Publications
Now showing items 561-580 of 4875 records
Sudden cardiac death, arrhythmias and abnormal electrocardiography in systemic sclerosis: A systematic review and meta-analysis.
01 Oct 2023
To calculate the frequency of sudden cardiac death(SCD), arrhythmia and conduction defects in SSc.MEDLINE/EMBASE were searched to January 2023. English-language studies reporting the incidence/frequency of SCD, arrhythmia and electrocardiography(ECG) abnormalities in SSc were included. Odds ratios(OR), estimations of annual incidence or pooled frequencies were calculated.Seventy-nine studies(n ...
Incorporating a polygenic risk score-triaged coronary calcium score into cardiovascular disease examinations to identify subclinical coronary artery disease (ESCALATE): Protocol for a prospective, nonrandomized implementation trial.
AMERICAN HEART JOURNAL - 01 Oct 2023
Identifying and targeting established modifiable risk factors has been a successful strategy for reducing the burden of coronary artery disease (CAD) at the population-level. However, up to 1-in-4 patients who present with ST elevation myocardial infarction do so in the absence of such risk factors. Polygenic risk scores (PRS) have demonstrated an ability to improve risk prediction models indep...
Exercise-induced myocardial T1 increase and right ventricular dysfunction in recreational cyclists: a CMR study.
01 Oct 2023
Although cardiac troponin I (cTnI) increase following strenuous exercise has been observed, the development of exercise-induced myocardial edema remains unclear. Cardiac magnetic resonance (CMR) native T1/T2 mapping is sensitive to the pathological increase of myocardial water content. Therefore, we evaluated exercise-induced acute myocardial changes in recreational cyclists by incorporating bi...
Correction to: The T1D Index: Implications of Initial Results, Data Limitations, and Future Development.
CURRENT DIABETES REPORTS - 01 Oct 2023
Current insights and emerging trends in early-onset type 2 diabetes.
THE LANCET. DIABETES & ENDOCRINOLOGY - 01 Oct 2023
Type 2 diabetes diagnosed in childhood or early adulthood is termed early-onset type 2 diabetes. Cases of early-onset type 2 diabetes are increasing rapidly globally, alongside rising obesity. Compared with a diagnosis later in life, an earlier-onset diagnosis carries an unexplained excess risk of microvascular complications, adverse cardiovascular outcomes, and earlier death. Women with early-...
Applying the WHO global targets for diabetes mellitus.
NATURE REVIEWS. ENDOCRINOLOGY - 01 Apr 2023
An atlas of genetic scores to predict multi-omic traits.
NATURE - 01 Apr 2023
The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics. Here we examine a large cohort (the INTERVAL study; n = 50,000 participants) with extensive multi-omic data for plas...
Interactions between the lipidome and genetic and environmental factors in autism.
NATURE MEDICINE - 01 Apr 2023
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. Here we explored the plasma lipidome (783 lipid species) in 765 children (485 diagnosed with a...
Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?
CARDIOVASCULAR RESEARCH - 20 Sep 2022
Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a significant collateral damage to the tissues and on the other hand, they help facilitate wound healing by a number of mechanisms. Recent studies have drastically changed the perception of neutrophils from being simple...
Heart Failure With Preserved Ejection Fraction as an Exercise Deficiency Syndrome: JACC Focus Seminar 2/4.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 20 Sep 2022
Across differing spectrums of cardiac function and cardiac pathologies, there are strong associations between measures of cardiorespiratory fitness and burden of symptoms, quality of life, and prognosis. In this part 2 of a 4-part series, we contend that there is a strong association among physical activity, cardiorespiratory fitness, and cardiac function. We argue that a chronic lack of exerci...
Supporting cardiovascular researchers takes a village but it starts with us.
EUROPEAN HEART JOURNAL - 21 Sep 2022
The Complement Pathway: New Insights into Immunometabolic Signaling in Diabetic Kidney Disease.
ANTIOXIDANTS & REDOX SIGNALING - 01 Oct 2022
The metabolic disorder, diabetes mellitus, results in microvascular complications, including diabetic kidney disease (DKD), which is partly believe to involve disrupted energy generation in the kidney, leading to injury that is characterized by inflammation and fibrosis. An increasing body of evidence indicates that the innate immune complement system is involved in the pathogenesis of DKD; how...
Dulaglutide and cardiovascular and heart failure outcomes in patients with and without heart failure: a post-hoc analysis from the REWIND randomized trial.
EUROPEAN JOURNAL OF HEART FAILURE - 01 Oct 2022
People with diabetes are at high risk for cardiovascular events including heart failure (HF). We examined the effect of the glucagon-like peptide 1 agonist dulaglutide on incident HF events and other cardiovascular outcomes in those with or without prior HF in the randomized placebo-controlled Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial.The REWIND major a...
Stepping up with GGIR: Validity of step cadence derived from wrist-worn research-grade accelerometers using the verisense step count algorithm.
JOURNAL OF SPORTS SCIENCES - 01 Oct 2022
The Verisense Step Count Algorithm facilitates generation of steps from wrist-worn accelerometers. Based on preliminary evidence suggesting a proportional bias with overestimation at low steps/day, but underestimation at high steps/day, the algorithm parameters have been revised. We aimed to establish validity of the original and revised algorithms relative to waist-worn ActiGraph step cadence....
Weight status change from birth to childhood and high carotid intima-media thickness in childhood.
PEDIATRIC OBESITY - 01 Oct 2022
High birth weight or childhood overweight increases the risk of high carotid intima-media thickness (cIMT) in childhood. However, no studies have assessed the association between change in weight status from birth to childhood and cIMT in childhood.We examined the association between weight status change from birth to childhood and cIMT in childhood based on a population-based study of Chinese ...
Association between hyperglycaemia in pregnancy and growth of offspring in early childhood: The PANDORA study.
PEDIATRIC OBESITY - 01 Oct 2022
Few studies have assessed whether children exposed to in utero hyperglycaemia experience different growth trajectories compared to unexposed children.To assess association of type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) with early childhood weight, length/height and body mass index (BMI) trajectories, and with timing and magnitude of peak BMI in infancy.PANDORA is a birth cohor...
Higher rates but similar causes of young out-of-hospital cardiac arrest in rural Australian patients.
THE AUSTRALIAN JOURNAL OF RURAL HEALTH - 01 Oct 2022
To determine whether young rural Australians have higher rates or different underlying causes of out-of-hospital cardiac arrest (OHCA).A case-control design identified patients experiencing an OHCA, then compared annual OHCA rates and underlying causes in rural versus metropolitan Victoria. OHCA causes were defined as either cardiac or non-cardiac, with specific aetiologies including coronary d...
Regional hypothalamic, amygdala, and midbrain periaqueductal gray matter recruitment during acute pain in awake humans: A 7-Tesla functional magnetic resonance imaging study.
NEUROIMAGE - 01 Oct 2022
Over the past two decades, magnetic resonance imaging (MRI) studies have explored brain activation patterns during acute noxious stimuli. Whilst these human investigations have detailed changes in primarily cortical regions, they have generally not explored discrete changes within small brain areas that are critical in driving behavioural, autonomic, and endocrine responses to pain, such as wit...
Brian Fowell Buxton (15/04/1940-20/05/2022)-Outstanding Achievements and Personal Memories.
HEART, LUNG & CIRCULATION - 01 Oct 2022
Brian F. Buxton, one of Australia's greatest cardiac surgeons, died in May 2022, aged 82 years. In June 2022, a memorial celebration of Brian's life was held in Melbourne, Australia, attended by 550 colleagues and friends from many walks of life-not only "medical people" but also friends involved in Brian's sailing and hiking activities. This Special Article includes an introduction from Profes...
In silico Prediction of Thrombosis Risk in a Ventricular Assist Device Supported Right Heart: The Impact of Cannulation Site.
ASAIO JOURNAL (AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS : 1992) - 01 Oct 2022
Right ventricular assist device (RVAD) associated thrombosis is a serious complication that may arise due to unfavorable blood flow dynamics (blood stasis) caused by RVAD cannula protrusion within the chambers. This study aims to investigate the thrombosis risk of cannulation via the right atrium (RA) and right ventricle (RV) (diaphragmatic) under full RVAD support using computational fluid dyn...
