Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 5118 records
The expanding spectrum of diabetes.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2024
Ergonomic endocrinology.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2024
In this opinion piece, we introduce the concept of ergonomic endocrinology. Ergonomic endocrinology is defined as the bidirectional and multifaceted relationship between endocrine health and dysfunction on one hand, and ergonomic design and engineering on the other. We describe the various domains of ergonomic endocrinology, using the classification rubric of physical, cognitive and organizatio...
Pragmatic person centred care.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2024
This conceptual paper defines and describes pragmatic person centred care as an enhanced and expanded version of the construct of person centred care (PCC). Pragmatic person centred care is defined as health care that is respectful of, and responsive to the person's preferences, needs and values, while being reflective of available resource, reserves, and restrictions, regulating and balancing ...
Kwashiorkor and sarcopenic obesity: Two Sides Of The Same Coin?
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2024
Kwashiorkor is a form of protein energy malnutrition, while obesity usually occurs due to overnutrition. These syndromes, therefore, are considered to be poles apart. However, there are many similarities between the two conditions. Both are forms of malnutrition, and have common features in causation, clinical presentation, comorbidities and complications, as well as strategies for management. ...
Primary Care-Based Digital Health-Enabled Stroke Management Intervention: Long-Term Follow-Up of a Cluster Randomized Clinical Trial.
JAMA NETWORK OPEN - 02 Dec 2024
Despite evidence of the short-term benefits of multicomponent primary care-based interventions, their long-term effects are unproven. To evaluate the long-term outcomes of a system-integrated technology-enabled model of care (SINEMA intervention) for stroke management for systolic blood pressure (BP) and other outcomes among patients with stroke in China. This long-term follow-up included commu...
Time restricted feeding alters the behavioural and physiological outcomes to repeated mild traumatic brain injury in male and female rats.
EXPERIMENTAL NEUROLOGY - 09 Dec 2024
Joint British Societies' position statement on cardiology training in the United Kingdom.
HEART (BRITISH CARDIAC SOCIETY) - 12 Dec 2024
Cardiology training in the UK is facing significant challenges due to a range of factors. Recent curriculum changes have further compounded this issue and significantly risk the ability to produce adequately trained consultants capable of managing patients with increasingly complex cardiovascular disease. The introduction of mandatory dual accreditation in general internal medicine (GIM) alongs...
Photoplethysmography as a noninvasive surrogate for microneurography in measuring stress-induced sympathetic nervous activation - A machine learning approach.
COMPUTERS IN BIOLOGY AND MEDICINE - 12 Dec 2024
The sympathetic nervous system (SNS) is essential for the body's immediate response to stress, initiating physiological changes that can be measured through sympathetic nerve activity (SNA). While microneurography (MNG) is the gold standard for direct SNA measurement, its invasive nature limits its practical use in clinical settings. This study investigates the use of multi-wavelength photoplet...
Risk of bradycardia and asystole during microelectrode recordings from the human vagus nerve.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 14 Dec 2024
MAFLD but not MASLD increases risk of all-cause mortality in regional Australia, with components of metabolic syndrome exacerbating factors: 20 year longitudinal, cohort study.
HEPATOLOGY INTERNATIONAL - 14 Dec 2024
Controversy remains whether the mortality risk in people with fatty liver disease (FLD) including metabolic-(dysfunction) associated steatotic liver disease (MASLD) and metabolic-(dysfunction) associated fatty liver disease (MAFLD) is higher than observed in those without FLD. We aimed to determine the mortality rate and mortality rate ratio (MRR) for these FLDs. The study population was a rand...
Change in Cardiorespiratory Fitness and the Risk of Colorectal and Prostate Cancer Incidence in Men.
CANCER MEDICINE - 01 Dec 2024
The aim of this prospective cohort study was to investigate the associations between changes in cardiorespiratory fitness (CRF) and the risk of colorectal and prostate cancer in men. Data from men who completed a health assessment both in military conscription in youth and an occupational health profile assessment (HPA) later in life were used. CRF was assessed as estimated V̇O<sub>2max</sub>, ...
Psychosocial well-being and diabetes distress in the transition to motherhood among women with type 1 or type 2 diabetes.
SEXUAL & REPRODUCTIVE HEALTHCARE : OFFICIAL JOURNAL OF THE SWEDISH ASSOCIATION OF MIDWIVES - 01 Dec 2024
To investigate the associations between psychological well-being, measured with the Postnatal Well-being in Transition (PostTrans) Questionnaire, and diabetes distress among mothers with type 1 or type 2 diabetes. Eighty-two postnatal women completed a cross-sectional survey. The survey included the Diabetes Distress Scale, and the PostTrans Questionnaire to assess the psychosocial well-being o...
Immediate Versus 5-Year Risk-Guided Initiation of Treatment for Primary Prevention of Cardiovascular Disease for Australians Aged 40 Years: A Health Economic Analysis.
PHARMACOECONOMICS - 02 Dec 2024
Current Australian cardiovascular disease (CVD) prevention guidelines calculate 5-year CVD risk and recommend treatment when risk crosses specific thresholds. This may leave risk factors untreated for people with a low short-term (i.e. 5 years), but high long-term (i.e. lifetime), risk of CVD. We aimed to evaluate the cost effectiveness of intervention for risk factor control at age 40 years (r...
Novel loci and biomedical consequences of iron homoeostasis variation.
COMMUNICATIONS BIOLOGY - 06 Dec 2024
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of whi...
Global analysis of endogenous protein disorder in cells.
NATURE METHODS - 25 Nov 2024
Disorder and flexibility in protein structures are essential for biological function but can also contribute to diseases, such as neurodegenerative disorders. However, characterizing protein folding on a proteome-wide scale within biological matrices remains challenging. Here we present a method using a bifunctional chemical probe, named TME, to capture in situ, enrich and quantify endogenous p...
Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank.
COMMUNICATIONS MEDICINE - 26 Nov 2024
Diagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and presence of comorbid conditions. ME/CFS patients often present with multiple health issues, therefore, incorporating comorbidities into research can provide a more accurate understanding of the condition's symptomatology and severity, to better reflect...
Estimating the cost of chronic kidney disease in Australia.
BMC HEALTH SERVICES RESEARCH - 26 Nov 2024
Chronic kidney disease (CKD) is a significant burden on health systems globally, with limited up-to-date information on health system costs, particularly for non-dialysis patients. This study estimates the direct healthcare costs of CKD within Australia. The study utilised the CKD.WA dataset, a linked repository for the state of Western Australia, containing public and private pathology, hospit...
Effects of interval training in cardiovascular disease populations: a clinical perspective.
01 Dec 2024
Nearly 20 years have elapsed since the first clinical trial investigated the impact of interval training on patients with cardiovascular disease (CVD). This clinical corner discusses the health outcomes of systematic reviews and meta-analyses and appropriately powered randomized clinical trials which have tested these interval training programs across various CVDs (i.e., coronary artery disease...
PRIMITI: A computational approach for accurate prediction of miRNA-target mRNA interaction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL - 01 Dec 2024
Current medical research has been demonstrating the roles of miRNAs in a variety of cellular mechanisms, lending credence to the association between miRNA dysregulation and multiple diseases. Understanding the mechanisms of miRNA is critical for developing effective diagnostic and therapeutic strategies. miRNA-mRNA interactions emerge as the most important mechanism to be understood despite the...
Current Emergency Medical Service Vasoactive Use for the Management of Shock.
CRITICAL CARE EXPLORATIONS - 01 Dec 2024
We sought to describe the indications for vasoactive medication administration, hemodynamic treatment targets, and specific agents used by various international emergency medical service (EMS) providers. In March 2022, we sent an online survey comprising of 20 questions to Medical Directors of EMSs across Australia, the Asia Pacific region, and North America. A total of 108 EMS directors were e...
