Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 4807 records
Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer's disease.
ISCIENCE - 16 Feb 2024
Alzheimer's disease (AD) is associated with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles (NFT). We characterized the behavioral, metabolic and lipidomic phenotype of the 5xFADxTg30 mouse model which contains overexpression of both Aβ and tau. Our results independently reproduce several phenotypic traits described previously for this model, w...
Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer's disease.
NPJ METABOLIC HEALTH AND DISEASE - 01 Jan 2024
Alzheimer's disease (AD) is influenced by a variety of modifiable risk factors, including a person's dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affecting AD progression, only a few studies have explored KD's metabolic impact, especially on blood and cerebrospinal fluid (CSF). Our study involved participants at risk for AD, either cogn...
Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment.
ADV HEALTHC MATER - 10 Jan 2024
Brain cancers, especially glioblastoma multiforme (GBM), are associated with poor prognosis due to the limited efficacy of current therapies. Nanomedicine has emerged as a versatile technology to treat various diseases, including cancers, and has played an indispensable role in combatting the COVID-19 pandemic as evidenced by the role that lipid nanocarrier-based vaccines have played. The tunab...
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
LANCET (LONDON, ENGLAND) - 16 Mar 2024
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. We used data from 3663 population-based studies with 222 million participants that mea...
The Ten Cs Of Chronic Care.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2024
Glucokathexis.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2024
Glucokathexis is a clinical state characterized by low plasma glucose levels, in the presence of adequate glucose precursor stores. We conceive and construct this rubric to initiate interest and inspire insight into this field of metabolic medicine. We list various conditions that can cause true as well as pseudo-glucokathexis.
Obesity is a communicable disease.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2024
Obesity has multiple causes and correlates. Usually studied as a metabolic and endocrine disease, with mechanical and musculoskeletal comorbidities, obesity also has a communicable angle to it. Obesity can be considered a communicable disease from the conventional point of view, as it is associated with viral etiology in animal and human models. It is also associated with increased prevalence a...
Withdrawal of Neurohormonal Antagonists in Breast Cancer Patients With Cardiotoxicity and Improved Left Ventricular Function.
JACC. CARDIOONCOLOGY - 01 Apr 2024
Canagliflozin/metformin Fixed-dose Combination: National Evidence, Global Relevance.
THE JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA - 01 Apr 2024
Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.
MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES - 16 Apr 2024
Blood cell phenotypes are routinely tested in healthcare to inform clinical decisions. Genetic variants influencing mean blood cell phenotypes have been used to understand disease aetiology and improve prediction; however, additional information may be captured by genetic effects on observed variance. Here, we mapped variance quantitative trait loci (vQTL), i.e. genetic loci associated with tra...
Cardiovascular Implications of Semaglutide in Obesity Management: Redefining Cardiovascular Health Strategies.
HEART INTERNATIONAL - 01 Jan 2024
Semaglutide is a glucagon-l ike peptide 1 receptor agonist that has been noted to have a significant role in the reduction of body weight and glycaemic control. An increasing body of evidence from recent trials (SUSTAIN-6, SELECT and STEP HF) has shown significant cardiovascular benefits of semaglutide in both patients with and without diabetes and in people who are obese or overweight. Additio...
Society for Cardiovascular Magnetic Resonance 2022 Cases of SCMR case series.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE - 01 Jan 2024
"Cases of SCMR" is a case series on the SCMR website (https://www.scmr.org) for the purpose of education. The cases reflect the clinical presentation, and the use of cardiovascular magnetic resonance (CMR) in the diagnosis and management of cardiovascular disease. The 2022 digital collection of cases are presented in this manuscript.
Reflecting on a Year at the Helm of Diabetes Care.
DIABETES CARE - 01 Jan 2024
Low-calorie diets for people with isolated impaired fasting glucose.
COMMUNICATIONS MEDICINE - 01 Mar 2024
Standard lifestyle interventions prove ineffective in preventing type 2 diabetes among individuals with isolated impaired fasting glucose, a highly prevalent prediabetes phenotype globally. Here, we propose low-calorie diets as a promising strategy for diabetes prevention in this high-risk population.
COX2 inhibitor use and type 2 diabetes treatment intensification: A registry-based cohort study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Jan 2024
This study examined the association between cyclooxygenase-2 inhibitor (COX2i) use and diabetes progression in people with type 2 diabetes. We conducted a nation-wide cohort study using an Australian diabetes registry linked to medication dispensing data. We assessed time to diabetes treatment intensification among new users of COX2i compared to mild opioids. Inverse probability of treatment-we...
Codesigning enhanced models of care for Northern Australian Aboriginal and Torres Strait Islander youth with type 2 diabetes: study protocol.
BMJ OPEN - 07 Mar 2024
Premature onset of type 2 diabetes and excess mortality are critical issues internationally, particularly in Indigenous populations. There is an urgent need for developmentally appropriate and culturally safe models of care. We describe the methods for the codesign, implementation and evaluation of enhanced models of care with Aboriginal and Torres Strait Islander youth living with type 2 diabe...
Response to letter from Geoffrey W. Stuart.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 04 Apr 2024
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Impact of Baseline Left Atrial Size on Outcomes Following Catheter Ablation for AF in Patients With Left Ventricular Systolic Dysfunction.
CIRCULATION. ARRHYTHMIA AND ELECTROPHYSIOLOGY - 17 Apr 2024
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Plasma Lipidomic Profiling Identifies Elevated Triglycerides as Potential Risk Factor in Chemotherapy-Induced Peripheral Neuropathy.
JCO PRECISION ONCOLOGY - 01 Apr 2024
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of cytotoxic cancer treatment, often necessitating dose reduction (DR) or chemotherapy discontinuation (CD). Studies on peripheral neuropathy related to chemotherapy, obesity, and diabetes have implicated lipid metabolism. This study examined the association between circulating lipids and CIPN. Lipidomic analysis w...
Comparing and assessing physical activity and sedentary behaviour guidelines for different populations with and without chronic conditions and/or disabilities: a systematic review protocol.
BMJ OPEN SPORT & EXERCISE MEDICINE - 01 Jan 2024
Physical activity guidelines targeting different populations with and without chronic diseases or disabilities are required to meet the diverse functional and physiological needs experienced by different subgroups of people to achieve optimal health benefits. As the importance of physical activity guidelines in promoting optimal health and well-being becomes increasingly recognised, there is a ...
