Publications
Now showing items 861-880 of 4875 records
Health effects of reduced occupational sedentary behaviour in type 2 diabetes using a mobile health intervention: a study protocol for a 12-month randomized controlled trial-the ROSEBUD study.
TRIALS - 27 Jul 2022
Short-term trials conducted in adults with type 2 diabetes mellitus (T2DM) showed that reducing sedentary behaviour by performing regular short bouts of light-intensity physical activity enhances health. Moreover, support for reducing sedentary behaviour may be provided at a low cost via mobile health technology (mHealth). There are a wide range of mHealth solutions available including SMS text...
Resource implications following expansion of computed tomography coronary angiography: An Australian experience.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY - 01 Aug 2022
To determine the downstream utilisation of Computed Tomography Coronary Angiography (CTCA) in a single Australian tertiary centre.A single-centre retrospective study analysed 1460 patients undergoing CTCA between 1st January 2015 to 31st December 2018 at a tertiary hospital in Victoria, Australia, with a catchment area of 500,000 people. The coronary stenosis grading, plaque characteristics and...
Health-related quality of life following percutaneous coronary intervention during the COVID-19 pandemic.
QUALITY OF LIFE RESEARCH : AN INTERNATIONAL JOURNAL OF QUALITY OF LIFE ASPECTS OF TREATMENT, CARE AND REHABILITATION - 01 Aug 2022
During the COVID-19 pandemic, widespread public health measures were implemented to control community transmission. The association between these measures and health-related quality of life (HRQOL) among patients following percutaneous coronary intervention has not been studied.We included consecutive patients undergoing percutaneous coronary intervention (PCI) in the state-wide Victorian Cardi...
Visions by WIMIN: Global Mentorship to Retain Underrepresented Trainees.
MOLECULAR IMAGING AND BIOLOGY - 01 Aug 2022
Mentorship is a fundamental aspect that contributes to the success of a career in science, technology, engineering, and mathematics (STEM), particularly in academia. Research suggests that underrepresented minorities (URMs) often experience less quality mentorship and face barriers to finding successful mentor-mentee relationships. URM trainees in STEM face challenges that are not encountered b...
Association Between the Gut Microbiome and Their Metabolites With Human Blood Pressure Variability.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Aug 2022
Blood pressure (BP) variability is an independent risk factor for cardiovascular events. Recent evidence supports a role for the gut microbiota in BP regulation. However, whether the gut microbiome is associated with BP variability is yet to be determined. Here, we aimed to investigate the interplay between the gut microbiome and their metabolites in relation to BP variability.Ambulatory BP mon...
IVIg-exposure and thromboembolic event risk: findings from the UK Biobank.
JOURNAL OF NEUROLOGY, NEUROSURGERY, AND PSYCHIATRY - 01 Aug 2022
Arterial and venous thromboembolic events (TEEs) have been associated with intravenous Ig use, but the risk has been poorly quantified. We aimed to calculate the risk of TEEs associated with exposure to intravenous Ig.We included participants from UK Biobank recruited over 3 years, data extracted September 2020.The study endpoints were incidence of myocardial infarction, other acute ischaemic h...
Cardiorenal Complications in Young-Onset Type 2 Diabetes Compared Between White Americans and African Americans.
DIABETES CARE - 01 Aug 2022
To explore risks and associated mediation effects of developing chronic kidney disease (CKD) and heart failure (HF) in young- and usual-onset type 2 diabetes (T2D) between White Americans (WAs) and African Americans (AAs).From U.S. medical records, 1,491,672 WAs and 31,133 AAs were identified and stratified by T2D age of onset (18-39, 40-49, 50-59, 60-70 years). Risks, mediation effects, and ti...
An Ultrasound-Responsive Theranostic Cyclodextrin-Loaded Nanoparticle for Multimodal Imaging and Therapy for Atherosclerosis.
SMALL (WEINHEIM AN DER BERGSTRASSE, GERMANY) - 01 Aug 2022
Atherosclerosis is a major cause of mortality and morbidity worldwide. Left undiagnosed and untreated, atherosclerotic plaques can rupture and cause cardiovascular complications such as myocardial infarction and stroke. Atherosclerotic plaques are composed of lipids, including oxidized low-density lipoproteins and cholesterol crystals, and immune cells, including macrophages. 2-Hydroxypropyl-be...
Vascular Aging and Vascular Disease Have Much in Common!
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Aug 2022
Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle.
BMC BIOLOGY - 18 Jul 2022
Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such as cellular bioenergetics and response to stress. In the metabolically active skeletal muscle, mitochondrial biogenesis is one important component contributing to a broad set of mitochondrial adaptations occurring in response to signals, which converge on t...
Human Milk Lipids and Small Metabolites: Maternal and Microbial Origins.
METABOLITES - 13 Mar 2023
Although there has been limited application in the field to date, human milk omics research continues to gain traction. Human milk lipidomics and metabolomics research is particularly important, given the significance of milk lipids and metabolites for infant health. For researchers conducting compositional milk analyses, it is important to consider the origins of these compounds. The current r...
Potential of plant secondary metabolite-based polymers to enhance wound healing.
ACTA BIOMATERIALIA - 15 Jul 2022
There is a global epidemic of non-healing wounds. Chronic inflammation, overexpression of pro-inflammatory cytokines, oxidative stress and bacterial infection are implicated in delayed wound healing. Natural extracts are a rich source of bioactive molecules called plant secondary metabolites (PSMs) that include terpenes and phenols. These molecules may facilitate wound healing through their ant...
Structural landscapes of PPI interfaces.
BRIEFINGS IN BIOINFORMATICS - 18 Jul 2022
Proteins are capable of highly specific interactions and are responsible for a wide range of functions, making them attractive in the pursuit of new therapeutic options. Previous studies focusing on overall geometry of protein-protein interfaces, however, concluded that PPI interfaces were generally flat. More recently, this idea has been challenged by their structural and thermodynamic charact...
Evaluating hierarchical machine learning approaches to classify biological databases.
BRIEFINGS IN BIOINFORMATICS - 18 Jul 2022
The rate of biological data generation has increased dramatically in recent years, which has driven the importance of databases as a resource to guide innovation and the generation of biological insights. Given the complexity and scale of these databases, automatic data classification is often required. Biological data sets are often hierarchical in nature, with varying degrees of complexity, i...
A solution NMR view of lipidic cubic phases: Structure, dynamics, and beyond
BIOCHIMICA ET BIOPHYSICA ACTA. ADVANCES - 01 Jan 2022
Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a range of time scales, the screening of drug candidates with site specificity, and for the quantitation of molecular translational diffusion. Lyotropic lipidic cubic phases...
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
CELL STEM CELL - 01 Aug 2019
Tumors are composed of phenotypically heterogeneous cancer cells that often resemble various differentiation states of their lineage of origin. Within this hierarchy, it is thought that an immature subpopulation of tumor-propagating cancer stem cells (CSCs) differentiates into non-tumorigenic progeny, providing a rationale for therapeutic strategies that specifically eradicate CSCs or induce th...
Defining cardiac fibrosis complexity and regulation towards therapeutic development
CLINICAL AND TRANSLATIONAL DISCOVERY - 01 Jan 2023
Abstract Cardiac fibrosis is insidious, accelerating cardiovascular diseases, heart failure, and death. With a notable lack of effective therapies, advances in both understanding and targeted treatment of fibrosis are urgently needed. Remodelling of the extracellular matrix alters the biomechanical and biochemical cardiac structure and function, disrupting cell-matrix interactions and exacerbat...
Device-measured physical activity, adiposity and mortality: a harmonised meta-analysis of eight prospective cohort studies.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Jul 2022
The joint associations of total and intensity-specific physical activity with obesity in relation to all-cause mortality risk are unclear.We included 34 492 adults (72% women, median age 62.1 years, 2034 deaths during follow-up) in a harmonised meta-analysis of eight population-based prospective cohort studies with mean follow-up ranging from 6.0 to 14.5 years. Standard body mass index categori...
A Comprehensive Approach to Managing Methamphetamine-Associated Cardiomyopathy.
01 Jul 2022
Methamphetamines are illicit drugs of the amphetamine-type stimulant class that have been increasing in popularity, availability, and purity in recent decades. As a result, rates of methamphetamine-associated cardiomyopathy (MAC) are rising globally. MAC is associated with high rates of sudden cardiac arrest, late presentation, and poor outcomes. This review discusses the medical management of ...
Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases.
PHARMACOLOGY & THERAPEUTICS - 01 Jul 2022
C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been recognized almost exclusively as a marker of inflammation and predictor of cardiovascular risk. However, accumulating evidence indicates that CRP is also a direct pathogenic pro-inflammatory mediator in atherosclerosis and cardiovascular diseases. The 'CRP system' consists of at least two protein conformations wi...
