Publications
Now showing items 41-60 of 5385 records
Obesity-related glomerulopathy: How it happens and future perspectives.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 14 Apr 2025
Obesity-related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria. ORG is a distinct histological diagnosis based on kidney biopsy, showing classical features of an enlarged glomerulus with and without f...
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery.
DIABETOLOGIA - 15 Apr 2025
Both the global prevalence of diabetes and the frequency of natural and man-made disasters are increasing. Of all chronic diseases, the consequences of sudden loss of medical supplies are most serious for those with diabetes, with people living with type 1 diabetes being at risk of death within a few days without insulin. This review considers how to prepare for and respond to sudden reductions...
Revivifying research on relaxin receptor-targeted therapy for cardiovascular diseases.
CARDIOVASCULAR RESEARCH - 17 Apr 2025
Making Sense: Feasibility of an education program to Empower adults with type 1 diabetes to interpret CGM data.
DIABETES RESEARCH AND CLINICAL PRACTICE - 17 Apr 2025
To assess the feasibility and acceptability of a structured education program focused on continuous glucose monitoring (CGM) data interpretation for adults living with type 1 diabetes. This was a multi-centre before and after feasibility study conducted in Australia. Adults with type 1 diabetes were enrolled in the Making Sense program. This two-week program, designed in consultation with adult...
Impact of Mitral Regurgitation on Outcomes of Catheter Ablation for AF With Left Ventricular Systolic Dysfunction.
JACC. CLINICAL ELECTROPHYSIOLOGY - 19 Apr 2025
Atrial fibrillation (AF) and left ventricular (LV) systolic dysfunction (LVSD) may be associated with function mitral and tricuspid regurgitation (FMR/FTR). Prior studies have largely assessed impact of MR on AF ablation outcomes in the presence of preserved LV ejection fraction. This study sought to determine the impact of FMR on the outcomes of catheter ablation (CA) in patients with AF and L...
Arrhythmias and structural remodeling in lifelong and retired master endurance athletes.
JOURNAL OF SPORT AND HEALTH SCIENCE - 22 Apr 2025
A greater prevalence of arrhythmias has been described in endurance athletes, but it remains unclear whether this risk persists after detraining. We aimed to evaluate the prevalence of arrhythmias and their relationship with cardiac remodeling in lifelong and retired master endurance athletes compared to non-athletic controls. We performed a cross-sectional analysis of observational studies tha...
Combining Polygenic with Clinical Risk Scores in Atrial Fibrillation Risk Prediction: Implications for Population Screening.
HEART RHYTHM - 22 Apr 2025
AF development is determined by clinical risk factors and genetic predisposition. Few studies have explored whether incorporating polygenic risk scores (PRS) improves clinical risk prediction beyond existing models. We evaluated the interaction between AF-PRS and the HARMS<sub>2</sub>-AF and CHARGE-AF clinical risk scores on incident AF risk among the UK Biobank. AF-PRS was examined in those wi...
Development of an Acute Coronary Syndrome-Cardiogenic Shock Risk Score for 30-day Mortality From the Victorian Cardiac Outcomes Registry (VCOR ACS-CS Risk Score).
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS - 23 Apr 2025
Acute coronary syndrome-cardiogenic shock (ACS-CS) confers a 30-day mortality rate of ~50%. A simple bed-side risk score for 30-day all-cause mortality may aid in rapid prognostication in these high-risk patients. We analyzed data from consecutive patients with ACS-CS enrolled in the Victorian Cardiac Outcomes Registry (VCOR), a state-wide procedure-based clinical quality registry, between 2013...
Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 24 Apr 2025
Inappropriate mineralocorticoid receptor (MR) activation in monocytes/macrophages promotes cardiac inflammation and fibrosis. However, the specific pathways whereby the MR regulates macrophage phenotype are not fully defined. We recently identified bidirectional regulation of the MR and the molecular circadian clock in cardiac cells. Given that immune cells are important regulators of cardiac p...
Neighbourhood, school and home food environment associations with dietary behaviours in Hong Kong adolescents: the iHealth study.
HEALTH & PLACE - 24 Apr 2025
This study is the first to examine whether neighbourhood, school and home food environments were associated with dietary behaviours in Hong Kong adolescents; and whether off-campus lunch school policy, bringing lunch from home and parental rules for eating behaviours moderated the associations. We used data from the international Healthy environments and active living in teenagers - (Hong Kong)...
Length of ischaemia duration is associated with fibrin film coverage of acute myocardial infarction thrombi.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH - 24 Apr 2025
Coronary artery disease (CAD) plaque rupture leads to occlusive thrombosis, causing acute myocardial infarction requiring immediate life-saving treatment. The blood clot is supported by a mesh of fibrin fibres that are generated through the polymerisation of fibrin. We recently showed that fibrin also produces a film on the surface of blood clots. Our aim was to study if fibrin film occurs intr...
Performing risk adjustment in observational datasets to compare coronary artery bypass grafting vs percutaneous coronary intervention in patients with left ventricular systolic dysfunction.
EUROPEAN HEART JOURNAL - 25 Apr 2025
Reply to "Reevaluating the impact of physical inactivity on cancer risk: Methodological limitations and considerations".
CANCER - 01 May 2025
Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan.
ISCIENCE - 16 May 2025
Rapid hematopoietic adaptations are important for building and sustaining the biological response to β-glucan. The signals involved in these early events have not yet been fully explored. Given that type I interferons are produced in response to β-glucan and can profoundly impact hematopoietic stem cell (HSC) function, we hypothesized that this pathway may be involved in the early bone marrow r...
Associations between obesity, physical and mental function, and low back pain intensity and disability: A 14-year population-based study.
OSTEOARTHRITIS AND CARTILAGE OPEN - 01 Jun 2025
This study aimed to examine the associations of overweight/obesity, physical function and mental function with back pain intensity and disability. A 14-year population-based study based on Australian Diabetes, Obesity and Lifestyle Study. Body mass index and the SF-36 Survey were used to determine baseline overweight/obesity and physical and mental status respectively. Back pain intensity and d...
Towards equitable access of innovative technologies such as continuous glucose monitoring and artificial intelligence for diabetes management.
DIABETES RESEARCH AND CLINICAL PRACTICE - 30 Mar 2025
Blood pressure measurement at kiosks in public spaces: systematic review and consensus statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability endorsed by the International Society of Hypertension and the World Hypertension League.
JOURNAL OF HYPERTENSION - 01 Apr 2025
Kiosk devices for unsupervised self-measurement of blood pressure (BP) are being used in public spaces and healthcare settings in several countries. This statement by the European Society of Hypertension (ESH) Working Group on BP Monitoring and Cardiovascular Variability provides a review of the published evidence on kiosk BP devices and consensus recommendations for their requirements and clin...
Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor-Positive Breast Cancer: A Case-Cohort Analysis.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 03 Apr 2025
Higher concentration of insulin-like growth factor-1 (IGF-1) increases postmenopausal breast cancer risk, but evidence for insulin and c-peptide is limited. Furthermore, not all studies have accounted for potential confounding by biomarkers from other biological pathways, and not all were restricted to estrogen receptor (ER)-positive breast cancer. This was a case-cohort study of 1,223 postmeno...
Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 03 Apr 2025
Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer. However, the mediating role of the circulating metabolome in this relationship remains unclear. Targeted metabolomics data from 6,055 participants in the European Prospective Investigation into Cancer and Nutrition cohort were used to identify metabolites associated with PA an...
Relationship of haptoglobin phenotype and levels with sight-threatening diabetic retinopathy in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in diabetes (FIELD) substudy.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Apr 2025
Haptoglobin (HP) phenotype has been reported to modulate fenofibrate benefit on coronary artery disease in type 2 diabetes. It is unknown whether HP phenotype and levels modulate fenofibrate benefit on sight-threatening diabetic retinopathy (STDR). In plasma from 8,047 Australasian adults with type 2 diabetes in the FIELD trial, HP phenotype was determined, and HP levels were measured at baseli...
