Publications
Now showing items 81-100 of 5027 records
Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial.
CIRCULATION - 01 Sep 2024
<b>Background:</b> Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, and health-related quality of life. The G allele of the noncoding single nucleotide polymorphism <i>RS9349379</i> enhances expression of the endothelin-1 gene (<i>EDN1</i>) in human vascular cells, potentially increasing circulating conce...
Glucofriendly couscous usage in diabetes.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Aug 2024
Couscous, a staple food of Northern Africa and the Middle East, is consumed across the world. Being carbohydrate - rich, it is often forbidden to persons with diabetes. Its social and cultural connotations, however, do not allow absolute avoidance of this dish in real life. This brief article explores various ways of preparing, serving and eating couscous, in a glucofriendly manner. The authors...
A Home for the Orphan?: Isolated Tricuspid Regurgitation as Part of HFpEF.
JACC. CARDIOVASCULAR IMAGING - 10 Aug 2024
Is public transport a promising strategy for increasing physical activity? Evidence from a study of objectively measured public transport use and physical activity.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 19 Aug 2024
Greater public transport use has been linked to higher physical activity levels. However, neither the amount of physical activity associated with each daily public transport trip performed, nor the potential total physical activity gain associated with an increase in trips/day, has been determined. Using objective measures, we aimed to quantify the association between public transport use, phys...
Community Control of Hypertension and Diabetes (CoCo-HD) program in the Indian states of Kerala and Tamil Nadu: a study protocol for a type 3 hybrid trial.
BMC PUBLIC HEALTH - 21 Aug 2024
India grapples with a formidable health challenge, with an estimated 315 million adults afflicted with hypertension and 100 million living with diabetes mellitus. Alarming statistics reveal rates for poor treatment and control of hypertension and diabetes. In response to these pressing needs, the Community Control of Hypertension and Diabetes (CoCo-HD) program aims to implement structured lifes...
Fair Allocation of GLP-1 and Dual GLP-1-GIP Receptor Agonists.
THE NEW ENGLAND JOURNAL OF MEDICINE - 22 Aug 2024
Haptoglobin phenotype and levels in type 2 diabetes and effects of fenofibrate.
JOURNAL OF DIABETES INVESTIGATION - 22 Aug 2024
In diabetes haptoglobin (Hp) 2 vs Hp 1 allelic product is associated with cardiac and renal complications. Few studies report both Hp phenotype and Hp levels. In a Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial substudy we evaluated the Hp phenotype, Hp levels, and fenofibrate effects. In 480 adults with type 2 diabetes (T2D) the Hp phenotype was assessed and the Hp level...
Initiating or switching to insulin degludec/insulin aspart in a real-world population of adults with type 2 diabetes in Australia: results from a prospective, non-interventional study.
INTERNAL MEDICINE JOURNAL - 22 Aug 2024
Insulin degludec/insulin aspart (IDegAsp) is a fixed-ratio co-formulation of insulin degludec and insulin aspart for the treatment of people with diabetes and suboptimal glycaemic control. Few real-world studies of IDegAsp treatment have been conducted. Here, we report results from the Australian cohort of the global ARISE study of real-world IDegAsp use. To investigate glycaemic control and ot...
Long-term risk of heart failure in adult cancer survivors: a systematic review and meta-analysis.
HEART (BRITISH CARDIAC SOCIETY) - 22 Aug 2024
Cancer survivors are at increased risk of heart failure (HF). While cardiotoxicity is commonly sought at the time of cancer chemotherapy, HF develops as a result of multiple 'hits' over time, and there is limited evidence regarding the frequency and causes of HF during survivorship. This systematic review sought to investigate the relationship between cardiotoxic cancer therapies and HF during ...
Piezo1 expression in neutrophils regulates shear-induced NETosis.
NATURE COMMUNICATIONS - 22 Aug 2024
Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood cells to attach to. In circulation, neutrophils are constantly exposed to hemodynamic forces such as shear stress, which in turn regulates many ...
Prognostication and Interventional Guidance Using Acceleration-Ejection Time Ratio in Undifferentiated Paradoxical Low-Flow Low-Gradient Aortic Stenosis.
JACC. CARDIOVASCULAR IMAGING - 30 Jul 2024
Studies in paradoxical low-flow low-gradient aortic stenosis (PLFAS) have demonstrated conflicting outcomes with variable survival advantage from aortic valve replacement (AVR). PLFAS is a heterogeneous composition of patients with uncertainty regarding true stenosis severity that continues to confound decision-making for AVR. The purpose of this study was to investigate the utility of the Dopp...
Definition and Validation of Prognostic Phenotypes in Moderate Aortic Stenosis.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2024
Adverse outcomes from moderate aortic stenosis (AS) may be caused by progression to severe AS or by the effects of comorbidities. In the absence of randomized trial evidence favoring aortic valve replacement (AVR) in patients with moderate AS, phenotyping patients according to risk may assist decision making. This study sought to identify and validate clusters of moderate AS that may be used to...
Use of artificial intelligence-guided echocardiography to detect cardiac dysfunction and heart valve disease in rural and remote areas: Rationale and design of the AGILE-echo trial.
AMERICAN HEART JOURNAL - 10 Aug 2024
Transthoracic echocardiography (TTE) is essential in the diagnosis of cardiovascular diseases (CVD), including but not limited to heart failure (HF) and heart valve disease (HVD). However, its dependence on expert acquisition means that its accessibility in rural areas may be limited, leading to delayed management decisions and potential missed diagnoses. Artificial intelligence-guided (AI)-TTE...
Mineralocorticoid receptors, macrophages and new mechanisms for cardiovascular disease.
MOLECULAR AND CELLULAR ENDOCRINOLOGY - 10 Aug 2024
Diffusion of Peptides and Small Molecules Encapsulated in Lipidic Cubic Phases by Band-Selective Excitation Short Transient <sup>1</sup>H PGSE NMR.
THE JOURNAL OF PHYSICAL CHEMISTRY LETTERS - 12 Aug 2024
In model membrane systems, such as lipidic cubic phases (LCPs), <sup>1</sup>H NMR spectra are dominated by resonances from water and lipid molecules. The measurement of translational diffusion of peptides/molecules encapsulated in LCPs using conventional <sup>1</sup>H pulsed-gradient spin-echo (PGSE) NMR is, therefore, immensely difficult due to the dynamic range caused by the intense resonance...
The influence of metabolic disorders on adaptive immunity.
12 Aug 2024
The immune system plays a crucial role in protecting the body from invading pathogens and maintaining tissue homoeostasis. Maintaining homoeostatic lipid metabolism is an important aspect of efficient immune cell function and when disrupted immune cell function is impaired. There are numerous metabolic diseases whereby systemic lipid metabolism and cellular function is impaired. In the context ...
Comparison of Pressure vs Volume Overload Ventricular Wall Stress in Patients With Valvular Heart Disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 13 Aug 2024
Aortic stenosis (AS) and mitral regurgitation (MR) result in different patterns of left ventricular remodeling and hypertrophy. We characterized left ventricular wall stress (LVWS) profiles in pressure and volume-overloaded systems, examined the relationship between baseline LVWS and cardiac remodeling, and assessed the acute effects of valve intervention on LVWS using invasive pressures combin...
Use of Feature Tracking to Predict Outcome in Epidemiologic Studies Using Cardiac Magnetic Resonance Imaging.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 13 Aug 2024
Update on Low-Renin Hypertension: Current Understanding and Future Direction.
HYPERTENSION (DALLAS, TEX. : 1979) - 13 Aug 2024
Low-renin hypertension is common and affects 1 in 4 people with hypertension. Understanding the different causes and management of low-renin hypertension is becoming increasingly relevant as renin measurements are more widely ordered in clinical practice. Importantly, many people with low-renin hypertension do not fit traditional definitions of known causes, and the approach to management of th...
Representation of obesity in contemporary atrial fibrillation ablation randomized controlled trials.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 13 Aug 2024
The prevalence and impact of obesity on outcomes of atrial fibrillation (AF) ablation randomized controlled trials (RCTs) have not been well studied. To examine the proportion of participants with obesity enrolled in RCTs of AF ablation and outcomes of ablation when subgroup analysis of participants with obesity were available. We systematically searched PubMed and EMBASE for AF ablation RCTs p...
