Publications
Now showing items 61-80 of 4875 records
Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer.
PROTEOMICS - 03 Apr 2024
Small extracellular vesicles (sEVs) are cell-derived vesicles evolving as important elements involved in all stages of cancers. sEVs bear unique protein signatures that may serve as biomarkers. Pancreatic cancer (PC) records a very poor survival rate owing to its late diagnosis and several cancer cell-derived proteins have been reported as candidate biomarkers. However, given the pivotal role p...
Randomized Trial of a Selective Aldose Reductase Inhibitor in Patients With Diabetic Cardiomyopathy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 03 Apr 2024
Progression to symptomatic heart failure is a complication of type 2 diabetes; heart failure onset in this setting is commonly preceded by deterioration in exercise capacity. The study sought to determine whether AT-001, a highly selective aldose reductase inhibitor, can stabilize exercise capacity among individuals with diabetic cardiomyopathy (DbCM) and reduced peak oxygen uptake (Vo<sub>2</s...
Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System: JACC Family Series.
JACC. CARDIOVASCULAR IMAGING - 04 Apr 2024
Population aging is one of the most important demographic transformations of our time. Increasing the "health span"-the proportion of life spent in good health-is a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular...
Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats.
05 Apr 2024
In recent years, the drainage of fluids, immune cells, antigens, fluorescent tracers, and other solutes from the brain has been demonstrated to occur along lymphatic outflow pathways to the deep cervical lymph nodes in the neck. To the best of our knowledge, no studies have evaluated the lymphatic transport of therapeutics from the brain. The objective of this study was to determine the lymphat...
The Role of Comorbidities in Predicting Functional Improvement After Transcatheter Aortic Valve Implantation.
HEART, LUNG & CIRCULATION - 05 Apr 2024
Patients undergoing transcatheter aortic valve implantation (TAVI) have a high comorbidity burden. We sought to stratify patients into functional outcomes using the Kansas City Cardiomyopathy Questionnaire (KCCQ-12), a patient-reported outcome with benefits over both the New York Heart Association (NYHA) classification and the original 23-item KCCQ, and to evaluate the importance of comorbiditi...
Associations of 24 h time-use compositions of sitting, standing, physical activity and sleeping with optimal cardiometabolic risk and glycaemic control: The Maastricht Study.
DIABETOLOGIA - 24 Apr 2024
The associations of sitting, standing, physical activity and sleep with cardiometabolic health and glycaemic control markers are interrelated. We aimed to identify 24 h time-use compositions associated with optimal metabolic and glycaemic control and determine whether these varied by diabetes status. Thigh-worn activPAL data from 2388 participants aged 40-75 years (48.7% female; mean age 60.1 [...
Extracellular vesicles-An omics view.
PROTEOMICS - 26 Apr 2024
A comparison of wavelet-based action potential detection from the NeuroAmp and the Iowa Bioengineering Nerve Traffic Analysis system.
JOURNAL OF NEUROPHYSIOLOGY - 17 Apr 2024
Microneurographic recordings of muscle sympathetic nerve activity (MSNA) reflects postganglionic sympathetic axonal activity directed toward the skeletal muscle vasculature. Recordings are typically evaluated for spontaneous bursts of MSNA; however, the filtering and integration of raw neurograms to obtain multi-unit bursts conceals the underlying c-fiber discharge behavior. The continuous wave...
Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer's disease.
ISCIENCE - 16 Feb 2024
Alzheimer's disease (AD) is associated with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles (NFT). We characterized the behavioral, metabolic and lipidomic phenotype of the 5xFADxTg30 mouse model which contains overexpression of both Aβ and tau. Our results independently reproduce several phenotypic traits described previously for this model, w...
Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer's disease.
NPJ METABOLIC HEALTH AND DISEASE - 01 Jan 2024
Alzheimer's disease (AD) is influenced by a variety of modifiable risk factors, including a person's dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affecting AD progression, only a few studies have explored KD's metabolic impact, especially on blood and cerebrospinal fluid (CSF). Our study involved participants at risk for AD, either cogn...
Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment.
ADV HEALTHC MATER - 10 Jan 2024
Brain cancers, especially glioblastoma multiforme (GBM), are associated with poor prognosis due to the limited efficacy of current therapies. Nanomedicine has emerged as a versatile technology to treat various diseases, including cancers, and has played an indispensable role in combatting the COVID-19 pandemic as evidenced by the role that lipid nanocarrier-based vaccines have played. The tunab...
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.
LANCET (LONDON, ENGLAND) - 16 Mar 2024
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. We used data from 3663 population-based studies with 222 million participants that mea...
The Ten Cs Of Chronic Care.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2024
Glucokathexis.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2024
Glucokathexis is a clinical state characterized by low plasma glucose levels, in the presence of adequate glucose precursor stores. We conceive and construct this rubric to initiate interest and inspire insight into this field of metabolic medicine. We list various conditions that can cause true as well as pseudo-glucokathexis.
Obesity is a communicable disease.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Apr 2024
Obesity has multiple causes and correlates. Usually studied as a metabolic and endocrine disease, with mechanical and musculoskeletal comorbidities, obesity also has a communicable angle to it. Obesity can be considered a communicable disease from the conventional point of view, as it is associated with viral etiology in animal and human models. It is also associated with increased prevalence a...
Withdrawal of Neurohormonal Antagonists in Breast Cancer Patients With Cardiotoxicity and Improved Left Ventricular Function.
JACC. CARDIOONCOLOGY - 01 Apr 2024
Canagliflozin/metformin Fixed-dose Combination: National Evidence, Global Relevance.
THE JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA - 01 Apr 2024
Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction.
MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES - 16 Apr 2024
Blood cell phenotypes are routinely tested in healthcare to inform clinical decisions. Genetic variants influencing mean blood cell phenotypes have been used to understand disease aetiology and improve prediction; however, additional information may be captured by genetic effects on observed variance. Here, we mapped variance quantitative trait loci (vQTL), i.e. genetic loci associated with tra...
Cardiovascular Implications of Semaglutide in Obesity Management: Redefining Cardiovascular Health Strategies.
HEART INTERNATIONAL - 01 Jan 2024
Semaglutide is a glucagon-l ike peptide 1 receptor agonist that has been noted to have a significant role in the reduction of body weight and glycaemic control. An increasing body of evidence from recent trials (SUSTAIN-6, SELECT and STEP HF) has shown significant cardiovascular benefits of semaglutide in both patients with and without diabetes and in people who are obese or overweight. Additio...
Society for Cardiovascular Magnetic Resonance 2022 Cases of SCMR case series.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE - 01 Jan 2024
"Cases of SCMR" is a case series on the SCMR website (https://www.scmr.org) for the purpose of education. The cases reflect the clinical presentation, and the use of cardiovascular magnetic resonance (CMR) in the diagnosis and management of cardiovascular disease. The 2022 digital collection of cases are presented in this manuscript.
