Publications
Now showing items 141-160 of 4875 records
Utilization of the EpiMed Coronabank Chemical Collection to identify potential SARS-CoV-2 antivirals: in silico studies targeting the nsp14 ExoN domain and PL<sup>pro</sup> naphthalene binding site.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING - 26 May 2024
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome encodes 29 proteins including four structural, 16 nonstructural (nsps), and nine accessory proteins (https://epimedlab.org/sars-cov-2-proteome/). Many of these proteins contain potential targetable sites for the development of antivirals. Despite the widespread use of vaccinations, the emergence of variants necessitates the...
Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study.
LANCET (LONDON, ENGLAND) - 29 May 2024
Coronary computed tomography angiography (CCTA) is the first line investigation for chest pain, and it is used to guide revascularisation. However, the widespread adoption of CCTA has revealed a large group of individuals without obstructive coronary artery disease (CAD), with unclear prognosis and management. Measurement of coronary inflammation from CCTA using the perivascular fat attenuation...
Iron Macrophages: Dance of Death and MMP Release in Intraplaque Hemorrhage.
THROMBOSIS AND HAEMOSTASIS - 01 Jun 2024
SGLT-2 Inhibitor Use and Cause-Specific Hospitalization Rates: An Outcome-Wide Study to Identify Novel Associations of SGLT-2 Inhibitors.
CLINICAL PHARMACOLOGY AND THERAPEUTICS - 01 Jun 2024
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) have demonstrated multifaceted pharmacological effects. In addition to type 2 diabetes, they are now indicated for heart failure and chronic kidney disease. This study aimed to identify novel associations between SGLT2i use and health outcomes using real-world data. Using linked data from a nationwide diabetes registry in Australia, we compar...
Sex-steroid hormones and risk of postmenopausal estrogen receptor-positive breast cancer: a case-cohort analysis.
01 Jun 2024
Sex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pathways is rarely considered. We estimated risk ratios for sex-steroid hormone biomarkers in relation to postmenopausal estrogen receptor (ER)-positive breast cancer, while accounting for biomarkers from insulin/insulin-like growth factor-signaling and inflammatory pathways. Th...
Strengthening research capacity of early-mid career researchers: Implementation and evaluation of the Excellence in Non-COmmunicable disease REsearch (ENCORE) program.
JOURNAL OF INVESTIGATIVE MEDICINE : THE OFFICIAL PUBLICATION OF THE AMERICAN FEDERATION FOR CLINICAL RESEARCH - 01 Jun 2024
High-quality training and networking are pivotal for enhancing the research capacity of early- to mid-career researchers in the prevention and control of non-communicable diseases. Beyond building research skills, these professionals gain valuable insights from interdisciplinary mentorship, networking opportunities, and exposure to diverse cultures and health systems. Despite the significance o...
Long-Term Blood Pressure Reductions Following Catheter-Based Renal Denervation: A Systematic Review and Meta-Analysis.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2024
Renal denervation is a recognized adjunct therapy for hypertension with clinically significant blood pressure (BP)-lowering effects. Long-term follow-up data are critical to ascertain durability of the effect and safety. Aside from the 36-month follow-up data available from randomized control trials, recent cohort analyses extended follow-up out to 10 years. We sought to analyze study-level dat...
Engineering G protein-coupled receptors for stabilization.
PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY - 01 Jun 2024
G protein-coupled receptors (GPCRs) are one of the most important families of targets for drug discovery. One of the limiting steps in the study of GPCRs has been their stability, with significant and time-consuming protein engineering often used to stabilize GPCRs for structural characterization and drug screening. Unfortunately, computational methods developed using globular soluble proteins ...
Non-additive effects of electrical stimulation of the dorsolateral prefrontal cortex and the vestibular system on muscle sympathetic nerve activity in humans.
EXPERIMENTAL BRAIN RESEARCH - 01 Jun 2024
Sinusoidal galvanic vestibular stimulation (sGVS) induces robust modulation of muscle sympathetic nerve activity (MSNA) alongside perceptions of side-to-side movement, sometimes with an accompanying feeling of nausea. We recently showed that transcranial alternating current stimulation (tACS) of the dorsolateral prefrontal cortex (dlPFC) also modulates MSNA, but does not generate any perception...
People who need insulin are particularly vulnerable in disasters and conflicts.
BMJ (CLINICAL RESEARCH ED.) - 17 May 2024
Upholding international humanitarian law and ending the weaponisation of aid and medical supplies is critical to protecting the health of people with diabetes during disasters and conflicts, say Alicia J Jenkins and colleagues
Immunometabolism in atherosclerotic disorders
NATURE CARDIOVASCULAR RESEARCH - 23 May 2024
Cardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction and heart failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence suggests a crucial role for immune cell dysfunction and inflammation in the progression of this complex set of diseases. Recent advances demonstrate that immune cells, tightly linked to CVD pathogenesis, are sensitive ...
Mechanobiology. Proceedings of the 4th International Symposium on Mechanobiology. 6th - 9th November 2022. Sydney, Australia.
SPRINGER SERIES IN BIOPHYSICS - 01 Mar 2024
The 4th International Symposium on Mechanobiology (ISMB) organized by the Australian Society for Mechanobiology (AuSMB) took place at the Sydney Nanoscience Hub at the University of Sydney, Australia, from the 6th to the 9th of November 2022. This conference started in 2011 with the founding of the Society in Shanghai, China, and has occurred every three years also visiting Okayama (2014) and m...
Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression.
MOLECULAR THERAPY. NUCLEIC ACIDS - 11 Jun 2024
Epigenetic processes involving long non-coding RNAs regulate endothelial gene expression. However, the underlying regulatory mechanisms causing endothelial dysfunction remain to be elucidated. Enhancer of zeste homolog 2 (EZH2) is an important rheostat of histone H3K27 trimethylation (H3K27me3) that represses endothelial targets, but EZH2 RNA binding capacity and EZH2:RNA functional interaction...
Impact of conjugation to different lipids on the lymphatic uptake and biodistribution of brush PEG polymers.
JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY - 01 May 2024
Delivery to peripheral lymphatics can be achieved following interstitial administration of nano-sized delivery systems (nanoparticles, liposomes, dendrimers etc) or molecules that hitchhike on endogenous nano-sized carriers (such as albumin). The published work concerning the hitchhiking approach has mostly focussed on the lymphatic uptake of vaccines conjugated directly to albumin binding moie...
Communication in Chronic Disease Care: A Collaborative Conversation Map.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 May 2024
Chronic diseases require long term commitment from both the patient and the treating physician for improving their clinical outcomes. This journey can be made more easier if a proper communication bridge can be made between both of them. This paper describes an alliterative C-based flow-chart to describe a Collaborative Conversation Map for chronic disease care. It crafts a map which serves as ...
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
DEVELOPMENTAL CELL - 20 May 2024
The transcription factor EHF is highly expressed in the lactating mammary gland, but its role in mammary development and tumorigenesis is not fully understood. Utilizing a mouse model of Ehf deletion, herein, we demonstrate that loss of Ehf impairs mammary lobuloalveolar differentiation at late pregnancy, indicated by significantly reduced levels of milk genes and milk lipids, fewer differentia...
Pilot implementation and evaluation of the Sit-Stand <i>e</i>-Guide: an <i>e</i>-training program on the use of sit-stand workstations.
ERGONOMICS - 22 May 2024
The 'Sit-Stand <i>e</i>-Guide' <i>e</i>-training program, designed to promote appropriate use of sit-stand workstations (SSWs), was evaluated for usability, acceptability and impact on various outcomes among SSW users. Participants from a large municipal organisation (25% male; mean age 45 [SD = 10.6] years) completed questionnaires pre-training (T0, <i>n</i> = 57), immediately post-training (T...
Intention-behaviour gap in physical activity: unravelling the critical role of the automatic tendency towards effort minimisation.
BRITISH JOURNAL OF SPORTS MEDICINE - 22 May 2024
Ten-Year Risk Equations for Incident Heart Failure in Established Atherosclerotic Cardiovascular Disease Populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 23 May 2024
Ten-year risk equations for incident heart failure (HF) are available for the general population, but not for patients with established atherosclerotic cardiovascular disease (ASCVD), which is highly prevalent in HF cohorts. This study aimed to develop and validate 10-year risk equations for incident HF in patients with known ASCVD. Ten-year risk equations for incident HF were developed using t...
International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 23 May 2024
Studies reporting on the incidence of sudden cardiac arrest and/or death (SCA/D) in athletes commonly lack methodological and reporting rigor, which has implications for screening and preventative policy in sport. To date, there are no tools designed for assessing study quality in studies investigating the incidence of SCA/D in athletes. The International Criteria for Reporting Study Quality fo...
