the healthy and failing heart: New insights and therapeutic opportunities.
CELLULAR SIGNALLING - 01 Mar 2022
Protein phosphatases have emerged as critical regulators of phosphoprotein homeostasis in settings of health and disease. Protein phosphatase 2A (PP2A) encompasses a large subfamily of enzymes that remove phosphate groups from serine/threonine residues within phosphoproteins. The heterogeneity in PP2A structure, which arises from the grouping of different catalytic, scaffolding and regulatory s...
Impact on adolescent mental health of replacing screen-use with exercise: A prospective cohort study.
JOURNAL OF AFFECTIVE DISORDERS - 15 Mar 2022
Screen-based device use could increase the risk of adolescent depression. Distinct modalities of screen-use may have differential effects on mental health. We used compositional data analysis to examine how theoretically replacing different screen-uses with exercise might influence future adolescent emotional distress.In 4,599 adolescents (55% female) from a nationally-representative, prospecti...
Arrhythmogenic Right Ventricular Cardiomyopathy.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Apr 2022
Arrhythmogenic right ventricular cardiomyopathy (ARVC) encompasses a group of conditions characterized by right ventricular fibrofatty infiltration, with a predominant arrhythmic presentation. First described in the late 1970s and early 1980s, it is now frequently recognized to have biventricular involvement. The prevalence is ∼1:2,000 to 1:5,000, depending on geographic location, and it has a ...
Vasoplegia Following Orthotopic Heart Transplantation: Prevalence, Predictors and Clinical Outcomes.
JOURNAL OF CARDIAC FAILURE - 01 Apr 2022
Patients undergoing heart transplant are at high risk for postoperative vasoplegia. Despite its frequency and association with poor clinical outcomes, there remains no consensus definition for vasoplegia, and the predisposing risk factors for vasoplegia remain unclear. Accordingly, the aim of this study was to evaluate the prevalence, predictors, and clinical outcomes associated with vasoplegia...
Screening-guided spironolactone treatment of subclinical left ventricular dysfunction for heart failure prevention in at-risk patients.
EUROPEAN JOURNAL OF HEART FAILURE - 01 Apr 2022
Subclinical left ventricular dysfunction (LVD) is a prelude to symptomatic heart failure (HF). We hypothesised that screening-guided treatment with spironolactone would prevent incident HF in at-risk patients.We randomised asymptomatic, community-dwelling subjects aged ≥65 years old, with at least one non-ischaemic HF risk factor (hypertension, type 2 diabetes mellitus or obesity) to echocardio...
Mechanosensing by Piezo1 and its implications for physiology and various pathologies.
BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY - 01 Apr 2022
Piezo1 is a mechanosensitive ion channel with essential roles in cardiovascular, lung, urinary, and immune functions. Piezo1 is widely distributed in different tissues in the human body and its specific roles have been identified following a decade of research; however, not all are well understood. Many structural and functional characteristics of Piezo1 have been discovered and are known to di...
Germline variants in tumor suppressor FBXW7 lead to impaired ubiquitination and a neurodevelopmental syndrome.
AMERICAN JOURNAL OF HUMAN GENETICS - 07 Apr 2022
Neurodevelopmental disorders are highly heterogenous conditions resulting from abnormalities of brain architecture and/or function. FBXW7 (F-box and WD-repeat-domain-containing 7), a recognized developmental regulator and tumor suppressor, has been shown to regulate cell-cycle progression and cell growth and survival by targeting substrates including CYCLIN E1/2 and NOTCH for degradation via th...
Using magnetic resonance imaging to map the hidden burden of muscle involvement in systemic sclerosis.
ARTHRITIS RESEARCH & THERAPY - 11 Apr 2022
Skeletal muscle can be directly affected by systemic sclerosis (SSc); however, a significant burden of SSc-associated myopathy is undetected because clinical parameters such as weakness and creatine kinase (CK) are unreliable biomarkers of muscle involvement. This study presents qualitative and quantitative magnetic resonance imaging (MRI) findings that quantify the prevalence of myopathy and e...
Vascular Responses Among Adults Four Years Post Exposure to 6 Weeks of Smoke from the Hazelwood Coal Mine Fire.
VASCULAR HEALTH AND RISK MANAGEMENT - 01 Jan 2022
Mega-wild fires are exposing large communities to weeks or months of high concentration smoke-related fine particulate air pollution (PM). However, little research has examined the long-term vascular responses from exposure to PM of this concentration and duration. We investigated whether level of exposure to 6 weeks of PM from the 2014 Hazelwood coal mine fire was associated with abnormal vasc...
First time use of manual pressure augmentation for ventricular fibrillation arrest in the community.
RESUSCITATION - 01 May 2022
Spontaneous generation of ASD astrocytes.
MOLECULAR PSYCHIATRY - 01 May 2022
Posterior Wall Isolation for Atrial Fibrillation: Time to Curb Our Enthusiasm?
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 May 2022
Prescription trends and costs of diabetes medications in Australia between 2003 and 2019: an analysis and review of the literature.
INTERNAL MEDICINE JOURNAL - 01 May 2022
Since the turn of the century, the prevalence of diabetes mellitus in Australia has increased, primarily due to rising rates of Type 2 diabetes. Simultaneously, the landscape of diabetes medications has evolved significantly. The change in prescribing trends and public spending on diabetes medications within Australia during this period are not well defined.To establish the frequency and cost o...
Application of a risk-guided strategy to secondary prevention of coronary heart disease: analysis from a state-wide data linkage in Queensland, Australia.
BMJ OPEN - 04 May 2022
This study sought whether higher risk patients with coronary heart disease (CHD) benefit more from intensive disease management.Longitudinal cohort study.State-wide public hospitals (Queensland, Australia).This longitudinal study included 20 426 patients hospitalised in 2010 with CHD as the principal diagnosis. Patients were followed-up for 5 years.The primary outcome was days alive and out of ...
Author Correction: Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length.
COMMUNICATIONS BIOLOGY - 19 May 2022
Individualized Beta-Blocker Treatment for High Blood Pressure Dictated by Medical Comorbidities: Indications Beyond the 2018 European Society of Cardiology/European Society of Hypertension Guidelines.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2022
Several hypertension guidelines have removed beta-blockers from their previous position as first-choice drugs for the treatment of hypertension. However, this downgrading may not be justified by available evidence because beta-blockers lower blood pressure as effectively as other major antihypertensive drugs and have solid documentation in preventing cardiovascular complications. Suspected inco...
Environmental determinants of human milk composition in relation to health outcomes.
ACTA PAEDIATRICA (OSLO, NORWAY : 1992) - 01 Jun 2022
Humans are exposed to environmental factors at every stage of life including infancy. The aim of this mini-review was to present a narrative of environmental factors influencing human milk composition. Current literature shows lactation is a dynamic process and is responsive to multiple environmental challenges including geographical location, lifestyle, persistent pollutants and maternal facto...
Feasibility of semi-recumbent bicycle exercise Doppler echocardiography for the evaluation of the right heart and pulmonary circulation unit in different clinical conditions: the RIGHT heart international NETwork (RIGHT-NET)
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 01 Jul 2021
Exercise Doppler echocardiography (EDE) is a well-validated tool in ischemic and valvular heart diseases. However, its use in the assessment of the right heart and pulmonary circulation unit (RH-PCU) is limited. The aim of this study is to assess the semi-recumbent bicycle EDE feasibility for the evaluation of RH-PCU in a large multi-center population, from healthy individuals and elite athlete...
