Publications
Now showing items 101-120 of 4509 records
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 09 Dec 2022
Cardiovascular disease (CVD) remains the leading cause of death worldwide. An ongoing challenge remains the development of novel pharmacotherapies to treat CVD, particularly atherosclerosis. Effective mechanism-informed development and translation of new drugs requires a deep understanding of the known and currently unknown biological mechanisms underpinning atherosclerosis, accompanied by opti...
Reasons for hospitalisation in Australians with type 2 diabetes compared to the general population, 2010-2017.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Dec 2022
We sought to quantify the burden and diversity of reasons for hospital admission amongst Australians with type 2 diabetes compared to the general population.We linked Australians aged 15 and above with type 2 diabetes on the National Diabetes Services Scheme (n = 456,265) to hospital admission data to determine hospitalisation risks at ICD-10 three-digit diagnosis level for 2010-2017. We perfor...
Trends in diabetes-related foot disease hospitalizations and amputations in Australia, 2010 to 2019.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Dec 2022
To determine trends in the incidence of hospitalizations and amputations for diabetes-related foot disease (DFD) in Australia.We included 70,766 people with type 1, and 1,087,706 with type 2 diabetes from the Australian diabetes registry from 2010 to 2019, linked to hospital admissions databases. Trends in age-adjusted incidence were summarized as annual percent changes (APC).In people with typ...
The flatlining of cardiac arrest survival: can we revive the upward trend?
EUROPEAN HEART JOURNAL - 07 Dec 2022
Causes, circumstances, and potential preventability of cardiac arrest in the young: insights from a state-wide clinical and forensic registry.
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 09 Dec 2022
The causes, circumstances, and preventability of young sudden cardiac arrest remain uncertain.A prospective state-wide multi-source registry identified all out-of-hospital cardiac arrests (OHCAs) in 1-50 year olds in Victoria, Australia, from 2019 to 2021. Cases were adjudicated using hospital and forensic records, clinic assessments and interviews of survivors and family members. For confirmed...
Assessment of Myocardial Texture: The Next Frontier in Echocardiographic Quantification.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 06 Dec 2022
Using Graph-Based Signatures to Guide Rational Antibody Engineering.
METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) - 01 Jan 2023
Antibodies are essential experimental and diagnostic tools and as biotherapeutics have significantly advanced our ability to treat a range of diseases. With recent innovations in computational tools to guide protein engineering, we can now rationally design better antibodies with improved efficacy, stability, and pharmacokinetics. Here, we describe the use of the mCSM web-based in silico suite,...
Soldiers' Heart: A Prospective Study of Cardiac Remodeling in Soldiers Undergoing Progressive Intensity Exercise Training.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 01 Dec 2022
Most studies reporting cardiac changes with exercise have been cross sectional. The few available longitudinal studies have lacked standardization for environmental confounders. We prospectively assessed the relationship between increasing exercise intensity and cardiac remodeling in a highly standardized cohort of healthy young army soldiers.Sixty-three male army recruits (22 ± 3 yr) underwent...
Assessing the Impact of Colchicine on Coronary Plaque Phenotype After Myocardial Infarction with Optical Coherence Tomography: Rationale and Design of the COCOMO-ACS Study.
CARDIOVASCULAR DRUGS AND THERAPY - 01 Dec 2022
Recurrent event rates after myocardial infarction (MI) remain unacceptably high, in part because of the continued growth and destabilization of residual coronary atherosclerotic plaques, which may occur despite lipid-lowering therapy. Inflammation is an important contributor to this ongoing risk. Recent studies have shown that the broad-acting anti-inflammatory agent, colchicine, may reduce adv...
Early offering transcatheter aortic valve replacement to patients with moderate aortic stenosis: quantifying costs and benefits - a Markov model-based simulation study.
BMJ OPEN - 22 Nov 2023
Aortic stenosis (AS) is one of the most common acquired cardiac valvular diseases. The success of transcatheter aortic valve implantation (TAVI) for severe AS has led to increasing interest in its use to earlier disease-moderate AS (MAS).Model-based study using a Markov microsimulation technique to evaluate the long-term costs and benefits associated with 'early' TAVI. Key data inputs were sour...
A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology.
JOURNAL OF MOLECULAR MEDICINE (BERLIN, GERMANY) - 21 Nov 2023
Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a higher risk of developing heart failure. Specific therapies to treat the diabetic heart are limited. A key mechanism involved in the progression of diabetic cardiomyopathy is dysregulation of cardiac energy metabolism. The aim of this study was to determine if increasing the...
Health economics of detection and treatment of children with familial hypercholesterolemia: to screen or not to screen is no longer the question.
CURRENT OPINION IN ENDOCRINOLOGY, DIABETES, AND OBESITY - 21 Nov 2023
Heterozygous familial hypercholesterolemia (HeFH) is one of the most common monogenic disorders and is safely treatable with lipid-lowering medication. However, most individuals with HeFH remain untreated and undetected, especially in paediatric populations where the potential for long-term therapeutic benefit is higher. Here, we review the recent literature on health economic outcomes for the ...
Modelling the replacement of red and processed meat with plant-based alternatives and the estimated effect on insulin sensitivity in a cohort of Australian adults.
THE BRITISH JOURNAL OF NUTRITION - 20 Nov 2023
Dietary guidelines are increasingly promoting mostly plant-based diets, limits on red meat consumption, and plant-based sources of protein for health and environmental reasons. It is unclear how the resulting food substitutions associate with insulin resistance, a risk factor for type 2 diabetes. We modelled the replacement of red and processed meat with plant-based alternatives and the estimat...
Graft-Host Interaction and Its Effect on Wound Repair Using Mouse Models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 13 Nov 2023
Autologous skin grafting has been commonly used in clinics for decades to close large wounds, yet the cellular and molecular interactions between the wound bed and the graft that mediates the wound repair are not fully understood. The aim of this study was to better understand the molecular changes in the wound triggered by autologous and synthetic grafting. Defining the wound changes at the mo...
Catheter Ablation Using Pulmonary Vein Isolation With vs Without Posterior Left Atrial Wall Isolation in Persistent AF-Reply.
JAMA - 23 May 2023
New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 23 Nov 2022
The status of lipoprotein (a) [Lp(a)] as a cardiovascular risk factor has been resurrected by advances in genetics. Mendelian randomization studies show a causal link of Lp(a) with coronary artery disease (CAD), peripheral artery disease (PAD), and calcific aortic valve stenosis (CAVS). The genetics of Lp(a) is complex and extends beyond the kringle-IV type 2, as it is also dependent on ancestr...
Effect of Hydralazine on Angiotensin II-Induced Abdominal Aortic Aneurysm in Apolipoprotein E-Deficient Mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 03 Nov 2023
The rupture of an abdominal aortic aneurysm (AAA) causes about 200,000 deaths worldwide each year. However, there are currently no effective drug therapies to prevent AAA formation or, when present, to decrease progression and rupture, highlighting an urgent need for more research in this field. Increased vascular inflammation and enhanced apoptosis of vascular smooth muscle cells (VSMCs) are i...
The impact of COVID-19 pandemic on out-of-hospital cardiac arrest: an individual patient data meta-analysis.
RESUSCITATION - 10 Nov 2023
Prior studies have reported increased out-of-hospital cardiac arrests (OHCA) incidence and lower survival during the COVID-19 pandemic. We evaluated how the COVID-19 pandemic affected OHCA incidence, bystander CPR rate and patients' outcomes, accounting for regional COVID-19 incidence and OHCA characteristics.individual patient data meta-analysis of studies which provided a comparison of OHCA i...
A repository of COVID-19 related molecular dynamics simulations and utilisation in the context of nsp10-nsp16 antivirals.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING - 10 Nov 2023
The coronavirus disease 2019 (COVID-19) pandemic highlighted the importance of establishing systems and infrastructure to develop vaccines, antiviral drugs, and therapeutic antibodies against emerging pathogens. Typical drug discovery processes involve targeting suitable proteins to effect pathogen replication or to attenuate host responses, by examining either large chemical databases or prote...
γH2AX in mouse embryonic stem cells: Distribution during differentiation and following γ-irradiation.
CELLS & DEVELOPMENT - 11 Nov 2023
Phosphorylated histone H2AX (γH2AX) represents a sensitive molecular marker of DNA double-strand breaks (DSBs) and is implicated in stem cell biology. We established a model of mouse embryonic stem cell (mESC) differentiation and examined the dynamics of γH2AX foci during the process. Our results revealed high numbers of γH2AX foci in undifferentiated mESCs, decreasing as the cells differentiat...
