Publications
Now showing items 41-60 of 5702 records
Global, regional, and national cascades of diabetes care, 2000-23: a systematic review and modelling analysis using findings from the Global Burden of Disease Study.
THE LANCET. DIABETES & ENDOCRINOLOGY - 08 Sep 2025
Diabetes is a serious global health challenge, with a rising prevalence and substantial effect on disability and mortality worldwide. Despite medical advancements, gaps in the cascade of diabetes care-comprising diagnosis, treatment, and glycaemic management-persist, hindering effective management. We aimed to comprehensively assess the state of the diabetes cascade of care globally, identifyin...
Distinct blood volume and left ventricular adaptation to severe obesity in middle-aged adults at risk for heart failure.
EUROPEAN JOURNAL OF HEART FAILURE - 09 Sep 2025
Obesity is commonly hypothesized to lead to the development of heart failure (HF) in part due to increases in blood volume (BV) and left ventricular (LV) remodelling. Whether adiposity and obesity severity are associated with BV expansion and subsequent LV remodelling in middle-aged individuals at increased risk (IR) prior to the onset of HF is unknown. We analysed data from 96 middle-aged (40-...
Socioeconomic inequalities and trends in self-reported hypertension and antihypertensive medication use in Australia between 2009 and 2021: a nationwide population-based cohort study.
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 10 Sep 2025
This study examined trends in the proportion of adults with self-reported hypertension and in antihypertensive medication use among community-dwelling Australian adults. We analysed data from a longitudinal panel study, covering four waves: 2009 (n = 8023), 2013 (n = 11,475), 2017 (n = 12,843), and 2021 (n = 14,571) for adults aged 18-74 years. Hypertension and antihypertensive medication use w...
Evidence-Based Guidelines for Intravitreal Anti-VEGF Therapy for Diabetic Retinopathy in Chronic Kidney Disease.
11 Sep 2025
Intravitreal therapy using anti-vascular endothelial growth factor (anti-VEGF) has transformed the approach to treating diabetic retinopathy (DR), but its application in individuals with diabetes and chronic kidney disease, the majority of whom have diabetic kidney disease, involves a complex evaluation of risks and benefits. Emerging evidence indicates that the systemic absorption of anti-VEGF...
Development of an Electronic Medical Record-Based Score for Heart Failure Prediction in Cancer Survivors.
11 Sep 2025
Awareness of heart failure (HF) as a long-term complication of cancer has led to an interest in HF surveillance among survivors. However, existing HF risk scores are not tailored for survivors and not designed for the use in electronic medical records (EMRs) or administrative data sets where clinical data such as blood pressure and pathology results are often unavailable. The objective of the s...
Evaluation of the Clinical Significance of Carotid Plaque Characteristics in Ischaemic Stroke: A Systematic Review and Meta-Analysis.
HEART, LUNG & CIRCULATION - 11 Sep 2025
There is a growing interest in the assessment of perivascular fat attenuation on cardiac computed tomography as a surrogate of inflammation and vascular risk. Although pericoronary adipose tissue is well-studied, there is a paucity of literature on pericarotid fat and its relationship with ischaemic stroke (IS). This systematic review aimed to characterise carotid plaque, particularly, pericaro...
Clarifying the CSANZ Expert Position Statement on Appropriate Training for AF Ablation: Mentoring for Qualified Electrophysiologists Adopting New Techniques.
HEART, LUNG & CIRCULATION - 11 Sep 2025
Documenting Cardiovascular-Kidney-Metabolic Risk and Disease Within an Aboriginal Cohort.
HEART, LUNG & CIRCULATION - 12 Sep 2025
Aboriginal and Torres Strait Islander people experience high burden of cardiovascular, kidney and metabolic conditions, often manifesting in multimorbidity and contributing to over one third of life expectancy differentials. This article explores cardiovascular-kidney-metabolic (CKM) health within an Aboriginal cohort by documenting the burden of early risk, disease and factors associated with ...
Synergistic Effect of Risk Factors and Cardiotoxic Cancer Therapies: Implications for Heart Failure Screening in Cancer Survivors.
JACC. CARDIOVASCULAR IMAGING - 21 Aug 2025
Prediabetes transitions to normoglycaemia or type 2 diabetes and associated risk factors in the Obesity, Diabetes and Cardiovascular Disease Collaboration: an individual-level pooled analysis of 19 prospective cohort studies.
THE LANCET. GLOBAL HEALTH - 01 Sep 2025
With the increasing global burden of type 2 diabetes, prevention strategies that target prediabetes, a state of hyperglycaemia that puts individuals at high risk of type 2 diabetes, are required. We aimed to estimate global rates of transition from prediabetes to normoglycaemia or type 2 diabetes, stratified by age, sex, and race and ethnicity. We also aimed to quantify the effect of modifiable...
Long COVID and chronic fatigue syndrome/myalgic encephalitis share similar pathophysiologic mechanisms of exercise limitation.
PHYSIOLOGICAL REPORTS - 01 Sep 2025
Post-acute sequelae of SARS-CoV-2 (PASC or "long COVID") and chronic fatigue syndrome/myalgic encephalitis (CFS/ME) share symptoms such as exertional dyspnea. We used exercise oxygen pathway analysis, comprising six parameters of oxygen transport and utilization, to identify limiting mechanisms in both conditions. Invasive cardiopulmonary exercise testing was performed on 15 PASC patients, 11 C...
Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 02 Sep 2025
Most studies investigating physical activity and cancer risk used a single-time measure of physical activity. The present analysis investigates whether changes in physical activity during midlife influence cancer risk. A prospective cohort of adults ≥40 years from the UK Biobank who provided self-reported physical activity data via the International Physical Activity Questionnaire at both basel...
Maladaptive trained immunity in viral infections.
THE JOURNAL OF CLINICAL INVESTIGATION - 02 Sep 2025
Trained immunity (TRIM) is a form of long-lasting functional reprogramming of innate immune cells and their progenitors that enhances responsiveness to subsequent stimuli. Although first characterized in myeloid cells, TRIM was recently extended to nonmyeloid cell types, including endothelial and glial cells, which also exhibit stimulus-driven, memory-like behavior. While initially recognized a...
Building the Australian Cardiovascular disease Data Commons.
NATURE REVIEWS. CARDIOLOGY - 02 Sep 2025
Parental diet and offspring health: a role for the gut microbiome via epigenetics.
NATURE REVIEWS. GASTROENTEROLOGY & HEPATOLOGY - 03 Sep 2025
The effects of diet and nutrition extend beyond individual health: food intake before conception or during pregnancy and lactation can affect the health of offspring. Diet is one of the most powerful modulators of the gut microbiome, influencing gene-environment interactions, with several emerging mechanisms pointing to the microbiome-metabolite-epigenome axis. In this Review, we discuss the ef...
From Cushion to Culprit: The Role of Epicardial Adipose Tissue in Cardiovascular Disease.
HEART, LUNG & CIRCULATION - 03 Sep 2025
Epicardial adipose tissue (EAT) is the layer of fat located between the visceral pericardium and the myocardium. Emerging research has signified its role in the development of various cardiovascular diseases. The pathogenesis is complex, involving various bioactive compounds that have been implicated in the development of coronary artery disease, heart failure, and arrhythmogenesis. The optimal...
Shear Stress as a Danger Signal: Inducing Inflammation and Thrombosis via Mechanosensitive NETosis.
BIOESSAYS : NEWS AND REVIEWS IN MOLECULAR, CELLULAR AND DEVELOPMENTAL BIOLOGY - 04 Sep 2025
Neutrophil extracellular traps (NETs)-web-like DNA structures extruded by neutrophils in response to various stimuli, including pathogens, sterile inflammation, and mechanical stress-play a dual role in immunity and disease. While NETs serve to trap and neutralize pathogens during host defense, excessive or dysregulated NET formation, known as NETosis, can amplify inflammation and contribute to...
Theranostic porphyrin nanoparticles identify atherosclerosis via multimodal imaging and elicit atheroprotective effects.
MATERIALS TODAY. BIO - 01 Oct 2025
Porphyrin-lipid nanoparticles (Por-NPs) have unrealized potential for atherosclerosis. Por-NPs incorporate porphyrin-lipid which permits fluorescence imaging and chelates Copper-64 (<sup>64</sup>Cu) for positron emission tomography (PET) imaging. Their outer shell contains a short peptide 'R4F' that enables macrophage targeting and therapeutic effects. Accordingly, this study investigates the s...
A deepening digital divide in cardiovascular disease management.
NATURE REVIEWS. CARDIOLOGY - 26 Aug 2025
Clinical Applications of Strain Echocardiography: A Clinical Consensus Statement From the American Society of Echocardiography Developed in Collaboration With the European Association of Cardiovascular Imaging of the European Society of Cardiology.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 26 Aug 2025
