Publications
Now showing items 141-160 of 4599 records
Vascular Aging Is Accelerated in Hematological Cancer Survivors Who Undergo Allogeneic Stem Cell Transplant.
HYPERTENSION (DALLAS, TEX. : 1979) - 21 Jul 2023
Survivors of allogeneic stem cell transplant (SCT) receive intensive cancer treatments that are associated with cardiovascular dysfunction. Markers of vascular age can indicate early signs of adverse (cardio)vascular changes; however, the impact of SCT on these makers is unknown. We aimed to determine the short (3 months) and longer-term (≥2 years) effect of SCT on markers of vascular age in he...
Temporal Change in the Remaining Life Expectancy in People Who Underwent Percutaneous Coronary Intervention.
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Jan 2023
Whether percutaneous coronary intervention (PCI) is effective in improving long-term survival in an Australian PCI cohort remains unclear. We aimed to examine the change in the remaining life expectancy for patients who underwent PCI over the past decade. Patient data from the Melbourne Interventional Group were divided into four 3-year periods (2005 to 2007, 2008 to 2010, 2011 to 2013, and 201...
Too Little of a Good Thing: Strong Associations Between Cardiac Size and Fitness Among Women.
JACC. CARDIOVASCULAR IMAGING - 05 Jan 2023
Cardiorespiratory fitness (CRF) is associated with functional impairment and cardiac events, particularly heart failure (HF). However, the factors predisposing women to low CRF and HF remain unclear.This study sought to evaluate the association between CRF and measures of ventricular size and function and to examine the potential mechanism linking these factors.A total of 185 healthy women aged...
Implementation and engagement of the SMART Work & Life sitting reduction intervention: an exploratory analysis on intervention effectiveness.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 19 Dec 2023
To enhance the impact of interventions, it is important to understand how intervention engagement relates to study outcomes. We report on the level of implementation and engagement with the SMART Work & Life (SWAL) programme (delivered with (SWAL plus desk) and without a height-adjustable desk (SWAL)) and explore the effects of different levels of this on change in daily sitting time in compari...
Professional care workforce: a rapid review of evidence supporting methods of recruitment, retention, safety, and education.
HUMAN RESOURCES FOR HEALTH - 13 Dec 2023
Across the care economy there are major shortages in the health and care workforce, as well as high rates of attrition and ill-defined career pathways. The aim of this study was to evaluate current evidence regarding methods to improve care worker recruitment, retention, safety, and education, for the professional care workforce.A rapid review of comparative interventions designed to recruit, r...
Reallocating desk workers' sitting time to standing or stepping: associations with work performance.
OCCUPATIONAL MEDICINE (OXFORD, ENGLAND) - 16 Dec 2023
Studies have suggested that sitting time at work may lead to underperformance but they may underestimate the benefits to desk workers' performance of reducing occupational sitting time without considering the relative effects of the specific activities replaced.To estimate differences in work performance (presenteeism, absenteeism and engagement) when occupational sitting time is reallocated to...
Participant and workplace champion experiences of an intervention designed to reduce sitting time in desk-based workers: SMART work & life.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 30 Nov 2023
A cluster randomised controlled trial demonstrated the effectiveness of the SMART Work & Life (SWAL) behaviour change intervention, with and without a height-adjustable desk, for reducing sitting time in desk-based workers. Staff within organisations volunteered to be trained to facilitate delivery of the SWAL intervention and act as workplace champions. This paper presents the experiences of t...
Environmental Impacts of Machine Learning Applications in Protein Science.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY - 01 Dec 2023
Computing tools and machine learning models play an increasingly important role in biology and are now an essential part of discoveries in protein science. The growing energy needs of modern algorithms have raised concerns in the computational science community in light of the climate emergency. In this work, we summarize the different ways in which protein science can negatively impact the env...
Effects of Different Thawing and Warming Processes on Human Milk Composition.
01 Dec 2023
The composition of human milk is influenced by storage and processing practices. The effects of thawing and warming practices on human milk composition remain poorly studied despite their prevalence in home, research, and donor milk bank settings. This review comprehensively examines the impact of different thawing and warming methods on nutritional and bioactive human milk components. While so...
Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes.
PHYSIOLOGICAL REPORTS - 01 Dec 2023
Long ncRNAs (lncRNAs) have been shown to play a biological and physiological role in various tissues including the heart. We and others have previously established that the lncRNA Oip5os1 (1700020I14Rik, OIP5-AS1, Cyrano) is enriched in striated muscles, and its deletion in mice leads to defects in both skeletal and cardiac muscle function. In the present study, we investigated the impact of gl...
Reply: Heart Failure With Atrial Fibrillation: Who Will Benefit the Most From Atrial Fibrillation Ablation?
JACC. HEART FAILURE - 01 Dec 2023
Decoding the role of platelets in tumour metastasis: enigmatic accomplices and intricate targets for anticancer treatments.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2023
The canonical role of platelets as central players in cardiovascular disease by way of their fundamental role in mediating thrombosis and haemostasis is well appreciated. However, there is now a large body of experimental evidence demonstrating that platelets are also pivotal in various physiological and pathophysiological processes other than maintaining haemostasis. Foremost amongst these is ...
Sympathetic vascular transduction and baroreflex sensitivity in the context of severe COPD.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 03 Dec 2023
Blood Pressure at Different Life Stages Over the Early Life Course and Intima-Media Thickness.
JAMA PEDIATRICS - 04 Dec 2023
Although cardiovascular disease (CVD) begins in early life, the extent to which blood pressure (BP) at different life stages contributes to CVD is unclear.To determine the relative contribution of BP at different life stages across the early-life course from infancy to young adulthood with carotid intima-media thickness (IMT).The analyses were performed in 2022 using data gathered from July 198...
Optimising the implementation of digital-supported interventions for the secondary prevention of heart disease: a systematic review using the RE-AIM planning and evaluation framework.
BMC HEALTH SERVICES RESEARCH - 04 Dec 2023
mHealth technologies are now widely utilised to support the delivery of secondary prevention programs in heart disease. Interventions with mHealth included have shown a similar efficacy and safety to conventional programs with improvements in access and adherence. However, questions remain regarding the successful wider implementation of digital-supported programs. By applying the Reach-Effecti...
Lessons learnt in the first year of an Australian pediatric cardio oncology clinic.
CARDIO-ONCOLOGY (LONDON, ENGLAND) - 07 Dec 2023
Modern oncological therapies together with chemotherapy and radiotherapy have broadened the agents that can cause cardiac sequelae, which can manifest for pediatric oncology patients while on active treatment. Recommendations for high-risk patients who should be monitored in a pediatric cardio-oncology clinic have previously been developed by expert Delphi consensus by our group. In 2022 we ope...
Bioengineered Vascular Model of Foam Cell Formation.
ACS BIOMATERIALS SCIENCE & ENGINEERING - 11 Dec 2023
Foam cell formation is a complex blood vessel pathology, which is characterized by a series of events, including endothelium dysfunction, inflammation, and accumulation of immune cells underneath the blood vessel walls. Novel bioengineered models capable of recapitulating these events are required to better understand the complex pathological processes underlying the development of foam cell fo...
Multi-organ denervation: a novel approach to combat cardiometabolic disease.
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 01 Jul 2023
Cardiometabolic disorders are associated with a substantial loss in quality of life and pose a large burden on healthcare systems worldwide. Overactivation of the sympathetic nervous system has been shown to be a key player in several aspects relating to cardiometabolic disturbances. While diet- and exercise-induced approaches to help reduce weight remains the main strategy to combat metabolic ...
A high-salt diet promotes atherosclerosis by altering haematopoiesis.
NATURE REVIEWS. CARDIOLOGY - 01 Jul 2023
Activated Coagulation FXII: A Unique Target for In Vivo Molecular Imaging.
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Jun 2023
Current clinical imaging of thromboembolic diseases often relies on indirect detection of thrombi, which may delay diagnosis and ultimately the institution of beneficial, potentially lifesaving treatment. Therefore, the development of targeting tools that facilitate the rapid, specific, and direct imaging of thrombi using molecular imaging is highly sought after. One potential molecular target ...