Publications
Now showing items 141-160 of 5702 records
Risk Prediction in Cardio-Oncology: Conceptual and Methodological Considerations: JACC: CardioOncology State-of-the-Art Review.
JACC. CARDIOONCOLOGY - 01 Apr 2026
Risk prediction models can guide prevention, monitoring, and treatment decisions in cardio-oncology, but their development requires careful attention to methodological challenges unique to cardiovascular disease arising in the context of cancer. In this state-of-the-art review, the authors use case scenarios to illustrate how prediction objectives, index dates, and time horizons must align with...
Spatio-temporal targeting of cardiac cells with lipid nanoparticles after myocardial infarction.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY PLUS - 01 Jun 2026
Ischemic heart disease remains the leading cause of morbidity and mortality worldwide. While current therapies prolong survival, they do not address underlying tissue damage. Messenger RNA (mRNA)-based therapies offer a promising alternative for repair and regeneration. However, targeted and effective delivery to the injured heart remains challenging. Lipid nanoparticles (LNPs) have emerged as ...
Artificial intelligence-powered virtual standardized patients in teaching history-taking skills to medical students: a randomized controlled trial.
BMC MEDICAL EDUCATION - 30 Apr 2026
Correction: Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2026
[This corrects the article DOI: 10.3389/fphar.2026.1756039.].
Prothrombotic genetic variants and cancer-associated venous thromboembolism: defining thrombotic risk across tumor types.
HAEMATOLOGICA - 07 May 2026
Cancer-associated venous thromboembolism (CAT) is a major cause of mortality in cancer patients. Prothrombotic genetic variants increase venous thromboembolism risk in the general population, but contribution to CAT remains unclear, particularly within different tumor types. We sought to determine whether the presence of thrombophilic variants influence relative and absolute CAT risk, and may b...
LIPID MAPS: Powering discovery in lipidomics.
SCIENCE SIGNALING - 05 May 2026
As lipidomics approaches its 25th anniversary, we explore how lipid research has matured over the years while highlighting emerging innovations that are expanding our ability to study these diverse, life-critical biomolecules. In particular, we showcase the community-driven, open-access databases, software, and educational resources made freely available through the ELIXIR Core Data Resource LI...
Unlocking the potential of light-intensity physical activity for public health: a call to action for research.
BRITISH JOURNAL OF SPORTS MEDICINE - 04 May 2026
User design and testing of SmartHeart: A mobile app for heart failure self-care.
DIGITAL HEALTH - 01 Jan 2026
Heart failure requires complex and daily self-care that many patients struggle with for a range of reasons including limited health literacy, cognitive impairment, comorbidities, and emotional distress. This study describes the user-centred design and development of a mobile app (SmartHeart) to support comprehensive self-monitoring and improve self-care engagement for people with heart failure....
Insights into the heterogeneous muscle lipidome of dysferlin-deficient mice: effects of age, muscle type, and sex.
SKELETAL MUSCLE - 22 May 2026
Dysferlinopathy is an age-dependent muscular dystrophy caused by loss of the membrane-associated protein dysferlin. Disease severity increases with age and selectively affects specific muscle groups, yet the molecular basis for this vulnerability remains unclear. Since lipid remodeling is a hallmark of dysferlinopathy and aging, we investigated how age, sex, and muscle fiber type interact to sh...
Exploring sedentary behaviour reduction interventions in the primary healthcare setting: a scoping review.
BMC PRIMARY CARE - 21 May 2026
Excessive sitting time is a risk factor for many non-communicable diseases and an increased risk of early mortality. Primary healthcare is a viable setting to target population health behaviour change. This scoping review investigated the scope, implementation, and effectiveness of interventions targeting sedentary behaviour outcomes in adults within primary healthcare settings. Four databases ...
Assessing the efficacy, safety and utility of fully closed-loop insulin delivery compared to standard insulin therapy with a continuous glucose monitor in adults with type 2 diabetes (COYOTE study): a randomised parallel study protocol.
BMJ OPEN - 19 May 2026
Type 2 diabetes (T2D) presents a global healthcare burden. Despite widespread use of non-insulin glucose lowering therapies, many individuals still require insulin to achieve recommended target glycated haemoglobin (HbA1c). Insulin injections improve HbA1c but can lead to problematic hypoglycaemia. The objective of this study is to determine whether fully closed-loop insulin delivery improves H...
EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: A translational epigenetic approach.
SCIENCE ADVANCES - 29 May 2026
Atherosclerosis drives cardiovascular morbidity in diabetes, with endothelial-to-mesenchymal transition (EndMT) as a key contributor. Whereas epigenetic regulators are increasingly implicated in atherosclerotic progression, the specific role of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, in EndMT in diabetes-associated atherosclerosis remains unclear. We show that EZH2-medi...
The readiness of primary healthcare facilities to address non-communicable diseases in rural Bangladesh.
BMC HEALTH SERVICES RESEARCH - 28 May 2026
Strengthening the capacity of primary healthcare (PHC) systems is essential to address the rising burden of non-communicable diseases (NCD) in Bangladesh. The study assessed the readiness of rural PHC facilities in addressing the five World Health Organization (WHO) priority NCDs: diabetes, cardiovascular diseases, chronic respiratory diseases, cervical cancer, and mental health disorders. Betw...
A lipidomics roadmap: from basic research to societal challenges.
NATURE COMMUNICATIONS - 28 May 2026
Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems. Driven by advances in mass spectrometry, chromatography and computational analysis, lipidomics has enabled the high-resolution mapping of lipid networks and their functional dynamics across molecular, cellular and orga...
Higher HbA1c Following Younger Age of Transfer From Pediatric to Adult Type 1 Diabetes Services: Data From the Australasian Diabetes Data Network (ADDN) Registry.
DIABETES CARE - 28 May 2026
To determine outcomes from early versus later age of transfer from pediatric to adult type 1 diabetes (T1D) services, and factors associated with adult service HbA1c. We used a longitudinal design from the Australasian Diabetes Data Network (ADDN) registry. Transferred youth (2013-2022) were compared by age group at last pediatric visit (<18 vs. ≥18 years). Multivariable generalized estimated e...
Beyond Reperfusion: Early Molecular Drivers and Therapeutic Opportunities in Acute Post-Infarction Cardiac Fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 15 May 2026
Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this approach fails to prevent the molecular cascades that drive the death of viable yet stressed cardiomyocytes within the infarct and peri-infarct zone. Effective anti...
Asia at the Epicenter of the Global Cardiometabolic Shift.
JACC. ASIA - 01 Mar 2026
Cardiometabolic disease has become the dominant noncommunicable health challenge of the 21st century, with its burden increasingly centered in Asia. Rising obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia now account for more than one-third of cardiovascular mortality. This escalation reflects the interaction of biological susceptibility with rapid urbanization, digitalized foo...
S100A8/A9 inhibition reduces splenic myelopoiesis and improves outcomes after stroke.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2026
Neutrophils are among the earliest immune cells to infiltrate the ischemic brain and contribute to secondary neuronal damage. The alarmin S100 calcium-binding protein A8/A9 (S100A8/A9), predominantly released by neutrophils, is upregulated during this process. Although the bone marrow is recognized as the principal site of neutrophil production via myelopoiesis, the role of the spleen as an imm...
Improving the quality of child and youth mental health care through an implementation science lens.
FRONTIERS IN HEALTH SERVICES - 01 Jan 2026
Mental disorders in children and youth are on the rise worldwide, affecting approximately one in five young people in Europe. The negative educational, social and economic consequences of mental health problems underline the urgent need for accessible, high-quality mental health services. In response, the WHO Regional Office for Europe has developed Quality Standards for Child and Youth Mental ...
Drivers of Atherosclerotic Cardiovascular Disease in South Asians: Current Insights and Future Directions.
JACC. ASIA - 01 Dec 2025
Atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality, with South Asians experiencing a disproportionately high burden. This excess risk is not fully explained by conventional risk factors, highlighting the need for a more nuanced understanding. However, progress has been hindered by a paucity of South Asian-specific research, limited validation studies, and ...
