Publications
Now showing items 161-180 of 5582 records
Intermittent fasting reprograms the brain proteome to prevent synaptic degeneration and cognitive impairment in vascular dementia.
THERANOSTICS - 01 Jan 2025
<b>Rationale:</b> Vascular dementia (VaD), driven by chronic cerebral hypoperfusion (CCH), leads to synaptic degeneration and cognitive decline, yet mechanisms linking vascular dysfunction to synaptic loss remain unclear. Intermittent fasting (IF) has emerged as a potential intervention, but its effects on synaptic integrity in VaD are unknown. This study aims to investigate the effects of IF a...
Preventing Diabetic Ketoacidosis with Continuous Ketone Monitoring: Insights from a Clinical Research Case.
DIABETES TECHNOLOGY & THERAPEUTICS - 24 Jul 2025
Delayed identification of impending diabetic ketoacidosis (DKA) often results in hospitalizations. We describe a case where continuous ketone monitor (CKM) use facilitated prompt identification and intervention for impending DKA, avoiding hospitalization. A 55-year-old male (total daily insulin dose of 0.5 units/kg/day; HbA1c 6.9% [51.9 mmol/mol]) with type 1 diabetes using automated insulin de...
Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial.
CIRCULATION - 25 Jul 2025
Public health and clinical guidelines identify the importance of sedentary behaviors for cardiovascular diseases, particularly among postmenopausal women. The goal of this trial was to compare the behavioral and physiological impacts of 2 distinct approaches to changing sedentary behaviors. Overweight or obese sedentary postmenopausal women (N=407) were randomly assigned to 1 of 3 study conditi...
Haemodynamic implications of cardiovascular magnetic resonance pulmonary capillary wedge pressure in acute myocardial infarction.
EUROPEAN HEART JOURNAL. IMAGING METHODS AND PRACTICE - 01 Jul 2025
Cardiovascular magnetic resonance (CMR)-derived pulmonary capillary wedge pressure (PCWP) has demonstrated diagnostic and prognostic utility in heart failure patients. However, its clinical value in acute myocardial infarction (AMI) remains undetermined. This study investigates the relationship between CMR-derived PCWP, myocardial injury, and left ventricular (LV) remodelling in re-perfused acu...
Fludrocortisone to treat patients with aneurysmal subarachnoid haemorrhage: Protocol for an international, phase 3, randomised, placebo-controlled, multicentre trial.
01 Jun 2025
Hyponatraemia is a common complication after aneurysmal subarachnoid haemorrhage (aSAH) and is associated with worse outcomes. Fludrocortisone, a synthetic mineralocorticoid, may be an effective treatment for hyponatraemia, but its effect on clinical outcomes is unknown. The objective of this study was to describe the study protocol for the Fludrocortisone in Aneurysmal Subarachnoid Haemorrhage...
Assessing LV Contractility Identifies Populations With Preserved Ejection Fraction at Risk of Adverse Heart Failure Outcomes.
CIRCULATION. CARDIOVASCULAR IMAGING - 16 Jul 2025
Left ventricular ejection fraction (LVEF) is an essential tool for heart failure (HF) assessment but is limited by load dependence. Additional tools are needed to risk-stratify normal LVEF populations. We aimed to assess the prognostic value of systolic blood pressure-indexed left ventricular end-systolic volume ratio, or cardiac contractility index (CCI). In a prospective observational cohort ...
In Memoriam: Scott M. Grundy (1933-2025).
JOURNAL OF LIPID RESEARCH - 16 Jul 2025
Association of Cognitive Impairment With Evolution of Heart Failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 17 Jul 2025
While many studies have suggested that heart failure (HF) may lead to cognitive impairment, our understanding about this relationship is limited. This study investigated the association of cognitive function with HF risk factors and how cognitive impairment may impact the development of incident clinical HF in people with subclinical HF. People with either preclinical (at risk and asymptomatic,...
Ventricular Arrhythmia and Cardiac Fibrosis in Endurance Experienced Athletes (VENTOUX).
CIRCULATION. CARDIOVASCULAR IMAGING - 17 Jul 2025
Sudden cardiac death due to primary arrhythmia is a leading cause of mortality in athletes, predominantly affecting older males. Myocardial fibrosis is strongly associated with arrhythmogenesis in nonischemic cardiomyopathy, but its clinical significance in asymptomatic endurance athletes is unknown. We aimed to investigate whether myocardial fibrosis on cardiovascular magnetic resonance in asy...
Prediabetes.
NATURE REVIEWS. DISEASE PRIMERS - 17 Jul 2025
Prediabetes or intermediate hyperglycaemia represents a preliminary stage in the development of type 2 diabetes mellitus (T2DM). In addition to an increased likelihood of developing T2DM, individuals with prediabetes have an elevated risk of various vascular and non-vascular complications. No consensus has been achieved on the ideal screening strategy for prediabetes, with fasting plasma glucos...
Acetate concentration correlates with MSNA in patients with resistant hypertension.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 17 Jul 2025
Short-chain fatty acids (SCFAs), metabolites of colonic microflora fermentation of dietary fibre, have been implicated in experimental models and clinical trials to impact blood pressure (BP) regulation. Dietary interventions increasing serum SCFA levels have been associated with reduced 24-h systolic BP in hypertensive patients. However, the underlying mechanisms remain elusive. Given the role...
Exercise Barriers Among Females With Type 2 Diabetes: Exploring Age-Related Differences.
THE SCIENCE OF DIABETES SELF-MANAGEMENT AND CARE - 20 Jul 2025
PurposeThe purpose of this study was to explore age-specific differences in exercise barriers among females with type 2 diabetes (T2D).MethodsAn online survey explored psychosocial and logistical barriers to exercise among Australian females with T2D (≥18 years). Participants were categorized into younger (18-54 years) and older (≥ 55 years) age groups to explore age-related differences. The su...
Clinical management of diabetic cardiomyopathy with insights into pathophysiology and diagnosis.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY - 05 Jul 2025
Diabetes mellitus is associated with significant morbidity and premature mortality for which heart failure (HF) is a major cause. HF may be due to ischaemia, hypertension, uraemia, or a specific diabetic cardiomyopathy, and multiple causes may co-exist. A recent systematic review suggests that >40 % of people with type 2 diabetes have diastolic dysfunction without a reduction of cardiac systoli...
Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease.
JOURNAL OF ARRHYTHMIA - 01 Aug 2025
Conduction system disease may represent an early manifestation of underlying structural heart disease, including infiltrative disorders. Timely diagnosis of underlying cardiomyopathy has significant implications for clinical management, guiding both disease-modifying medical therapy and decisions around device implantation. We sought to investigate the utility of cardiac magnetic resonance imag...
Variation in uptake of sodium glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor analogues in adults with type 2 diabetes at high cardiovascular risk.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY - 30 Jun 2025
We quantified variation in the uptake of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor analogues (GLP-1RA) across sociodemographic, behavioural and clinical characteristics of people with type 2 diabetes (T2D) at high cardiovascular risk. We used the 45 and Up Study survey data (2018-2020) linked to dispensing and service claims for 10,171 people with ...
Trajectory of plasma lipidome associated with the risk of late-onset Alzheimer's disease: a longitudinal cohort study.
EBIOMEDICINE - 30 Jun 2025
Comprehensive lipidomic studies have demonstrated strong cross-sectional associations between the blood lipidome and late-onset Alzheimer's disease (AD) dementia and its risk factors, yet the longitudinal relationship between lipidome changes and AD progression remains unclear. We employed longitudinal lipidomic profiling on 4730 plasma samples from 1517 participants of the Alzheimer's Disease ...
Including Indigenous knowledge in biomedical research: a co-autoethnography.
THE LANCET. GLOBAL HEALTH - 01 Jul 2025
The need to improve biomedical research for the safe inclusion of Indigenous peoples is well documented. However, how one achieves this improvement, particularly in multisite, hospital-based research, is largely absent from the published literature. We aimed to conduct a reflexive dialogue to examine the challenges faced when adapting a hospital-based, biomedical acute rheumatic fever project i...
Letter to the Editor: Quader M, Kiernan Z, Labate G, Chen Q. Hypothermic myocardial preservation: the freezing debate. Transplant Proc. 2025;57(4):653-662. Fear of Freezing Fallacy: Storage in Melting Ice Cannot Damage the Donor Heart.
TRANSPLANTATION PROCEEDINGS - 01 Jul 2025
The recent report by Quader et al (Quader M, Kiernan Z, Labate G, et al. Hypothermic myocardial preservation: the freezing debate. Transplant Proc. 2025;57(4):653-662) addresses a critical question in donor heart preservation: does storage at 0 °C cause myocardial injury? Their findings show that hearts stored in melting water ice for 4 hours retain structural and functional integrity, contradi...
Emerging evidence and potential avenues to achieve durable outcomes in patients with obesity: the confluence of nutrition, and Microbiome on body composition.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS - 02 Jul 2025
Obesity is a global health concern that impacts health, quality of life, and longevity in affected individuals. Comorbid cardiovascular disease, type 2 diabetes, cancer, and other conditions often accompany obesity, and researchers are actively investigating therapeutic strategies to treat obesity and mitigate the health risks associated with excess adiposity. Restrictive nutritional intake and...
Relationships of Cognitive Function With Subsequent Device-Measured Physical Activity and Sedentary Time in Healthy Individuals and Those With Bipolar Disorder: Findings From the UK Biobank.
ACTA PSYCHIATRICA SCANDINAVICA - 03 Jul 2025
In bipolar disorder (BD), physical inactivity and sedentary behaviour are prevalent and have been linked to BD's cognitive symptoms, although the directionality of these links is not clear. This proof-of-concept study examined whether cognitive function during mid- and later-life was prospectively related to physical activity and sedentary time, and whether the association differed in presence ...
