Publications
Now showing items 961-980 of 5702 records
Pediatric Blood Pressure and Cardiovascular Health in Adulthood.
CURRENT HYPERTENSION REPORTS - 15 Jun 2024
This review summarizes current knowledge on blood pressure in children and adolescents (youth), with a focus on primary hypertension-the most common form of elevated blood pressure in this demographic. We examine its etiology, progression, and long-term cardiovascular implications. The review covers definitions and recommendations of blood pressure classifications, recent developments in measur...
The worldwide trend in diabetes awareness, treatment, and control from 1985 to 2022: a systematic review and meta-analysis of 233 population-representative studies.
FRONTIERS IN PUBLIC HEALTH - 01 Jan 2024
With the rapid increase in the prevalence of DM, studies on the awareness, treatment, and control of this condition are essential. Therefore, this study aimed to review the literature and pool the awareness, treatment, and control of diabetes at the global, regional, and national levels. In this systematic review and meta-analysis, several databases, including MEDLINE/PubMed, Institute of Scien...
Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer.
ANNALS OF ONCOLOGY : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY - 01 Jun 2024
The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. CRC has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mend...
Health economic analysis of polygenic risk score use in primary prevention of coronary artery disease - A system dynamics model.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY - 01 Jun 2024
Primary prevention programs utilising traditional risk scores fail to identify all individuals who suffer acute cardiovascular events. We aimed to model the impact and cost effectiveness of incorporating a Polygenic risk scores (PRS) into the cardiovascular disease CVD primary prevention program in Australia, using a whole-of-system model. System dynamics models, encompassing acute and chronic ...
The impact of lifestyle factors on atrial fibrillation.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY - 03 Jun 2024
Atrial fibrillation (AF), with its significant associated morbidity and mortality contributes to significant healthcare utilisation and expenditure. Given its progressively rising incidence, strategies to limit AF development and progression are urgently needed. Lifestyle modification is a potentially potent but underutilised weapon against the AF epidemic. The purpose of this article is to rev...
The effects of electrical stimulation of ventromedial prefrontal cortex on skin sympathetic nerve activity.
CEREBRAL CORTEX (NEW YORK, N.Y. : 1991) - 04 Jun 2024
Skin sympathetic nerve activity (SSNA) is primarily involved in thermoregulation and emotional expression; however, the brain regions involved in the generation of SSNA are not completely understood. In recent years, our laboratory has shown that blood-oxygen-level-dependent signal intensity in the ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are positively ...
Prevalence and outcomes of patients with SMuRF-less acute coronary syndrome undergoing percutaneous coronary intervention.
OPEN HEART - 05 Jun 2024
There is increasing awareness that patients without standard modifiable risk factors (SMuRFs; diabetes, hypercholesterolaemia, hypertension and smoking) may represent a unique subset of patients with acute coronary syndrome (ACS). We aimed to investigate the prevalence and outcomes of patients with SMuRF-less ACS undergoing percutaneous coronary intervention (PCI) compared with those with SMuRF...
Utilization of the EpiMed Coronabank Chemical Collection to identify potential SARS-CoV-2 antivirals: in silico studies targeting the nsp14 ExoN domain and PL<sup>pro</sup> naphthalene binding site.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING - 26 May 2024
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome encodes 29 proteins including four structural, 16 nonstructural (nsps), and nine accessory proteins (https://epimedlab.org/sars-cov-2-proteome/). Many of these proteins contain potential targetable sites for the development of antivirals. Despite the widespread use of vaccinations, the emergence of variants necessitates the...
Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study.
LANCET (LONDON, ENGLAND) - 29 May 2024
Coronary computed tomography angiography (CCTA) is the first line investigation for chest pain, and it is used to guide revascularisation. However, the widespread adoption of CCTA has revealed a large group of individuals without obstructive coronary artery disease (CAD), with unclear prognosis and management. Measurement of coronary inflammation from CCTA using the perivascular fat attenuation...
Iron Macrophages: Dance of Death and MMP Release in Intraplaque Hemorrhage.
THROMBOSIS AND HAEMOSTASIS - 01 Jun 2024
SGLT-2 Inhibitor Use and Cause-Specific Hospitalization Rates: An Outcome-Wide Study to Identify Novel Associations of SGLT-2 Inhibitors.
CLINICAL PHARMACOLOGY AND THERAPEUTICS - 01 Jun 2024
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) have demonstrated multifaceted pharmacological effects. In addition to type 2 diabetes, they are now indicated for heart failure and chronic kidney disease. This study aimed to identify novel associations between SGLT2i use and health outcomes using real-world data. Using linked data from a nationwide diabetes registry in Australia, we compar...
Sex-steroid hormones and risk of postmenopausal estrogen receptor-positive breast cancer: a case-cohort analysis.
01 Jun 2024
Sex-steroid hormones are associated with postmenopausal breast cancer but potential confounding from other biological pathways is rarely considered. We estimated risk ratios for sex-steroid hormone biomarkers in relation to postmenopausal estrogen receptor (ER)-positive breast cancer, while accounting for biomarkers from insulin/insulin-like growth factor-signaling and inflammatory pathways. Th...
Strengthening research capacity of early-mid career researchers: Implementation and evaluation of the Excellence in Non-COmmunicable disease REsearch (ENCORE) program.
JOURNAL OF INVESTIGATIVE MEDICINE : THE OFFICIAL PUBLICATION OF THE AMERICAN FEDERATION FOR CLINICAL RESEARCH - 01 Jun 2024
High-quality training and networking are pivotal for enhancing the research capacity of early- to mid-career researchers in the prevention and control of non-communicable diseases. Beyond building research skills, these professionals gain valuable insights from interdisciplinary mentorship, networking opportunities, and exposure to diverse cultures and health systems. Despite the significance o...
Long-Term Blood Pressure Reductions Following Catheter-Based Renal Denervation: A Systematic Review and Meta-Analysis.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2024
Renal denervation is a recognized adjunct therapy for hypertension with clinically significant blood pressure (BP)-lowering effects. Long-term follow-up data are critical to ascertain durability of the effect and safety. Aside from the 36-month follow-up data available from randomized control trials, recent cohort analyses extended follow-up out to 10 years. We sought to analyze study-level dat...
Engineering G protein-coupled receptors for stabilization.
PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY - 01 Jun 2024
G protein-coupled receptors (GPCRs) are one of the most important families of targets for drug discovery. One of the limiting steps in the study of GPCRs has been their stability, with significant and time-consuming protein engineering often used to stabilize GPCRs for structural characterization and drug screening. Unfortunately, computational methods developed using globular soluble proteins ...
Non-additive effects of electrical stimulation of the dorsolateral prefrontal cortex and the vestibular system on muscle sympathetic nerve activity in humans.
EXPERIMENTAL BRAIN RESEARCH - 01 Jun 2024
Sinusoidal galvanic vestibular stimulation (sGVS) induces robust modulation of muscle sympathetic nerve activity (MSNA) alongside perceptions of side-to-side movement, sometimes with an accompanying feeling of nausea. We recently showed that transcranial alternating current stimulation (tACS) of the dorsolateral prefrontal cortex (dlPFC) also modulates MSNA, but does not generate any perception...
People who need insulin are particularly vulnerable in disasters and conflicts.
BMJ (CLINICAL RESEARCH ED.) - 17 May 2024
Upholding international humanitarian law and ending the weaponisation of aid and medical supplies is critical to protecting the health of people with diabetes during disasters and conflicts, say Alicia J Jenkins and colleagues
Immunometabolism in atherosclerotic disorders
NATURE CARDIOVASCULAR RESEARCH - 23 May 2024
Cardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction and heart failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence suggests a crucial role for immune cell dysfunction and inflammation in the progression of this complex set of diseases. Recent advances demonstrate that immune cells, tightly linked to CVD pathogenesis, are sensitive ...
Mechanobiology. Proceedings of the 4th International Symposium on Mechanobiology. 6th - 9th November 2022. Sydney, Australia.
SPRINGER SERIES IN BIOPHYSICS - 01 Mar 2024
The 4th International Symposium on Mechanobiology (ISMB) organized by the Australian Society for Mechanobiology (AuSMB) took place at the Sydney Nanoscience Hub at the University of Sydney, Australia, from the 6th to the 9th of November 2022. This conference started in 2011 with the founding of the Society in Shanghai, China, and has occurred every three years also visiting Okayama (2014) and m...
Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression.
MOLECULAR THERAPY. NUCLEIC ACIDS - 11 Jun 2024
Epigenetic processes involving long non-coding RNAs regulate endothelial gene expression. However, the underlying regulatory mechanisms causing endothelial dysfunction remain to be elucidated. Enhancer of zeste homolog 2 (EZH2) is an important rheostat of histone H3K27 trimethylation (H3K27me3) that represses endothelial targets, but EZH2 RNA binding capacity and EZH2:RNA functional interaction...
