Publications
Now showing items 81-100 of 5153 records
Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α
NPJ METABOLIC HEALTH AND DISEASE - 06 Nov 2024
Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing HDAC5/MEF2 signalling in cardiomyocytes. We created and characterised two mouse models with global or cardiomyocyte-specific disruption of the gene encoding B55α (Ppp2r2a) to conduct the first detailed exploration of B55α in the heart. Global ...
Polydopamine Nanobowl-Armoured Perfluorocarbon Emulsions: Tracking Thermal- and Photothermal-Induced Phase Change through Neutron Scattering.
SMALL (WEINHEIM AN DER BERGSTRASSE, GERMANY) - 10 Nov 2024
Anisotropic polydopamine nanobowls (PDA NBs) show significant promise in biomedicine, distinguished by their unique optical properties and superior cellular uptake compared to spherical nanoparticles. This study presents a novel approach for creating multistimuli-activated PDA NB-armored emulsions, encapsulating perfluorohexane (NB-H) and perfluoropentane (NB-P) cores, with applications in cont...
Trends in the incidence of young-adult-onset diabetes by diabetes type: a multi-national population-based study from an international diabetes consortium.
THE LANCET. DIABETES & ENDOCRINOLOGY - 11 Nov 2024
Population-based incidence data on young-adult-onset type 1 diabetes and type 2 diabetes are limited. We aimed to examine secular trends in the incidence of diagnosed type 1 diabetes and type 2 diabetes with an age of onset between 15 and 39 years. In this multicountry aggregate data analysis, we assembled eight administrative datasets from high-income jurisdictions and countries (Australia, De...
The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity.
NUCLEIC ACIDS RESEARCH - 12 Nov 2024
The NHGRI-EBI GWAS Catalog serves as a vital resource for the genetic research community, providing access to the most comprehensive database of human GWAS results. Currently, it contains close to 7 000 publications for >15 000 traits, from which more than 625 000 lead associations have been curated. Additionally, 85 000 full genome-wide summary statistics datasets-containing association data f...
Applications and potential of machine learning augmented chest X-ray interpretation in cardiology.
MINERVA CARDIOLOGY AND ANGIOLOGY - 13 Nov 2024
The chest X-ray (CXR) has a wide range of clinical indications in the field of cardiology, from the assessment of acute pathology to disease surveillance and screening. Despite many technological advancements, CXR interpretation error rates have remained constant for decades. The application of machine learning has the potential to substantially improve clinical workflow efficiency, pathology d...
Metformin: decelerates biomarkers of aging clocks.
SIGNAL TRANSDUCTION AND TARGETED THERAPY - 13 Nov 2024
Divergent roles of RIPK3 and MLKL in high-fat diet-induced obesity and MAFLD in mice.
LIFE SCIENCE ALLIANCE - 01 Jan 2025
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction-associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined. Here, we show via the direct comparison of mice genetically deficient in the essential necroptotic regulators, receptor-interacting protein kinase-3 (RIPK3) and mi...
Novel approaches to define responders to interventional treatment in hypertension: insights from the SPYRAL HTN-OFF and HTN-ON MED trials.
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 14 Nov 2024
Multiple sham-controlled clinical trials have demonstrated significant reductions in both office and 24-h blood pressure (BP) following radiofrequency renal denervation (RDN) in the uncontrolled hypertension population. Notably, the blood pressure response varies widely within individual participants, thus showing a clinical need to identify potential RDN "responders" prior to the procedure. De...
Recent advances in bioactive wound dressings.
WOUND REPAIR AND REGENERATION : OFFICIAL PUBLICATION OF THE WOUND HEALING SOCIETY [AND] THE EUROPEAN TISSUE REPAIR SOCIETY - 14 Nov 2024
Traditional wound dressings, despite their widespread use, face limitations, such as poor infection control and insufficient healing promotion. To address these challenges, bioactive materials have emerged as a promising solution in wound care. This comprehensive review explores the latest developments in wound healing technologies, starting with an overview of the importance of effective wound...
Are area-level socioeconomic inequalities in obesity moderated by neighbourhood greenery?
BMC PUBLIC HEALTH - 15 Nov 2024
Reducing socioeconomic inequalities in obesity is a public health priority. Limited research exists on the role of neighbourhood environmental attributes in mitigating these inequalities. However, it has been shown that neighbourhoods with more greenery tend to have lower levels of socioeconomic inequalities in non-obesity health outcomes. We examined whether neighbourhood greenery moderates th...
The interplay of climate change and physical activity: Implications for cardiovascular health.
AMERICAN HEART JOURNAL PLUS : CARDIOLOGY RESEARCH AND PRACTICE - 01 Nov 2024
Cardiovascular disease (CVD) is one of the top contributors to global disease burden. Meeting the physical activity guidelines can effectively control and prevent several CVD risk factors, including obesity, hypertension and diabetes mellitus. The effects of climate change are multifactorial and have direct impacts on cardiovascular health. Increasing ambient temperatures, worsening air and wat...
Left Ventricular Volume as a Predictor of Exercise Capacity and Functional Independence in Individuals with Normal Ejection Fraction.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 04 Nov 2024
Low cardiorespiratory fitness (CRF) is associated with functional disability, heart failure and mortality. Left ventricular (LV) end-diastolic volume (LVEDV) has been linked with CRF, but its utility as a diagnostic marker of low CRF has not been tested. This multi-center international cohort examined the relationship between LV size on echocardiography and CRF (peak oxygen uptake [peak VO2] fr...
Preventing Allogeneic Stem Cell Transplant-Related Cardiovascular Dysfunction: ALLO-Active Trial.
CIRCULATION - 04 Nov 2024
Allogeneic stem cell transplantation (allo-SCT) is an efficacious treatment for hematologic malignancies but can be complicated by cardiac dysfunction and exercise intolerance impacting quality of life and longevity. We conducted a randomized controlled trial testing whether a multicomponent activity intervention could attenuate reductions in cardiorespiratory fitness and exercise cardiac funct...
Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis.
CIRCULATION - 04 Nov 2024
Low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) levels are independently associated with atherosclerotic cardiovascular disease (ASCVD). However, the relationship between Lp(a) level, LDL-C level, and ASCVD risk at different thresholds is not well defined. A participant-level meta-analysis of 27 658 participants enrolled in 6 placebo-controlled statin trials was performed...
Tracking and Transition Probability of Blood Pressure From Childhood to Midadulthood.
JAMA PEDIATRICS - 04 Nov 2024
Despite its relevance for pediatric blood pressure (BP) screening, the long-term predictive utility and natural progression of pediatric BP classification remain understudied. To evaluate BP tracking from childhood to midadulthood using the American Academy of Pediatrics (AAP) thresholds and estimate transition probabilities among BP classifications over time considering multiple time points. T...
Diabetic Cardiomyopathy: What Clinicians Should Know.
THE AMERICAN JOURNAL OF MEDICINE - 04 Nov 2024
Diabetes has classically been associated with atherosclerotic cardiovascular disease. However, heart failure is now increasingly recognized as a prevalent and often first cardiovascular complication among patients with diabetes. Investigation of this epidemiological relationship has led to recognition of diabetic cardiomyopathy, or structural heart disease that develops in patients with diabete...
Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess.
SCIENTIFIC REPORTS - 06 Nov 2024
Cardiorenal fibrosis is a common feature of chronic cardiovascular disease and recent data suggests that cytokines and chemokines may also drive fibrosis. Here we tested the hypothesis that CXCR7, a highly conserved chemokine receptor, contributes to cardiac and renal fibrosis. We generated an anti-mouse CXCR7-specific monoclonal antibody (CXCR7 mAb) and tested its anti-fibrotic actions in card...
Effect of Interrupting Prolonged Sitting with Frequent Activity Breaks on Postprandial Glycemia and Insulin Sensitivity in Adults with Type 1 Diabetes on Continuous Subcutaneous Insulin Infusion Therapy: A Randomized Crossover Pilot Trial.
DIABETES TECHNOLOGY & THERAPEUTICS - 07 Nov 2024
<b><i>Objective:</i></b> This study examined acute effects of interrupting prolonged sitting with short activity breaks on postprandial glucose/insulin responses and estimations of insulin sensitivity in adults with type 1 diabetes (T1D). <b><i>Method:</i></b> In a randomized crossover trial, eight adults (age = 46 ± 14 years [mean ± SD], body mass index [BMI] = 27.2 ± 3.8 kg/m<sup>2</sup>) rec...
First-in-human microelectrode recordings from the vagus nerve during clinical vagus nerve stimulation.
EPILEPSIA OPEN - 28 Oct 2024
Vagus nerve stimulation (VNS) is an effective treatment for people with drug-resistant epilepsy. However, its mechanisms of action are poorly understood, including which nerve fibers are activated in humans during VNS in typical clinical settings and which are required for clinical efficacy. In particular, there have been no intraneural recordings of vagus nerve fiber activation in awake humans...
Artificial Intelligence-based Software for Breast Arterial Calcification Detection on Mammograms.
JOURNAL OF BREAST IMAGING - 29 Oct 2024
The performance of a commercially available artificial intelligence (AI)-based software that detects breast arterial calcifications (BACs) on mammograms is presented. This retrospective study was exempt from IRB approval and adhered to the HIPAA regulations. Breast arterial calcification detection using AI was assessed in 253 patients who underwent 314 digital mammography (DM) examinations and ...
