Publications
Now showing items 601-620 of 5325 records
Immunometabolism in atherosclerotic disorders
NATURE CARDIOVASCULAR RESEARCH - 23 May 2024
Cardiovascular diseases (CVDs), including atherosclerosis, myocardial infarction and heart failure, are the leading causes of morbidity and mortality worldwide. Emerging evidence suggests a crucial role for immune cell dysfunction and inflammation in the progression of this complex set of diseases. Recent advances demonstrate that immune cells, tightly linked to CVD pathogenesis, are sensitive ...
Mechanobiology. Proceedings of the 4th International Symposium on Mechanobiology. 6th - 9th November 2022. Sydney, Australia.
SPRINGER SERIES IN BIOPHYSICS - 01 Mar 2024
The 4th International Symposium on Mechanobiology (ISMB) organized by the Australian Society for Mechanobiology (AuSMB) took place at the Sydney Nanoscience Hub at the University of Sydney, Australia, from the 6th to the 9th of November 2022. This conference started in 2011 with the founding of the Society in Shanghai, China, and has occurred every three years also visiting Okayama (2014) and m...
Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression.
MOLECULAR THERAPY. NUCLEIC ACIDS - 11 Jun 2024
Epigenetic processes involving long non-coding RNAs regulate endothelial gene expression. However, the underlying regulatory mechanisms causing endothelial dysfunction remain to be elucidated. Enhancer of zeste homolog 2 (EZH2) is an important rheostat of histone H3K27 trimethylation (H3K27me3) that represses endothelial targets, but EZH2 RNA binding capacity and EZH2:RNA functional interaction...
Impact of conjugation to different lipids on the lymphatic uptake and biodistribution of brush PEG polymers.
JOURNAL OF CONTROLLED RELEASE : OFFICIAL JOURNAL OF THE CONTROLLED RELEASE SOCIETY - 01 May 2024
Delivery to peripheral lymphatics can be achieved following interstitial administration of nano-sized delivery systems (nanoparticles, liposomes, dendrimers etc) or molecules that hitchhike on endogenous nano-sized carriers (such as albumin). The published work concerning the hitchhiking approach has mostly focussed on the lymphatic uptake of vaccines conjugated directly to albumin binding moie...
Communication in Chronic Disease Care: A Collaborative Conversation Map.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 May 2024
Chronic diseases require long term commitment from both the patient and the treating physician for improving their clinical outcomes. This journey can be made more easier if a proper communication bridge can be made between both of them. This paper describes an alliterative C-based flow-chart to describe a Collaborative Conversation Map for chronic disease care. It crafts a map which serves as ...
Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
DEVELOPMENTAL CELL - 20 May 2024
The transcription factor EHF is highly expressed in the lactating mammary gland, but its role in mammary development and tumorigenesis is not fully understood. Utilizing a mouse model of Ehf deletion, herein, we demonstrate that loss of Ehf impairs mammary lobuloalveolar differentiation at late pregnancy, indicated by significantly reduced levels of milk genes and milk lipids, fewer differentia...
Pilot implementation and evaluation of the Sit-Stand <i>e</i>-Guide: an <i>e</i>-training program on the use of sit-stand workstations.
ERGONOMICS - 22 May 2024
The 'Sit-Stand <i>e</i>-Guide' <i>e</i>-training program, designed to promote appropriate use of sit-stand workstations (SSWs), was evaluated for usability, acceptability and impact on various outcomes among SSW users. Participants from a large municipal organisation (25% male; mean age 45 [SD = 10.6] years) completed questionnaires pre-training (T0, <i>n</i> = 57), immediately post-training (T...
Intention-behaviour gap in physical activity: unravelling the critical role of the automatic tendency towards effort minimisation.
BRITISH JOURNAL OF SPORTS MEDICINE - 22 May 2024
Ten-Year Risk Equations for Incident Heart Failure in Established Atherosclerotic Cardiovascular Disease Populations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 23 May 2024
Ten-year risk equations for incident heart failure (HF) are available for the general population, but not for patients with established atherosclerotic cardiovascular disease (ASCVD), which is highly prevalent in HF cohorts. This study aimed to develop and validate 10-year risk equations for incident HF in patients with known ASCVD. Ten-year risk equations for incident HF were developed using t...
International Criteria for Reporting Study Quality for Sudden Cardiac Arrest/Death Tool.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 23 May 2024
Studies reporting on the incidence of sudden cardiac arrest and/or death (SCA/D) in athletes commonly lack methodological and reporting rigor, which has implications for screening and preventative policy in sport. To date, there are no tools designed for assessing study quality in studies investigating the incidence of SCA/D in athletes. The International Criteria for Reporting Study Quality fo...
DDMut-PPI: predicting effects of mutations on protein-protein interactions using graph-based deep learning.
NUCLEIC ACIDS RESEARCH - 23 May 2024
Protein-protein interactions (PPIs) play a vital role in cellular functions and are essential for therapeutic development and understanding diseases. However, current predictive tools often struggle to balance efficiency and precision in predicting the effects of mutations on these complex interactions. To address this, we present DDMut-PPI, a deep learning model that efficiently and accurately...
Acute Kidney Injury after Heart Transplantation: Risk Stratification is Good; Risk Modification is Better-But can we do it?
TRANSPLANTATION DIRECT - 01 Jun 2024
Trends in Cardiovascular Health Among US Adolescents Aged 12-19 Years Using the New "Life's Essential 8" Metrics, 2007-2018.
THE JOURNAL OF ADOLESCENT HEALTH : OFFICIAL PUBLICATION OF THE SOCIETY FOR ADOLESCENT MEDICINE - 11 May 2024
The American Heart Association recently issued a substantial update to the definition and scoring of cardiovascular health (CVH), now called "Life's Essential 8" (LE8). We aimed to assess the trends in overall and individual LE8 CVH metrics among adolescents in the United States. A total of 6,999 United States adolescents aged 12-19 years from six cycles of the National Health and Nutrition Exa...
Counseling for Insulin Icodec: A Proposed Practitioner's Guide.
14 May 2024
Despite insulin being a lifesaving medication, insulin distress, insulin hesitancy, and insulin inertia remain oft-repeated themes in diabetes discourse. The current model lists three issues: temperament, troublesomeness, and technicality, which contribute to insulin perceptions. Therapeutic patienteducation (TPE), value-added therapy (VAT), and medication counseling are concepts that assist in...
A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH : IJTR - 01 Jan 2024
Stem cells are ubiquitously found in various tissues and organs in the body, and underpin the body's ability to repair itself following injury or disease initiation, though repair can sometimes be compromised. Understanding how stem cells are produced, and functional signaling systems between different niches is critical to understanding the potential use of stem cells in regenerative medicine....
Associations of plant-based foods, red and processed meat, and dairy with gut microbiome in Finnish adults.
EUROPEAN JOURNAL OF NUTRITION - 16 May 2024
Population-based studies on the associations of plant-based foods, red meat or dairy with gut microbiome are scarce. We examined whether the consumption of plant-based foods (vegetables, potatoes, fruits, cereals), red and processed meat (RPM) or dairy (fermented milk, cheese, other dairy products) are related to gut microbiome in Finnish adults. We utilized data from the National FINRISK/FINDI...
Efficacy and safety of sympathetic mapping and ablation of renal nerves for the treatment of hypertension (SMART): 6-month follow-up of a randomised, controlled trial.
ECLINICALMEDICINE - 01 Jun 2024
Previous trials of renal denervation (RDN) have been designed to investigate reduction of blood pressure (BP) as the primary efficacy endpoint using non-selective RDN without intraoperatively verified RDN success. It is an unmet clinical need to map renal nerves, selectively denervate renal sympathetic nerves, provide readouts for the interventionalists and avoid futile RDN. We aimed to examine...
Set7 Methyltransferase and Phenotypic Switch in Diabetic Glomerular Endothelial Cells.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : JASN - 17 Apr 2024
Diet to Stop Hypertension: Should Fats be Included?
CURRENT HYPERTENSION REPORTS - 07 May 2024
International guidelines emphasize advice to incorporate dietary measures for the prevention and in the management of hypertension. Current data show that modest reductions in weight can have an impact on blood pressure. Reducing salt and marine oils have also shown consistent benefit in reducing blood pressure. Whether other dietary constituents, in particular the amount and type of fat that p...
Glucose Targets Using Continuous Glucose Monitoring Metrics in Older Adults With Diabetes: Are We There Yet?
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY - 07 May 2024
The older population is increasing worldwide and up to 30% of older adults have diabetes. Older adults with diabetes are at risk of glucose-related acute and chronic complications. Recently, mostly in type 1 diabetes (T1D), continuous glucose monitoring (CGM) devices have proven beneficial in improving time in range (TIR glucose, 70-180 mg/dL or glucose 3.9-10 mmol/L), glycated hemoglobin (HbA1...
