Publications
Now showing items 921-940 of 5027 records
Stroke genetics informs drug discovery and risk prediction across ancestries.
NATURE - 01 Nov 2022
Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (6...
kinCSM: Using graph-based signatures to predict small molecule CDK2 inhibitors.
PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY - 01 Nov 2022
Protein phosphorylation acts as an essential on/off switch in many cellular signaling pathways. This has led to ongoing interest in targeting kinases for therapeutic intervention. Computer-aided drug discovery has been proven a useful and cost-effective approach for facilitating prioritization and enrichment of screening libraries, but limited effort has been devoted providing insights on what ...
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
MICROBIAL GENOMICS - 01 Nov 2022
is a leading cause of bacterial meningitis in South-East Asia, with frequent zoonotic transfer to humans associated with close contact with pigs. A small number of invasive lineages are responsible for endemic infection in the swine industry, causing considerable global economic losses. A lack of surveillance and a rising trend in clinical treatment failure has raised concerns of growing antimi...
The Cost-Effectiveness of the SMART Work & Life Intervention for Reducing Sitting Time.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 11 Nov 2022
Sedentary behaviours continue to increase and are associated with heightened risks of morbidity and mortality. We assessed the cost-effectiveness of SMART Work & Life (SWAL), an intervention designed to reduce sitting time inside and outside of work, both with (SWAL-desk) and without (SWAL-only) a height-adjustable workstation compared to usual practice (control) for UK office workers. Health o...
Impact of within-visit systolic blood pressure change patterns on blood pressure classification: the Cardiovascular Risk in Young Finns Study.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 15 Nov 2022
Most international guidelines recommend that repeat blood pressure (BP) readings are required for BP classification. Two international guidelines diverge from this by recommending that no further BP measurements are required if the first clinic BP is below a hypertension threshold. The extent to which within-visit BP variability patterns change over time, and whether this could impact BP classi...
Prevalence of waterpipe smoking and its associated factors among adolescents aged 12-16 years in 73 countries/territories.
FRONTIERS IN PUBLIC HEALTH - 01 Jan 2022
To describe the recent prevalence of, and trends in, waterpipe smoking and to examine its associated factors among adolescents aged 12-16 years in 73 countries/territories (hereafter "countries").Data from 72 countries that had conducted a Global Youth Tobacco Survey (GYTS) in 2010-2019 and from the National Youth Tobacco Survey in the United States in 2019 were used to assess the recent preval...
Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 18 Nov 2022
Extracellular vesicles (EVs) from stem cells have shown significant therapeutic potential to repair injured cardiac tissues and regulate pathological fibrosis. However, scalable generation of stem cells and derived EVs for clinical utility remains a huge technical challenge. Here, we report a rapid size-based extrusion strategy to generate EV-like membranous nanovesicles (NVs) from easily sourc...
Long term all-cause and cardiovascular disease mortality among women who undergo fertility treatment.
THE MEDICAL JOURNAL OF AUSTRALIA - 21 Nov 2022
To compare age-adjusted all-cause and CVD mortality, relative to the general female population, for women registered for fertility treatment who received it and those who did not.Prospective cohort study; analysis of Monash IVF clinical registries data, 1975-2018, linked with National Death Index mortality data.All women who registered for fertility treatment at Monash IVF (Melbourne, Victoria)...
Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2022
Cardiac fibrosis is central to heart failure (HF), especially HF with preserved ejection fraction (HFpEF), often caused by hypertension. Despite fibrosis causing diastolic dysfunction and impaired electrical conduction, responsible for arrhythmia-induced sudden cardiac death, the mechanisms are poorly defined and effective therapies are lacking. Here we show that crosstalk between cardiac cytot...
The Importance of Research on Occupational Sedentary Behaviour and Activity Right Now.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 28 Nov 2022
The workplace has been identified as a key setting for public health interventions to 'promote and maintain the highest degree of physical, mental and social well-being of workers in all occupations' by the World Health Organisation [...].
Proportion and trend in the age of cigarette smoking initiation among adolescent smoking experiencers aged 13-15 years in 148 countries/territories.
FRONTIERS IN PUBLIC HEALTH - 01 Jan 2022
Limited studies have assessed the recent proportion and trend in the age of cigarette smoking initiation among adolescent smoking experiencers globally. We aimed to assess the recent global proportion, associated factors and the long-term trend of the initiated age of cigarette smoking among adolescent smoking experiencers.We used data from the most recent Global Youth Tobacco Survey on 99,728 ...
Quantification and Selective Use of Multimodality Imaging in the Assessment of Valvular Regurgitation.
JACC. CARDIOVASCULAR IMAGING - 01 May 2022
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A roadmap of strategies to support cardiovascular researchers: from policy to practice.
NATURE REVIEWS. CARDIOLOGY - 01 Nov 2022
Cardiovascular disease remains the leading cause of death worldwide. Cardiovascular research has therefore never been more crucial. Cardiovascular researchers must be provided with a research environment that enables them to perform at their highest level, maximizing their opportunities to work effectively with key stakeholders to address this global issue. At present, cardiovascular researcher...
Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
EUROPEAN JOURNAL OF NUTRITION - 01 Oct 2022
In several studies, exploratory dietary patterns (DP), derived by principal component analysis, were inversely or positively associated with incident type 2 diabetes (T2D). However, findings remained study-specific, inconsistent and rarely replicated. This study aimed to investigate the associations between DPs and T2D in multiple cohorts across the world.This federated meta-analysis of individ...
The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact.
01 Oct 2022
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurr...
Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Oct 2022
Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk...
Psychological-health correlates of physical activity and sedentary behaviour during the COVID pandemic.
01 Oct 2022
While physical inactivity is associated with adverse psychological outcomes, less is known about the psychological outcomes associated with sedentary behaviour, and specifically, its mentally active and passive forms. The COVID-19 pandemic represents a unique opportunity to study associations between these variables in light of widespread stay-at-home mandates and restrictions on outdoor exerci...
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
COMMUNICATIONS BIOLOGY - 08 Oct 2022
Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzheimer's disease. However, the molecular mechanisms of sphingomyelin and ceramide disruption remain to be determined. We focus on the sphingoli...
Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk.
11 Oct 2022
Smoking is one of the most prominent addictions of the modern world, and one of the leading preventable causes of death worldwide. Although the number of tobacco smokers is believed to be at a historic low, electronic cigarette use has been on a dramatic rise over the past decades. Used as a replacement for cigarette smoking, electronic cigarettes were thought to reduce the negative effects of ...
Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians.
NATURE COMMUNICATIONS - 13 Oct 2022
Despite extensive efforts to address it, the vastness of uncharacterized 'dark matter' microbial genetic diversity can impact short-read sequencing based metagenomic studies. Population-specific biases in genomic reference databases can further compound this problem. Leveraging advances in hybrid assembly (using short and long reads) and Hi-C technologies in a cross-sectional survey, we deeply ...
