Publications
Now showing items 541-560 of 5027 records
Factors Contributing to the Change in Overweight/Obesity Prevalence Among Indian Adults: A multivariate decomposition analysis of data from the National Family Health Surveys.
ADVANCES IN THERAPY - 01 Dec 2023
Concerns over the escalating burden of non-communicable diseases call for the redressal of behavioral risk factors like increased body mass index. Most studies have failed to quantify the contribution of socio-demographic characteristics in a linear trend. The present study aims to estimate the current prevalence of overweight and obesity in Indian adults and the contribution of different socio...
Improving traffic-related air pollution estimates by modelling minor road traffic volumes.
ENVIRONMENTAL POLLUTION (BARKING, ESSEX : 1987) - 01 Dec 2023
Accurately estimating annual average daily traffic (AADT) on minor roads is essential for assessing traffic-related air pollution (TRAP) exposure, particularly in areas where most people live. Our study assessed the direct and indirect external validity of three methods used to estimate AADT on minor roads in Melbourne, Australia. We estimated the minor road AADT using a fixed-value approach (a...
Evolution and transmission of antibiotic resistance is driven by Beijing lineage in Vietnam.Mycobacterium tuberculosis
MICROBIOLOGY SPECTRUM - 12 Dec 2023
Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that genetic line...
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity.
NATURE COMMUNICATIONS - 15 Jan 2024
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer's disease. The role of amyloid beta 42 (Aβ<sub>42</sub>) in these diverse chronic diseases is obscure. Here we show that adipose tissue releases Aβ<sub>42</sub>, which is increased from adipose tissue of male mice with obesity and is associated with higher plasma Aβ<sub>42</sub>. Inc...
Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.
THE JOURNAL OF CLINICAL INVESTIGATION - 15 Feb 2023
Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic view to distinguish key sequence elements that influence gene expression. This is particularly challenging for DN because genome-wide methylation patterns are ...
Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms.
CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - 01 Nov 2022
Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the ovalbumin (OVA)-induced chronic allergic airways murine model, with key hallmarks of asthma. Histological analysis indicated that LSF prevented or reversed OVA-induced epithelial thickening, collagen deposition, goble...
Trends in Intra-Aortic Balloon Pump Use in Cardiogenic Shock After the SHOCK-II Trial.
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Mar 2023
Myocardial infarction complicated by cardiogenic shock (MI-CS) has a poor prognosis, even with early revascularization. Previously, intra-aortic balloon pump (IABP) use was thought to improve outcomes, but the IABP-SHOCK-II (Intra-aortic Balloon Pump in Cardiogenic Shock-II study) trial found no survival benefit. We aimed to determine the trends in IABP use in patients who underwent percutaneou...
Pericoronary Adipose Tissue as a Marker of Cardiovascular Risk: JACC Review Topic of the Week.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 07 Mar 2023
Vascular inflammation is a key driver in atherosclerotic progression and plaque rupture. Recent evidence has shown that coronary computed tomography provides a noninvasive method of quantifying coronary inflammation by mapping changes in pericoronary adipose tissue (PCAT) radiodensity, which are associated with cardiovascular diseases. However, there are significant knowledge gaps in the perfor...
Morbidity and utilisation of healthcare services among people with cardiometabolic disease in three diverse regions of rural India.
CHRONIC ILLNESS - 01 Dec 2023
To assess the prevalence and determinants of cardiometabolic disease (CMD), and the factors associated with healthcare utilisation, among people with CMD.Using a cross-sectional design, 11,657 participants were recruited from randomly selected villages in 3 regions located in Kerala and Andhra Pradesh from 2014 to 2016. Multivariable logistic regression was used to identify factors independentl...
Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status.
ESC HEART FAILURE - 01 Dec 2023
Heart failure (HF) is a common cause of morbidity and mortality, related to a broad range of sociodemographic, lifestyle, cardiometabolic, and comorbidity risk factors, which may differ according to the presence of atherosclerotic cardiovascular disease (ASCVD). We assessed the association between incident HF with baseline status across these domains, overall and separated according to ASCVD st...
Clinical outcomes of 10 years of cardiac screening in elite New Zealand athletes.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 01 Dec 2023
To report findings from the High Performance Sport New Zealand cardiac screening programme, including comparisons between sexes and ethnicities.Retrospective cohort study.Elite Olympic-sport athletes were screened (2012-2022) with personal/family history, physical examination, resting 12-lead ECG and followed from the date of first screening until July 2022. An audit reviewed screening records,...
Postpartum uptake of diabetes screening tests in women with gestational diabetes: The PANDORA study.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 01 Mar 2023
To determine rates and predictors of postpartum diabetes screening among Aboriginal and/or Torres Strait Islander and non-Indigenous women with gestational diabetes mellitus (GDM).PANDORA is a prospective longitudinal cohort of women recruited in pregnancy. Postpartum diabetes screening rates at 12 weeks (75-g oral glucose tolerance test (OGTT)) and 6, 12 and 18 months (OGTT, glycated haemoglob...
Omics insights into extracellular vesicles in embryo implantation and their therapeutic utility.
PROTEOMICS - 01 Mar 2023
Implantation success relies on intricate interplay between the developing embryo and the maternal endometrium. Extracellular vesicles (EVs) represent an important player of this intercellular signalling through delivery of functional cargo (proteins and RNAs) that reprogram the target cells protein and RNA landscape. Functionally, the signalling reciprocity of endometrial and embryo EVs regulat...
Self-reported walking pace: A simple screening tool with lowest risk of all-cause mortality in those that 'walk the talk'.
JOURNAL OF SPORTS SCIENCES - 01 Mar 2023
To determine whether the association between self-reported walking pace and all-cause mortality (ACM) persists across categories of accelerometer-assessed physical activity status. Data from 93,709 UK Biobank participants were included. Physical activity was assessed using wrist-worn accelerometers for 7-days. Participants accumulating <150 min/week moderate-to-vigorous- activity were classed a...
Myocarditis: causes, mechanisms, and evolving therapies.
EXPERT OPINION ON THERAPEUTIC TARGETS - 01 Mar 2023
Myocarditis is a severe lymphocyte-mediated inflammatory disorder of the heart, mostly caused by viruses and immune checkpoint inhibitors (ICIs). Recently, myocarditis as a rare adverse event of mRNA vaccines for SARS-CoV-2 has caused global attention. The clinical consequences of myocarditis can be very severe, but specific treatment options are lacking or not yet clinically proven.This paper ...
Central apnoeas, sympathetic activation and mortality in heart failure: look before you leap.
THE EUROPEAN RESPIRATORY JOURNAL - 01 Mar 2023
Cardioprotection Using Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy: 3-Year Results of the SUCCOUR Trial.
JACC. CARDIOVASCULAR IMAGING - 01 Mar 2023
Global longitudinal strain (GLS) can predict cancer therapeutics-related cardiac dysfunction and guide initiation of cardioprotection (CPT).In this study, the authors sought to determine whether echocardiography GLS-guided CPT provides less cardiac dysfunction in survivors of potentially cardiotoxic chemotherapy, compared with usual care at 3 years.In this international multicenter prospective ...
Exercise-Induced Cardiac Remodeling and Atrial Fibrillation in Female Endurance Athletes.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Mar 2023
Normal Ranges of Right Atrial Strain: A Systematic Review and Meta-Analysis.
JACC. CARDIOVASCULAR IMAGING - 01 Mar 2023
Standard measures for the clinical assessment of right atrial (RA) function are lacking.In this systematic review and meta-analysis, the authors sought to report a reference range for RA deformation parameters in healthy subjects and to identify factors that contribute to reported variations.The authors conducted a comprehensive search of MEDLINE; MEDLINE In-Process & Other Non-Indexed Citation...
Australian Atherosclerosis Society Position Statement on Lipoprotein(a): Clinical and Implementation Recommendations.
HEART, LUNG & CIRCULATION - 01 Mar 2023
This position statement provides guidance to cardiologists and related specialists on the management of adult patients with elevated lipoprotein(a) [Lp(a)]. Elevated Lp(a) is an independent and causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve disease (CAVD). While circulating Lp(a) levels are largely determined by ancestry, they are also influenced...
