Publications
Now showing items 81-100 of 5325 records
Double or nothing: Alternative defibrillation strategies reduces downtime in ventricular fibrillation.
RESUSCITATION - 05 Mar 2025
ELECTRICAL STIMULATION OF THE DORSOLATERAL PREFRONTAL CORTEX INHIBITS VESTIBULAR SIGNALLING IN HUMANS: A BOLD FMRI STUDY.
BRAIN STIMULATION - 05 Mar 2025
Low-frequency sinusoidal galvanic vestibular stimulation (sGVS) can induce perceptions of sway and nausea through entraining vestibular afferent firing to the sinusoidal stimulus. As recently shown, concurrent dorsolateral prefrontal cortex (dlPFC) stimulation via transcranial alternating current stimulation (tACS) greatly attenuates these vestibular perceptions. Given that both vestibular affe...
Assessing the impact of COmorbidities and Sociodemographic factors on Multiorgan Injury following COVID-19: rationale and protocol design of COSMIC, a UK multicentre observational study of COVID-negative controls.
BMJ OPEN - 06 Mar 2025
SARS-CoV-2 disease (COVID-19) has had an enormous health and economic impact globally. Although primarily a respiratory illness, multi-organ involvement is common in COVID-19, with evidence of vascular-mediated damage in the heart, liver, kidneys and brain in a substantial proportion of patients following moderate-to-severe infection. The pathophysiology and long-term clinical implications of m...
Evaluating the implementation of a rapid access atrial fibrillation clinic utilising a pharmacist-physician model of care.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY : RSAP - 06 Mar 2025
Time to assessment and treatment of atrial fibrillation (AF) is critical for reducing stroke risk. However, Australian data have shown low uptake of timely anticoagulation, with people in regional areas having a greater risk of low uptake compared to people in metropolitan areas. To conduct a retrospective, mixed methods evaluation of a pharmacist-physician model of care for a rapid access atri...
Phenotypes of Myocardial Dysfunction on Serial Echocardiography and CMR in Women With Early-Stage Breast Cancer.
JACC. CARDIOVASCULAR IMAGING - 06 Mar 2025
Understanding phenotypic variations in left ventricular (LV) dysfunction during cancer therapy may allow for tailored surveillance and prevention. The study sought to determine LV dysfunction phenotypes during cancer therapy and their interrelated-ness and association with cancer therapy-related cardiac dysfunction (CTRCD), myocardial tissue changes, and blood biomarkers. This is a secondary an...
In Silico Investigation of Mineralocorticoid Receptor Antagonists: Insights into Binding Mechanisms and Structural Dynamics.
MOLECULES (BASEL, SWITZERLAND) - 09 Mar 2025
The mineralocorticoid receptor (MR) is a steroid hormone receptor that plays a key role in regulating sodium and water homeostasis and blood pressure. MR antagonists are a guideline recommended for therapy for the treatment of hypertension and cardiovascular disease but can cause hyperkalaemia. Modelling was performed for binding of the endogenous ligands aldosterone and cortisol and MR antagon...
Make hematopoiesis great again: countering oxidative stress!
BLOOD - 13 Mar 2025
Mitigating the environmental effects of healthcare: the role of the endocrinologist.
NATURE REVIEWS. ENDOCRINOLOGY - 13 Mar 2025
Human health depends on planetary health, and yet healthcare provision can have unintended consequences for the health of the planet. Emissions from the healthcare sector include greenhouse gases, air pollution and plastic pollution, alongside chemical contamination. Chemical pollution resulting in endocrine disruption has been associated with plastics, which are a source of concerning additive...
Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1.
REDOX BIOLOGY - 14 Mar 2025
Cardiomyocyte loss by regulated death modes, like apoptosis and ferroptosis, has been implicated in the development of dilated cardiomyopathy (DCM). It remains unclear whether cardiomyocyte ferroptosis occurs as a consequence of Hippo pathway activation. Using a mouse model of DCM by overexpression of Mst1 transgene (Mst1-TG) leading to Hippo pathway activation, we showed that cardiomyocyte fer...
Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes.
DIABETES CARE - 17 Mar 2025
To investigate the potential progression rate of cerebral small vessel disease (CSVD) in brain MRI among neurologically asymptomatic middle-aged individuals with type 1 diabetes. A total of 172 individuals with type 1 diabetes were re-examined with brain MRI 7.5 years after their initial visit. Baseline predictors of changes in CSVD, particularly cerebral microbleeds (CMBs) and white matter hyp...
The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project.
NATURE GENETICS - 17 Mar 2025
Genetic mutation and drift, coupled with natural and human-mediated selection and migration, have produced a wide variety of genotypes and phenotypes in farmed animals. We here introduce the Farm Animal Genotype-Tissue Expression (FarmGTEx) Project, which aims to elucidate the genetic determinants of gene expression across 16 terrestrial and aquatic domestic species under diverse biological and...
An Expert Opinion on the Management of Frailty in Heart Failure from the Australian Cardiovascular Alliance National Taskforce.
HEART, LUNG & CIRCULATION - 18 Mar 2025
Approximately 50% of all adults with heart failure (HF) are classified as frail. Frailty is a clinical state of 'accelerated ageing' that complicates management and results in adverse health outcomes. Despite recommendations for frailty assessment in HF guidelines, its implementation into routine clinical practice has been slow. Further, evidence to inform models of care and pharmacological tre...
Proteomics and machine learning-based approach to decipher subcellular proteome of mouse heart.
MOLECULAR & CELLULAR PROTEOMICS : MCP - 18 Mar 2025
Protein compartmentalisation to distinctive subcellular niches is critical for cardiac function and homeostasis. Here, we employed a rapid and robust workflow based on differential centrifugal-based fractionation with mass spectrometry (MS)-based proteomics and bioinformatic analyses for systemic mapping of the subcellular proteome of mouse heart. Using supervised machine learning (ML) of 450 h...
Proximal tubular deletion of superoxide dismutase-2 reveals disparate effects on kidney function in diabetes.
REDOX BIOLOGY - 18 Mar 2025
There is a large body of evidence implicating mitochondrial reactive oxygen species (ROS) overproduction and oxidative stress in the development of diabetic kidney disease and the deficiency of mitochondrial antioxidant systems in the kidney, such as manganese superoxide dismutase (MnSOD/SOD2) have been identified. The proximal tubules of the kidney are densely packed with mitochondria thereby ...
Combined Mammographic Breast Density and Breast Arterial Calcification as an Incremental Predictor of Coronary Artery Disease.
JOURNAL OF WOMEN'S HEALTH (2002) - 19 Mar 2025
<b><i>Background:</i></b> Contemporary risk calculators underestimate coronary artery disease (CAD) risk in women. Breast arterial calcification (BAC) associates with CAD. Low breast density (BD) (greater breast adipose tissue) associates with cardiometabolic disease. Both are readily identifiable on screening mammography. We sought to evaluate the association between the combined features of B...
Association Between Diabetes and Anemia: Evidence From NHANES and the UK Biobank.
DIABETES CARE - 21 Mar 2025
To explore the association between diabetes and anemia. We included 9,026 and 389,616 participants from the U.S. National Health and Nutrition Examination Surveys and the UK Biobank study (UKB), respectively. Multivariable logistic regression was used to examine the cross-sectional association of diabetes with anemia, as defined by hemoglobin measurement. For the UKB follow-up, multivariable Co...
GPX4 methylation puts a brake on ferroptosis.
NATURE CELL BIOLOGY - 21 Mar 2025
Renoprotective mechanisms of glucagon-like peptide-1 receptor agonists.
DIABETES & METABOLISM - 22 Mar 2025
Glucagon-like peptide-1 (GLP-1) is an incretin hormone, secreted from gut endocrine cells, which acts to potentiate nutrient-induced insulin secretion. Activation of its receptor, GLP-1R, decreases glucagon secretion and gastric emptying, thereby decreasing blood glucose and body weight. It is largely through these mechanisms that Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transf...
Shorter-term and longer-term mortality prediction in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.
INTERNAL MEDICINE JOURNAL - 25 Mar 2025
While identification of key risk factors for mortality has contributed to advances in healthcare, the effect of these risk factors in predicting mortality over different time horizons remains unclear. We sought to determine how risk factors predicted shorter-term and longer-term mortality across the age spectrum in adults. We used data from 11 247 adults of the Australian Diabetes, Obesity and ...
Blood pressure in childhood, young- and mid-adulthood: association with carotid plaque severity.
EUROPEAN HEART JOURNAL - 25 Mar 2025
Blood pressure (BP) is a key modifiable risk factor for atherosclerosis. How BP across different life stages associates with carotid plaque in mid-adulthood remains unclear, which is the aim of this study. The sample included 1889 participants from the Cardiovascular Risk in Young Finns Study who had their BP measured in childhood (6-18 years), young adulthood (21-39 years), and mid-adulthood (...
