Circadian challenges such as social and travel jetlag, poor sleep health or undertaking shift-work is becoming increasingly linked to incidences of cardiovascular disease, metabolic syndrome and hypertension due to the impact of circadian disruption. Currently, studies that address how such challenges can become specific risk factors for the development of hypertension show inconsistent findings and the underlying pathophysiology is not well understood. Using a cross-sectional study approach, we investigate the associations between markers of circadian strain, including sleep length, sleep quality and shift-work, and blood pressure. Furthermore, we explore whether systemic inflammation could be a potential driving mechanism in these associations. Systolic and diastolic blood pressure (SBP and DBP, respectively) measurements collected from European White participants recruited under the UK Biobank …