Publications
Now showing items 41-60 of 5595 records
User design and testing of SmartHeart: A mobile app for heart failure self-care.
DIGITAL HEALTH - 01 Jan 2026
Heart failure requires complex and daily self-care that many patients struggle with for a range of reasons including limited health literacy, cognitive impairment, comorbidities, and emotional distress. This study describes the user-centred design and development of a mobile app (SmartHeart) to support comprehensive self-monitoring and improve self-care engagement for people with heart failure....
Insights into the heterogeneous muscle lipidome of dysferlin-deficient mice: effects of age, muscle type, and sex.
SKELETAL MUSCLE - 22 May 2026
Dysferlinopathy is an age-dependent muscular dystrophy caused by loss of the membrane-associated protein dysferlin. Disease severity increases with age and selectively affects specific muscle groups, yet the molecular basis for this vulnerability remains unclear. Since lipid remodeling is a hallmark of dysferlinopathy and aging, we investigated how age, sex, and muscle fiber type interact to sh...
Exploring sedentary behaviour reduction interventions in the primary healthcare setting: a scoping review.
BMC PRIMARY CARE - 21 May 2026
Excessive sitting time is a risk factor for many non-communicable diseases and an increased risk of early mortality. Primary healthcare is a viable setting to target population health behaviour change. This scoping review investigated the scope, implementation, and effectiveness of interventions targeting sedentary behaviour outcomes in adults within primary healthcare settings. Four databases ...
Assessing the efficacy, safety and utility of fully closed-loop insulin delivery compared to standard insulin therapy with a continuous glucose monitor in adults with type 2 diabetes (COYOTE study): a randomised parallel study protocol.
BMJ OPEN - 19 May 2026
Type 2 diabetes (T2D) presents a global healthcare burden. Despite widespread use of non-insulin glucose lowering therapies, many individuals still require insulin to achieve recommended target glycated haemoglobin (HbA1c). Insulin injections improve HbA1c but can lead to problematic hypoglycaemia. The objective of this study is to determine whether fully closed-loop insulin delivery improves H...
EZH2 inhibition via GSK-126 mitigates EndMT and atherosclerosis in diabetes: A translational epigenetic approach.
SCIENCE ADVANCES - 29 May 2026
Atherosclerosis drives cardiovascular morbidity in diabetes, with endothelial-to-mesenchymal transition (EndMT) as a key contributor. Whereas epigenetic regulators are increasingly implicated in atherosclerotic progression, the specific role of enhancer of zeste homolog 2 (EZH2), a histone methyltransferase, in EndMT in diabetes-associated atherosclerosis remains unclear. We show that EZH2-medi...
The readiness of primary healthcare facilities to address non-communicable diseases in rural Bangladesh.
BMC HEALTH SERVICES RESEARCH - 28 May 2026
Strengthening the capacity of primary healthcare (PHC) systems is essential to address the rising burden of non-communicable diseases (NCD) in Bangladesh. The study assessed the readiness of rural PHC facilities in addressing the five World Health Organization (WHO) priority NCDs: diabetes, cardiovascular diseases, chronic respiratory diseases, cervical cancer, and mental health disorders. Betw...
A lipidomics roadmap: from basic research to societal challenges.
NATURE COMMUNICATIONS - 28 May 2026
Lipidomics, a rapidly evolving discipline at the interface of biology and analytical chemistry, seeks to comprehensively characterize the lipid composition of biological systems. Driven by advances in mass spectrometry, chromatography and computational analysis, lipidomics has enabled the high-resolution mapping of lipid networks and their functional dynamics across molecular, cellular and orga...
Higher HbA1c Following Younger Age of Transfer From Pediatric to Adult Type 1 Diabetes Services: Data From the Australasian Diabetes Data Network (ADDN) Registry.
DIABETES CARE - 28 May 2026
To determine outcomes from early versus later age of transfer from pediatric to adult type 1 diabetes (T1D) services, and factors associated with adult service HbA1c. We used a longitudinal design from the Australasian Diabetes Data Network (ADDN) registry. Transferred youth (2013-2022) were compared by age group at last pediatric visit (<18 vs. ≥18 years). Multivariable generalized estimated e...
Beyond Reperfusion: Early Molecular Drivers and Therapeutic Opportunities in Acute Post-Infarction Cardiac Fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 15 May 2026
Heart failure is a leading cause of global morbidity and mortality, often developing as a consequence of acute myocardial infarction. Current management focuses on timely reperfusion via percutaneous coronary intervention. Yet, this approach fails to prevent the molecular cascades that drive the death of viable yet stressed cardiomyocytes within the infarct and peri-infarct zone. Effective anti...
Asia at the Epicenter of the Global Cardiometabolic Shift.
JACC. ASIA - 01 Mar 2026
Cardiometabolic disease has become the dominant noncommunicable health challenge of the 21st century, with its burden increasingly centered in Asia. Rising obesity, type 2 diabetes mellitus, hypertension, and dyslipidemia now account for more than one-third of cardiovascular mortality. This escalation reflects the interaction of biological susceptibility with rapid urbanization, digitalized foo...
S100A8/A9 inhibition reduces splenic myelopoiesis and improves outcomes after stroke.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2026
Neutrophils are among the earliest immune cells to infiltrate the ischemic brain and contribute to secondary neuronal damage. The alarmin S100 calcium-binding protein A8/A9 (S100A8/A9), predominantly released by neutrophils, is upregulated during this process. Although the bone marrow is recognized as the principal site of neutrophil production via myelopoiesis, the role of the spleen as an imm...
Improving the quality of child and youth mental health care through an implementation science lens.
FRONTIERS IN HEALTH SERVICES - 01 Jan 2026
Mental disorders in children and youth are on the rise worldwide, affecting approximately one in five young people in Europe. The negative educational, social and economic consequences of mental health problems underline the urgent need for accessible, high-quality mental health services. In response, the WHO Regional Office for Europe has developed Quality Standards for Child and Youth Mental ...
Drivers of Atherosclerotic Cardiovascular Disease in South Asians: Current Insights and Future Directions.
JACC. ASIA - 01 Dec 2025
Atherosclerotic cardiovascular disease remains a leading cause of morbidity and mortality, with South Asians experiencing a disproportionately high burden. This excess risk is not fully explained by conventional risk factors, highlighting the need for a more nuanced understanding. However, progress has been hindered by a paucity of South Asian-specific research, limited validation studies, and ...
Pretreatment Circulating Vascular Biomarkers Predict Cancer Therapy-Related Cardiac Dysfunction During HER2<sup>+</sup> Breast Cancer Treatment.
JACC. CARDIOONCOLOGY - 01 Dec 2025
Blood biomarkers to predict cancer therapy-related cardiac dysfunction (CTRCD) risk remain limited. The aim of this study was to identify circulating biomarkers associated with CTRCD risk in HER2<sup>+</sup> breast cancer patients. In the discovery cohort, women with early-stage HER2<sup>+</sup> breast cancer receiving anthracycline and trastuzumab therapy underwent serial evaluation with cardi...
Anaesthesia in patients with severe obesity: An uncharted journey.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Nov 2025
Administration of anaesthesia to patients with severe obesity comes with its own challenges. This has become even more relevant in current day times as the number of people with severe obesity is increasing rapidly. There is a need for all treating doctors, including the referring physician, the anaesthetist, the operating surgeon, and the post-operative intensivist, to understand and counsel a...
Chronic complications of diabetes: Contemporary classification.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Nov 2025
Traditionally, chronic complications of diabetes have been classified as microvascular and macrovascular. As our knowledge and understanding of diabetes develops, we increasingly find that conventional classifications and frameworks are unable to encapsulate the wide spectrum of the syndrome. We propose a seven-angled rubric, to serve as a contemporary taxonomic structure for diabetes complicat...
Dysregulated Redox Signaling and Its Impact on Inflammatory Pathways, Mitochondrial Dysfunction, Autophagy and Cardiovascular Diseases.
ANTIOXIDANTS (BASEL, SWITZERLAND) - 24 Oct 2025
Dysregulated redox signaling, mitochondrial dysfunction and impaired autophagy form an interconnected network that drives inflammatory and immune responses in cardiovascular disease. Among these, disturbances in redox balance, largely mediated by reactive oxygen species (ROS), serve as key drivers linking inflammatory signaling to adverse cardiovascular outcomes. Mitochondria are essential for ...
Collagen-targeted tracers for molecular imaging of atrial fibrosis and sensitive detection of atrial fibrillation.
NPJ CARDIOVASCULAR HEALTH - 06 Oct 2025
Atrial fibrillation (AF), often accompanied by atrial fibrosis, is challenging to diagnose sub-clinically and reverse once established. Molecular imaging targeting excess atrial collagen may enable earlier detection of atrial fibrosis and its associated arrhythmias. We used the collagen I-binding peptide EP-3533 and our novel 'T-peptide' targeting matrix metalloproteinases-2-digested collagen I...
Glucodynia.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Sep 2025
Pain in patients with diabetes can be unpleasant, but at times protective as well. We propose the term 'glucodynia' i.e., an unpleasant sensory and emotional experience, associated with or without any organ-system dysfunction, in people living with diabetes. Glucodynia may be due to microvascular, musculoskeletal, metabolic, mood-related, miasmatic, mitogenic, visceral myogenic, malnutritionrel...
Obesity as a Psychosomatic Syndrome.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Sep 2025
Obesity is a psychosomatic syndrome. In this unique opinion piece, we describe the epidemic of obesity, and approach it from a psychosomatic perspective. We list the multiple causative, contributory, comorbid, complicating, confounding and curative aspects of obesity which require comprehensive psychosomatic addressal. The points discussed should be used as checklists for evaluation of person l...
