Publications
Now showing items 81-100 of 4875 records
Reflecting on a Year at the Helm of Diabetes Care.
DIABETES CARE - 01 Jan 2024
Low-calorie diets for people with isolated impaired fasting glucose.
COMMUNICATIONS MEDICINE - 01 Mar 2024
Standard lifestyle interventions prove ineffective in preventing type 2 diabetes among individuals with isolated impaired fasting glucose, a highly prevalent prediabetes phenotype globally. Here, we propose low-calorie diets as a promising strategy for diabetes prevention in this high-risk population.
COX2 inhibitor use and type 2 diabetes treatment intensification: A registry-based cohort study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Jan 2024
This study examined the association between cyclooxygenase-2 inhibitor (COX2i) use and diabetes progression in people with type 2 diabetes. We conducted a nation-wide cohort study using an Australian diabetes registry linked to medication dispensing data. We assessed time to diabetes treatment intensification among new users of COX2i compared to mild opioids. Inverse probability of treatment-we...
Codesigning enhanced models of care for Northern Australian Aboriginal and Torres Strait Islander youth with type 2 diabetes: study protocol.
BMJ OPEN - 07 Mar 2024
Premature onset of type 2 diabetes and excess mortality are critical issues internationally, particularly in Indigenous populations. There is an urgent need for developmentally appropriate and culturally safe models of care. We describe the methods for the codesign, implementation and evaluation of enhanced models of care with Aboriginal and Torres Strait Islander youth living with type 2 diabe...
Response to letter from Geoffrey W. Stuart.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 04 Apr 2024
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Impact of Baseline Left Atrial Size on Outcomes Following Catheter Ablation for AF in Patients With Left Ventricular Systolic Dysfunction.
CIRCULATION. ARRHYTHMIA AND ELECTROPHYSIOLOGY - 17 Apr 2024
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Plasma Lipidomic Profiling Identifies Elevated Triglycerides as Potential Risk Factor in Chemotherapy-Induced Peripheral Neuropathy.
JCO PRECISION ONCOLOGY - 01 Apr 2024
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of cytotoxic cancer treatment, often necessitating dose reduction (DR) or chemotherapy discontinuation (CD). Studies on peripheral neuropathy related to chemotherapy, obesity, and diabetes have implicated lipid metabolism. This study examined the association between circulating lipids and CIPN. Lipidomic analysis w...
Comparing and assessing physical activity and sedentary behaviour guidelines for different populations with and without chronic conditions and/or disabilities: a systematic review protocol.
BMJ OPEN SPORT & EXERCISE MEDICINE - 01 Jan 2024
Physical activity guidelines targeting different populations with and without chronic diseases or disabilities are required to meet the diverse functional and physiological needs experienced by different subgroups of people to achieve optimal health benefits. As the importance of physical activity guidelines in promoting optimal health and well-being becomes increasingly recognised, there is a ...
Evolocumab in metastatic castration-resistant prostate cancer: study protocol for a single-arm, phase II trial, and initial experience with use of a validated lipid biomarker to direct therapy.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY - 01 Jan 2024
Despite advances in the treatment of metastatic castration-resistant prostate cancer (mCRPC), primary and secondary resistance to current therapies remains. Elevated circulating sphingolipids are associated with poor outcomes in patients with mCRPC, including therapeutic resistance and shorter overall survival. PCPro is a clinically accessible, regulatory compliant plasma lipid biomarker of poo...
Computational modelling of valvular heart disease: haemodynamic insights and clinical implications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY - 01 Jan 2024
An aging population and an increasing incidence of cardiovascular risk factors form the basis for a global rising prevalence of valvular heart disease (VHD). Research to further our understanding of the pathophysiology of VHD is often confined to the clinical setting. However, in recent years, sophisticated computational models of the cardiovascular system have been increasingly used to investi...
Validation of the CRAVE-C scale in Chinese adults: a four-study examination of competing motivations for physical activity versus rest.
FRONTIERS IN PSYCHOLOGY - 01 Jan 2024
The study aimed to validate the Cravings for Rest and Volitional Energy Expenditure (CRAVE) scale among Chinese adults with different health conditions (healthy control, chronic illnesses, and psychiatric disorders) and skill levels (athletes vs. non-athletes). In Study 1, a confirmatory factor analysis (CFA) using the Maximum Likelihood Method (MLM) was performed on a Chinese sample of emergin...
A Physical Activity and Sitting Time Balance Index and All-Cause Mortality Risk.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE - 23 Jul 2024
Achieving a healthier balance of more time spent in physical activity (PA) and less time in sedentary behaviour is now widely advocated for achieving multiple health benefits. This study introduces a Physical Activity and Sitting Time Balance Index (PASTBI), a potential risk identification tool addressing the interplay between PA and sedentary behaviour; and aims to explore its association with...
Remote myocardial zone characteristics in type 2 diabetes patients with prior myocardial infarction and comparisons with diabetes patients with no prior infarction.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM - 01 Jan 2024
HIV-1 Nef is carried on the surface of extracellular vesicles.
01 Jul 2024
Extracellular vesicles (EVs) serve as pivotal mediators of intercellular communication in both health and disease, delivering biologically active molecules from vesicle-producing cells to recipient cells. In the context of HIV infection, EVs have been shown to carry the viral protein Nef, a key pathogenic factor associated with HIV-related co-morbidities. Despite this recognition, the specific ...
The KgA1c Paradox: Widening the spectrum.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Jul 2024
The term KgA1c paradox is used to describe the unwanted rise in weight that occurs when HbA1c is controlled using conventional therapy. We highlight facets of pathophysiology, prevention, pharmacology, person centred care, and epidemiology, which correspond to the concept of KgA1c paradox. We suggest a novel index, KgA1c product [(BMI) x (HbA1c)], which can be used to evaluate efficacy of drugs...
NAFLD and MAFLD independently increase the risk of major adverse cardiovascular events (MACE): a 20-year longitudinal follow-up study from regional Australia.
HEPATOLOGY INTERNATIONAL - 15 Jul 2024
The association between fatty liver disease (FLD) and cardiovascular disease (CVD) in an Australian context has yet to be defined. The primary aim of this study was to investigate the association between FLD and 3-point major adverse cardiovascular events (MACE). This was a longitudinal follow-up study of a randomly sampled adult cohort from regional Australia between 2001 and 2003. Baseline co...
Maternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring.
CIRCULATION RESEARCH - 17 Jul 2024
Apicolateral bulge: A potential mimic of arrhythmogenic right ventricular cardiomyopathy in a professional athlete-A case report and literature review.
JOURNAL OF CLINICAL ULTRASOUND : JCU - 17 Jul 2024
Soccer is the most popular sport in the world, with over 265 million active players and approximately 0.05% professional players worldwide. The Fédération Internationale de Football Association (FIFA) has made preparticipation screening recommendations which involve electrocardiography and echocardiography being performed prior to international competition. The aim of preparticipation cardiovas...
Early Use of Aspirin for Coronary Allograft Prophylaxis in Heart Transplant Recipients.
TRANSPLANTATION - 18 Jul 2024
Coronary allograft vasculopathy (CAV) remains a significant cause of morbidity and mortality after heart transplantation. The use of aspirin for CAV prophylaxis has recently garnered interest as a possible therapeutic adjunct in this setting. This 2-center retrospective cohort study included 372 patients who underwent heart transplantation between January 2009 and March 2018 and were stratified...
Clinical Significance of Exercise Pulmonary Hypertension With a Negative Diastolic Stress Test for Suspected Heart Failure With Preserved Ejection Fraction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 19 Jul 2024
Half of patients with heart failure with preserved ejection fraction (HFpEF) remain undiagnosed by resting evaluation alone. Therefore, exercise testing is proposed. The diastolic stress test (DST), however, has limited sensitivity. We aimed to determine the clinical significance of adding the mean pulmonary artery pressure over cardiac output (mPAP/CO) slope to the DST in suspected HFpEF. In t...
