Publications
Now showing items 161-180 of 5325 records
Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 30 Dec 2024
The pathophysiology of myocardial injury following COVID-19 remains uncertain. COVID-HEART was a prospective, multicentre study utilising cardiovascular magnetic resonance (CMR) to characterise COVID-related myocardial injury. In this pre-specified analysis, the objectives were to examine (1) the frequency of myocardial ischaemia following COVID-19, and (2) the association between ischaemia and...
Incidence, Characteristics and Prognostic Significance of Early Recurrences Following Different Ablation Approaches for Persistent Atrial Fibrillation.
HEART RHYTHM - 30 Dec 2024
Early recurrence of atrial tachyarrhythmia (ERAT) is common following catheter ablation of atrial fibrillation (AF). The specific clinical and arrhythmia characteristics of ERAT influencing late recurrence risk in persistent AF is unclear. Additionally, the impact of different ablation strategies on the incidence and prognostic significance of ERAT remains unknown. This study aimed to assess th...
Iron, lipid peroxidation and ferroptosis play pathogenic roles in atherosclerosis.
CARDIOVASCULAR RESEARCH - 31 Dec 2024
Oxidation of lipids, excessive cell death and iron deposition are prominent features of human atherosclerotic plaques. While extensive research has established the detrimental roles of lipid oxidation and apoptosis in atherosclerosis development, the involvement of iron in atherogenesis is not yet fully understood. With the emergence of an iron-dependent form of cell death termed ferroptosis, n...
Cardiomyocyte-Specific FoxO1 Knockout Mice as Tools to Assess Cardiac Hypertrophy and Key Experimental Considerations Using Cre-loxP.
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2025
The generation of tissue-specific mouse models has provided a powerful strategy to understand the role of genes in specific tissues/cells of interest under control/basal conditions and in response to physiological and pathological stimuli. Here we describe the generation of cardiomyocyte-specific FoxO1 knockout mice using Cre-loxP technology to examine the role of FoxO1 for the induction of hea...
Atrial fibrillation ablation timing: where is the sweet spot?
EUROPEAN HEART JOURNAL - 03 Jan 2025
Convincing evidence for the efficacy of ablation as first-line therapy in paroxysmal AF (PAF) and its clear superiority to medical therapy for rhythm control in both PAF and persistent AF (PsAF) has generated considerable interest in the optimal timing of ablation. Based on this data, there is a widespread view that the principle of 'the earlier the better' should be generally applied. However,...
Real-world experience of adjunct weekly semaglutide in Type 1 diabetes. Is it worth it?
DIABETES RESEARCH AND CLINICAL PRACTICE - 26 Dec 2024
Cost-effectiveness of catheter-based radiofrequency renal denervation for the treatment of uncontrolled hypertension: an analysis for the UK based on recent clinical evidence.
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES - 19 Dec 2024
Catheter-based radiofrequency renal denervation (RF RDN) has recently been approved for clinical use in the European Society of Hypertension guidelines and by the US Food and Drug Administration. This study evaluated the lifetime cost-effectiveness of RF RDN using contemporary evidence. A decision-analytic model based on multivariate risk equations projected clinical events, quality-adjusted li...
Reply to Letter to the Editor "Addressing Gaps in Post-MI Medication Use Study" regarding: "Patterns of 12-Month Post-Myocardial Infarction Medication Use According to Revascularisation Strategy: Analysis of 15,339 Admissions in Victoria, Australia".
HEART, LUNG & CIRCULATION - 01 Dec 2024
Meeting 24-hour movement behaviour guidelines is linked to core symptoms and school engagement in youth with moderate / severe ADHD.
JOURNAL OF AFFECTIVE DISORDERS - 10 Dec 2024
The independent associations of physical activity (PA), sleep duration (SL), and screen time (ST) with health outcome measures have been well-documented among children and adolescents, but not in youth with moderate/severe ADHD. To this end, the present study aimed to investigate the associations between three components within 24-hour movement behaviour (24-HMB) framework and core symptoms and...
Prognostic impact of inducible ischaemia in ischaemic left ventricular dysfunction: the REVIVED-BCIS2 trial.
EUROPEAN HEART JOURNAL - 11 Dec 2024
Results of an Australian trial of an automated insulin delivery (AID) system and other studies support likely benefit of AID use for many Australian adults with type 1 diabetes.
INTERNAL MEDICINE JOURNAL - 27 Nov 2024
Less than 20% of Australians with type 1 diabetes (T1D) meet recommended glucose targets. Technology use is associated with better glycaemia, with the most advanced being automated insulin delivery (AID) systems, which are now recommended as gold-standard T1D care. Our Australian AID trial shows a wide spectrum of adults with T1D can achieve recommended targets. Other studies, including lived e...
Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial.
CARDIOVASCULAR DIABETOLOGY - 13 Jan 2025
Diabetic myocardial disorder (DbMD, evidenced by abnormal echocardiography or cardiac biomarkers) is a form of stage B heart failure (SBHF) at high risk for progression to overt HF. SBHF is defined by abnormal LV morphology and function and/or abnormal cardiac biomarker concentrations. To compare the evolution of four DbMD groups based on biomarkers alone, systolic and diastolic dysfunction alo...
The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding.
BLOOD ADVANCES - 14 Jan 2025
The G haplotype is a group of co-inherited single nucleotide variants in the F5 gene that reduce venous thromboembolism (VTE) risk. Although 7% of the population is homozygous for the G haplotype (F5-G/G), the underlying mechanism of VTE protection is poorly understood. Using RNA sequencing data from 4651 blood donors in the INTERVAL study, we detected a rare excision event at the factor V (FV)...
Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized controlled trial.
BMJ OPEN DIABETES RESEARCH & CARE - 22 Dec 2024
This analysis aimed to investigate diabetes-specific psychological outcomes among adults with type 1 diabetes (T1D) using hybrid closed-loop (HCL) versus standard therapy. In this multicenter, open-label, randomized, controlled, parallel-group clinical trial, adults with T1D were allocated to 26 weeks of HCL (MiniMed™ 670G) or standard therapy (insulin pump or multiple daily injections without ...
Small Heart Size and Premature Death in 366,484 Individuals With Normal Ejection Fraction.
01 Jan 2025
In patients with preserved left ventricular ejection fraction (LVEF), small ventricular size has been associated with reduced functional capacity, but its impact on clinical outcomes is unclear. The goal of this study was to determine the relationship between small heart size and premature mortality within a large multicenter adult patient cohort with transthoracic echocardiographic examination...
A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation.
BMC BIOLOGY - 07 Jan 2025
C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular mechanisms. In a multi-translational study of systemic inflammation, we found a time- and inflammation-dependent pCRP...
Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans.
COMMUNICATIONS MEDICINE - 09 Jan 2025
Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset and progression. Although previous studies have suggested that certain diets may reduce the incidence of AD, the underlying mechanisms remain unclear. In this post-hoc analysis of a randomized crossover study of 20 elderly adults, we investig...
Piloting a citizen science approach to auditing rural walkability in Tasmania.
HEALTH PROMOTION JOURNAL OF AUSTRALIA : OFFICIAL JOURNAL OF AUSTRALIAN ASSOCIATION OF HEALTH PROMOTION PROFESSIONALS - 01 Jan 2025
People living in 'walkable' areas are more active, but common approaches to assessing walkability using audit tools and geospatial data have limitations in rural areas. This project explored the feasibility, acceptability and benefits of using a citizen science approach to audit walkability in rural communities. Using a citizen science approach, community members in rural towns completed audit ...
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis.
NATURE REVIEWS. CARDIOLOGY - 02 Jan 2025
Computed tomography coronary angiography provides a non-invasive evaluation of coronary artery disease that includes phenotyping of atherosclerotic plaques and the surrounding perivascular adipose tissue (PVAT). Image analysis techniques have been developed to quantify atherosclerotic plaque burden and morphology as well as the associated PVAT attenuation, and emerging radiomic approaches can a...
