Letter to the Editor: Quader M, Kiernan Z, Labate G, Chen Q. Hypothermic myocardial preservation: the freezing debate. Transplant Proc. 2025;57(4):653-662. Fear of Freezing Fallacy: Storage in Melting Ice Cannot Damage the Donor Heart.

Franklin Rosenfeldt
Abstract
The recent report by Quader et al (Quader M, Kiernan Z, Labate G, et al. Hypothermic myocardial preservation: the freezing debate. Transplant Proc. 2025;57(4):653-662) addresses a critical question in donor heart preservation: does storage at 0 °C cause myocardial injury? Their findings show that hearts stored in melting water ice for 4 hours retain structural and functional integrity, contradicting earlier assumptions about freezing damage. This editorial places their findings in historical context, evaluates prior conflicting evidence, and underscores important implications for clinical practice.
Journal TRANSPLANTATION PROCEEDINGS
ISSN 1873-2623
Published 01 Jul 2025
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Issue
Pages
DOI 10.1016/j.transproceed.2025.06.005
Type Journal Article
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