Letter to the Editor: Quader M, Kiernan Z, Labate G, Chen Q. Hypothermic myocardial preservation: the freezing debate. Transplant Proc. 2025;57(4):653-662. Fear of Freezing Fallacy: Storage in Melting Ice Cannot Damage the Donor Heart.
Franklin Rosenfeldt
Abstract
The recent report by Quader et al (Quader M, Kiernan Z, Labate G, et al. Hypothermic myocardial preservation: the freezing debate. Transplant Proc. 2025;57(4):653-662) addresses a critical question in donor heart preservation: does storage at 0 °C cause myocardial injury? Their findings show that hearts stored in melting water ice for 4 hours retain structural and functional integrity, contradicting earlier assumptions about freezing damage. This editorial places their findings in historical context, evaluates prior conflicting evidence, and underscores important implications for clinical practice.
| Journal | TRANSPLANTATION PROCEEDINGS |
| ISSN | 1873-2623 |
| Published | 01 Jul 2025 |
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| DOI | 10.1016/j.transproceed.2025.06.005 |
| Type | Journal Article |
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