Now showing items 41-60 of 3288 records
The End Unexplained Cardiac Death (EndUCD) Registry for Young Australian Sudden Cardiac Arrest.
HEART, LUNG & CIRCULATION - 13 Nov 2020
In 2019, the first multi-source registry of sudden cardiac arrest and death for patients aged 1-50 years launched in Victoria, Australia. Sudden cardiac arrest (SCA) affects approximately fifteen hundred younger Victorians per year. The End Unexplained Cardiac Death (EndUCD) Registry enrols SCA/D cases aged 1-50 years, providing family screening, access to psychological support through clinical...
Persistent Troponin Elevation in Left-Dominant Arrhythmogenic Cardiomyopathy.
CIRCULATION. GENOMIC AND PRECISION MEDICINE - 01 Dec 2020
Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 16 Nov 2020
In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardio-protective therapy (CPT) is constrained by the low sensitivity of EF for minor changes in LV function. Global longitudinal strain (GLS) is a robust and sensitive marker of LV dysfunction, but existing observational data have been insufficient to support a routine GLS-guided strategy for CPT.To identi...
Prescription trends and costs of diabetes medications in Australia between 2003 and 2019: an analysis and review of the literature.
INTERNAL MEDICINE JOURNAL - 16 Nov 2020
Since the turn of the century, the prevalence of diabetes mellitus in Australia has increased, primarily due to rising rates of type 2 diabetes. Simultaneously, the landscape of diabetes medications has evolved significantly. The change in prescribing trends and public spending on diabetes medications within Australia during this period are not well defined.We sought to establish the frequency ...
Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin.
EUROPEAN HEART JOURNAL - 16 Nov 2020
Recent European Guidelines for Diabetes, Prediabetes and Cardiovascular Diseases introduced a shift in managing patients with type 2 diabetes at high risk for or established cardiovascular (CV) disease by recommending GLP-1 receptor agonists and SGLT-2 inhibitors as initial glucose-lowering therapy. This is questioned since outcome trials of these drug classes had metformin as background therap...
Is replacing sedentary time with bouts of physical activity associated with inflammatory biomarkers in children?
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS - 17 Nov 2020
This study aimed to investigate the theoretical impact of reallocating a specific amount of sedentary time with an equal amount of (a) total, and (b) ≥1min-bout-accumulated time spent in different activity intensities, on inflammatory biomarkers in 8-9 year old children. Accelerometry and inflammatory biomarker baseline data from the Transform-Us! Study (complete cases n=149) was utilized. Isot...
Evolution of Myocardial Dysfunction in Asymptomatic Patients at Risk of Heart Failure.
JACC. CARDIOVASCULAR IMAGING - 18 Nov 2020
The determinants of changes in systolic and diastolic parameters in patients aged >65 years, at risk of heart failure (HF), and with and without asymptomatic type 2 diabetes mellitus (T2DM) was assessed by echocardiography. The association between metformin and myocardial function was also assessed.The increasing prevalence of T2DM will likely further fuel the epidemic of HF. Understanding the ...
Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure with Preserved Ejection Fraction.
CIRCULATION - 18 Nov 2020
Chronotropic incompetence (CI) is common in HFpEF and is linked to impaired aerobic capacity. Whether upstream autonomic signaling pathways responsible for raising exercise heart rate (HR) are impaired in HFpEF is unknown. We investigated the integrity of central command and muscle metaboreceptor function, two predominant mechanisms responsible for exertional increases in HR, in HFpEF and senio...
Metabolic profiles of socio-economic position: a multi-cohort analysis.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 21 Nov 2020
Low socio-economic position (SEP) is a risk factor for multiple health outcomes, but its molecular imprints in the body remain unclear.We examined SEP as a determinant of serum nuclear magnetic resonance metabolic profiles in ∼30 000 adults and 4000 children across 10 UK and Finnish cohort studies.In risk-factor-adjusted analysis of 233 metabolic measures, low educational attainment was associa...
The conundrum of the gut microbiome and blood pressure: the importance of studying sex and ethnicity.
EUROPEAN HEART JOURNAL - 21 Nov 2020
IGF1-PI3K-induced physiological cardiac hypertrophy: Implications for new heart failure therapies, biomarkers, and predicting cardiotoxicity.
JOURNAL OF SPORT AND HEALTH SCIENCE - 24 Nov 2020
Heart failure represents the end point of a variety of cardiovascular diseases. It is a growing health burden and a leading cause of death worldwide. To date, limited treatment options exist for the treatment of heart failure, but exercise has been well-established as one of the few safe and effective interventions, leading to improved outcomes in patients. However, a lack of patient adherence ...
Serial Cardiovascular Magnetic Resonance Strain Measurements to Identify Cardiotoxicity in Breast Cancer: Comparison With Echocardiography.
JACC. CARDIOVASCULAR IMAGING - 25 Nov 2020
This study sought to compare the prognostic value of cardiovascular magnetic resonance (CMR) and 2-dimensional echocardiography (2DE) derived left ventricular (LV) strain, volumes, and ejection fraction for cancer therapy-related cardiac dysfunction (CTRCD) in women with early stage breast cancer.There are limited comparative data on the association of CMR and 2DE derived strain, volumes, and L...
Interpretation of clinical studies in electrophysiology: statistical considerations for the clinician.
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 25 Nov 2020
Atrial fibrillation (AF) outcome studies play an essential role in the development of clinical evidence to improve the management of AF patients. Understanding the statistical considerations involved in study design and interpretation is crucial if electrophysiologists are to change practice. In this review, with the guidance of a medical statistician and a clinical trialist we provide an overv...
Screening of Potential Cardiac Involvement in Competitive Athletes Recovering From COVID-19: An Expert Consensus Statement.
JACC. CARDIOVASCULAR IMAGING - 01 Dec 2020
As our understanding of the complications of coronavirus disease-2019 (COVID-19) evolve, subclinical cardiac pathology such as myocarditis, pericarditis, and right ventricular dysfunction in the absence of significant clinical symptoms represents a concern. The potential implications of these findings in athletes are significant given the concern that exercise, during the acute phase of viral m...
Walking-friendly built environments and objectively measured physical function in older adults.
JOURNAL OF SPORT AND HEALTH SCIENCE - 01 Dec 2020
Few studies have examined the associations between urban design attributes and older adults' physical function. Especially, it is not well known how built-environment attributes may influence physical function in Asian cities. The aim of this study was to examine associations between objectively measured environmental attributes of walkability and objectively assessed physical function in a sam...
Vascular compression of the rostral ventrolateral medulla: a relevant indicator of sympathetically driven blood pressure variability?
JOURNAL OF HYPERTENSION - 01 Dec 2020
Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities.
CARDIOVASCULAR RESEARCH - 01 Dec 2020
The high mortality rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is a critical concern of the coronavirus disease 2019 (COVID-19) pandemic. Strikingly, men account for the majority of COVID-19 deaths, with current figures ranging from 59% to 75% of total mortality. However, despite clear implications in relation to COVID-19 mortality, most research has not consi...
Supine blood pressure-A clinically relevant determinant of vascular target organ damage in hypertensive patients.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 03 Dec 2020
Night-time blood pressure (BP) is an important predictor of cardiovascular outcomes. Its assessment, however, remains challenging due to limited accessibility to ambulatory BP devices in many settings, costs, and other factors. We hypothesized that BP measured in a supine position during daytime may perform similarly to night-time BP when modeling their association with vascular hypertension-me...
Reducing Intracranial Pressure by Reducing Central Venous Pressure: Assessment of potential countermeasures to spaceflight associated neuro-ocular syndrome.
JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) - 03 Dec 2020
Spaceflight-associated neuro-ocular syndrome (SANS) involves unilateral or bilateral optic disc edema, widening of the optic nerve sheath, and posterior globe flattening. Due to posterior globe flattening, it is hypothesized that microgravity causes a disproportionate change in intracranial pressure (ICP) relative to intraocular pressure. Countermeasures capable of reducing ICP include thigh cu...
Comparison of ambulatory blood pressure between patients with primary aldosteronism and other forms of hypertension.
CLINICAL ENDOCRINOLOGY - 03 Dec 2020
Primary aldosteronism (PA) is a potentially curable cause of hypertension associated with worse cardiovascular prognosis than blood pressure-matched essential hypertension (EH). Effective targeted treatment for PA is available with the greatest benefit seen if treatment is started early, prior to the development of end-organ damage. However, PA is currently substantially under-diagnosed. The st...