Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 4580 records
Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk.
NATURE GENETICS - 01 Nov 2023
The analysis of longitudinal data from electronic health records (EHRs) has the potential to improve clinical diagnoses and enable personalized medicine, motivating efforts to identify disease subtypes from patient comorbidity information. Here we introduce an age-dependent topic modeling (ATM) method that provides a low-rank representation of longitudinal records of hundreds of distinct diseas...
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 26 Sep 2023
Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary atherosclerosis despite no SMuRFs. SMuRFless patients presenting with myocardial infarction have been observed to have an unexpected higher early mortality compa...
Prevalence of illicit drug use in young patients with sudden cardiac death.
HEART RHYTHM - 01 Oct 2023
Illicit drug use may accelerate coronary disease and cardiac hypertrophy or stimulate arrhythmias. Rates of illicit drug use in young patients with sudden cardiac death (SCD) are uncertain.The purpose of this study was to identify rates of illicit drug use in young patients with SCD.A prospective statewide registry identified out-of-hospital patients with cardiac arrest aged 18-50 years from Ap...
New-onset atrial fibrillation prediction: the HARMS2-AF risk score.
EUROPEAN HEART JOURNAL - 21 Sep 2023
Lifestyle risk factors are a modifiable target in atrial fibrillation (AF) management. The relative contribution of individual lifestyle risk factors to AF development has not been described. Development and validation of an AF lifestyle risk score to identify individuals at risk of AF in the general population are the aims of the study.The UK Biobank (UKB) and Framingham Heart Study (FHS) are ...
Circulating epigenomic biomarkers correspond with kidney disease susceptibility in high-risk populations with type 2 diabetes mellitus.
DIABETES RESEARCH AND CLINICAL PRACTICE - 24 Sep 2023
To investigate epigenomic indices of diabetic kidney disease (DKD) susceptibility among high-risk populations with type 2 diabetes mellitus.KDIGO (Kidney Disease: Improving Global Outcomes) clinical guidelines were used to classify people living with or without DKD. Differential gene methylation of DKD was then assessed in a discovery Aboriginal Diabetes Study cohort (PROPHECY, 89 people) and a...
Phenotyping heart failure by genetics and associated conditions.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 26 Sep 2023
Heart failure is a highly heterogeneous disease, and genetic testing may allow phenotypic distinctions that are incremental to those obtainable from imaging. Advances in genetic testing have allowed for the identification of deleterious variants in patients with specific heart failure phenotypes (dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and hypertrophic cardiomyo...
Multidisciplinary team discussion: the emerging gold standard for management of cardiopulmonary complications of connective tissue disease.
INTERNAL MEDICINE JOURNAL - 29 Sep 2023
Cardiopulmonary complications of connective tissue diseases (CTDs), particularly pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD), are major determinants of morbidity and mortality. Multidisciplinary meetings may improve diagnostic accuracy and optimise treatment. We review the literature regarding multidisciplinary meetings in CTD-ILD and PAH and describe our tertiary ...
Physiology of sedentary behavior.
PHYSIOLOGICAL REVIEWS - 01 Oct 2023
Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or reclining posture. Evidence relevant to understanding the physiology of SB can be derived from studies employing several experimental models: bed rest, immobilization, reduced step count, and reducing/interrupting prolonged SB. We examine the relevant physiological evidence relating to body weight and ene...
Cost-effectiveness of screening for primary aldosteronism in hypertensive patients in Australia: a Markov modelling analysis.
JOURNAL OF HYPERTENSION - 01 Oct 2023
Primary aldosteronism affects 3-14% of hypertensive patients in the primary care setting and up to 30% in the hypertensive referral units. Although primary aldosteronism screening is recommended in patients with treatment-resistant hypertension, diagnosis at an earlier stage of disease may prevent end-organ damage and optimize patient outcomes.A Markov model was used to estimate the cost-effect...
Influence of exercise training on the left atrium: implications for atrial fibrillation, heart failure, and stroke.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Oct 2023
The left atrium (LA) plays a critical role in receiving pulmonary venous return and modulating left ventricular (LV) filling. With the onset of exercise, LA function contributes to the augmentation in stroke volume. Due to the growing focus on atrial imaging, there is now evidence that structural remodeling and dysfunction of the LA is associated with adverse outcomes including incident cardiov...
Effect of Concomitant Cardiac Arrest on Outcomes in Patients With Acute Coronary Syndrome-Related Cardiogenic Shock.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Oct 2023
Patients with acute coronary syndrome (ACS)-related cardiogenic shock (CS) with or without concomitant CA may have disparate prognoses. We compared clinical characteristics and outcomes of patients with CS secondary to ACS with and without cardiac arrest (CA). Between 2014 and 2020, 1,573 patients with ACS-related CS with or without CA who underwent percutaneous coronary intervention enrolled i...
Left Ventricular End-Diastolic Pressure for the Prediction of Contrast-Induced Nephropathy and Clinical Outcomes in Patients With ST-Elevation Myocardial Infarction Who Underwent Primary Percutaneous Intervention (the ELEVATE Study).
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Sep 2023
Contrast-induced nephropathy (CIN) is an important complication of percutaneous coronary intervention (PCI). We investigated whether left ventricular end-diastolic pressure (LVEDP) in patients who underwent PCI might be additive to current risk stratification of CIN. Data from consecutive patients who underwent primary PCI for ST-elevation myocardial infarction between 2013 and 2018 at Western ...
A Digital Application to Assist With Device Selection in Patients Who Undergo Transcatheter Aortic Valve Implantation.
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Sep 2023
Recent studies of lyotropic lipidic cubic phases
ANNUAL REPORTS ON NMR SPECTROSCOPY - 20 Oct 2023
Lyotropic lipidic cubic phases (LCPs), a subgroup of liquid-crystalline mesophases, are formed spontaneously via the self-assembly of certain lipids in an aqueous environment within a defined range of temperature. Nowadays, LCPs are deeply rooted in the crystallization of integral membrane proteins for their structural characterization by X-ray crystallography. Moreover, these nanomaterials are...
Recurrent Palpitations In A Masters Cyclist Post Cardiac Arrest And AICD Implantation
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 01 Sep 2023
HISTORY: A 50-year-old male suffered a cardiac arrest after an endurance cycling event. After prompt cardiopulmonary resuscitation and electrical cardioversion, coronary angiography demonstrated severe intermediate vessel stenosis treated with percutaneous coronary intervention. Echocardiography showed mildly reduced Left Ventricular (LV) systolic function and wall motion abnormalities discorda...
Impaired Oxygen Uptake Recovery Is Associated With Disease Severity In Systemic Sclerosis.
MED SCI SPORTS EXERC - 01 Sep 2023
Systemic sclerosis (SSc) is a multisystem autoimmune disease with near-universal cardiopulmonary involvement. Delayed VO2 recovery measured by cardiopulmonary exercise testing (CPET) is a biomarker of disease severity in heart failure but has not been investigated in SSc.
Neurovascular coupling and cerebrovascular hemodynamics are modified by exercise training status at different stages of maturation during youth.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Sep 2023
Neurovascular coupling (NVC) is mediated via nitric oxide signaling, which is independently influenced by sex hormones and exercise training. Whether exercise training differentially modifies NVC pre- versus postpuberty, where levels of circulating sex hormones will differ greatly within and between sexes, remains to be determined. Therefore, we investigated the influence of exercise training s...
Aortic stiffness contributes to greater pressor responses during static hand grip exercise in healthy young and middle-aged normotensive men.
AUTONOMIC NEUROSCIENCE : BASIC & CLINICAL - 01 Sep 2023
Central arterial stiffness can influence exercise blood pressure (BP) by increasing the rise in arterial pressure per unit increase in aortic inflow. Whether central arterial stiffness influences the pressor response to isometric handgrip exercise (HG) and post-exercise muscle ischemia (PEMI), two common laboratory tests to study sympathetic control of BP, is unknown. We studied 46 healthy non-...
The impact of age on ablation outcomes in AF-mediated cardiomyopathy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 11 Sep 2023
The absence of ventricular scar in patients with atrial fibrillation (AF) and systolic heart failure (HF) predicts left ventricular (LV) recovery following AF ablation. It is unknown whether age impacts the degree of LV recovery, reverse remodeling, or AF recurrence following catheter ablation (CA) among this population.To evaluate the impact of age on LV recovery and AF recurrence in a populat...
Rapid generation of functional nanovesicles from human trophectodermal cells for embryo attachment and outgrowth.
PROTEOMICS - 12 Sep 2023
Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth critical for successful implantation. While EVs have garnered immense interest in their therapeutic potential in assisted reproductive technology by improving implantation success, their large-scale generation remains a major challenge. Here, we report a rapid and scalable production of nanovesicles (NVs) di...
