Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 5027 records
Lipidomic Risk Score to Enhance Cardiovascular Risk Stratification for Primary Prevention
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 22 Jul 2024
Background
Accurate risk stratification is vital for primary prevention of cardiovascular disease (CVD). However, traditional tools such as the Framingham Risk Score (FRS) may underperform within the diverse intermediate-risk group, which includes individuals requiring distinct management strategies.
Objectives
This study aimed to develop a lipidomic-enhanced risk score (LRS), specifically tar...
GLUT1 and cerebral glucose hypometabolism in human focal cortical dysplasia is associated with hypermethylation of key glucose regulatory genes.
RESEARCH SQUARE - 17 Oct 2024
Focal cortical dysplasia (FCD) is recognized as a significant etiological factor in pharmacoresistant intractable epilepsy, linked with disturbances in neurovascular metabolism. Our study investigated regulation of glucose-transporter1 (GLUT1) and cerebral hypometabolism within FCD subtypes. Surgically excised human brain specimens underwent histopathological categorization. A subset of samples...
General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants.
LANCET (LONDON, ENGLAND) - 31 Aug 2024
Adiposity can be measured using BMI (which is based on weight and height) as well as indices of abdominal adiposity. We examined the association between BMI and waist-to-height ratio (WHtR) within and across populations of different world regions and quantified how well these two metrics discriminate between people with and without hypertension. We used data from studies carried out from 1990 t...
Diagnosis to Ablation in Persistent AF: Any Time Can Be a Good Time to Ablate.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jul 2024
Nonrandomized data suggest that longer diagnosis-to-ablation time (DAT) is associated with poorer outcomes; however, a recent randomized trial found no difference in recurrences when ablation was delayed by 12 months. This study sought to assess the impact of DAT on atrial fibrillation (AF) recurrence in patients undergoing catheter ablation for persistent AF. CAPLA (Effect of Catheter Ablation...
Predictors of Late Atrial Fibrillation Recurrence After Cardiac Surgery.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jul 2024
Although postoperative atrial fibrillation (POAF) frequently occurs early after cardiac surgery, there is a paucity of data evaluating predictors and timing of late atrial fibrillation (AF) recurrence. The authors sought to evaluate predictors of late AF recurrence in patients undergoing cardiac surgery. We retrospectively reviewed cardiac surgery patients from 2010 to 2018 with no preoperative...
Cancer Therapy and Exercise Intolerance: The Heart Is But a Part: <i>JACC: CardioOncology</i> State-of-the-Art Review.
JACC. CARDIOONCOLOGY - 01 Aug 2024
The landscape of cancer therapeutics is continually evolving, with successes in improved survivorship and reduced disease progression for many patients with cancer. Improved cancer outcomes expose competing comorbidities, some of which may be exacerbated by cancer therapies. The leading cause of disability and death for many early-stage cancers is cardiovascular disease (CVD), which is often at...
A Broad-Spectrum α-Glucosidase of Glycoside Hydrolase Family 13 from Marinovum sp., a Member of the Roseobacter Clade.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY - 01 Sep 2024
Glycoside hydrolases (GHs) are a diverse group of enzymes that catalyze the hydrolysis of glycosidic bonds. The Carbohydrate-Active enZymes (CAZy) classification organizes GHs into families based on sequence data and function, with fewer than 1% of the predicted proteins characterized biochemically. Consideration of genomic context can provide clues to infer possible enzyme activities for prote...
Cardiac-targeted delivery of a novel Drp1 inhibitor for acute cardioprotection.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY PLUS - 01 Sep 2024
Dynamin-related protein 1 (Drp1) is a mitochondrial fission protein and a viable target for cardioprotection against myocardial ischaemia-reperfusion injury. Here, we reported a novel Drp1 inhibitor (DRP1i1), delivered using a cardiac-targeted nanoparticle drug delivery system, as a more effective approach for achieving acute cardioprotection. DRP1i1 was encapsulated in cubosome nanoparticles w...
The International Evidence-based Guidelines for the Assessment and Management of Polycystic Ovary Syndrome: An Exemplar of Person-centred Care.
TOUCHREVIEWS IN ENDOCRINOLOGY - 01 Oct 2024
In this opinion piece, we appraise the International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome 2023 from a person-centric perspective. We discuss how the authors balance evidence with empathy and offer excellence in clinical decision-making while ensuring the empowerment of the affected individual. We note how they skilfully use powerful words and p...
Fulminant eosinophilic myocarditis and refractory ventricular arrhythmias requiring mechanical circulatory support: a case report.
EUROPEAN HEART JOURNAL. CASE REPORTS - 01 Oct 2024
Fulminant eosinophilic myocarditis (EM) is a rare and often fatal condition that may present atypically and be complicated by ventricular arrhythmias. Treatment involves high-dose corticosteroids to suppress eosinophilia, as well as increasing use of mepolizumab, an anti-interleukin-5 antibody with evidence for long-term efficacy and safety. A 38-year-old woman presented to the emergency depart...
Zein nanoencapsulation enhances the antifungal activity of thymol for postharvest decay control in bananas
EMERGENT MATERIALS - 16 Sep 2024
The current work describes a nanoparticle system-based approach to enhance the antifungal activity of thymol, a ubiquitous natural antifungal phenolic compound, in postharvest control against banana anthracnose. Thymol was encapsulated within the amphiphilic protein zein by high-shear emulsification, yielding highly dispersible thymol-loaded zein nanoparticles with a high encapsulation efficien...
Use of Polygenic Risk Score for Prediction of Heart Failure in Cancer Survivors.
JACC. CARDIOONCOLOGY - 01 Oct 2024
The risk for heart failure (HF) is increased among cancer survivors, but predicting individual HF risk is difficult. Polygenic risk scores (PRS) for HF prediction summarize the combined effects of multiple genetic variants specific to the individual. The aim of this study was to compare clinical HF prediction models with PRS in both cancer and noncancer populations. Cancer and HF diagnoses were...
Integrated clinical risk prediction of type 2 diabetes with a multifactorial polygenic risk score.
MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES - 26 Aug 2024
Combining information from multiple GWASs for a disease and its risk factors has proven a powerful approach for development of polygenic risk scores (PRSs). This may be particularly useful for type 2 diabetes (T2D), a highly polygenic and heterogeneous disease where the additional predictive value of a PRS is unclear. Here, we use a meta-scoring approach to develop a metaPRS for T2D that incorp...
The Reply.
THE AMERICAN JOURNAL OF MEDICINE - 01 Nov 2024
Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis: The EVOLVED Randomized Clinical Trial.
JAMA - 28 Oct 2024
Development of myocardial fibrosis in patients with aortic stenosis precedes left ventricular decompensation and is associated with an adverse long-term prognosis. To investigate whether early valve intervention reduced the incidence of all-cause death or unplanned aortic stenosis-related hospitalization in asymptomatic patients with severe aortic stenosis and myocardial fibrosis. This prospect...
Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL - 01 Dec 2024
Nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) is a negative regulator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway, with a significant role in the context of inflammation. Altered expression of NLRX1 is prevalent in inflammatory diseases leading to interest in NLRX1 as a drug target. There is a lack of structural inf...
Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.
NATURE - 23 Oct 2024
Multidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health<sup>1</sup>. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action<sup>2</sup>, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to pr...
The epidemiology of type 1 diabetes mellitus in older adults.
NATURE REVIEWS. ENDOCRINOLOGY - 24 Oct 2024
Although type 1 diabetes mellitus (T1DM) is traditionally viewed as a youth-onset disorder, the number of older adults being diagnosed with this disease is growing. Improvements in the average life expectancy of people with T1DM have also contributed to the growing number of older people living with this disease. We summarize the evidence regarding the epidemiology (incidence, prevalence and ex...
Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells.
30 Sep 2024
We previously reported that Oxy210, an oxysterol-based drug candidate, exhibits antifibrotic and anti-inflammatory properties. We also showed that, in mice, it ameliorates hepatic hallmarks of non-alcoholic steatohepatitis (NASH), including inflammation and fibrosis, and reduces adipose tissue inflammation. Here, we aim to investigate the effects of Oxy210 on atherosclerosis, an inflammatory di...
Cardiomyopathy characterizing and heart failure risk predicting by echocardiography and pathoanatomy in aged male mice.
PHYSIOLOGICAL REPORTS - 01 Oct 2024
Correlation between echocardiographic and pathoanatomic variables and their prognostic value in murine cardiomyopathy models remain unknown. Using echocardiography, morphometrics, and survival monitoring, we characterized transgenic (TG) mice with dilated cardiomyopathy due to cardiac overexpression of β<sub>2</sub>-adrenoceptors focusing on predicting heart failure (HF) risk and HF mortality. ...
