New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics.
Crisdion Krstevski; Charles D Cohen; Alexander R Pinto; Malathi Imiyage Dona
Abstract
Single-cell transcriptomics enables inference of context-dependent phenotypes of individual cells and determination of cellular diversity of complex tissues. Cardiac fibrosis is a leading factor in the development of heart failure and a major cause of morbidity and mortality worldwide with no effective treatment. Single-cell RNA-sequencing (scRNA-seq) offers a promising new platform to identify new cellular and molecular protagonists that may drive cardiac fibrosis and development of heart failure. This review will summarize the application scRNA-seq for understanding cardiac fibrosis and development of heart failure. We will also discuss some key considerations in interpreting scRNA-seq data and some of its limitations.
Journal | BIOCHEMICAL SOCIETY TRANSACTIONS |
ISSN | 1470-8752 |
Published | 01 Dec 2020 |
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DOI | 10.1042/BST20191255 |
Type | Journal Article |
Sponsorship |