Publications
Now showing items 81-100 of 5595 records
Glycemic Outcomes During Outpatient Use of Automated Insulin Delivery Without Meal Announcement in Adults with Type 1 Diabetes: Results from the CLOSE IT Randomized Controlled Trial.
DIABETES TECHNOLOGY & THERAPEUTICS - 12 Feb 2026
Current automated insulin delivery (AID) systems recommend manual insulin delivery prior to meals (hybrid closed-loop [HCL]). Data are needed on the efficacy of an AID system without meal announcement. In this randomized, open-label, parallel-arm trial, we established participants with type 1 diabetes aged 18-70 years on an open-source AID system, with meal announcement, during a 12-week run-in...
Structural and functional modifications of neuronal lipid rafts: implications for HIV-associated neurological disorders.
JOURNAL OF NEUROINFLAMMATION - 11 Feb 2026
The association between smoking and diabetic neuropathy: a systematic review and meta-analysis.
24 Dec 2025
The study aimed to systematically review the evidence on the association between smoking and the risk of diabetic neuropathy, with a particular emphasis on the risk of peripheral neuropathy among individuals with diabetes mellitus. MEDLINE, EMBASE, SCOPUS, and CENTRAL databases were searched for studies published before August 2024. Cross-sectional, case-control, and cohort studies that assesse...
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance.
AGING AND DISEASE - 25 Dec 2025
The decline in ovarian endocrine function represents a pivotal event in female aging, initiating systemic biological deterioration well before the end of reproductive capacity. We propose that Hormone Replacement Therapy (HRT) may constitute an early stage geroprotective intervention with mechanistic relevance across the 12 hallmarks of aging. Despite extensive clinical use, HRT remains underut...
Emotional Management In Chronic Disease.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2025
Persons living with chronic disease present with a wide array of emotions. These range from affable and accepting, action- oriented attitude, to anxious, afraid or apathic, adynamic acceptance of disease. Yet others may be argumentative and angry, or openly aggressive and antisocial. Increasingly, primary care practitioners also encounter 'pseudo academic' or hyperaware' patients, who base thei...
Impactful behavioural therapy (IBT) in obesity care.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2025
Intensive behavioural therapy is said to be the first line treatment of obesity. The choice of the adjective 'intensive', however, is open to debate. The term 'impactful behavioural therapy' seems more appropriate for the management of persons living with obesity. This refers to a sustained supportive psychosocial intervention, embedded in routine care, designed to modify existing behaviours, a...
High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma.
CELL DEATH & DISEASE - 20 Dec 2025
High salt diet (HSD) is known to reduce cancer growth in some tumor models, which has been attributed to tissue accumulation of sodium that enhances local anti-tumor immunity. Here, we show that a HSD inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung. Melanoma cells from mice on a HSD upregulated the metabolic inhibitor Tuberous sclerosis complex 2 (T...
Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson's disease.
NPJ PARKINSON'S DISEASE - 20 Dec 2025
Parkinson's disease (PD) is a progressive neurodegenerative disorder defined by motor impairments. However, people with PD (PwPD) experience a defined spectrum of non-motor symptoms, with gastrointestinal dysfunction the most common and earliest-presenting. Evidence suggests that PD pathology may originate in the gut, where microbial dysbiosis and immune dysregulation contribute to neuroinflamm...
PM2.5 promotes non-small cell lung cancer tumorigenesis by miR-21-5p targeting <i>PDE4DIP</i> accumulated.
TRANSLATIONAL CANCER RESEARCH - 30 Nov 2025
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Fine particulate matter (PM2.5) is associated with increased risk of lung cancer. microRNAs (miRNAs) play an important role in a variety of cancers, including NSCLC. In NSCLC, existing literature has revealed upregulation of miR-21-5p. Nonetheless, the molecular mechanism of miR-21-5p in NSCLC develop...
Diabetes in adolescents without obesity in India: An underrecognized phenotype.
WORLD JOURNAL OF CLINICAL PEDIATRICS - 09 Dec 2025
Adolescent type 2 diabetes mellitus (T2DM) is on the rise in India and is commonly attributed to co-existence of overweight and obesity in adolescents. In this line, a study by Maheshwari <i>et al</i> titled 'Prevalence of obesity, determinants, and its association with hyperglycaemia among community dwelling older adolescents in India' concluded that overweight, obesity, socioeconomic factors ...
Soluble RAGE further stratifies risk of coronary artery and end-stage kidney disease in high-risk individuals with type 1 diabetes and treatment-resistant hypertension.
CARDIOVASCULAR DIABETOLOGY - 12 Dec 2025
Soluble receptor for advanced glycation end-products (sRAGE) modulates RAGE-mediated inflammation and oxidative stress. We investigated if sRAGE stratifies cardiovascular and kidney disease risk in individuals with type 1 diabetes and baseline treatment-resistant hypertension (TRH). This study included 1262 adults with type 1 diabetes from the FinnDiane study who were on antihypertensive therap...
Midlife and the menopause transition in type 2 diabetes mellitus prevention.
NATURE REVIEWS. ENDOCRINOLOGY - 01 Dec 2025
Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants.
BMC MEDICINE - 03 Dec 2025
Engaging in regular physical activity and obtaining recommended amounts of sleep are touted as strategies to promote healthy brain aging. However, as each day is only 24 h long, changing time spent in one activity must come at the expense or gain of another, making it necessary to understand how the whole 24-h activity composition is associated with dementia risk. We investigated the effect of ...
Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 09 Dec 2025
To understand the biological function of genomic regions, vast molecular data have been generated to annotate mammalian genomes. However, how to effectively use such extensive information to improve the mapping and prediction of complex traits, including those that respond to climate change, remains unresolved. Here, we apply a Bayesian framework to estimate a Functional-And-Evolutionary Multi-...
Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma.
NATURE CELL BIOLOGY - 28 Nov 2025
Extracellular vesicles (EVs) are an essential signalling entity in human plasma implicated in health and disease. Still, their core protein and lipid componentry, which lie at the centre of EV form and function, remain poorly defined. Here we performed high-resolution density gradient fractionation of over 140 human plasma samples to isolate circulating EVs, and systematically constructed their...
Pre-storage leucoreduction of platelet concentrates reduced biological response modifier concentrations and TRALI incidence in an in vivo sheep model.
SCIENTIFIC REPORTS - 26 Nov 2025
Transfusion-related acute lung injury (TRALI) is a potentially fatal transfusion reaction. It can be caused by the transfusion of proteins, lipids, and extracellular vesicles that accumulate in blood components during routine storage and are collectively referred to as biological response modifiers (BRMs). It has been suggested that leucoreduction might reduce TRALI risk by limiting the accumul...
Stimulation at the frontal cortex influences the exercise activity and skeletal muscle status in senescence-accelerating mice.
NPJ AGING - 25 Nov 2025
Senescence-associated frailty and sarcopenia are global challenges. We here investigated neuronal activity and skeletal muscle biology in senescence-accelerated mouse prone 8 (SAMP8) mice with scalp acupuncture stimulation (SAPS). Excise activity was assessed using rotarod test in the three groups: SAMP8 mice receiving SAPS (SP8-Ap), SAMP8 controls (SP8-C), and senescence-accelerated mouse resi...
Depression as a moderator and mediator of functional status in patients with Long COVID: a cross-sectional and longitudinal observational study from the PERCEIVE cohort in Australia.
BMJ OPEN - 21 Nov 2025
In patients with post-acute sequelae of COVID-19 (PASC), depression has been associated with symptom severity, the duration since infection and ongoing functional impairment. However, the interconnections between these factors remain inadequately understood. This study aimed to explore the roles of depressive symptoms in moderating and mediating the relationships between post-COVID-19 condition...
Rethinking diabetes care for Indigenous Australians: the need for Indigenous-codesigned and led diabetes models of care.
THE MEDICAL JOURNAL OF AUSTRALIA - 17 Nov 2025
Automated Insulin Delivery Beyond Glycemic Outcomes: Endpoints and Evidence.
DIABETES TECHNOLOGY & THERAPEUTICS - 14 Nov 2025
Automated insulin delivery (AID) systems have been shown to be an effective therapeutic option for people with type 1 diabetes and, more recently, for people with type 2 diabetes. To date, the benefit of AID systems has been primarily assessed by glycemic parameters and has been shown to optimize glucose control for people living with diabetes. However, it is increasingly recognized that diabet...
