Publications
Now showing items 61-80 of 5595 records
Foetal Metformin Exposure, Childhood Adiposity and Future Cardiovascular Risk: Can We Connect the Dots?
TOUCHREVIEWS IN ENDOCRINOLOGY - 01 Oct 2025
The prevalence of gestational diabetes (GD) and pre-existing diabetes during pregnancy has been increasing. Insulin is the accepted pharmacological treatment for hyperglycaemia in pregnancy. Metformin has emerged as a promising alternative or adjunct due to its ease of use, lower cost and reduced risk of hypoglycaemia. Beyond GD, metformin also shows potential utility in early GD and polycystic...
Role of lifestyle interventions in reducing UTI burden among Individuals with obesity.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Aug 2025
Urinary tract infections (UTIs) are a prevalent health concern globally, and their incidence is disproportionately higher among individuals with obesity. Obesity increases the likelihood of UTIs due to a range of physiological, immunological, and behavioural factors. This article explores the relationship between obesity and UTIs while emphasizing evidence-based lifestyle changes to lower this ...
Obesity And The Spleen.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Aug 2025
This review describes the relationship of splenomegaly, or "splenic obesity", with metabolic syndrome, obesity and metabolic - associated steatohepatic disease (MAFLD), based on animal and human studies. The spleen is enlarged in obesity. It may play a protective role against obesity-associated inflammation and complications. This protection may be lost after splenomegaly. Persons with splenic ...
Biohacks And Diabetes: Obstacle Or Opportunity.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Aug 2025
This communication describes the concept of biohacking, and relates it to primary diabetes care. Biohacking can be defined as the use of self-developed, informal non evidence based means of managing and monitoring disease, or promoting health. In the context of diabetes care, biohacks may be related to lifestyle, diet, physical activity or spiritual management, pharmacological therapy, or monit...
Pharmacosimilars In Obesity Medicine: Informed Choice, Appropriate Choice.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Aug 2025
Newer developments in endocrine pharmacology have blurred the distinction between biosimilars and generics. The originator semaglutide, for example, is a biologically active compound, but later versions are chemically synthesized generics. Tirzepatide is a synthetic polypeptide. These molecules are marketed in different strengths and delivery devices across the world. The word 'pharmaco-similar...
Renal denervation in 2026: trial evidence, guideline recommendations and implementation strategies for clinical practice.
HEART (BRITISH CARDIAC SOCIETY) - 12 Mar 2026
Renal nerves are critical modulators of kidney function and blood pressure (BP) control. Their influence on sodium and fluid retention, renin release and vasoconstriction rendered them a therapeutic target more than a century ago when surgical splanchnicectomy emerged as one of the first effective antihypertensive therapies. Revisiting the concept using catheter-based approaches to ablate renal...
An Equity Audit of a Statewide Cardiometabolic Risk Reduction Pilot Programme for Women with a History of Gestational Diabetes.
NUTRIENTS - 02 Feb 2026
This equity audit assessed enrolment and completion of a state-funded cardiometabolic risk-reduction programme for women with prior gestational diabetes in Victoria, Australia. The analyses compared completion rates between the standard prevention programme <i>Life!</i> with one specifically adapted for women with prior gestational diabetes (<i>Life!</i> GDM) using the PROGRESS equity framework...
Pharmacogenomic predictors of drug response and choice in dyslipidemia and hypertension.
MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES - 30 Jan 2026
Drug suitability is determined by safety, efficacy, and pathological appropriateness. The pharmacogenomics of drug suitability can be assessed by analyzing drug response and drug choice in large population cohorts. We investigated drug response and drug choice for dyslipidemia and hypertension using genetic, phenotypic, and prescribing data from the UK Biobank and the All of Us Research Program...
Leveraging the shared and opposing genetic mechanisms in the heritable cardiomyopathies.
RESEARCH SQUARE - 27 Jan 2026
Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are heart muscle diseases with largely opposing structural and functional phenotypes. Yet, both may lead to the same devastating outcomes of advanced heart failure and life-threatening arrhythmias. Using genome-wide association data from 9,365 DCM cases, 5,900 HCM cases, and over 1.2 million controls, we show that DCM and HCM ar...
Macrovascular complications in type 2 diabetes: a multiregional study in rural Bangladesh.
FRONTIERS IN ENDOCRINOLOGY - 01 Jan 2026
To assess the prevalence and determinants of macrovascular complications (coronary artery disease, stroke, and diabetic foot) among adults living with T2DM in rural Bangladesh. A population-based cross-sectional study was conducted between December 2023 and September 2024, involving 1094 adults with diagnosed T2DM from rural areas of three regions/divisions in Bangladesh. Data were collected th...
Epigenetic Regulation of VCAM-1 by Lipoxin A4 Is Renoprotective Against Diabetic Kidney Disease.
DIABETES - 18 Feb 2026
Chronic low-grade inflammation underlies many microvascular complications of diabetes, including diabetic kidney disease (DKD). Lipoxins (LXs), an endogenously produced family of lipid mediators, resolve inflammation and protect against renal scarring as occurs in DKD. This study examined the mechanism by which LXs protect against DKD, focusing on the regulation of VCAM-1 and the recruitment of...
Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study.
BMC MEDICINE - 16 Feb 2026
Cardiovascular disease (CVD) is a major global health burden, particularly among overweight and obese individuals. We aimed to investigate associations between different physical activity patterns (concentrated activity vs. regularly active) and incident CVD, and to compare their effects in this specific population. Data were from the UK Biobank, with 49,368 overweight and obese individuals (63...
Addressing Gaps in the Hypertension and Diabetes Care Continuum in Rural Bangladesh Through Digital Technology Supported Decentralized Primary Care: Study Protocol and Baseline Results for a Hybrid Effectiveness-Implementation Trial.
02 Feb 2026
Hypertension and diabetes are very common, interrelated chronic conditions. Awareness, diagnosis, treatment, and control rates of these conditions remain low, and access to quality care-particularly in rural areas-is a persistent challenge in many low- and middle-income countries. Strengthening primary health care, including the use of digital tools, is important to improve management of these ...
Redefining Osteoporosis: A Global Call for Equity, Evidence, and Access- Perspectives from Asia and Africa.
ENDOCRINE PRACTICE : OFFICIAL JOURNAL OF THE AMERICAN COLLEGE OF ENDOCRINOLOGY AND THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS - 30 Jan 2026
Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study.
CARDIOVASCULAR DIABETOLOGY - 29 Jan 2026
Endothelial to mesenchymal transition (EndMT), the transformation of endothelial cells into a mesenchymal-like state, is regulated by various factors, including transcription factors such as activator protein 1 (AP-1). While recent studies have confirmed the role of EndMT in atherosclerosis, the involvement of AP-1 in EndMT, particularly in the context of human diabetes, remains unclear. This s...
Global, Regional, and National Estimates of Undiagnosed Diabetes in Adults: Findings From the 2025 IDF Diabetes Atlas.
DIABETES CARE - 28 Jan 2026
Undiagnosed diabetes leads to delayed treatment and increased risk of complications, exacerbating global disease burdens. In this study, we estimated the prevalence and absolute numbers of individuals with undiagnosed diabetes globally and across regions and quantified gaps in national diabetes detection efforts. We systematically compiled estimates of biomarker-based diabetes prevalence and se...
Statin initiation among cancer survivors with asymptomatic coronary atherosclerosis.
CARDIO-ONCOLOGY (LONDON, ENGLAND) - 19 Jan 2026
Multi-omic analysis of human PHACTR1 signaling networks.
COMMUNICATIONS BIOLOGY - 19 Jan 2026
Genetic studies have linked PHACTR1 to a range of vascular diseases, underscoring its pivotal role in vascular biology. However, the full spectrum of PHACTR1-mediated signaling pathways remains largely unexplored. To bridge this gap, we employ a multi-omics pipeline combining pairwise differential expression analysis, multi-omics pathway integration, and feature-level correlation analyses acros...
A Context-Adapted Diabetes Prevention Program (Small Steps for Big Changes) in Australia: Protocol for a Hybrid Implementation-Effectiveness Study.
19 Jan 2026
With type 2 diabetes rates escalating worldwide, including in Australia, effective, acceptable, sustainable, and scalable diabetes prevention programs are needed. Small Steps for Big Changes (SSBC) is a Canadian-developed, community-delivered diet and exercise counseling intervention for individuals at risk of type 2 diabetes. The 3- to 6-week intervention can be delivered by trained non-health...
Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.
DIABETES TECHNOLOGY & THERAPEUTICS - 12 Feb 2026
We aimed to assess continuous ketone monitor (CKM) profiles in community-dwelling adults with type 1 diabetes. Two-weeks CKM (Abbott, Alameda, CA) run-in data (PARTNER study: ACTRN12624000448549) were analyzed by groups <0.6, 0.6-0.9, and ≥1.0 mmol/L defined as at least one reading in the highest ketone range. Results are median interquartile range (IQR). Sixty-four participants (age 49.8 [40.2...
