Publications
Now showing items 141-160 of 5582 records
Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification.
ALZHEIMER'S & DEMENTIA : THE JOURNAL OF THE ALZHEIMER'S ASSOCIATION - 01 Mar 2025
An integrative polygenic risk score (iPRS) capturing the neurodegenerative and vascular contribution to dementia could identify high-risk individuals and improve risk prediction. We developed an iPRS for dementia (iPRS-DEM) in Europeans (aged 65+), comprising genetic risk for Alzheimer's disease (AD) and 23 vascular or neurodegenerative traits (excluding apolipoprotein E [APOE]). iPRS-DEM was e...
Renal Denervation-"Gizmo Idolatry" Fact Checker.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 01 Mar 2025
Motivational Therapeutics and Medicine.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Mar 2025
Adrenal Asthenia.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Mar 2025
The terms 'adrenal asthenia', 'adrenal fatigue' and 'adrenal burnout', sometimes used in lay language, are not a part of the medical or endocrine lexicon. In this opinion piece, we explore the relevance of adrenal asthenia and describe how it can be used in different clinical situations, with varying connotations. Adrenal asthenia may refer to adrenocortical insufficiency, increased parasympath...
The 6M Classification of Nutrients.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Mar 2025
Nutrition is a complex and sometimes confusing subject. The existing classification of nutrients into two groups, macro and micronutrients, does not do justice to the wide spectrum of nutritional foods available. In this opinion piece, we suggest a six-layered 6M hierarchal classification of nutrients that offers a comprehensive and complete understanding of nutrition. Mega, macro, meso, micro,...
Analysing Obesity Epidemicity and Endemicity: Introducing New Quantitative Indices.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Mar 2025
As obesity becomes more and more common, it will get (or may already have) converted from an epidemic to an endemic. This opinion piece discusses these epidemiological definitions in the context of obesity and proposes three obesity epidemicity indices to quantify their indices. It discusses the rationale behind using such ratios to measure endemicity. The discussion notes how the different rat...
Balanodynia.
INDIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM - 01 Jan 2025
Prediabetes Knowledge, Attitudes, Practices, and Risk Levels in the United Arab Emirates: A Cross-Sectional Study.
CUREUS - 01 Apr 2025
Background and aims Prediabetes is a reversible state of mild hyperglycemia that significantly increases the risk of developing type 2 diabetes mellitus (T2DM). This study aimed to assess knowledge, attitudes, and practices (KAP), risk levels, and associated factors related to prediabetes among adults in the United Arab Emirates (UAE). Methods This cross-sectional study was conducted between Fe...
Atrial Fibrillation in the Young: Pathogenesis and Clinical Implications.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 May 2025
Atrial fibrillation (AF) in the young is unique, with a distinct set of pathophysiologic factors that influence disease onset, response to treatment, and prognosis. AF in the young remains relatively uncommon, and a detailed clinical assessment is crucial to ensuring optimal outcomes. Where relevant, genetic assessment is an important element of management. Catheter ablation remains effective f...
Familial clustering of diabetic kidney disease and retinopathy in offspring of parents with type 1 diabetes: a population-based study.
ECLINICALMEDICINE - 01 May 2025
Familial clustering of diabetic kidney disease and diabetic retinopathy has been reported among siblings with type 1 diabetes. We aimed to further unveil the phenomenon among parent-offspring pairs. Among all individuals diagnosed with type 1 diabetes between 1965 and 1979 in Finland (n = 5144) with at least one child with the same disease and a diabetes duration of 15 years or more, we compile...
Obesity: Obvious Obstacle; Oblivious To Opportunity.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jun 2025
Gonadal guardianship-ergonomic endocrinology.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jun 2025
Reproductive and sexual health is not only an important aspect of human health; it is essential for propagation of the human race. It is imperative, therefore, to focus on prevention of illness as well as promotion of reproductive and sexual health. We term this approach as gonadal guardianship.
The 5C model: Clinical approach to peripheral neuropathy.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jun 2025
Peripheral neuropathy is a common condition which is often missed in primary care. The 5C model simplifies the clinical approach to peripheral neuropathy, listing steps of history taking, physical examination and investigations. One begins by eliciting complaints and concerns, and "classifying by the calendar". Comorbid and contributory diseases, concomitant medications and contacted toxins, ar...
The 4BE quinqunx: A model for obesity pathogenesis.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jun 2025
For obesity management to be effective, one must appreciate its causes and consequences. To do so, the seemingly complex science of obesity must be made simpler. A model which helps us explain its causes, contributory factors, as well as potential corrective measures, is needed. We share the 4BE winged quincunx model of obesity etiopathogenesis. Four central players - the Brain, Bowel, Beta/alp...
Obestasis.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jun 2025
Obestasis, a commonly experienced phenomenon, is the term given to the mild, pitting oedema that is associated with obesity. Obestasis can be due to various disorders, including lymphatic, microcirculatory and venous dysfunction, as well as sarcopenia. It can be worsened by protein deficiency, excessive salt intake, poor physical conditioning, and tight clothing or foot wear. Obestasis can also...
Effects of a digitally enabled cardiac rehabilitation intervention on risk factors, recurrent hospitalization and mortality.
EUROPEAN HEART JOURNAL. DIGITAL HEALTH - 01 Jul 2025
Cardiac rehabilitation (CR) programmes are effective, but they are underutilized. Digitally enabled CR programmes (DeCR) offer alternative means of healthcare delivery. We aimed to assess the effects of a DeCR programme on cardiovascular risk factors and healthcare utilization. In this observational cohort study that used propensity score matching, privately insured Australian patients, recruit...
The Peptide Paradox in Pharmacology of Obesity.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jul 2025
Peptide biology is a fascinating subject, and peptide pharmacology even more so. Peptides have multiple bodily functions, including their work as hormones and metabolic modulators. However, certain pharmacodynamic and kinetic properties of peptides used in obesity result in paradoxical outcomes. It is helpful for the treating clinician to be aware of these peptide paradoxes, which not only help...
Preventive Metabolic Medicine in Primary Care.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jul 2025
The responsibility, and right, of promoting metabolic health, and preventing metabolic disease, is that of the primary care physician. This communication lists the facets of metabolic care in a simple (Seven Rs) manner, connecting them with the various levels of prevention. All individuals should be counselled about regulation of lifestyle and mindstyle (primordial prevention). Those at risk of...
Coping with the Stress of Obesity.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jul 2025
Coping with chronic disease, such as obesity, is central to effective management. Coping skills enhancement, therefore, should be made part of obesity therapy. The AEIOU model, coupled with the five Bad Bs and five Positive Ps, allows health care professionals to integrate coping skills enhancement in routine care. Analysis and elimination of negative coping mechanisms, initiation and integrati...
Renal Barocrinology: The Interface between Obesity and Kidney Health.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jul 2025
Obesity is been acknowledged to be a major risk factor for chronic kidney disease (CKD), contributing to both its onset and progression. Over past few decades, the obesity epidemic has lead to an increased incidence of obesityrelated nephropathy, characterised by glomerular hyperfiltration, hypertrophy, and progressive glomerulosclerosis. This review highlights the need for multidisciplinary ac...
