Frailty represents a state of increased physiological vulnerability and diminished reserve, as well as a complex interaction between age, comorbidities, demographics, and lifestyle. Frailty has repeatedly been demonstrated to be an independent prognostic factor across the spectrum of cardiovascular disease; however, frail patients are often excluded from major clinical trials, leading to a significant gap in the evidence. In this review, we discuss the impact of nutrition and exercise interventions on frailty and, consequently, on cardiovascular disease.