Publications
Now showing items 41-60 of 5153 records
Time restricted feeding alters the behavioural and physiological outcomes to repeated mild traumatic brain injury in male and female rats.
EXPERIMENTAL NEUROLOGY - 09 Dec 2024
Joint British Societies' position statement on cardiology training in the United Kingdom.
HEART (BRITISH CARDIAC SOCIETY) - 12 Dec 2024
Cardiology training in the UK is facing significant challenges due to a range of factors. Recent curriculum changes have further compounded this issue and significantly risk the ability to produce adequately trained consultants capable of managing patients with increasingly complex cardiovascular disease. The introduction of mandatory dual accreditation in general internal medicine (GIM) alongs...
Photoplethysmography as a noninvasive surrogate for microneurography in measuring stress-induced sympathetic nervous activation - A machine learning approach.
COMPUTERS IN BIOLOGY AND MEDICINE - 12 Dec 2024
The sympathetic nervous system (SNS) is essential for the body's immediate response to stress, initiating physiological changes that can be measured through sympathetic nerve activity (SNA). While microneurography (MNG) is the gold standard for direct SNA measurement, its invasive nature limits its practical use in clinical settings. This study investigates the use of multi-wavelength photoplet...
Risk of bradycardia and asystole during microelectrode recordings from the human vagus nerve.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 14 Dec 2024
MAFLD but not MASLD increases risk of all-cause mortality in regional Australia, with components of metabolic syndrome exacerbating factors: 20 year longitudinal, cohort study.
HEPATOLOGY INTERNATIONAL - 14 Dec 2024
Controversy remains whether the mortality risk in people with fatty liver disease (FLD) including metabolic-(dysfunction) associated steatotic liver disease (MASLD) and metabolic-(dysfunction) associated fatty liver disease (MAFLD) is higher than observed in those without FLD. We aimed to determine the mortality rate and mortality rate ratio (MRR) for these FLDs. The study population was a rand...
Change in Cardiorespiratory Fitness and the Risk of Colorectal and Prostate Cancer Incidence in Men.
CANCER MEDICINE - 01 Dec 2024
The aim of this prospective cohort study was to investigate the associations between changes in cardiorespiratory fitness (CRF) and the risk of colorectal and prostate cancer in men. Data from men who completed a health assessment both in military conscription in youth and an occupational health profile assessment (HPA) later in life were used. CRF was assessed as estimated V̇O<sub>2max</sub>, ...
Psychosocial well-being and diabetes distress in the transition to motherhood among women with type 1 or type 2 diabetes.
SEXUAL & REPRODUCTIVE HEALTHCARE : OFFICIAL JOURNAL OF THE SWEDISH ASSOCIATION OF MIDWIVES - 01 Dec 2024
To investigate the associations between psychological well-being, measured with the Postnatal Well-being in Transition (PostTrans) Questionnaire, and diabetes distress among mothers with type 1 or type 2 diabetes. Eighty-two postnatal women completed a cross-sectional survey. The survey included the Diabetes Distress Scale, and the PostTrans Questionnaire to assess the psychosocial well-being o...
Immediate Versus 5-Year Risk-Guided Initiation of Treatment for Primary Prevention of Cardiovascular Disease for Australians Aged 40 Years: A Health Economic Analysis.
PHARMACOECONOMICS - 02 Dec 2024
Current Australian cardiovascular disease (CVD) prevention guidelines calculate 5-year CVD risk and recommend treatment when risk crosses specific thresholds. This may leave risk factors untreated for people with a low short-term (i.e. 5 years), but high long-term (i.e. lifetime), risk of CVD. We aimed to evaluate the cost effectiveness of intervention for risk factor control at age 40 years (r...
Novel loci and biomedical consequences of iron homoeostasis variation.
COMMUNICATIONS BIOLOGY - 06 Dec 2024
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of whi...
Global analysis of endogenous protein disorder in cells.
NATURE METHODS - 25 Nov 2024
Disorder and flexibility in protein structures are essential for biological function but can also contribute to diseases, such as neurodegenerative disorders. However, characterizing protein folding on a proteome-wide scale within biological matrices remains challenging. Here we present a method using a bifunctional chemical probe, named TME, to capture in situ, enrich and quantify endogenous p...
Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank.
COMMUNICATIONS MEDICINE - 26 Nov 2024
Diagnosing complex illnesses like Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is complicated due to the diverse symptomology and presence of comorbid conditions. ME/CFS patients often present with multiple health issues, therefore, incorporating comorbidities into research can provide a more accurate understanding of the condition's symptomatology and severity, to better reflect...
Estimating the cost of chronic kidney disease in Australia.
BMC HEALTH SERVICES RESEARCH - 26 Nov 2024
Chronic kidney disease (CKD) is a significant burden on health systems globally, with limited up-to-date information on health system costs, particularly for non-dialysis patients. This study estimates the direct healthcare costs of CKD within Australia. The study utilised the CKD.WA dataset, a linked repository for the state of Western Australia, containing public and private pathology, hospit...
Effects of interval training in cardiovascular disease populations: a clinical perspective.
01 Dec 2024
Nearly 20 years have elapsed since the first clinical trial investigated the impact of interval training on patients with cardiovascular disease (CVD). This clinical corner discusses the health outcomes of systematic reviews and meta-analyses and appropriately powered randomized clinical trials which have tested these interval training programs across various CVDs (i.e., coronary artery disease...
PRIMITI: A computational approach for accurate prediction of miRNA-target mRNA interaction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL - 01 Dec 2024
Current medical research has been demonstrating the roles of miRNAs in a variety of cellular mechanisms, lending credence to the association between miRNA dysregulation and multiple diseases. Understanding the mechanisms of miRNA is critical for developing effective diagnostic and therapeutic strategies. miRNA-mRNA interactions emerge as the most important mechanism to be understood despite the...
Current Emergency Medical Service Vasoactive Use for the Management of Shock.
CRITICAL CARE EXPLORATIONS - 01 Dec 2024
We sought to describe the indications for vasoactive medication administration, hemodynamic treatment targets, and specific agents used by various international emergency medical service (EMS) providers. In March 2022, we sent an online survey comprising of 20 questions to Medical Directors of EMSs across Australia, the Asia Pacific region, and North America. A total of 108 EMS directors were e...
Left ventricular size and heart failure: A cardiac MRI assessment of 38,129 individuals from the UK Biobank.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 26 Oct 2024
Previous studies suggest that prevalent heart failure (HF) differs based on left ventricular ejection fraction (LVEF) and left ventricular (LV) chamber size. Furthermore, the prevalence of HF with preserved ejection fraction (HFpEF) is often considered approaching, or exceeding that of HF with reduced ejection fraction in the community. The aim of this study was to evaluate prevalent and incide...
Left Ventricular Summit Arrhythmias: State-of-the-Art Review of Anatomy, Mapping, and Ablation Strategies.
JACC. CLINICAL ELECTROPHYSIOLOGY - 22 Oct 2024
The left ventricular summit (LVS) is the most common site of epicardial arrhythmias. Ablation of LVS arrhythmias continue to pose a challenge to the electrophysiologist because of its complex and intimate anatomical location. In this review, we undertake a detailed examination of the intricate anatomy of the LVS alongside a comprehensive synthesis of mapping and ablation strategies used to trea...
Outcomes After Percutaneous Coronary Intervention in Patients with Prior Coronary Artery Bypass Grafting.
THE AMERICAN JOURNAL OF CARDIOLOGY - 27 Oct 2024
In patients with prior CABG requiring subsequent PCI there is uncertainty whether bypass grafts or native coronary arteries should be targeted. We analysed data from 2,764 patients with prior CABG in the Melbourne Interventional Group registry (2005-2018), divided into two groups: those undergoing PCI to a native vessel (n=1,928) and those with PCI to a graft vessel (n=836).Patients with a graf...
Acute Inhibition of Drp1 Mitigates Adverse Cardiac Remodelling following Chronic Reperfused Myocardial Infarction.
CARDIOVASCULAR DRUGS AND THERAPY - 21 Oct 2024
Behavioral and Psychosocial Dynamics in Diabetes Management: A Path Analysis to Examine the Influence of Acculturation in Arab Immigrant Communities.
21 Oct 2024
Type 2 diabetes mellitus (T2DM) prevalence is rising globally. Arab immigrants with T2DM, one of the least studied ethnic minorities, have a higher diabetes prevalence and more prominent management-related challenges compared with mainstream host societies. Acculturation's impact on self-care activities and diabetes distress (DD) is understudied globally. To examine how acculturation affects se...
