Publications
Now showing items 781-800 of 4875 records
A roadmap of strategies to support cardiovascular researchers: from policy to practice.
NATURE REVIEWS. CARDIOLOGY - 01 Nov 2022
Cardiovascular disease remains the leading cause of death worldwide. Cardiovascular research has therefore never been more crucial. Cardiovascular researchers must be provided with a research environment that enables them to perform at their highest level, maximizing their opportunities to work effectively with key stakeholders to address this global issue. At present, cardiovascular researcher...
Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
EUROPEAN JOURNAL OF NUTRITION - 01 Oct 2022
In several studies, exploratory dietary patterns (DP), derived by principal component analysis, were inversely or positively associated with incident type 2 diabetes (T2D). However, findings remained study-specific, inconsistent and rarely replicated. This study aimed to investigate the associations between DPs and T2D in multiple cohorts across the world.This federated meta-analysis of individ...
The Dual Pandemics of COVID-19 and Obesity: Bidirectional Impact.
01 Oct 2022
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, has been shown to disrupt many organ systems in the human body. Though several medical disorders have been affected by this infection, a few illnesses in addition may also play a role in determining the outcome of COVID-19. Obesity is one such disease which is not only affected by the occurr...
Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Oct 2022
Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk...
Psychological-health correlates of physical activity and sedentary behaviour during the COVID pandemic.
01 Oct 2022
While physical inactivity is associated with adverse psychological outcomes, less is known about the psychological outcomes associated with sedentary behaviour, and specifically, its mentally active and passive forms. The COVID-19 pandemic represents a unique opportunity to study associations between these variables in light of widespread stay-at-home mandates and restrictions on outdoor exerci...
Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease.
COMMUNICATIONS BIOLOGY - 08 Oct 2022
Dysregulation of sphingomyelin and ceramide metabolism have been implicated in Alzheimer's disease. Genome-wide and transcriptome-wide association studies have identified various genes and genetic variants in lipid metabolism that are associated with Alzheimer's disease. However, the molecular mechanisms of sphingomyelin and ceramide disruption remain to be determined. We focus on the sphingoli...
Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk.
11 Oct 2022
Smoking is one of the most prominent addictions of the modern world, and one of the leading preventable causes of death worldwide. Although the number of tobacco smokers is believed to be at a historic low, electronic cigarette use has been on a dramatic rise over the past decades. Used as a replacement for cigarette smoking, electronic cigarettes were thought to reduce the negative effects of ...
Genome-centric analysis of short and long read metagenomes reveals uncharacterized microbiome diversity in Southeast Asians.
NATURE COMMUNICATIONS - 13 Oct 2022
Despite extensive efforts to address it, the vastness of uncharacterized 'dark matter' microbial genetic diversity can impact short-read sequencing based metagenomic studies. Population-specific biases in genomic reference databases can further compound this problem. Leveraging advances in hybrid assembly (using short and long reads) and Hi-C technologies in a cross-sectional survey, we deeply ...
GASS-Metal: identifying metal-binding sites on protein structures using genetic algorithms.
BRIEFINGS IN BIOINFORMATICS - 20 Sep 2022
Metals are present in >30% of proteins found in nature and assist them to perform important biological functions, including storage, transport, signal transduction and enzymatic activity. Traditional and experimental techniques for metal-binding site prediction are usually costly and time-consuming, making computational tools that can assist in these predictions of significant importance. Here ...
toxCSM: comprehensive prediction of small molecule toxicity profiles.
BRIEFINGS IN BIOINFORMATICS - 20 Sep 2022
Drug discovery is a lengthy, costly and high-risk endeavour that is further convoluted by high attrition rates in later development stages. Toxicity has been one of the main causes of failure during clinical trials, increasing drug development time and costs. To facilitate early identification and optimisation of toxicity profiles, several computational tools emerged aiming at improving success...
Prospective associations between diet quality and health-related quality of life in the Australian Diabetes, Obesity and Lifestyle (AusDiab) study.
THE BRITISH JOURNAL OF NUTRITION - 21 Sep 2022
Changes between diet quality and health-related quality of life (HR-QoL) over 12 years were examined in men and women. In 2844 adults (46% males; mean age 47.3 (SD 9.7) years) from the Australian Diabetes, Obesity and Lifestyle study with data at baseline, 5 and 12 years. Dietary intake was assessed with a 74-item FFQ. Diet quality was estimated with the Dietary Guideline Index (DGI); Mediterra...
Changes in excess mortality among adults with diabetes-related end-stage kidney disease: a comparison between the USA and Australia.
NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION - 22 Sep 2022
The number of people with diabetes-related end-stage kidney disease (ESKD-DM) has doubled in the last two decades. We examined changes in excess mortality for people with ESKD-DM in the USA and Australia.In this retrospective cohort study, we included adults (ages 20-84 years) receiving renal replacement therapy (RRT) for ESKD-DM in the USA (n = 1 178 860 from the United States Renal Data Syste...
Modulation of Plasma Lipidomic Profiles in Metastatic Castration-Resistant Prostate Cancer by Simvastatin.
CANCERS - 30 Sep 2022
Elevated circulating sphingolipids are associated with shorter overall survival and therapeutic resistance in metastatic castration-resistant prostate cancer (mCRPC), suggesting that perturbations in sphingolipid metabolism promotes prostate cancer growth. This study assessed whether addition of simvastatin to standard treatment for mCRPC can modify a poor prognostic circulating lipidomic profi...
On the characterization of athlete's heart using 3D echocardiography.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 07 Sep 2022
The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapy.
FRONTIERS IN MEDICINE - 01 Jan 2022
Colorectal cancer (CRC) is considered as a global major cause of cancer death. Surgical resection is the main line of treatment; however, chemo-, radiotherapy and other adjuvant agents are crucial to achieve good outcomes. The tumor microenvironment (TME) is a well-recognized key player in CRC progression, yet the processes linking the cancer cells to its TME are not fully delineated. Autophagy...
RUV-III-NB: normalization of single cell RNA-seq data.
NUCLEIC ACIDS RESEARCH - 09 Sep 2022
Normalization of single cell RNA-seq data remains a challenging task. The performance of different methods can vary greatly between datasets when unwanted factors and biology are associated. Most normalization methods also only remove the effects of unwanted variation for the cell embedding but not from gene-level data typically used for differential expression (DE) analysis to identify marker ...
Integrative multi-omics database (iMOMdb) of Asian pregnant women.
HUMAN MOLECULAR GENETICS - 10 Sep 2022
Asians are underrepresented across many omics databases, thereby limiting the potential of precision medicine in nearly 60% of the global population. As such, there is a pressing need for multi-omics derived quantitative trait loci (QTLs) to fill the knowledge gap of complex traits in populations of Asian ancestry. Here, we provide the first blood-based multi-omics analysis of Asian pregnant wo...
Effect of Different Anthropometric Body Indexes on Radiation Exposure in Patients Undergoing Cardiac Catheterisation and Percutaneous Coronary Intervention.
TOMOGRAPHY (ANN ARBOR, MICH.) - 11 Sep 2022
Patient factors, such as sex and body mass index (BMI), are known to influence patient radiation exposure. Body surface area (BSA) and its association with patient radiation exposure has not been well studied.We analysed height, weight, BMI and BSA in consecutive patients undergoing cardiac catheterisation and percutaneous coronary intervention (PCI) at a high-volume Australian centre between S...
C-reactive protein, immunothrombosis and venous thromboembolism.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2022
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation. There is now increasing evidence that CRP is not only a marker of inflammation, but also that destabilized isoforms of CRP possess pro-inflammatory and pro-thrombotic properties. CRP circulates as a functionally inert pe...
Piezo1 Response to Shear Stress Is Controlled by the Components of the Extracellular Matrix.
ACS APPLIED MATERIALS & INTERFACES - 14 Sep 2022
Piezo1 is a recently discovered Ca permeable ion channel that has emerged as an integral sensor of hemodynamic forces within the cardiovascular system, contributing to vascular development and blood pressure regulation. However, how the composition of the extracellular matrix (ECM) affects the mechanosensitivity of Piezo1 in response to hemodynamic forces remains poorly understood. Using a comb...
