Publications
Now showing items 5641-5660 of 5702 records
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection
FEBS LETT - 01 Oct 2017
High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in CD4+Glut1+ T cells from HIV+ subjects. TCR engagement of CD4+Glut1+ T cells from HIV+ subjects demonstrates hyperresponsive PI3K-mammalian target of rapamycin signaling. High ...
Association of diabetic macular edema and proliferative diabetic retinopathy with cardiovascular disease a systematic review and meta-analysis
JAMA OPHTHALMOL - 01 Jun 2017
Importance:
Previous studies on the relationship between diabetic retinopathy (DR) and cardiovascular disease (CVD) focused on the early stages of DR. Understanding whether patients with type 2 diabetes and severe stages of DR (diabetic macular edema [DME] and proliferative diabetic retinopathy [PDR]) have a higher risk of CVD will allow physicians to more effectively counsel patients.
Obje...
Association of neighborhood demographics with out-of-hospital cardiac arrest treatment and outcomes: where you live may matter
JAMA CARDIOL - 01 Oct 2017
Importance:
We examined whether resuscitation care and outcomes vary by the racial composition of the neighborhood where out-of-hospital cardiac arrests (OHCAs) occur.
Objective:
To evaluate the association between bystander treatments (cardiopulmonary resuscitation and automatic external defibrillation) and timing of emergency medical services personnel on OHCA outcomes according to the...
Predictive score for 30-day readmission or death in heart failure
JAMA CARDIOL - 01 Jun 2016
Readmissions shortly after heart failure (HF) are common, expensive, and usually considered preventable. However, despite the use of several interventions, rates of readmission after HF remain stable. An effective risk score might permit the targeting of resource-intensive interventions (such as disease-management programs) specifically on high-risk patients. We sought to determine the combinat...
Association of cardiometabolic multimorbidity with mortality
JAMA - 07 Jul 2015
IMPORTANCE:
The prevalence of cardiometabolic multimorbidity is increasing.
OBJECTIVE:
To estimate reductions in life expectancy associated with cardiometabolic multimorbidity.
DESIGN, SETTING, AND PARTICIPANTS:
Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689,300 particip...
Effect of vericiguat, a soluble guanylate cyclase stimulator, on natriuretic peptide levels in patients with worsening chronic heart failure and reduced ejection fraction: the SOCRATES-REDUCED randomized trial
JAMA - 01 Dec 2015
IMPORTANCE:
Worsening chronic heart failure (HF) is a major public health problem.
OBJECTIVE:
To determine the optimal dose and tolerability of vericiguat, a soluble guanylate cyclase stimulator, in patients with worsening chronic HF and reduced left ventricular ejection fraction (LVEF).
DESIGN, SETTING, AND PARTICIPANTS:
Dose-finding phase 2 study that randomized 456 patients across...
Effect of finerenone on albuminuria in patients with diabetic nephropathy a randomized clinical trial
JAMA - 01 Sep 2015
IMPORTANCE:
Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with chronic kidney disease but may be underused because of a high risk of adverse events.
OBJECTIVE:
To evaluate the safety and efficacy of different oral doses of the nonsteroidal mineralocorticoid receptor antagonist finerenone, given f...
Glycated hemoglobin measurement and prediction of cardiovascular disease
JAMA - 26 Mar 2014
IMPORTANCE:
The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain.
OBJECTIVE:
To determine whether adding information on HbA1c values to conventional cardiovascular risk factors is associated with improvement in prediction of cardiovascular disease (CVD) risk.
DESIGN, SETTING, AND PARTICIPANTS:
Analysis of individual-par...
Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: a randomized controlled trial
JAMA - 06 Feb 2013
IMPORTANCE: Approximately one-third of patients with peripheral artery disease experience intermittent claudication, with consequent loss of quality of life.
OBJECTIVE: To determine the efficacy of ramipril for improving walking ability, patient-perceived walking performance, and quality of life in patients with claudication.
DESIGN, SETTING, AND PATIENTS: Randomized, double-blind, placebo-co...
Surgical vs conventional therapy for weight loss treatment of obstructive sleep apnea: a randomized controlled trial
JAMA - 19 Sep 2012
CONTEXT: Obstructive sleep apnea (OSA) is strongly related to obesity. Weight loss is recommended as part of the overall management plan for obese patients diagnosed with OSA.
OBJECTIVE: To determine whether surgically induced weight loss is more effective than conventional weight loss therapy in the management of OSA.
DESIGN, SETTING, AND PATIENTS: A randomized controlled trial of 60 obe...
Percutaneous re-circulating isolated limb perfusion of gentamicin in a large animal model: targeted delivery of gentamicin to limb
AM J TRANSL RES - 01 Jan 2013
OBJECTIVE: We have developed a percutaneous recirculation system (V-Vascular, V-V) to enable delivery of high levels of antibiotic to the limb in an isolated and targeted manner for the treatment of limb infection.
BACKGROUND: Chronic and acute limb infections are relatively commonplace in a variety of wound types. Infection can become refractory to existing treatment strategies and can cause ...
Inhibition of the NF-κB pathway by R65 ribozyme gene via adeno-associated virus serotype 9 ameliorated oxidized LDL induced human umbilical vein endothelial cell injury
INT J CLIN EXP PATHOL - 01 Sep 2015
OBJECTIVE:
NF-κB signaling plays a central role in the regulation of inflammatory responses in atherosclerosis. R65 ribozyme gene suppresses activation of NF-κB pathway, therefore we studied whether R65 gene therapy can ameliorate oxidized low-density lipoprotein (ox-LDL) induced human umbilical vein endothelial cells (HUVECs) injury.
METHODS AND RESULTS:
Recombinant adeno-associated vir...
Self-reported access to and quality of healthcare for diabetes: do the severely obese experience equal access?
AUST FAM PHYSICIAN - 01 Aug 2014
BACKGROUND:
Given reported pejorative views that health professionals have about patients who are severely obese, we examined the self-reported views of the quality and availability of diabetes care from the perspective of adults with type 2 diabetes (T2DM), stratified by body mass index (BMI).
METHODS:
1795 respondents to the Diabetes MILES - Australia national survey had T2DM. Of these, 53...
A user assessment of the potential for shared medical appointments in Australia
AUST FAM PHYSICIAN - 01 Jan 2014
BACKGROUND:
In some countries, shared medical appointments (SMAs) have been shown to be more effective than single consultations for managing chronic diseases. Our study was designed as the first stage of a Royal Australian College of General Practitioners (RACGP) funded project to assess potential patient and provider support for SMAs if they were to become available in Australia.
METHODS:
...
Exploration of mechanisms in nutriepigenomics: identification of chromatin-modifying compounds from Olea Europaea
HELL J NUCL MED - 01 Sep 2015
Chemical modification of histones represents an important epigenetic mechanism critical for DNA metabolism including, transcription, replication and repair. A well-known example is maintenance of histone acetylation status by the opposing actions of histone acetyltransferase and histone deacetylase enzymes which add and remove acetyl groups on lysine residues on histone tails, respectively. Sim...
Patients' and providers' satisfaction with shared medical appointments
AUST FAM PHYSICIAN - 01 Sep 2015
BACKGROUND:
Shared medical appointments (SMAs) are comprehensive medical visits conducted with groups of patients. We have previously discussed the potential and assessed likely support for SMAs in Australia. In this paper, we report on patient and provider satisfaction, and some subjective outcomes.
OBJECTIVE:
To measure patients' and providers' attitude and satisfaction with SMAs after...
Laparoscopic adrenalectomy for phaeochromocytoma: a case series
N Z MED J - 01 Oct 2015
AIM:
To describe our 13-year experience in laparoscopic adrenalectomy for phaeochromocytoma.
METHOD:
We performed a retrospective analysis of case notes of 29 patients who underwent laparoscopic adrenalectomy for phaeochromocytoma between 2000 and 2013.
RESULTS:
Twenty-nine patients (16 female), aged 16 to 67 years, underwent laparoscopic adrenalectomy for phaeochromocytoma. All pati...
Shared medical appointments for Aboriginal and Torres Strait Islander men
AUST FAM PHYSICIAN - 01 Jun 2016
BACKGROUND:
Aboriginal and Torres Strait Islander health is generally the worst of any population group in Australia. Inaccessibility to health services is one possible cause of this. Shared medical appointments (SMAs) appear to be a culturally competent and appropriate way of improving access to, and the quality of, primary healthcare services for Aboriginal and Torres Strait Islander peopl...
Descriptive epidemiology of physical activity among Omani adults: the Oman World Health Survey, 2008
EAST MEDITERR HEALTH J - 01 Apr 2016
There is an increasing burden of obesity and obesity-related noncommunicable diseases in Gulf Cooperation Council countries, including Oman. This descriptive, epidemiological study assessed physical activity among 2977 Omani adults using a population-based household survey in 2008. Overall, 54.2% of men and 41.6% of women were physically active; the rate was higher in younger cohorts and varied...
High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice
SCI TRANSL MED - 11 Oct 2017
Protecting the heart after an acute coronary syndrome is a key therapeutic goal to support cardiac recovery and prevent progression to heart failure. A potential strategy is to target cardiac glucose metabolism at the early stages after ischemia when glycolysis is critical for myocyte survival. Building on our discovery that high-density lipoprotein (HDL) modulates skeletal muscle glucose metab...
