Publications
Now showing items 601-620 of 5027 records
Cumulative dyslipidemia with arterial stiffness and carotid IMT progression in asymptomatic adolescents: A simulated intervention longitudinal study using temporal inverse allocation model.
ATHEROSCLEROSIS - 01 Jan 2023
We aimed to examine the longitudinal associations of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, and low-density lipoprotein cholesterol (LDL-C) with carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT) progression.We studied 1779, 15-year-old participants from the Avon...
Aerosol Generation During High Intensity Exercise-Implications for COVID-19 Transmission.
HEART, LUNG & CIRCULATION - 01 Jan 2023
COVID-19 can be transmitted through aerosolised respiratory particles. The degree to which exercise enhances aerosol production has not been previously assessed. We aimed to quantify the size and concentration of aerosol particles and evaluate the impact of physical distance and surgical mask wearing during high intensity exercise (HIE).Using a prospective observational crossover study, three h...
DockNet: high-throughput protein-protein interface contact prediction.
BIOINFORMATICS (OXFORD, ENGLAND) - 01 Jan 2023
Over 300 000 protein-protein interaction (PPI) pairs have been identified in the human proteome and targeting these is fast becoming the next frontier in drug design. Predicting PPI sites, however, is a challenging task that traditionally requires computationally expensive and time-consuming docking simulations. A major weakness of modern protein docking algorithms is the inability to account f...
Comprehensive IDF-WPR diabetes and disasters manual, 2nd edition available.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Jan 2023
Methamphetamine-associated cardiomyopathy: an addiction medicine perspective.
INTERNAL MEDICINE JOURNAL - 01 Jan 2023
Methamphetamine-associated cardiomyopathy (MaCM) is an increasingly recognised serious complication from methamphetamine (MA) use. It is characterised as the development of otherwise unexplained heart failure in the context of MA use. MaCM predominantly affects a young and vulnerable population with high morbidity and mortality. It is the second leading cause of mortality in patients with MA us...
Left atrial enlargement is associated with pulmonary vascular disease in heart failure with preserved ejection fraction.
EUROPEAN JOURNAL OF HEART FAILURE - 27 Feb 2023
Elevated left atrial (LA) pressure is a pathophysiologic hallmark of heart failure with preserved ejection fraction (HFpEF). Chronically elevated LA pressure leads to LA enlargement, which may impair LA function and increase pulmonary pressures. We sought to evaluate the relationship between LA volume and pulmonary arterial haemodynamics in patients with HFpEF.Data from 85 patients (aged 69 ± 8...
Clinician Perspectives on Cannulation for Extracorporeal Cardiopulmonary Resuscitation: A Mixed Methods Analysis.
ASAIO JOURNAL (AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS : 1992) - 01 Mar 2023
Out-of-hospital cardiac arrest is a leading cause of mortality with survival rates of less than 10%. In selected patients, survival may be improved via timely application of extracorporeal cardiopulmonary resuscitation (ECPR). However, ECPR is a complex and resource intensive intervention with a high risk of complications that impair widespread clinical adoption. This study employed a mixed app...
An Engineered Nanosugar Enables Rapid and Sustained Glucose-Responsive Insulin Delivery in Diabetic Mice.
12 Mar 2023
Glucose-responsive insulin-delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge-switchable phytoglycogen nanoparticles capable of glucose-stimulated insulin release are engineered. The nanoparticles are ...
Blood pressure variability: methodological aspects, clinical relevance and practical indications for management - a European Society of Hypertension position paper ∗.
JOURNAL OF HYPERTENSION - 01 Apr 2023
Blood pressure is not a static parameter, but rather undergoes continuous fluctuations over time, as a result of the interaction between environmental and behavioural factors on one side and intrinsic cardiovascular regulatory mechanisms on the other side. Increased blood pressure variability (BPV) may indicate an impaired cardiovascular regulation and may represent a cardiovascular risk factor...
Device therapy with interatrial shunt devices for heart failure with preserved ejection fraction.
HEART FAILURE REVIEWS - 01 Mar 2023
Heart failure with preserved ejection fraction is responsible for half of all heart failure and confers substantial morbidity and mortality, and yet to date, there have been no effective pharmacologic interventions. Although the pathophysiology is complex, the primary aetiology of exercise intolerance is due to an elevated left atrial pressure, particularly with exercise. In this context, devic...
Corrigendum to 'Temporal Change in the Remaining Life Expectancy in People Who Underwent Percutaneous Coronary Intervention' The American Journal of Cardiology Volume 187, 15 January 2023, Pages 154-161.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Mar 2023
Diagnostic evaluation of unexplained ventricular tachyarrhythmias in younger adults.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 17 Feb 2023
The diagnostic work-up for cardiac arrest from ventricular tachyarrhythmias occurring in younger adults and structurally normal hearts is variable and often incomplete.We reviewed records for all recipients of a secondary prevention implantable cardiac defibrillator (ICD) younger than 60 years at a single quaternary referral hospital from 2010 to 2021. Patients with unexplained ventricular arrh...
Association of socioeconomic Status in the incidence, Quality-of-care metrics and outcomes for patients with cardiogenic shock in a pre-hospital setting.
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES - 17 Feb 2023
The relationship between lower socioeconomic status(SES) and poor cardiovascular outcomes is well-described, however there exists a paucity of data exploring this association in cardiogenic shock(CS). This study aimed to investigate whether any disparities exist between SES and the incidence, quality-of-care or outcomes of CS patients attended by emergency medical services(EMS).This population-...
Echocardiographic detection of heart valve disease in a community cohort of asymptomatic Australians > 65 years with cardiovascular risk factors.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 15 Feb 2023
Valvular heart disease is becoming an increasingly prevalent with population ageing. We sought to define the current prevalence of valvular heart disease in Australia.The TasELF and VicELF studies prospectively recruited 962 asymptomatic participants ≥65 years, with at least one cardiovascular risk factor, from the Tasmanian and Victorian communities. People were excluded if they had a previous...
Detailed organisation of the human midbrain periaqueductal grey revealed using ultra-high field magnetic resonance imaging.
NEUROIMAGE - 01 Feb 2023
The midbrain periaqueductal grey (PAG) is a critical region for the mediation of pain-related behavioural responses. Neuronal tract tracing techniques in experimental animal studies have demonstrated that the lateral column of the PAG (lPAG) displays a crude somatotopy, which is thought to be critical for the selection of contextually appropriate behavioural responses, without the need for high...
Multispectroscopic, virtual and insights into the photoaging defense mediated by the natural food colorant bixin.in vivo
03 Jan 2023
An upsurge in early onset of photoaging due to repeated skin exposure to environmental stressors such as UV radiation is a challenge for pharmaceutical and cosmeceutical divisions. Current reports indicate severe side effects because of chemical or synthetic inhibitors of matrix metalloproteases (MMPs) in anti-skin aging cosmeceuticals. We evaluated the adequacy of bixin, a well-known FDA certi...
Managing peri-mitral flutter.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 04 Jan 2023
The exponential rise in the incidence of peri-mitral flutter has paralleled the increasing use of more extensive atrial substrate ablation for atrial fibrillation (AF). Given the relative paucity of randomized evidence to support its role in AF management, mitral isthmus ablation should largely be reserved for patients with peri-mitral flutter. Catheter ablation for peri-mitral flutter is chall...
Back to the future: Can retrospective analyses fill in the gaps left by prospective data?
INTERNATIONAL JOURNAL OF CARDIOLOGY - 15 Jan 2023
Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 05 Dec 2022
Perturbation of the insulin/insulin-like growth factor (IGF) signaling system is often cited as a mechanism driving breast cancer risk. A systematic review identified prospective cohort studies and Mendelian randomization studies that examined the effects of insulin/IGF signaling (IGF, their binding proteins (IGFBP), and markers of insulin resistance] on breast cancer risk. Meta-analyses genera...
Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 05 Dec 2022
Physical activity may reduce the risk of developing breast cancer via its effect on the insulin/insulin-like growth factor (IGF) signaling system. A systematic review searched for randomized controlled trials (RCT), Mendelian randomization and prospective cohort studies that examined the effects of physical activity on insulin/IGF signaling [IGFs, their binding proteins (IGFBP), and markers of ...
