The 4BE quinqunx: A model for obesity pathogenesis.

Sanjay Kalra; Madhur Verma; Nitin Kapoor
Abstract
For obesity management to be effective, one must appreciate its causes and consequences. To do so, the seemingly complex science of obesity must be made simpler. A model which helps us explain its causes, contributory factors, as well as potential corrective measures, is needed. We share the 4BE winged quincunx model of obesity etiopathogenesis. Four central players - the Brain, Bowel, Beta/alpha cell and Bulk (adipose tissue)- form a causative quadruple, with four wings- Environmental determinants, Endocrine factors, Enteric microbiome and Extraneous limitations. The centre of the quincunx is occupied, in a stylish manner, by the ABC of weight management: Attitude, Behaviour and Choices. The 4BE concept makes it easy for health care professionals to understand, and explain, obesity.
Journal JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
ISSN 0030-9982
Published 01 Jun 2025
Volume 75
Issue 6
Pages 1002-1003
DOI 10.47391/JPMA.25-46
Type Journal Article | Review
Sponsorship