Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 5153 records
Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial.
CARDIOVASCULAR DIABETOLOGY - 13 Jan 2025
Diabetic myocardial disorder (DbMD, evidenced by abnormal echocardiography or cardiac biomarkers) is a form of stage B heart failure (SBHF) at high risk for progression to overt HF. SBHF is defined by abnormal LV morphology and function and/or abnormal cardiac biomarker concentrations. To compare the evolution of four DbMD groups based on biomarkers alone, systolic and diastolic dysfunction alo...
The common VTE-protective G haplotype of F5 increases factor V-short, TFPI function, and risk of bleeding.
BLOOD ADVANCES - 14 Jan 2025
The G haplotype is a group of co-inherited single nucleotide variants in the F5 gene that reduce venous thromboembolism (VTE) risk. Although 7% of the population is homozygous for the G haplotype (F5-G/G), the underlying mechanism of VTE protection is poorly understood. Using RNA sequencing data from 4651 blood donors in the INTERVAL study, we detected a rare excision event at the factor V (FV)...
Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized controlled trial.
BMJ OPEN DIABETES RESEARCH & CARE - 22 Dec 2024
This analysis aimed to investigate diabetes-specific psychological outcomes among adults with type 1 diabetes (T1D) using hybrid closed-loop (HCL) versus standard therapy. In this multicenter, open-label, randomized, controlled, parallel-group clinical trial, adults with T1D were allocated to 26 weeks of HCL (MiniMed™ 670G) or standard therapy (insulin pump or multiple daily injections without ...
Small Heart Size and Premature Death in 366,484 Individuals With Normal Ejection Fraction.
01 Jan 2025
In patients with preserved left ventricular ejection fraction (LVEF), small ventricular size has been associated with reduced functional capacity, but its impact on clinical outcomes is unclear. The goal of this study was to determine the relationship between small heart size and premature mortality within a large multicenter adult patient cohort with transthoracic echocardiographic examination...
A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation.
BMC BIOLOGY - 07 Jan 2025
C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular mechanisms. In a multi-translational study of systemic inflammation, we found a time- and inflammation-dependent pCRP...
Consuming a modified Mediterranean ketogenic diet reverses the peripheral lipid signature of Alzheimer's disease in humans.
COMMUNICATIONS MEDICINE - 09 Jan 2025
Alzheimer's disease (AD) is a major neurodegenerative disorder with significant environmental factors, including diet and lifestyle, influencing its onset and progression. Although previous studies have suggested that certain diets may reduce the incidence of AD, the underlying mechanisms remain unclear. In this post-hoc analysis of a randomized crossover study of 20 elderly adults, we investig...
Piloting a citizen science approach to auditing rural walkability in Tasmania.
HEALTH PROMOTION JOURNAL OF AUSTRALIA : OFFICIAL JOURNAL OF AUSTRALIAN ASSOCIATION OF HEALTH PROMOTION PROFESSIONALS - 01 Jan 2025
People living in 'walkable' areas are more active, but common approaches to assessing walkability using audit tools and geospatial data have limitations in rural areas. This project explored the feasibility, acceptability and benefits of using a citizen science approach to audit walkability in rural communities. Using a citizen science approach, community members in rural towns completed audit ...
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis.
NATURE REVIEWS. CARDIOLOGY - 02 Jan 2025
Computed tomography coronary angiography provides a non-invasive evaluation of coronary artery disease that includes phenotyping of atherosclerotic plaques and the surrounding perivascular adipose tissue (PVAT). Image analysis techniques have been developed to quantify atherosclerotic plaque burden and morphology as well as the associated PVAT attenuation, and emerging radiomic approaches can a...
Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.
NATURE COMMUNICATIONS - 02 Jan 2025
Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary metabolite profiling, as widely applied for blood biomarker studie...
Single-pulse transcranial magnetic stimulation of the dorsolateral prefrontal cortex does not directly affect muscle sympathetic nerve activity in humans.
CEREBRAL CORTEX (NEW YORK, N.Y. : 1991) - 03 Dec 2024
Transcranial magnetic stimulation (TMS) is applied both in research settings and clinically, notably in treating depression through the dorsolateral prefrontal cortex (dlPFC). We have recently shown that transcranial alternating current stimulation of the dlPFC partially entrains muscle sympathetic nerve activity (MSNA) to the stimulus. We, therefore, aimed to further explore the sympathetic pr...
Computed Tomography Coronary Angiography Is Feasible and Reliable for Proximal Coronary Segment Interpretation in Patients with Elevated Body Mass Index.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE - 11 Dec 2024
Computed tomography coronary angiography (CTCA) is under-utilised in detecting coronary artery disease (CAD) in obese patients due to concerns about non-evaluable testing. We hypothesise that these concerns are predominantly related to smaller and branch coronary vessels, and CTCA remains adequate for proximal segment stenosis interpretation, which has significant clinical implications. This re...
Advancing type 1 diabetes therapy: autologous islet transplant breakthrough.
SIGNAL TRANSDUCTION AND TARGETED THERAPY - 23 Dec 2024
Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges.
HUMAN GENETICS - 23 Dec 2024
Recent thermodynamic and functional studies have been conducted to evaluate the impact of amino acid substitutions on Calmodulin (CaM). The Critical Assessment of Genome Interpretation (CAGI) data provider at University of Verona (Italy) measured the melting temperature (T<sub>m</sub>) and the percentage of unfolding (%unfold) of a set of CaM variants (CaM challenge dataset). Thermodynamic meas...
Predicting Type 2 Diabetes and Testosterone Effects in high-risk Australian men: Development and external validation of a 2 year risk model.
25 Dec 2024
We have shown that men aged 50 years+ at high risk of type 2 diabetes treated with testosterone together with a lifestyle program reduced the risk of type 2 diabetes at two years by 40% compared to a lifestyle program alone. To develop a personalized approach to treatment, we aimed to explore a prognostic model for incident type 2 diabetes at two years and investigate biomarkers predictive of t...
IUPHAR Themed Review: The Gut Microbiome in Schizophrenia.
PHARMACOLOGICAL RESEARCH - 26 Dec 2024
Gut microbial dysbiosis or altered gut microbial consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, and cognitive symptoms. Paradoxically, conventional psychotropic interventions may exacerbate this dysbiosis, with antipsychotics, particularly olanzapine, demonstrating ...
Blood methylation biomarkers are associated with diabetic kidney disease progression in type 1 diabetes.
MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES - 29 Nov 2024
DNA methylation differences are associated with kidney function and diabetic kidney disease (DKD), but prospective studies are scarce. Therefore, we aimed to study DNA methylation in a prospective setting in the Finnish Diabetic Nephropathy Study type 1 diabetes (T1D) cohort. We analysed baseline blood sample-derived DNA methylation (Illumina's EPIC array) of 403 individuals with normal albumin...
Cost-effectiveness of oral immunotherapy for egg allergy according to age of therapy commencement.
THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE - 13 Dec 2024
Egg oral immunotherapy can induce desensitization or remission of egg allergy in children. To determine the cost-effectiveness of OIT for raw egg allergy in school-aged children compared to egg avoidance, and the most cost-effective age at which to commence treatment. A decision-analytic Markov model estimated the health and cost outcomes of 1000 children aged four years with egg allergy, compa...
Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms.
ANALYTICAL CHEMISTRY - 16 Dec 2024
Applications of advanced omics methodologies are increasingly popular in biomedicine. However, large-scale studies aiming at clinical translation are typically siloed to single technologies. Here, we present the first comprehensive large-scale population data combining 209 lipoprotein measures from a quantitative NMR spectroscopy platform and 809 lipid classes and species from a quantitative LC...
Circadian disruption and its impact on the cardiovascular system.
TRENDS IN ENDOCRINOLOGY AND METABOLISM: TEM - 19 Dec 2024
Circadian rhythms are highly conserved biorhythms of ~24 h that govern many fundamental biological processes, including cardiovascular (CV) homeostasis. Disrupting the timing of cellular oscillators promotes cellular stress, and induction of pathogenic pathways underpins the pathogenesis of many CV diseases (CVDs). Thus, shift work, late eating, sleep disturbances, and other disruptors can resu...
Hippo pathway activation causes multiple lipid derangements in a murine model of cardiomyopathy.
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS - 19 Dec 2024
Metabolic reprogramming occurs in cardiomyopathy and heart failure contributing to progression of the disease. Activation of cardiac Hippo pathway signaling has been implicated in mediating mitochondrial dysfunction and metabolic reprogramming in cardiomyopathy, albeit influence of Hippo pathway on lipid profile is unclear. Using a dual-omics approach, we determined alterations of cardiac lipid...
