Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

Visit the Baker Institute website for more information on Baker Institute research, lifestyle books and health fact sheets.

Follow our OAR Twitter account to keep in touch with our latest research publications.

This open access repository contains the full text of articles, subject to copyright constraints.

Publications
By Year
Now showing items 1-20 of 4112 records
Rationale and design of the Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial (ARISE-HF) in patients with high-risk diabetic cardiomyopathy.
James L Januzzi; Javed Butler; Stefano Del Prato; Justin A Ezekowitz; Nasrien E Ibrahim; Carolyn S P Lam; Gregory D Lewis; Thomas H Marwick; Julio Rosenstock; W H Wilson Tang; Faiez Zannad; Francesca Lawson; Riccardo Perfetti; Alessia Urbinati
AMERICAN HEART JOURNAL - 11 Nov 2022
Diabetic cardiomyopathy (DbCM) is a specific form of heart muscle disease that may result in substantial morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). Hyperactivation of the polyol pathway is one of the primary mechanisms in the pathogenesis of diabetic complications, including development of DbCM. There is an unmet need for therapies targeting the underlying meta...
Associations between data-driven lifestyle profiles and cognitive function in the AusDiab study.
Sara E Dingle; Steven J Bowe; Melissa Bujtor; Catherine M Milte; Robin M Daly; Kaarin J Anstey; Jonathan E Shaw; Susan J Torres
BMC PUBLIC HEALTH - 29 Nov 2022
Mounting evidence highlights the importance of combined modifiable lifestyle factors in reducing risk of cognitive decline and dementia. Several a priori additive scoring approaches have been established; however, limited research has employed advanced data-driven approaches to explore this association. This study aimed to examine the association between data-driven lifestyle profiles and cogni...
Genetically personalised organ-specific metabolic models in health and disease.
Carles Foguet; Yu Xu; Scott C Ritchie; Samuel A Lambert; Elodie Persyn; Artika P Nath; Emma E Davenport; David J Roberts; Dirk S Paul; Emanuele Di Angelantonio; John Danesh; Adam S Butterworth; Christopher Yau; Michael Inouye
NATURE COMMUNICATIONS - 29 Nov 2022
Understanding how genetic variants influence disease risk and complex traits (variant-to-function) is one of the major challenges in human genetics. Here we present a model-driven framework to leverage human genome-scale metabolic networks to define how genetic variants affect biochemical reaction fluxes across major human tissues, including skeletal muscle, adipose, liver, brain and heart. As ...
Television-viewing time and bodily pain in Australian adults with and without type 2 diabetes: 12-year prospective relationships.
Francis Q S Dzakpasu; Neville Owen; Alison Carver; Parneet Sethi; Christian J Brakenridge; Agus Salim; Donna M Urquhart; Flavia Cicuttini; David W Dunstan
BMC PUBLIC HEALTH - 29 Nov 2022
Bodily pain is a common presentation in several chronic diseases, yet the influence of sedentary behaviour, common in ageing adults, is unclear. Television-viewing (TV) time is a ubiquitous leisure-time sedentary behaviour, with a potential contribution to the development of bodily pain. We examined bodily pain trajectories and the longitudinal relationships of TV time with the bodily pain seve...
Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia.
Ellen Menkhorst; Wei Zhou; Leilani Santos; Jian-Guo Zhang; Yves St-Pierre; Morag J Young; Evdokia Dimitriadis
PREGNANCY HYPERTENSION - 01 Dec 2022
Preeclampsia is a life-threatening disorder of pregnancy unique to humans. Poor placentation in the first trimester of pregnancy is widely accepted to be an underlying cause of preeclampsia. Galectin-7 is abnormally elevated in chorionic villous samples and serum from women that subsequently develop pre-term preeclampsia. Administration of exogenous galectin-7 to pregnant mice causes preeclamps...
Cardiovascular magnetic resonance imaging characteristics in patients with methamphetamine-associated cardiomyopathy.
Michael B Stokes; Fiona Thoi; Daniel J Scherer; Kyi T H Win; David M Kaye; Karen S Teo; Prashanthan Sanders
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE - 01 Dec 2022
Methamphetamine-associated cardiomyopathy (MA-CMP) is an increasingly recognised aetiology of cardiomyopathy. Cardiovascular magnetic resonance (CMR) is a specialised cardiac imaging modality commonly used in assessment of cardiomyopathy. We aimed to identify specific CMR features associated with MA-CMP.A retrospective cohort study of CMR scans was performed in a single centre between January 2...
In Vivo Inhibition of miR-34a Modestly Limits Cardiac Enlargement and Fibrosis in a Mouse Model with Established Type 1 Diabetes-Induced Cardiomyopathy, but Does Not Improve Diastolic Function.
Bianca C Bernardo; Gunes S Yildiz; Helen Kiriazis; Claudia A Harmawan; Celeste M K Tai; Rebecca H Ritchie; Julie R McMullen
03 Oct 2022
MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology, and we previously reported that inhibition of miR-34a in vivo provided protection in a setting of pressure overload-induced pathological cardiac hypertrophy and dilated cardiomyopathy. Prior work had also shown that circulating or cardiac miR-34a was elevated in a setting of diabetes. However, the thera...
Both Short and Long Sleep Durations Are Associated with Poor Cognition and Memory in Chinese Adults Aged 55+ Years-Results from China Health and Nutrition Survey.
Yingting Cao; Xiaoyue Xu; Ming Li; Jianghong Liu; Zumin Shi
LIFE (BASEL, SWITZERLAND) - 06 Nov 2022
We aimed to examine the associations between sleep duration and cognitive functions and memory in older Chinese adults attending the China Health and Nutrition Survey. A total of 7924 participants 55 years and older who reported their sleep duration and had a cognitive screen test in 2004, 2006, and 2015 were included in the analysis. Mixed-effects logistic regression models were used to assess...
Do neighbourhood traffic-related air pollution and socio-economic status moderate the associations of the neighbourhood physical environment with cognitive function? Findings from the AusDiab study.
Ester Cerin; Anthony Barnett; Yu-Tzu Wu; Erika Martino; Jonathan E Shaw; Luke D Knibbs; Govinda Poudel; Bin Jalaludin; Kaarin J Anstey
THE SCIENCE OF THE TOTAL ENVIRONMENT - 08 Nov 2022
Characteristics of the neighbourhood environment, including the built and natural environment, area-level socio-economic status (SES) and air pollution, have been linked to cognitive health. However, most studies have focused on single neighbourhood characteristics and have not considered the extent to which the effects of environmental factors may interact. We examined the associations of meas...
The Cost-Effectiveness of the SMART Work & Life Intervention for Reducing Sitting Time.
Edward Cox; Simon Walker; Charlotte L Edwardson; Stuart J H Biddle; Alexandra M Clarke-Cornwell; Stacy A Clemes; Melanie J Davies; David W Dunstan; Helen Eborall; Malcolm H Granat; Laura J Gray; Genevieve N Healy; Benjamin D Maylor; Fehmidah Munir; Thomas Yates; Gerry Richardson
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 11 Nov 2022
Sedentary behaviours continue to increase and are associated with heightened risks of morbidity and mortality. We assessed the cost-effectiveness of SMART Work & Life (SWAL), an intervention designed to reduce sitting time inside and outside of work, both with (SWAL-desk) and without (SWAL-only) a height-adjustable workstation compared to usual practice (control) for UK office workers. Health o...
Disease specific determinants of cardiopulmonary fitness in systemic sclerosis.
Laura Ross; Benedict Costello; Anniina Lindqvist; Dylan Hansen; Zoe Brown; Wendy Stevens; Andrew Burns; David Prior; Marcus Pianta; Warren Perera; André La Gerche; Mandana Nikpour
17 Nov 2022
We aimed to quantify the burden of exercise intolerance in systemic sclerosis (SSc) and explore the disease features that contribute to impaired exercise capacity (measured as peak oxygen uptake, peak VO) to provide novel mechanistic insights into the causes of physical disability in SSc.2Thirty-three SSc patients with no history of cardiac disease and no active myositis underwent cardiac and s...
Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair.
Jonathan Lozano; Alin Rai; Jarmon G Lees; Haoyun Fang; Bethany Claridge; Shiang Y Lim; David W Greening
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 18 Nov 2022
Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to repair injured cardiac tissues and regulate pathological fibrosis. However, scalable generation of stem cells and derived EVs for clinical utility remains a huge technical challenge. Here, we report a rapid size-based extrusion strategy to generate EV-like membranous nanovesicles (NVs) from easily sourc...
Prevalence and trend of smokeless tobacco use and its associated factors among adolescents aged 12-16 years in 138 countries/territories, 1999-2019.
Hui Yang; Chuanwei Ma; Min Zhao; Costan G Magnussen; Bo Xi
BMC MEDICINE - 25 Nov 2022
Smokeless tobacco use is popular in some regions worldwide, but it receives less attention compared to cigarette smoking. We aimed to estimate the recent prevalence of, and trends in, smokeless tobacco use and to examine its associated factors among adolescents aged 12-16 years in 138 countries/territories (hereafter "countries") from 1999 to 2019.Data from the Global Youth Tobacco Survey condu...
Lost therapeutic benefit of delayed LDL-C control in statin treated patients and cost-effectiveness analysis of lipid-lowering intensification.
Clara Marquina; Jedidiah Morton; Ella Zomer; Stella Talic; Sean Lybrand; David Thomson; Danny Liew; Zanfina Ademi
VALUE IN HEALTH : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR PHARMACOECONOMICS AND OUTCOMES RESEARCH - 25 Nov 2022
Attainment of low-density lipoprotein cholesterol (LDL-C) therapeutic goals in statin-treated patients remains suboptimal. We quantified the health-economic impact of delayed lipid-lowering intensification from an Australian healthcare and societal perspective.A lifetime Markov cohort model (n = 1,000) estimating the impact on coronary heart disease (CHD) of intensifying lipid-lowering treatmen...
Tissue-Mimicking Materials for Ultrasound-Guided Needle Intervention Phantoms: A Comprehensive Review.
Sophie A Armstrong; Rezan Jafary; John S Forsythe; Shaun D Gregory
ULTRASOUND IN MEDICINE & BIOLOGY - 01 Jan 2023
Ultrasound-guided needle interventions are common procedures in medicine, and tissue-mimicking phantoms are widely used for simulation training to bridge the gap between theory and clinical practice in a controlled environment. This review assesses tissue-mimicking materials from 24 studies as candidates for a high-fidelity ultrasound phantom, including methods for evaluating relevant acoustic ...
Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
Franziska Jannasch; Stefan Dietrich; Tom R P Bishop; Matthew Pearce; Anouar Fanidi; Gráinne O'Donoghue; Donal O'Gorman; Pedro Marques-Vidal; Peter Vollenweider; Maira Bes-Rastrollo; Liisa Byberg; Alicja Wolk; Maryam Hashemian; Reza Malekzadeh; Hossein Poustchi; Vivian C Luft; Sheila M Alvim de Matos; Jihye Kim; Mi Kyung Kim; Yeonjung Kim; Dalia Stern; Martin Lajous; Dianna J Magliano; Jonathan E Shaw; Tasnime Akbaraly; Mika Kivimaki; Gertraud Maskarinec; Loïc Le Marchand; Miguel Ángel Martínez-González; Sabita S Soedamah-Muthu; ; Nicholas J Wareham; Nita G Forouhi; Matthias B Schulze
EUROPEAN JOURNAL OF NUTRITION - 01 Oct 2022
In several studies, exploratory dietary patterns (DP), derived by principal component analysis, were inversely or positively associated with incident type 2 diabetes (T2D). However, findings remained study-specific, inconsistent and rarely replicated. This study aimed to investigate the associations between DPs and T2D in multiple cohorts across the world.This federated meta-analysis of individ...
Incidence and Predictors of Eosinophilic Myocardial Hypersensitivity in Patients Receiving Home Dobutamine.
Misha Dagan; Malanka Lankaputhra; Timothy Yeung; Su Ling Tee; Illona Bader; Kellie Easton; Ashlee Linton; Catriona McLean; Andrew Taylor; Peter Bergin; David M Kaye; Angeline Leet; James L Hare; Hitesh C Patel
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY - 01 Oct 2022
We sought to examine incidence and predictors of eosinophilic myocardial hypersensitivity (EMH) in a cohort of patients in the home inotrope program of a quaternary cardiac transplant center. Patients on home inotropes with progression to heart transplantation or ventricular assist device (VAD) between January 2000 and May 2020 were included. EMH was diagnosed by the presence of an interstitial...
Assessing and addressing diabetes distress among adults with type 2 diabetes: An online survey of Australian general practitioners.
Rita McMorrow; Barbara Hunter; Christel Hendrieckx; Jane Speight; Jon Emery; Jo-Anne Manski-Nankervis
PRIMARY CARE DIABETES - 01 Oct 2022
Diabetes distress is experienced by up to 36% of adults with type 2 diabetes. Australian type 2 diabetes guidelines recommend annual assessment of diabetes distress in general practice. This study explores general practitioners' knowledge, current practice, and factors influencing implementation of guidelines, including Person Reported Outcome Measure (PROM) use.A cross-sectional online survey ...
Cognitive Dysfunction in Heart Failure: Pathophysiology and Implications for Patient Management.
Sylvia Ye; Quan Huynh; Elizabeth L Potter
CURRENT HEART FAILURE REPORTS - 01 Oct 2022
There is increasing recognition of the prevalence and impact of cognitive dysfunction (CD) in heart failure (HF) patients. This contemporary review appraises the evidence for epidemiological association, direct pathophysiological links and emerging pharmacological and non-pharmacological interventions. Furthermore, we present evidence for care models that aim to mitigate the morbidity and poor ...
Daytime napping and cardiovascular risk factors, cardiovascular disease, and mortality: A systematic review.
Jiahong Sun; Chuanwei Ma; Min Zhao; Costan G Magnussen; Bo Xi
SLEEP MEDICINE REVIEWS - 01 Oct 2022
Associations between night sleep duration and cardiovascular risk factors in adults have been well documented. However, the associations for daytime napping remain unclear. In this review, six databases were searched for eligible publications to April 8, 2022. A total of 11 articles were identified for umbrella review on the association of daytime napping with diabetes, metabolic syndrome (MetS...
Show more...