Now showing items 61-80 of 3288 records
Feasibility, Reproducibility, and Clinical Implications of the Novel Fully Automated Assessment for Global Longitudinal Strain.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 05 Dec 2020
Despite evidence of its usefulness, measurement of global longitudinal strain (GLS) has not been widely accepted as a clinical routine, because it requires proficiency and is time consuming. Automated assessment of GLS may be the solution for this situation. The aim of this study was to investigate the feasibility, reproducibility, and predictive value of automated strain analysis compared with...
Prognostic value of coronary artery calcium scoring and computed tomography coronary angiography in remote indigenous and non-indigenous Australians.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 09 Dec 2020
The long-term prognostic utility of coronary calcification and coronary artery disease on computed tomography coronary angiography (CTCA) in remote Indigenous and non-Indigenous Australians is not known.Consecutive patients undergoing CTCA from 2013 to 2017 in Central Australia were followed-up for major adverse cardiovascular events (MACE).347 patients were included (50 ± 12 years; 47% female;...
The adrenal medulla in cardiovascular medicine: an untold story.
JOURNAL OF HYPERTENSION - 12 Dec 2020
: Unlike noradrenaline, the sympathetic neurotransmitter which overflows to the circulation, adrenaline (ADR) is a secreted hormone, with a low plasma concentration, and plasma concentration for biological action a log order lower than that of noradrenaline. The venous drainage of the left adrenal medulla into the left renal vein does expose this vein to uniquely high plasma ADR concentrations ...
Proof that exercise works, now it's time for optimizing delivery to our patients with pulmonary hypertension.
EUROPEAN HEART JOURNAL - 12 Dec 2020
Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses.
DIABETOLOGIA - 14 Dec 2020
Few studies examine the association between age at diagnosis and subsequent complications from type 2 diabetes. This paper aims to summarise the risk of mortality, macrovascular complications and microvascular complications associated with age at diagnosis of type 2 diabetes.Data were sourced from MEDLINE and All EBM (Evidence Based Medicine) databases from inception to July 2018. Observational...
Echocardiography in Long QT Syndrome: The Mechanical Face of an Electrical Disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 15 Dec 2020
Identifying Genotype-Phenotype Correlations via Integrative Mutation Analysis.
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2021
Mutations in protein-coding regions can lead to large biological changes and are associated with genetic conditions, including cancers and Mendelian diseases, as well as drug resistance. Although whole genome and exome sequencing help to elucidate potential genotype-phenotype correlations, there is a large gap between the identification of new variants and deciphering their molecular consequenc...
Impact of disease stage on the performance of strain markers in the prediction of atrial fibrillation.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 26 Sep 2020
Assessing atrial fibrillation (AF) risk may be useful in primary prevention (PP; people with risk factors) and secondary prevention (SP; eg. embolic stroke of unknown source). We sought whether disease stage influenced the prediction of AF by echocardiography.We compared a PP cohort (351 community-based participants ≥65 years with ≥1 risk factor for AF) and a SP cohort (453 patients after trans...
Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.
CARDIOVASCULAR DRUGS AND THERAPY - 26 Sep 2020
HFpEF (heart failure with preserved ejection fraction) is a major consequence of diabetic cardiomyopathy with no effective treatments. Here, we have characterized Akita mice as a preclinical model of HFpEF and used it to confirm the therapeutic efficacy of the mitochondria-targeted dicarbonyl scavenger, MitoGamide.A longitudinal echocardiographic analysis confirmed that Akita mice develop diast...
Changing dietary approaches to prevent cardiovascular disease.
CURRENT OPINION IN LIPIDOLOGY - 29 Sep 2020
We have focused on recent research relevant to effects of dietary patterns and major food groups on cardiovascular outcomes, taking into account guidelines and position statements from expert authorities, with an emphasis on important changes in recommendations, some of which remain controversial.Major findings include: refocusing on qualitative patterns of food consumption replacing quantitati...
Differential sympathetic response to lesion-induced chronic kidney disease in rabbits.
KIDNEY INTERNATIONAL - 01 Oct 2020
Chronic kidney disease (CKD) is associated with greater sympathetic nerve activity but it is unclear if this is a kidney-specific response or due to generalized stimulation of sympathetic nervous system activity. To determine this, we used a rabbit model of CKD in which quantitative comparisons with control rabbits could be made of kidney sympathetic nerve activity and whole-body norepinephrine...
Built environment correlates of objectively-measured sedentary behaviours in densely-populated areas.
HEALTH & PLACE - 02 Oct 2020
Few studies examine associations between objectively-calculated neighbourhood built environment attributes and objectively-assessed sedentary behaviour in different geographical locations, especially in highly-populated environments. Additionally, no study, to our knowledge, has investigated associations between objective measures of neighbourhood built environment attributes and objectively-as...
Long-Term Outcomes Stratified by Body Mass Index in Patients Undergoing Transcatheter Aortic Valve Implantation.
THE AMERICAN JOURNAL OF CARDIOLOGY - 02 Oct 2020
Transcatheter aortic valve implantation (TAVI) is emerging as the default strategy for older patients with severe, symptomatic, and trileaflet aortic stenosis. Increased body-mass index (BMI) is associated with a protective effect in patients undergoing percutaneous coronary intervention. We assessed whether elevated BMI was associated with a similar association in TAVI. We evaluated prospectiv...
Nocturnal hypertension: a common phenotype in a tertiary clinical setting associated with increased arterial stiffness and central blood pressure.
JOURNAL OF HYPERTENSION - 06 Oct 2020
Although the detrimental effect of increased mean blood pressure (BP) is well established, the role of the dynamic and circadian features of BP is less well defined but may be similarly important. In this prospective analysis of hypertensive patients from a tertiary hospital hypertension clinic, we investigated whether the presence of night-time systolic hypertension is associated with more pro...
Changes in prevalence of diabetes over 15 years in a rural Australian population: The Crossroads Studies.
DIABETES RESEARCH AND CLINICAL PRACTICE - 08 Oct 2020
Secular trends in diabetes prevalence vary globally. We compared the prevalence of diabetes in two surveys 15 years apart in rural Australia.Two cross-sectional household surveys and clinics (biomedical assessments including oral glucose tolerance tests (OGTTs)) in 2001-2003 (Crossroads) and 2016-2018 (Crossroads-II).Four rural Victorian towns.Residents of randomly selected households (Crossroa...
Endothelial specific overexpression of cationic amino acid transporter-1 prevents loss of renal function in cardiorenal syndrome type 2.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 09 Oct 2020
Heart failure (HF) is associated with impaired L-arginine transport. In the present study, we tested the hypothesis that augmented L-arginine transport prevents the loss of kidney function in HF. Renal function was assessed in wild-type mice (WT), transgenic mice with HF (DCM) and double transgenic mice (HFCAT-1) with HF and endothelial specific overexpression of the predominant L-arginine tran...
Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis.
JOURNAL OF HEPATOLOGY - 19 Apr 2021
Obesity often leads to nonalcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (nonalcoholic fatty liver (NAFL)) to nonalcoholic steatohepatitis (NASH). The accumulation of certain lipid subtypes is linked with worsening metabolic and liver disease, however, specific changes during progression from No-NAFL to NAFL then NASH are unresolved. Here, we characterise the li...
Medical Evaluation of Athletes: Further Imaging Modalities—Stress Echo, CT and MRI
TEXTBOOK OF SPORTS AND EXERCISE CARDIOLOGY - 01 Jan 2020
Switzerland: Springer International Publishing
Machine Learning Applied To Energy Waveform ECG for Prediction of Stage B Heart Failure in the Community
J AM COLL CARDIOL - 01 Mar 2020
Energy waveform (ew) ECG uses continuous wavelet transforms (CWT) to create time-frequency energy characterizations. Although ewECG changes reflect myocardial disease, optimal features for prediction of subclinical left ventricular dysfunction (Stage B heart failure [SBHF]) are unclear. Using machine learning (ML), we investigated whether ewECG could predict SBHF in at-risk community subjects t...
New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics.
BIOCHEMICAL SOCIETY TRANSACTIONS - 01 Dec 2020
Single-cell transcriptomics enables inference of context-dependent phenotypes of individual cells and determination of cellular diversity of complex tissues. Cardiac fibrosis is a leading factor in the development of heart failure and a major cause of morbidity and mortality worldwide with no effective treatment. Single-cell RNA-sequencing (scRNA-seq) offers a promising new platform to identify...