Publications
Now showing items 501-520 of 5027 records
Lifelong endurance exercise and its relation with coronary atherosclerosis.
EUROPEAN HEART JOURNAL - 07 Jul 2023
The impact of long-term endurance sport participation (on top of a healthy lifestyle) on coronary atherosclerosis and acute cardiac events remains controversial.The Master@Heart study is a well-balanced prospective observational cohort study. Overall, 191 lifelong master endurance athletes, 191 late-onset athletes (endurance sports initiation after 30 years of age), and 176 healthy non-athletes...
Long-term cost-effectiveness of implementing a lifestyle intervention during pregnancy to reduce the incidence of gestational diabetes and type 2 diabetes.
DIABETOLOGIA - 01 Jul 2023
The aim of this study was to determine the long-term cost-effectiveness and return on investment of implementing a structured lifestyle intervention to reduce excessive gestational weight gain and associated incidence of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus.A decision-analytic Markov model was used to compare the health and cost-effectiveness outcomes for (1) a struc...
Asia-Pacific consensus recommendations for application of continuous glucose monitoring in diabetes management.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Jul 2023
Glucose monitoring has evolved from self-monitoring of blood glucose to glycated hemoglobin, and the latest continuous glucose monitoring (CGM). A key challenge to adoption of CGM for management of diabetes in Asia is the lack of regional CGM recommendations. Hence, thirteen diabetes-specialists from eight Asia-Pacific (APAC) countries/regions convened to formulate evidence-based, APAC-specific...
Weaponizing platelets for cancer treatment: Converting allies to deadly foes!
MATTER - 02 Aug 2023
The capability of platelets to adhere to cancer cells allows tumors/metastatic cells to camouflage and avoid immune recognition. This mechanism has been elegantly highjacked by Yang et al. for the delivery of cytotoxic reagents imitating the cancer-fighting action of cytotoxic T cells.
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021.
LANCET (LONDON, ENGLAND) - 15 Jul 2023
Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the...
Clinical Features and Outcomes Among Patients With Refractory Out-of-Hospital Cardiac Arrest and an Initial Shockable Rhythm.
CIRCULATION. CARDIOVASCULAR INTERVENTIONS - 26 Sep 2023
Clinical features among patients with refractory out-of-hospital cardiac arrest (OHCA) and initial shockable rhythms of ventricular fibrillation/pulseless ventricular tachycardia are not well-characterized.We compared clinical characteristics and coronary angiographic findings between patients with refractory OHCA (incessant ventricular fibrillation/pulseless ventricular tachycardia after ≥3 di...
Association between maternal hyperglycemia in pregnancy and offspring anthropometry in early childhood: the pandora wave 1 study.
INTERNATIONAL JOURNAL OF OBESITY (2005) - 01 Nov 2023
In-utero hyperglycemia exposure influences later cardiometabolic risk, although few studies include women with pre-existing type 2 diabetes (T2D) or assess maternal body mass index (BMI) as a potential confounder.To explore the association of maternal T2D and gestational diabetes mellitus (GDM) with childhood anthropometry, and the influence of maternal BMI on these associations.The PANDORA coh...
Role of Gut Microbiota in Statin-Associated New-Onset Diabetes-a Cross-Sectional and Prospective Analysis of the FINRISK 2002 Cohort.
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 16 Nov 2023
Dyslipidemia is treated effectively with statins, but treatment has the potential to induce new-onset type-2 diabetes. Gut microbiota may contribute to this outcome variability. We assessed the associations of gut microbiota diversity and composition with statins. Bacterial associations with statin-associated new-onset type-2 diabetes (T2D) risk were also prospectively evaluated.We examined sha...
Transcriptional Control of Endothelial Senescence and Vascular Repair.
CIRCULATION RESEARCH - 27 Oct 2023
Is "Normal for Age" a Legitimate Assessment?: Significance of Left Ventricular Dysfunction in the Elderly.
JACC. CARDIOVASCULAR IMAGING - 26 Jun 2023
Understanding the complementarity and plasticity of antibody-antigen interfaces.
BIOINFORMATICS (OXFORD, ENGLAND) - 29 Jun 2023
While antibodies have been ground-breaking therapeutic agents, the structural determinants for antibody binding specificity remain to be fully elucidated, which is compounded by the virtually unlimited repertoire of antigens they can recognise. Here, we have explored the structural landscapes of antibody-antigen interfaces to identify the structural determinants driving target recognition by as...
LEGO-CSM: a tool for functional characterisation of proteins.
BIOINFORMATICS (OXFORD, ENGLAND) - 29 Jun 2023
With the development of sequencing techniques, the discovery of new proteins significantly exceeds the human capacity and resources for experimentally characterising protein functions. LEGO-CSM is a comprehensive web-based resource that fills this gap by leveraging the well-established and robust graph-based signatures to supervised learning models using both protein sequence and structure info...
Catheter Ablation vs Antiarrhythmic Drug Therapy for Treatment of Premature Ventricular Complexes: A Systematic Review.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jun 2023
There is variability in treatment modalities for premature ventricular complexes (PVCs), including use of antiarrhythmic drug (AAD) therapy or catheter ablation (CA). This study reviewed evidence comparing CA vs AADs for the treatment of PVCs. A systematic review was performed from the Medline, Embase, and Cochrane Library databases, as well as the Australian and New Zealand Clinical Trials Reg...
Effect of Oral Contraception on Screening Tests for Primary Aldosteronism: A 10-Year Longitudinal Study.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 16 Jun 2023
Primary aldosteronism (PA) and oral contraception (OC) can both cause hypertension in young women. However, the effect of OC on the screening test for PA, the aldosterone to renin ratio (ARR), is not clear.We evaluated the impact of OC on the screening test for PA.In this retrospective cohort study, we analyzed data from the female offspring (Gen2) of women enrolled in the Raine Study, a popula...
The burden of type 2 diabetes in Australia during the period 1990-2019: Findings from the global burden of disease study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 May 2023
To describe morbidity and mortality trends of type 2 diabetes in Australia, from 1990 to 2019, compared with similar sociodemographic index (SDI) countries.Australia-specific Global Burden of Diseases data were used to estimate age-standardised, age-specific, and sex-specific rates for prevalence, years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life years (DAL...
The mechanism of Pseudomonas aeruginosa outer membrane vesicle biogenesis determines their protein composition.
PROTEOMICS - 01 May 2023
Gram-negative bacteria produce outer membrane vesicles (OMVs) and contain bacterial cargo including nucleic acids and proteins. The proteome of OMVs can be altered by various factors including bacterial growth stage, growth conditions, and environmental factors. However, it is currently unknown if the mechanism of OMV biogenesis can determine their proteome. In this study, we examined whether t...
The rate of transition to a suicide attempt among people with suicidal thoughts in the general population: A systematic review.
JOURNAL OF AFFECTIVE DISORDERS - 15 Jun 2023
While suicidal thoughts are relatively common in the general population, roughly affecting one in ten people during their lifetime, the transition from suicidal thoughts to a suicide attempt is rarer. There is limited consensus on the transition rate from suicidal ideation to suicide attempts.To review and summarize evidence on the rate of transition from suicidal ideation to a suicide attempt,...
Interferon regulatory factor 4 a master regulator of hypertensive kidney fibrosis and inflammation?
JOURNAL OF HYPERTENSION - 01 Jun 2023
Risk of kidney disease following a pregnancy complicated by diabetes: a longitudinal, population-based data-linkage study among Aboriginal women in the Northern Territory, Australia.
DIABETOLOGIA - 01 May 2023
The aim of this work was to investigate the risk of developing chronic kidney disease (CKD) or end-stage kidney disease (ESKD) following a pregnancy complicated by gestational diabetes mellitus (GDM) or pre-existing diabetes among Aboriginal women in the Northern Territory (NT), Australia.We undertook a longitudinal study of linked healthcare datasets. All Aboriginal women who gave birth betwee...
Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes.
CARDIOVASCULAR RESEARCH - 02 May 2023
We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality.This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence ...
