Baker Institute open access repository

This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.

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Publications
By Year
Now showing items 1-20 of 3123 records
Reducing occupational sitting time in adults with type 2 diabetes: Qualitative experiences of an office adapted mHealth intervention.
M Brännholm Syrjälä; E Fharm; P C Dempsey; M Nordendahl; P Wennberg
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 08 Jan 2021
Understanding barriers and facilitators for limiting occupational sitting and what impact it has on health on those with Type 2 diabetes (T2D) is essential for future trials and intervention development in primary health care settings. This study aimed to explore the feasibility and acceptability of an intervention using mobile health (mHealth) technology, together with counselling by a diabete...
Catheter Ablation Versus Medication in Atrial Fibrillation and Systolic Dysfunction: Late Outcomes of CAMERA-MRI Study.
Hariharan Sugumar; Sandeep Prabhu; Ben Costello; David Chieng; Sonia Azzopardi; Aleksandr Voskoboinik; Ramanathan Parameswaran; Geoffrey R Wong; Robert Anderson; Ahmed M Al-Kaisey; Liang-Han Ling; Emily Kotschet; Andrew J Taylor; Jonathan M Kalman; Peter M Kistler
JACC. CLINICAL ELECTROPHYSIOLOGY - 14 Dec 2020
This study sought to determine the long-term outcomes of restoring sinus rhythm with catheter ablation (CA).The CAMERA-MRI (Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Heart Failure-An MRI-Guided Multicenter Randomized Controlled Trial) study demonstrated that restoration of sinus rhythm with CA significantly improved left ventricular ejection fraction (LVEF) compar...
Association Between Depressive Symptoms and Incident Cardiovascular Diseases.
Eric L Harshfield; Lisa Pennells; Joseph E Schwartz; Peter Willeit; Stephen Kaptoge; Steven Bell; Jonathan A Shaffer; Thomas Bolton; Sarah Spackman; Sylvia Wassertheil-Smoller; Frank Kee; Philippe Amouyel; Steven J Shea; Lewis H Kuller; Jussi Kauhanen; E M van Zutphen; Dan G Blazer; Harlan Krumholz; Paul J Nietert; Daan Kromhout; Gail Laughlin; Lisa Berkman; Robert B Wallace; Leon A Simons; Elaine M Dennison; Elizabeth L M Barr; Haakon E Meyer; Angela M Wood; John Danesh; Emanuele Di Angelantonio; Karina W Davidson;
JAMA - 15 Dec 2020
It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs).To characterize the association between depressive symptoms and CVD incidence across the spectrum of lower mood.A pooled analysis of individual-participant data from the Emerging Risk Factors Collaboration (ERFC; 162 036 participants; 21 cohorts; baseline surveys, 1960...
Which Blood Pressure Measurement Best Predicts Cardiovascular Outcomes?
Robert M Carey; Thomas H Marwick
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 22 Dec 2020
Reassuring News for Athletes With Atrial Fibrillation, But Perhaps Not All Athletes.
Andre La Gerche
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Oct 2020
Comparison of Circulatory Unloading Techniques for Venoarterial Extracorporeal Membrane Oxygenation.
Andrew F Stephens; Devindi Wanigasekara; Vincent A Pellegrino; Aidan J C Burrell; Silvana F Marasco; David M Kaye; Ulrich Steinseifer; Shaun D Gregory
ASAIO JOURNAL (AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS : 1992) - 01 Jun 2021
Left ventricular (LV) distention and pulmonary congestion are major complications inherent to venoarterial extracorporeal membrane oxygenation (ECMO). This study aimed to quantitatively compare the hemodynamic differences between common circulatory unloading methods for ECMO. Ten circulatory unloading techniques were evaluated on a mock circulatory loop simulating acute LV failure supported by ...
Modified Precordial Lead R-Wave Deflection Interval Predicts Left- and Right-Sided Idiopathic Outflow Tract Ventricular Arrhythmias.
Robert D Anderson; Saurabh Kumar; Simon Binny; Mukund Prabhu; Ahmed Al-Kaisey; Ramanathan Parameswaran; Hariharan Sugumar; David Chieng; Joshua Hawson; Timothy Campbell; Subodh Joshi; Elaine Lui; Paul B Sparks; Stephen A Joseph; Joseph B Morton; Alex McLellan; Jonathan Lipton; Bhupesh Pathik; Peter M Kistler; Jonathan Kalman; Geoffrey Lee
JACC. CLINICAL ELECTROPHYSIOLOGY - 26 Oct 2020
This study evaluated if modifying electrocardiographic (ECG) precordial leads to a higher intercostal position improved the accuracy of outflow tract ventricular arrhythmia (OTVA) localization.Precordial ECG prediction algorithms that use a standard lead configuration localize OTVA with variable accuracy.Patients who underwent OTVA ablation were prospectively enrolled to have a standard and mod...
Genetic Susceptibility to Atrial Fibrillation Is Associated With Atrial Electrical Remodeling and Adverse Post-Ablation Outcome.
Geoffrey R Wong; Chrishan J Nalliah; Geoffrey Lee; Aleksandr Voskoboinik; Sandeep Prabhu; Ramanathan Parameswaran; Hariharan Sugumar; Robert D Anderson; Liang-Han Ling; Alex McLellan; Renee Johnson; Prashanthan Sanders; Peter M Kistler; Diane Fatkin; Jonathan M Kalman
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Nov 2020
This study sought to assess the atrial electrophysiological properties and post-ablation outcomes in patients with atrial fibrillation (AF) with and without the rs2200733 single nucleotide variant.The phenotype associated with chromosome 4q25 of the AF-susceptibility locus remains unknown.In this study, 102 consecutive patients (ages 61 ± 9 years, 64% male) with paroxysmal or persistent AF were...
Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes.
Frances C Taylor; David W Dunstan; Ashleigh R Homer; Paddy C Dempsey; Bronwyn A Kingwell; Rachel E Climie; Neville Owen; Neale D Cohen; Robyn N Larsen; Megan Grace; Nina Eikelis; Michael J Wheeler; Melanie K Townsend; Nirav Maniar; Daniel J Green
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Jan 2021
In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts mitigates impairment in vascular function. However, it is unknown whether these benefits extend to those with type 2 diabetes (T2D), nor whether an optimal frequency of activity interruptions exist. We examined the acute effects on vascular function in T2D of interrupting prolonged sitting with simple res...
Characterisation of the circulating and tissue-specific alterations to the lipidome in response to moderate and major cold stress in mice.
Gerard Pernes; Pooranee K Morgan; Kevin Huynh; Natalie A Mellett; Peter J Meikle; Andrew J Murphy; Darren C Henstridge; Graeme I Lancaster
AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY - 11 Nov 2020
This study analysed the effects of 24 hours of cold stress (22°C or 5°C vs. mice maintained at 30°C) on the plasma, brown adipose tissue (BAT), subcutaneous (SubQ) and epididymal (Epi) white adipose tissue (WAT), liver, and skeletal muscle lipidome of mice. Using mass spectrometry-lipidomics 624 lipid species were detected, of which 239 were significantly altered in plasma, 134 in BAT, and 51 i...
Persistent Troponin Elevation in Left-Dominant Arrhythmogenic Cardiomyopathy.
Kunal P Verma; Timothy Roberts; Sarah Parsons; Ingrid M Winship; David Prior; Andre La Gerche; Dominica Zentner
CIRCULATION. GENOMIC AND PRECISION MEDICINE - 01 Dec 2020
The conundrum of the gut microbiome and blood pressure: the importance of studying sex and ethnicity.
Rikeish R Muralitharan; Michael E Nakai; Francine Z Marques
EUROPEAN HEART JOURNAL - 21 Nov 2020
Screening of Potential Cardiac Involvement in Competitive Athletes Recovering From COVID-19: An Expert Consensus Statement.
Dermot Phelan; Jonathan H Kim; Michael D Elliott; Meagan M Wasfy; Paul Cremer; Amer M Johri; Michael S Emery; Partho P Sengupta; Sanjay Sharma; Matthew W Martinez; Andre La Gerche
JACC. CARDIOVASCULAR IMAGING - 01 Dec 2020
As our understanding of the complications of coronavirus disease-2019 (COVID-19) evolve, subclinical cardiac pathology such as myocarditis, pericarditis, and right ventricular dysfunction in the absence of significant clinical symptoms represents a concern. The potential implications of these findings in athletes are significant given the concern that exercise, during the acute phase of viral m...
Walking-friendly built environments and objectively measured physical function in older adults.
Mohammad Javad Koohsari; Gavin R McCormack; Tomoki Nakaya; Ai Shibata; Kaori Ishii; Akitomo Yasunaga; Yung Liao; Koichiro Oka
JOURNAL OF SPORT AND HEALTH SCIENCE - 01 Dec 2020
Few studies have examined the associations between urban design attributes and older adults' physical function. Especially, it is not well known how built-environment attributes may influence physical function in Asian cities. The aim of this study was to examine associations between objectively measured environmental attributes of walkability and objectively assessed physical function in a sam...
Vascular compression of the rostral ventrolateral medulla: a relevant indicator of sympathetically driven blood pressure variability?
Markus P Schlaich; Janis M Nolde; Revathy Carnagarin; Luca I Schlaich; Marcio G Kiuchi
JOURNAL OF HYPERTENSION - 01 Dec 2020
Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities.
Laura A Bienvenu; Jonathan Noonan; Xiaowei Wang; Karlheinz Peter
CARDIOVASCULAR RESEARCH - 01 Dec 2020
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic. Strikingly, men account for the majority of COVID-19 deaths, with current figures ranging from 59% to 75% of total mortality. However, despite clear implications in relation to COVID-19 mortality, most research has not consi...
Echocardiography in Long QT Syndrome: The Mechanical Face of an Electrical Disease.
Thomas H Marwick
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 15 Dec 2020
Identifying Genotype-Phenotype Correlations via Integrative Mutation Analysis.
Edward Airey; Stephanie Portelli; Joicymara S Xavier; Yoo Chan Myung; Michael Silk; Malancha Karmakar; João P L Velloso; Carlos H M Rodrigues; Hardik H Parate; Anjali Garg; Raghad Al-Jarf; Lucy Barr; Juliana A Geraldo; Pâmela M Rezende; Douglas E V Pires; David B Ascher
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2021
Mutations in protein-coding regions can lead to large biological changes and are associated with genetic conditions, including cancers and Mendelian diseases, as well as drug resistance. Although whole genome and exome sequencing help to elucidate potential genotype-phenotype correlations, there is a large gap between the identification of new variants and deciphering their molecular consequenc...
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
Min Park; Takanori Nishimura; Carlos D Baeza-Garza; Stuart T Caldwell; Pamela Boon Li Pun; Hiran A Prag; Tim Young; Olga Sauchanka; Angela Logan; Marleen Forkink; Anja V Gruszczyk; Tracy A Prime; Sabine Arndt; Alba Naudi; Reinald Pamplona; Melinda T Coughlan; Mitchel Tate; Rebecca H Ritchie; Federico Caicci; Nina Kaludercic; Fabio Di Lisa; Robin A J Smith; Richard C Hartley; Michael P Murphy; Thomas Krieg
CARDIOVASCULAR DRUGS AND THERAPY - 01 Dec 2020
HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used it to confirm the therapeutic efficacy of the mitochondria-targeted dicarbonyl scavenger, MitoGamide.A longitudinal echocardiographic analysis confirmed that Akita mice develop diast...
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