Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs.
Its purpose is to make our research findings available to the widest possible audience.
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This open access repository contains the full text of articles, subject to copyright constraints.
Now showing items 1-20 of 3123 records
Association Between Depressive Symptoms and Incident Cardiovascular Diseases.
JAMA - 15 Dec 2020
It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs).To characterize the association between depressive symptoms and CVD incidence across the spectrum of lower mood.A pooled analysis of individual-participant data from the Emerging Risk Factors Collaboration (ERFC; 162 036 participants; 21 cohorts; baseline surveys, 1960...
Comparison of Circulatory Unloading Techniques for Venoarterial Extracorporeal Membrane Oxygenation.
ASAIO JOURNAL (AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS : 1992) - 01 Jun 2021
Left ventricular (LV) distention and pulmonary congestion are major complications inherent to venoarterial extracorporeal membrane oxygenation (ECMO). This study aimed to quantitatively compare the hemodynamic differences between common circulatory unloading methods for ECMO. Ten circulatory unloading techniques were evaluated on a mock circulatory loop simulating acute LV failure supported by ...
Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Jan 2021
In healthy and overweight/obese adults, interrupting prolonged sitting with activity bouts mitigates impairment in vascular function. However, it is unknown whether these benefits extend to those with type 2 diabetes (T2D), nor whether an optimal frequency of activity interruptions exist. We examined the acute effects on vascular function in T2D of interrupting prolonged sitting with simple res...
Walking-friendly built environments and objectively measured physical function in older adults.
JOURNAL OF SPORT AND HEALTH SCIENCE - 01 Dec 2020
Few studies have examined the associations between urban design attributes and older adults' physical function. Especially, it is not well known how built-environment attributes may influence physical function in Asian cities. The aim of this study was to examine associations between objectively measured environmental attributes of walkability and objectively assessed physical function in a sam...
Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities.
CARDIOVASCULAR RESEARCH - 01 Dec 2020
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic. Strikingly, men account for the majority of COVID-19 deaths, with current figures ranging from 59% to 75% of total mortality. However, despite clear implications in relation to COVID-19 mortality, most research has not consi...
Identifying Genotype-Phenotype Correlations via Integrative Mutation Analysis.
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2021
Mutations in protein-coding regions can lead to large biological changes and are associated with genetic conditions, including cancers and Mendelian diseases, as well as drug resistance. Although whole genome and exome sequencing help to elucidate potential genotype-phenotype correlations, there is a large gap between the identification of new variants and deciphering their molecular consequenc...
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
CARDIOVASCULAR DRUGS AND THERAPY - 01 Dec 2020
HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used it to confirm the therapeutic efficacy of the mitochondria-targeted dicarbonyl scavenger, MitoGamide.A longitudinal echocardiographic analysis confirmed that Akita mice develop diast...