EasyVS is a web-based platform built to simplify molecule library selection and virtual screening. With an intuitive interface, the tool allows users to go from selecting a protein target with a known structure and tailoring a purchasable molecule library to performing and visualising docking in a few clicks. Our system also allows users to filter screening libraries based on molecule properties, cluster molecules by similarity and personalise docking parameters.EasyVS is freely available as an easy-to-use web interface at http://biosig.unimelb.edu.au/easyvs.Supplementary data are available at Bioinformatics online.