Publications
Now showing items 401-420 of 5027 records
Prevalence of Multiple Causes of Death Within Young and Middle-Aged People Experiencing Sudden Cardiac Arrest.
HEART, LUNG & CIRCULATION - 01 Dec 2023
Multiple causes of death are increasingly reported, particularly in older populations. Rates of multiple causes of young sudden death have not been quantified.The End Unexplained Cardiac Death (EndUCD) registry was utilised to identify cases of young sudden death (aged 1-50 years) referred for forensic assessment from April 2019 to April 2022. Causes of death were coded according to whether one...
Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products-induced inflammation.
KIDNEY INTERNATIONAL - 05 Dec 2023
Glucagon like peptide-1 (GLP-1) is a hormone produced and released by cells of the gastrointestinal tract following meal ingestion. GLP-1 receptor agonists (GLP-1RA) exhibit kidney-protective actions through poorly understood mechanisms. Here we interrogated whether the receptor for advanced glycation end products (RAGE) plays a role in mediating the actions of GLP-1 on inflammation and diabeti...
Toxicology Screening in Sports-Related Sudden Cardiac Death: A Multinational Observational Study.
JACC. CLINICAL ELECTROPHYSIOLOGY - 07 Dec 2023
Knowledge of toxicological findings among sports-related sudden cardiac death (SrSCD) is scarce.This study aimed to describe postmortem toxicology findings in a multinational cohort of young SrSCD.Patients with sudden cardiac death (SCD) aged 12 to 49 years with a complete post mortem were included from Denmark, Spain, and Australia. Postmortem findings were compared between SrSCD and non-SrSCD...
In a large primary care data set, the CHA2DS2-VASc score leads to an almost universal recommendation for anticoagulation treatment in those aged ≥65 years with atrial fibrillation.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING : JOURNAL OF THE WORKING GROUP ON CARDIOVASCULAR NURSING OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 14 Dec 2023
Incidence and trends of type 1 diabetes before and after 2000 in the Western Pacific Region: A systematic review and meta-analysis.
DIABETES RESEARCH AND CLINICAL PRACTICE - 15 Dec 2023
To undertake a systematic review of publications describing Type 1 diabetes (T1DM) incidence, trends over time and associated factors in the Western Pacific Region (WPR).As per the PROSPERO-registered (CRD42019122646) protocol English (MEDLINE, Embase, Global Health) and Chinese data-bases (China National Knowledge Infrastructure, VIP, Wanfang) from onset to 31/12/2019 were searched for T1DM in...
Steatotic liver disease in rural and regional Victoria, according to the NAFLD and newer diagnostic criteria: retrospective cohort analyses of 2001-03 and 2016-18 data.
THE MEDICAL JOURNAL OF AUSTRALIA - 19 Dec 2023
Long-term Outcomes of Testosterone Treatment in Men: A T4DM Postrandomization Observational Follow-up Study.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 21 Dec 2023
The T4DM study randomized 1007 men with impaired glucose tolerance or newly diagnosed diabetes to testosterone undecanoate (TU, 1000 mg) or matching placebo (P) injections every 12 weeks for 24 months with a lifestyle program with testosterone (T) treatment reducing diabetes diagnosis by 40%.The long-term effects on new diagnosis of diabetes, cardiovascular and prostate disease, sleep apnea, we...
Association of number of siblings with preclinical markers of cardiovascular disease. The cardiovascular risk in Young Finns study.
INTERNATIONAL JOURNAL OF CARDIOLOGY. CARDIOVASCULAR RISK AND PREVENTION - 01 Mar 2024
To investigate the association of number of siblings with preclinical cardiovascular disease (CVD) markers in adulthood. The sample comprised 2776 participants (54 % female) from the Cardiovascular Risk in Young Finns Study who had CVD risk factor data measured in childhood in 1980 (aged 3-18 years) and markers of preclinical CVD measured in adulthood. Echocardiography was performed in 2011, an...
The effect of altered pH growth conditions on the production, composition, and proteomes of Helicobacter pylori outer membrane vesicles.
PROTEOMICS - 22 Nov 2023
Gram-negative bacteria release outer membrane vesicles (OMVs) that contain cargo derived from their parent bacteria. Helicobacter pylori is a Gram-negative human pathogen that produces urease to increase the pH of the surrounding environment to facilitate colonization of the gastric mucosa. However, the effect of acidic growth conditions on the production and composition of H. pylori OMVs is un...
No relationship between socioeconomic status, education level and development and progression of diabetic retinopathy in type 2 diabetes: a FIELD trial substudy.
INTERNAL MEDICINE JOURNAL - 01 Nov 2023
In 6002 Australian adults with type 2 diabetes and a median 5-year follow-up in the FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) trial, baseline socioeconomic status (SES) and self-reported education level were not related to development of on-trial sight-threatening diabetic retinopathy. Similarly, in a retinal photography substudy (n = 549), two-step diabetic retinopathy pr...
Between a rock and a hard place: resumption of oral anticoagulant therapy after intracranial hemorrhage.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH - 31 Oct 2023
Intracranial hemorrhage (ICH) is the most feared and lethal complication of oral anticoagulant (OAC) therapy. Resumption of OAC after ICH has long posed a challenge for clinicians, complicated by the expanding range of anticoagulant agents available in modern clinical practice, including direct OACs and, more recently, factor XI and XII inhibitors. A review of the current literature found suppo...
Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules.
01 Nov 2023
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the persistence of cytokine producing T cells during memory cell maintenance and secondary responses. We interrogated antigen-specific CD4 T cells using a mouse influenza A virus infection model. Although CD4 T cells detected using MHCII tetramers declined in lymphoi...
Association between secondhand smoke exposure across the life course and depressive symptoms among Chinese older adults.
JOURNAL OF AFFECTIVE DISORDERS - 11 Nov 2023
There are limited data on the association between secondhand smoke (SHS) exposure across the life course and depressive symptoms among older adults. We aimed to investigate the association of childhood household SHS exposure, adulthood household SHS exposure, lifetime social SHS exposure, and their coexistence with depressive symptoms in older adults.Data were from the 2011-2012 and 2014 waves ...
No effect of remoteness on clinical outcomes following myocardial infarction: An analysis of 43,729 myocardial infarctions in Victoria, Australia.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 16 Nov 2023
Remoteness has been shown to predict poor clinical outcomes following myocardial infarction (MI). This study investigated 1-year clinical outcomes following MI by remoteness in Victoria, Australia.We included all admissions for people discharged from hospital following MI between July 2012 and June 2017 (n = 43,729). Remoteness was determined using the Accessibility/Remoteness Index of Australi...
Contribution of reduced skeletal muscle perfusion reserve to exercise intolerance in heart failure with preserved ejection fraction.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 21 Oct 2023
Skeletal muscle (SM)-associated mechanisms of exercise intolerance in HFpEF are insufficiently defined, and inadequate augmentation of SM blood flow during physical effort may be one of the contributors. Therefore, we sought to investigate the association of SM perfusion response to exertion with exercise capacity in this clinical condition.Echocardiography and SM microvascular perfusion by con...
Prognostic Signals From Moderate Valve Disease in Big Data: An Artefact of Digital Imaging and Communications in Medicine Structured Reporting?
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Nov 2023
Recent studies have identified an association between moderate aortic stenosis (AS) and outcome. We assessed whether Digital Imaging and Communications in Medicine (DICOM) structured reporting (SR), which captures and inserts echocardiographic measurements and text data directly into radiological reports, may lead to misclassifying patients with severe AS as moderate.Moderate or severe AS cases...
Epidemiology of pediatric out-of-hospital cardiac arrest compared with adults.
HEART RHYTHM - 01 Nov 2023
Out-of-hospital cardiac arrest (OHCA) is associated with ∼90% mortality rate. In the pediatric population, this would equate to a large number of years of life lost, posing a heavy medical and economic burden to society.The purpose of this study was to outline the characteristics and causes of pediatric OHCA (pOHCA) and associations with survival until discharge in patients enrolled in the End ...
Sex differences in the association between stroke risk factors and pre-clinical predictors of stroke in the childhood determinants of Adult Health study.
ATHEROSCLEROSIS - 01 Nov 2023
It is unclear why blood pressure (BP), metabolic markers and smoking increase stroke incidence in women more than men. We examined these associations with carotid artery structure and function in a prospective cohort study.Participants in the Australian Childhood Determinants of Adult Health study at ages 26-36 years (2004-06) were followed-up at 39-49 years (2014-19). Baseline risk factors inc...
Tracking handgrip strength asymmetry from childhood to mid-life.
ACTA PAEDIATRICA (OSLO, NORWAY : 1992) - 01 Nov 2023
Determine if asymmetric handgrip strength exists in childhood and adulthood and quantify the degree of tracking of handgrip strength asymmetry over time.Participants from the Childhood Determinants of Adult Health Study had their right and left handgrip strength measured using handgrip dynamometry in childhood (1985: 9-15 y), young adulthood (2004-06: 26-36 y) and/or mid-adulthood (2014-19: 36-...
Atorvastatin lowers Ga-DOTATATE uptake in coronary arteries, bone marrow and spleen in individuals with type 2 diabetes.68
DIABETOLOGIA - 01 Nov 2023
Inflammation is a core component of residual cardiovascular risk in type 2 diabetes. With new anti-inflammatory therapeutics entering the field, accurate markers to evaluate their effectiveness in reducing cardiovascular disease are paramount. Gallium-68-labelled DOTATATE (Ga-DOTATATE) has recently been proposed as a more specific marker of arterial wall inflammation than F-fluorodeoxyglucose (...
