Publications
Now showing items 161-180 of 5153 records
Relationship Between Renin, Aldosterone, Aldosterone-to-Renin Ratio and Arterial Stiffness and Left Ventricular Mass Index in Young Adults.
CIRCULATION - 01 Oct 2024
Primary aldosteronism, characterized by renin-independent aldosterone production, is associated with adverse cardiovascular remodeling and outcomes. Elevated cardiovascular risk is observed even in subclinical forms of primary aldosteronism according to studies conducted primarily in middle-aged and elderly populations. This study aimed to assess whether early changes in primary aldosteronism b...
Changes in the incidence of type 2 diabetes in Australia, 2005-2019, overall and by socio-demographic characteristics: a population-based study.
THE MEDICAL JOURNAL OF AUSTRALIA - 01 Oct 2024
To estimate changes in the incidence of clinically diagnosed type 2 diabetes in Australia, overall and by age, sex, socio-economic disadvantage, geographic remoteness, and country of birth. Population-based study; analysis of National Diabetes Services Scheme (NDSS) data (age-period-cohort models). Data were extracted for incident cases of type 2 diabetes, 1 January 2005 to 31 December 2019, in...
Hepatic Retinol Dehydrogenase 11 Dampens Stress Associated with the Maintenance of Cellular Cholesterol Levels.
MOLECULAR METABOLISM - 01 Oct 2024
Dysregulation of hepatic cholesterol metabolism can contribute to elevated circulating cholesterol levels, which is a significant risk factor for cardiovascular disease. Cholesterol homeostasis in mammalian cells is tightly regulated by an integrated network of transcriptional and post-transcriptional signalling pathways. Whilst prior studies have identified many of the central regulators of th...
Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021.
THE LANCET. PUBLIC HEALTH - 01 Oct 2024
Smoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking prevalence has slowed in recent years for many countries, and although strategies have recently been proposed to achieve tobacco-free generations, none have been implemented to date....
Does insulin pump therapy offer benefits for behaviour, mood, cognition and HbA1c in children and adolescents with type 1 diabetes? A randomised controlled trial with observational follow-up.
ARCHIVES OF DISEASE IN CHILDHOOD - 25 Sep 2024
Improved behaviour, mood, cognition and HbA1c have been reported with short-term use of continuous subcutaneous insulin infusion (CSII) in youth with type 1 diabetes (T1D). We sought to re-examine these findings in a randomised controlled trial (RCT), with longitudinal follow-up. RCT of youth aged 7-15 years with T1D, at two tertiary paediatric centres. Participants were randomised to commence ...
The Digital Divide: Examining the Associations Between Mobile Health Services Use, Health Literacy, Self-Efficacy, and Social Adaptation Among Older Adults in China.
STUDIES IN HEALTH TECHNOLOGY AND INFORMATICS - 24 Sep 2024
Despite mobile health services becoming a vital tool for improving accessibility and connectivity for older people, there is limited understanding of how they use mHealth services in China. This research hoped to determine the use of health services, health literacy, self-efficacy, and social adaptation among over 60-year-old people in China. Results showed that 48% of participants used mHealth...
The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL.
SCIENCE ADVANCES - 04 Oct 2024
Reversal of ischemia is mediated by neo-angiogenesis requiring endothelial cell (EC) and pericyte interactions to form stable microvascular networks. We describe an unrecognized role for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in potentiating neo-angiogenesis and vessel stabilization. We show that the endothelium is a major source of TRAIL in the healthy circulation comp...
Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards.
NATURE COMMUNICATIONS - 03 Oct 2024
In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (National Institute of Standards and Technology) human blood plasma Standard Reference Material (SRM) 1950, as well as a set of candidate plasma reference mate...
Engineering Hyperechogenic Colloids with Clot-Targeting Capabilities from Platelet-Derived Membranes.
ACS APPLIED MATERIALS & INTERFACES - 03 Oct 2024
Thrombosis-related cardiovascular diseases remain the leading global cause of mortality and morbidity. In this study, we present a pioneering approach in the field of nanobiotechnology, with a focus on clinical translation, aimed at advancing early diagnosis and enhancing treatment options for thrombotic disorders. We introduce the fabrication of Platelet Membrane-Derived Bubbles (PMBs), which ...
Are the Relationships of Physical Activity and Television Viewing Time With Mortality Robust to Confounding? A Study, Utilizing E-Values, From the Melbourne Collaborative Cohort Study.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 25 Sep 2024
Physical activity and sedentary behavior are associated with health outcomes. However, evidence may be affected by confounding bias. This study aimed to examine the relationships of physical activity and television (TV) viewing time with all-cause, cardiovascular, and cancer mortality in a cohort of Australian adults, and determine the robustness of these relationships to residual and unmeasure...
Enhancing the Polygenic Score Catalog with tools for score calculation and ancestry normalization.
NATURE GENETICS - 26 Sep 2024
Contemporary national and international guidelines on physical activity and sedentary behaviour for people living with chronic conditions, disability and advanced age: a scoping review.
BRITISH JOURNAL OF SPORTS MEDICINE - 27 Sep 2024
Physical activity guidelines inform policy and practice in promoting healthier lifestyles. The WHO advocates for distinct recommendations for each country to address variation in needs, resources and context. Specific regional recommendations for three underactive populations facing unique barriers to movement are lacking-people with chronic conditions, disability and advanced age. We review wh...
Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia.
CARDIOVASCULAR DIABETOLOGY - 28 Sep 2024
Hyperglycemia-induced oxidative stress is a well-established pathological mediator of vascular complications in diabetes. We assessed plasma oxidant and antioxidant levels in response to acute and chronic hyperglycemia in relation to vascular stiffness and varying degrees of kidney disease in type 1 diabetes individuals. The acute hyperglycemia study included 22 type 1 diabetic individuals with...
Anthropometric indices in predicting 10-year cardiovascular risk among males and females aged 40-74 years in south and southeast Asia: analysis of 12 WHO STEPS survey data.
THE LANCET REGIONAL HEALTH. SOUTHEAST ASIA - 01 Oct 2024
The relevance of anthropometric indices in predicting cardiovascular disease (CVD) or CVD risk factors is established across different countries, particularly in the high-income countries. However, past studies severely lacked representation from the south and southeast Asian countries. The main aim of this study was to determine the performance of conventional and new anthropometric indices to...
The role of finerenone in the management of CKD in T2D -Practical considerations for primary care.
PRIMARY CARE DIABETES - 15 Sep 2024
The prevalence of diabetes and chronic kidney disease (CKD) is increasing worldwide. Diabetic kidney disease is a chronic condition characterized by a gradual increase in urinary albumin excretion, blood pressure, cardiovascular risk, and a decline in glomerular filtration rate (GFR) that can progress to end-stage kidney disease (ESKD). Individuals with diabetes should be screened for CKD annua...
A co-design case study of the development of heart failure e-TIPS to support self-management.
JMIR CARDIO - 09 Sep 2024
Heart failure (HF) is a complex syndrome associated with high morbidity and mortality and increased healthcare utilisation. Patient education is key to improving health outcomes, achieved by promoting self-management to optimise medical management. Newer digital tools like text messaging and smartphone applications provide novel patient education approaches. To partner with clinicians and peopl...
3D Sapiotyping: A Three Dimensional Definition.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Sep 2024
Precision medicine and personalized care have been at centre-stage in diabetology, and rightfully so. Various means of classification and clustering have been proposed to help identify clinical features, causative factors and 'curative' strategies for people living with diabetes. Sapiotype describes "the various attitudes that person with diabetes may have towards their disease, their doctor or...
Adherence to Medical Nutrition Therapy: From Barriers to Bridgers.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Sep 2024
Response to Letter to the Editor From Spence: [Prevalence and Characteristics of Low-renin Hypertension in a Primary Care Population].
JOURNAL OF THE ENDOCRINE SOCIETY - 27 Aug 2024
Depletion of the paternal gut microbiome alters sperm small RNAs and impacts offspring physiology and behavior in mice.
BRAIN, BEHAVIOR, AND IMMUNITY - 16 Sep 2024
The paternal environment prior to conception has been demonstrated to influence offspring physiology and behavior, with the sperm epigenome (including noncoding RNAs) proposed as a potential facilitator of non-genetic inheritance. Whilst the maternal gut microbiome has been established as an important influence on offspring development, the impact of the paternal gut microbiota on offspring dev...
