Publications
Now showing items 41-60 of 2807 records
Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases.
JOURNAL OF LIPID RESEARCH - 30 Aug 2019
Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells. In hematopoietic stem and progenitor cells, lipid rafts house receptors critical for normal hematopoiesis. Lipid rafts also can bind and sequester kinases that induce negative feedback pathways to limit proliferative cytokine receptor cycling b...
Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys.
LANCET (LONDON, ENGLAND) - 24 Aug 2019
Antihypertensive medicines are effective in reducing adverse cardiovascular events. Our aim was to compare hypertension awareness, treatment, and control, and how they have changed over time, in high-income countries.We used data from people aged 40-79 years who participated in 123 national health examination surveys from 1976 to 2017 in 12 high-income countries: Australia, Canada, Finland, Ger...
Rising rural body-mass index is the main driver of the global obesity epidemic in adults.
NATURE - 01 May 2019
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report nat...
National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 18 Jul 2019
Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.We pooled 458 population-based studies with 82.1 million participant...
World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions.
THE LANCET. GLOBAL HEALTH - 01 Oct 2019
To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions.In this model ...
Burden of macro- and micro-vascular complications of type 2 diabetes in Bangladesh.
DIABETES & METABOLIC SYNDROME - 01 Jan 2001
The aim was to estimate the burden of macro- and micro-vascular complications on hospitalisation and healthcare cost among people with type 2 diabetes mellitus in Bangladesh.A cross-sectional study was carried out in 2017. A total of 1253 patients were recruited from six hospitals. Information related to cost and complications of type 2 diabetes were collected. Multiple logistic and non-paramet...
Glycaemic Control for People with Type 2 Diabetes Mellitus in Bangladesh - An urgent need for optimization of management plan.
SCIENTIFIC REPORTS - 15 Jul 2019
The objective of this study was to identify the determinants of glycaemic control among people with type 2 diabetes mellitus in Bangladesh. A cross-sectional study was carried out during March to September 2017, and 1253 adult patients with type 2 diabetes mellitus were recruited from six hospitals. Data were collected from patients via face-to-face interview, and their medical records were rev...
Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9 edition.th
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Nov 2019
To provide global estimates of diabetes prevalence for 2019 and projections for 2030 and 2045.A total of 255 high-quality data sources, published between 1990 and 2018 and representing 138 countries were identified. For countries without high quality in-country data, estimates were extrapolated from similar countries matched by economy, ethnicity, geography and language. Logistic regression was...
Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes.
BMJ OPEN DIABETES RESEARCH & CARE - 01 Jan 2019
There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful.We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease ...
Living liveable? RESIDE's evaluation of the "Liveable Neighborhoods" planning policy on the health supportive behaviors and wellbeing of residents in Perth, Western Australia.
SSM - POPULATION HEALTH - 01 Apr 2020
The RESIDential Environments (RESIDE) project is a unique longitudinal natural experiment designed to evaluate the health impacts of the "Liveable Neighbourhoods" planning policy, which was introduced by the Western Australian government to create more walkable suburbs.To summarize the RESIDE evidence of the impact of the planning policy on a range of health-supportive behaviours and wellbeing ...
The application of artificial intelligence (AI) techniques to identify frailty within a residential aged care administrative data set.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS - 04 Feb 2020
Research has shown that frailty, a geriatric syndrome associated with an increased risk of negative outcomes for older people, is highly prevalent among residents of residential aged care facilities (also called long term care facilities or nursing homes). However, progress on effective identification of frailty within residential care remains at an early stage, necessitating the development of...
Process evaluation of a workplace-based health promotion and exercise cluster-randomised trial to increase productivity and reduce neck pain in office workers: a RE-AIM approach.
BMC PUBLIC HEALTH - 04 Feb 2020
This study uses the RE-AIM framework to provide a process evaluation of a workplace-based cluster randomised trial comparing an ergonomic plus exercise intervention to an ergonomic plus health promotion intervention; and to highlight variations across organisations; and consider the implications of the findings for intervention translation.This study applied the RE-AIM (reach, effectiveness, ad...
Structure guided prediction of Pyrazinamide resistance mutations in pncA.
SCIENTIFIC REPORTS - 05 Feb 2020
Pyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing. Resistance to pyrazinamide is largely driven by mutations in pyrazinamidase (pncA), responsible for drug activation, but genetic heterogeneity has hindered development of a molecular diagnostic test. We proposed to use informat...
The role of afferent renal denervation in renovascular hypertension-another brick in the wall.
PFLUGERS ARCHIV : EUROPEAN JOURNAL OF PHYSIOLOGY - 05 Feb 2020
A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study.
TRIALS - 12 Feb 2020
Patients with rheumatoid arthritis spend most of their daily hours in sedentary behavior (sitting), a predisposing factor to poor health-related outcomes and all-cause mortality. Interventions focused on reducing sedentary time could be of novel therapeutic relevance. However, studies addressing this topic remain scarce. We aim to investigate the feasibility and efficacy of a newly developed in...
A Cost and Cost-Benefit Analysis of the Stand More AT Work (SMArT Work) Intervention.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 13 Feb 2020
This study conducted a cost and cost-benefit analysis of the Stand More AT (SMArT) Work workplace intervention, designed to reduce sitting time. The study was a cluster two-armed randomised controlled trial involving 37 office clusters (146 desk-based workers) in a National Health Service Trust. The intervention group received a height-adjustable workstation with supporting behaviour change str...
Benefit of lifestyle-based T2DM prevention is influenced by prediabetes phenotype.
NATURE REVIEWS. ENDOCRINOLOGY - 14 Feb 2020
The prevention of type 2 diabetes mellitus (T2DM) is a target priority for the WHO and the United Nations and is a key priority in the 2018 Berlin Declaration, which is a global call for early actions related to T2DM. Health-care policies advocate that individuals at high risk of developing T2DM undertake lifestyle modification, irrespective of whether the prediabetes phenotype is defined by hy...
Outcomes of cardiogenic shock complicating acute coronary syndromes.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS - 03 Feb 2020
We aimed to assess the outcomes of cardiogenic shock (CS) complicating acute coronary syndromes (ACS).CS remains the leading cause of mortality in patients presenting with ACS despite advances in care.We studied 13,184 patients undergoing percutaneous coronary intervention (PCI) for all subtypes of ACS enrolled prospectively in a large multicentre Australian registry (Melbourne Interventional G...
Mapping the Associations of the Plasma Lipidome with Insulin Resistance and Response to an Oral Glucose Tolerance Test.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 04 Feb 2020
Insulin resistance (IR) remains a global health challenge. Lipidomics offers an opportunity to identify biomarkers and better understand mechanisms of IR associated with abnormal lipid metabolism.To determine plasma lipid species associated with indices of insulin resistance and evaluate the lipidome response to an OGTT.Community based cross-sectional.Plasma samples (collected at 0 and 120 min ...
Association between heart rate variability indices and features of spontaneous ventricular tachyarrhythmias in mice.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY & PHYSIOLOGY - 06 Feb 2020
Direct evidence is limited for the association between heart rate variability (HRV) indices and ventricular tachyarrhythmias (VTAs). While galectin-3 (Gal-3) is regarded as a causal factor for cardiac remodelling and a biomarker for arrhythmias, its regulation on VTAs and HVR is unknown. Using aged transgenic (TG) mice with cardiac overexpression of β -adrenoceptors and spontaneous VTAs, we stu...
