OBJECTIVE: To examine associations of accelerometer-assessed sedentary time and self-reported screen time with sleep outcomes. METHODS: Cross-sectional study of 1674 adults from the 2005-2006 US National Health and Nutrition Examination Survey. Accelerometers were used to assess sedentary time. Screen time and sleep metrics were assessed via self-report. RESULTS: Accelerometer-assessed sedentary time was not associated with sleep outcomes. Compared to participants with the least screen time (<2h/ day), participants with the most screen time (>6h/day) were more likely to report trouble falling asleep (OR = 2.78, 95% CI: 1.21, 6.40) and wake during the night (OR = 2.55, 95% CI: 1.17, 5.52). CONCLUSIONS: With respect to sleep outcomes, context-specific sedentary behaviors may be more important than overall sedentary time.