Publications
Now showing items 141-160 of 5325 records
Stereotactic Arrhythmia Radioablation (STAR) for refractory ventricular tachycardia- the initial Australian experience.
HEART RHYTHM - 06 Feb 2025
Stereotactic arrhythmia radioablation (STAR) is a novel, noninvasive technique for the management of refractory ventricular tachycardia (VT). This retrospective study aimed to assess the feasibility, efficacy, and safety of STAR in an Australian cohort. From February 2020 to August 2023, 12 patients with drug-refractory VT who had either failed catheter ablation or were unsuitable, were treated...
A qualitative exploration of the educational needs of people living with heart failure: BANDAIDD-Explore study.
PLOS ONE - 01 Jan 2025
This is an exploratory qualitative study of cardiovascular clinicians, people living with heart failure (HF), and their caregivers. The aim was to understand the unmet educational needs in self-management for adults living with HF. Four focus groups were conducted face-to-face or via videoconference, recorded, and transcribed verbatim for thematic analysis. A total of 23 participants were recru...
Ethnic Differences in Pericoronary Adipose Tissue Attenuation.
JACC. ASIA - 01 Jan 2025
Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants.
BMC MEDICINE - 27 Jan 2025
Mechanisms underlying the association of life-course adiposity with incident hypertension in adulthood have not been comprehensively investigated. In this study, we aimed to investigate the potential biochemical and metabolomic mechanisms underlying the association between adiposity and incident hypertension. A total of 180,527 participants from the UK Biobank aged 37 to 73 years were included....
Digital Home-Based Self-Monitoring System for People with Heart Failure: Protocol for Development of SmartHeart and Evaluation of Feasibility and Acceptability.
28 Jan 2025
Heart failure (HF) is a chronic, progressive condition where the heart cannot pump enough blood to meet the body's needs. In addition to the daily challenges that HF poses, acute exacerbations can lead to costly hospitalizations and increased mortality. High health care costs and the burden of HF have led to the emerging application of new technologies to support people living with HF to stay w...
Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation.
BMC CANCER - 28 Jan 2025
Hematopoietic stem cell transplantation (HSCT) is a common therapy for many hematologic malignancies. While advances in transplant practice have improved cancer-specific outcomes, multiple and debilitating long term physical and psychologic effects remain. Patients undergoing allogeneic bone marrow transplantation (allo-BMT) are often critically ill at initial diagnosis and with necessary seque...
Prevalence of chronic kidney disease in Western Australia, 2010-2020.
BMJ OPEN - 28 Jan 2025
To assess the prevalence and trends of chronic kidney disease (CKD) in Western Australia (WA) from 2010 to 2020 using linked pathology data. A retrospective observational cohort study using linked de-identified data from WA pathology providers, hospital morbidity records and mortality records. A Western Australian population-based study. All individuals aged 18 years and older with at least one...
Integration of Apolipoprotein B into the SCORE2 Framework: Implications for Cardiovascular Risk Prediction.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 29 Jan 2025
To evaluate whether integrating Apolipoprotein B (ApoB) into the SCORE2 cardiovascular risk prediction framework improves its predictive accuracy and clinical applicability within the UK Biobank population. A 10-year prospective cohort study was conducted with 448,303 UK Biobank participants eligible for SCORE2 calculation. Three approaches were employed: (1) threshold analysis to determine the...
Impaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis.
CIRCULATION. HEART FAILURE - 30 Jan 2025
Objective indices of functional capacity in patients with diabetic cardiomyopathy and stage B heart failure (HF) have not been comprehensively defined. We sought to characterize the cardiopulmonary exercise characteristics of individuals with diabetic cardiomyopathy at high risk for overt HF. The relationships from cardiopulmonary exercise testing with clinical and laboratory characteristics of...
Acute and chronic effects of an intervention aiming to reduce prolonged sitting on glucose regulation in individuals with dysglycaemia.
JOURNAL OF SPORTS SCIENCES - 30 Jan 2025
Acute studies have consistently demonstrated small-to-medium glycaemic responses to breaking prolonged sitting, yet it is not known whether acute effects are maintained following a period of intervention or whether behavioural interventions lead to sustained benefits. A single arm, 4-week intervention with pre and post "two-arm" randomised cross-over conditions, study was conducted to investiga...
Heart-derived factors and organ cross-talk in settings of health and disease: new knowledge and clinical opportunities for multimorbidity.
THE JOURNAL OF PHYSIOLOGY - 31 Jan 2025
Cardiovascular disease affects millions of people worldwide and often presents with other conditions including metabolic, renal and neurological disorders. A variety of secreted factors from multiple organs/tissues (proteins, nucleic acids and lipids) have been implicated in facilitating organ cross-talk that may contribute to the development of multimorbidity. Secreted proteins have received t...
Association of Year-to-Year Lipid Variability With Risk of Cognitive Decline and Dementia in Community-Dwelling Older Adults.
NEUROLOGY - 25 Feb 2025
Lipid metabolism in older adults is affected by various factors including biological aging, functional decline, reduced physiologic reserve, and nutrient intake. The dysregulation of lipid metabolism could adversely affect brain health. This study investigated the association between year-to-year intraindividual lipid variability and subsequent risk of cognitive decline and dementia in communit...
Sleep Stewardship.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jan 2025
Sleep stewardship is a systematic effort to ensure relaxed and restorative sleep, by optimizing pre-sleep, intra-sleep and post-sleep environment and ambience, in a rational manner. It includes not only sleep hygiene and prevention of sleeping pill abuse, but also macro- and meso-level interventions to improve sleep quality. The person living with sleep disorder, their family, members of societ...
The Obese Heart.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jan 2025
Analysis of cellular NO-GC expression in the murine heart and lineage determination in angiotensin II-induced fibrosis.
ISCIENCE - 17 Jan 2025
NO-sensitive guanylyl cyclase (NO-GC) is involved in the (patho)physiology of the mammalian heart. However, little is known about the individual cardiac cell types that express NO-GC and the role of the enzyme in cardiac fibrosis. Here, we describe the cellular expression of NO-GC in healthy and fibrotic murine myocardium; these data were compared with scRNA-seq data. In healthy myocardium, NO-...
Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension.
CIRCULATION RESEARCH - 22 Jan 2025
Fermentation of dietary fiber by the gut microbiota leads to the production of metabolites called short-chain fatty acids, which lower blood pressure and exert cardioprotective effects. Short-chain fatty acids activate host signaling responses via the functionally redundant receptors GPR41 and GPR43, which are highly expressed by immune cells. Whether and how these receptors protect against hyp...
Distress and coping mechanisms among people with diabetes: cross-sectional assessment from an NCD screening clinic of a tertiary care hospital in North India.
DIABETOLOGY & METABOLIC SYNDROME - 25 Jan 2025
Of the numerous complications encountered by people with diabetes (PWD), the effect on mental health is concerning. Within mental health, diabetes distress (DD) occurs when a patient has unfavourable emotional stress while managing their condition, which can be managed by coping strategies but are less studied together in Indian settings. So, the present study aimed to determine the proportion ...
The associations between prenatal plastic phthalate exposure and lipid acylcarnitine levels in humans and mice.
REPRODUCTIVE TOXICOLOGY (ELMSFORD, N.Y.) - 10 Jan 2025
Phthalates are ubiquitous environmental pollutants known for their endocrine-disrupting properties, particularly during critical periods such as pregnancy and early childhood. Phthalates alter lipid metabolism, but the role of prenatal exposure on the offspring lipidome is less understood. In particular, we focused on long chain acylcarnitines - intermediates of fatty acid oxidation that serve ...
The role of multi-modality imaging for the assessment of left atrium and left atrial appendage. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC).
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 15 Jan 2025
Structural, architectural, contractile or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodeling has become a cornerstone diagnostic and prognostic marker. The structure and the function of LA and left atrial appendage (LAA) which is an integral part of the LA, are key el...
The Proteomic Landscape of the Coronary Accessible Heart Cell Surfaceome.
PROTEOMICS - 10 Jan 2025
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling and cellular phenotyping in physiological and pathological states. Here, we employed coronary artery perfusion with membrane-impermeant biotin to label and capture the surface-accessible proteome in the neo-native (intact) heart. Using quantitative proteomics, we ...
