Publications
Now showing items 81-100 of 5702 records
Proteomic Effects of Colchicine on Human Macrophages Loaded With Oxidised Low-Density Lipoprotein Cholesterol.
HEART, LUNG & CIRCULATION - 14 Aug 2025
Effects of omega-3 fatty acids on skeletal muscle vascular health and metabolism.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE - 01 Aug 2025
This review aims to summarise recent findings on the effects of omega-3 fatty acids (FAs) on skeletal muscle vascular and metabolic health. We particularly focus on macrovascular (large blood vessel) outcomes, skeletal muscle microvascular (capillary) blood flow and skeletal muscle health and metabolism. Recent meta-analysis and intervention studies suggest that omega-3 FAs improve macrovascula...
Metformin suppresses atherosclerosis by dampening extramedullary myelopoiesis.
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM - 04 Aug 2025
Impaired cholesterol homeostasis is a major factor contributing to the development and progression of atherosclerosis. Previous studies have shown that metformin, the first-line antidiabetic therapy, has cardioprotective effects in diabetic patients. However, the anti-atherogenic effect of metformin in non-diabetic individuals remains unclear. The aim of this study was to determine the anti-ath...
Variation in type 2 diabetes prevalence across different populations: the key drivers.
DIABETOLOGIA - 04 Aug 2025
The global prevalence of type 2 diabetes has risen sharply in recent decades, with significant regional and demographic variation. While high- and middle-income countries generally report a higher diabetes prevalence than low-income countries, substantial differences exist within these categories. The highest prevalence is observed in regions such as the Middle East and North Africa, whereas pa...
Sex Differences in the Genetic Causes of Dilated Cardiomyopathy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 05 Aug 2025
Adherence patterns to cardiovascular medications in people with type 2 diabetes mellitus: a retrospective cohort study using group-based trajectory analysis in primary care.
DIABETES RESEARCH AND CLINICAL PRACTICE - 05 Aug 2025
To assess adherence to glucose-, lipid-, and blood pressure-lowering medications in people with T2DM and identify predictors of non-persistent adherence behaviours. We conducted a retrospective cohort study using primary care data from 2013 to 2023 for people diagnosed with T2DM. Medication adherence was assessed over 60 months, defined as receiving at least one prescription every six months. G...
Current Status and Pending Developments of Robotic Tele-Echocardiography.
JACC. CARDIOVASCULAR IMAGING - 06 Aug 2025
Echocardiography is the gateway to appropriate therapy for many cardiovascular diseases, but access to this test is sometimes challenging. The consequence is that patients in rural and remote areas need to travel for testing, and the resulting time and monetary costs may prove a barrier, especially for hospital inpatients. Delays in obtaining echocardiograms lead to delayed diagnosis and treatm...
Artificial intelligence-generated deepfakes in healthcare and biomedical research: major adverse implications for patients, public and professionals.
INTERNAL MEDICINE JOURNAL - 07 Aug 2025
False advertising is a long-term problem, but, with modern technology, it is now possible to create rapidly and inexpensively and widely distribute fake video, audio and written social media presentations attributed to people without their knowledge or permission. Such 'deepfake' videos and other promotional material, allegedly by healthcare and biomedical research experts, are increasingly bei...
Mechanistic Insights Into Reduced Arrhythmia Prevalence in Female Endurance Athletes.
JACC. CLINICAL ELECTROPHYSIOLOGY - 23 Jul 2025
Female athletes exhibit lower rates of atrial fibrillation (AF) and sudden cardiac death compared with male athletes, but the mechanisms behind this sex disparity in arrhythmia risk remain unclear. This study analyzed findings from Holter monitors, echocardiograms, and cardiac magnetic resonance imaging in a cohort of 397 endurance athletes enriched with prevalent AF. Athletes with cardiomyopat...
Impact of eligibility for diabetes remission on response to intensive lifestyle intervention in overweight and obese people with type 2 diabetes: The Look AHEAD trial.
DIABETES, OBESITY & METABOLISM - 24 Jul 2025
To achieve remission of type 2 diabetes, resources to support intensive lifestyle intervention (ILI) are directed toward people with diabetes for whom remission is achievable, that is, people with short diabetes duration and lower HbA1c. We aimed to determine if responses to ILI, other than remission, justify this resource allocation. We analysed participants from the Look AHEAD randomised cont...
Australia and New Zealand consensus statement on the cardiovascular management of patients with chronic lymphocytic leukaemia treated with Bruton's tyrosine kinase inhibitors.
INTERNAL MEDICINE JOURNAL - 26 Jul 2025
Bruton's tyrosine kinase inhibitors (BTKi) reduce mortality and morbidity in chronic lymphocytic leukaemia (CLL) but have an association with cardiotoxicities, including hypertension, atrial fibrillation (AF), ventricular arrhythmias (VA) and bleeding. There is currently no specific advice for Australian and New Zealand clinicians. In this paper, we aim to provide evidence-based recommendations...
Whole Heart Changes During Cancer Therapy and Its Potential Relevance in Women with Breast Cancer.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 28 Jul 2025
The simultaneous impact of breast cancer therapy on the heart beyond the left ventricle (LV) and its prognostic implications are not understood. Our objective was to determine how breast cancer therapy affects all four cardiac chambers; whether patient clusters based on similarities in changes in multi-chamber measures have different prognosis; and how these patient clusters could be differenti...
Adult-onset type 1 diabetes: new insights but still much to learn.
EUROPEAN HEART JOURNAL - 31 Jul 2025
Cardio-oncology rehabilitation and exercise: evidence, priorities, and research standards from the ICOS-CORE working group.
EUROPEAN HEART JOURNAL - 01 Aug 2025
The aim of this whitepaper is to review the current state of the literature on the effects of cardio-oncology rehabilitation and exercise (CORE) programmes and provide a roadmap for improving the evidence-based to support the implementation of CORE. There is an urgent need to reinforce and extend the evidence informing the cardiovascular care of cancer survivors. CORE is an attractive model tha...
Dynamic Proteome Landscape During Preimplantation Human Embryo Development and Trophectoderm Stem Cell-Differentiation.
PROTEOMICS - 01 Aug 2025
Embryo development involves fertilization of a mature ovum, which, after sequential cell divisions (2-,4-8-cells and morula), undergoes differentiation into implantation competent blastocyst. The blastocyst comprises of inner cell mass surrounded by an outer layer of cells called the trophoblast (TSblast) that, upon attachment to the endometrium, differentiates into extravillous trophoblasts (E...
Long-Term Electrocardiographic Changes Following Renal Denervation-Left Ventricular Mass and Arrhythmia Burden.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 01 Aug 2025
Renal denervation (RDN) is an adjunct therapy for resistant hypertension, reducing blood pressure (BP) by inhibiting both afferent sensory and efferent sympathetic renal nerve activity. The resulting reduction in central sympathetic outflow including that directed toward the heart may beneficially impact cardiac remodeling, left ventricular hypertrophy (LVH) and atrial fibrillation (AF). RDN ha...
Atrial Fibrillation Ablation in Older Patients Is Associated With Cognitive Improvement at 1 Year.
JACC. CLINICAL ELECTROPHYSIOLOGY - 28 Jun 2025
Exercise blood pressure in adults with high-risk left ventricular hypertrophy: the importance of normalizing blood pressure to oxygen uptake.
JOURNAL OF HYPERTENSION - 03 Jul 2025
Exaggerated exercise blood pressure (EEBP) is typically defined using systolic blood pressure (SBP) thresholds at maximal exercise of ≥190 (women) and ≥210 mmHg (men). However, SBP/workload and SBP/oxygen uptake (V̇O2) slopes have been shown to be more sensitive predictors of all-cause mortality and/or cardiovascular morbidity than peak exercise SBP. Hypertensive adults with left ventricular hy...
Novel data-driven pathophysiological phenotypes among women with prediabetes in an Indian population.
DIABETES RESEARCH AND CLINICAL PRACTICE - 14 Jul 2025
Data on pathophysiological phenotypes for prediabetes in Indian ethnic populations are scarce. We investigated data-driven, pathophysiological phenotypes of prediabetes associated with the incidence of diabetes mellitus. We characterised pathophysiological prediabetes phenotypes in a survey sample (n = 1455), and its progression to diabetes at one year. Data-driven clusters were identified usin...
Comparative Prognosis by Stress ECG and Stress Imaging: Results From the ISCHEMIA Trial.
JACC. CARDIOVASCULAR IMAGING - 26 Jun 2025
Limited contemporary evidence exists on risk prediction by stress imaging and exercise electrocardiography (ECG) among patients with chronic coronary syndromes (CCS). Objectives From the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) study, prognosis was examined by core laboratory-defined stress imaging and exercise ECG findings in CCS p...
