Determinants of oxygen utilization in breast cancer: Similarities between heart failure with preserved ejection fraction.

Mark J Haykowsky; Amy A Kirkham; Todd Li; Edith Pituskin; Richard B Thompson; D Ian Paterson; Stephen J Foulkes; Martin Halle; Satyam Sarma; Erin Howden; Michael D Nelson; Andre La Gerche
Abstract
Reduced exercise tolerance and fatigue are hallmark features in both breast cancer (BC) and heart failure with preserved ejection fraction (HFpEF) and are associated with decreased physical function and quality of life. This brief review focuses on the mechanisms of exercise intolerance in women with BC across the survivorship continuum and highlights how these disturbances within the oxygen transport cascade are similar to that of HFpEF patients. Specifically, the role that impaired cardiac, peripheral vascular and skeletal muscle function play in limiting peak oxygen uptake are discussed. We propose that women with BC are at increased risk of developing HFpEF potentially due to the adverse effects of chemotherapy and concurrent adverse lifestyle behaviors on cardiovascular and skeletal muscle function.
Journal PROGRESS IN CARDIOVASCULAR DISEASES
ISSN 1873-1740
Published 22 Oct 2022
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DOI 10.1016/j.pcad.2022.10.005
Type Journal Article | Review
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