Publications
Now showing items 41-60 of 4864 records
An Old Drug Learning New Tricks: A REPRIEVE for Cardiovascular Disease in HIV Infection.
CLINICAL CHEMISTRY - 02 May 2024
2023 Cardiac Society of Australia and New Zealand Expert Position Statement on Catheter and Surgical Ablation for Atrial Fibrillation.
HEART, LUNG & CIRCULATION - 02 May 2024
Catheter ablation for atrial fibrillation (AF) has increased exponentially in many developed countries, including Australia and New Zealand. This Expert Position Statement on Catheter and Surgical Ablation for Atrial Fibrillation from the Cardiac Society of Australia and New Zealand (CSANZ) recognises healthcare factors, expertise and expenditure relevant to the Australian and New Zealand healt...
Co-design and development of the sit-stand e-guide: An e-training program for the optimal use of sit-stand workstations.
APPLIED ERGONOMICS - 01 Apr 2024
This paper describes the co-design and development process of an evidence-informed e-training program (Sit-Stand e-Guide) to support the safe and optimal use of sit-stand workstations from ergonomics and behavioural change perspectives. Using an instructional system design process, supported by a participatory design approach, data was collected through three workshops with workplace consumers ...
Acculturation and glycaemic control in Arab immigrants with type 2 diabetes in Australia.
DIABETOLOGIA - 01 Apr 2024
This study aimed to investigate acculturation's direct and mediated effects on HbA<sub>1c</sub> levels in individuals with type 2 diabetes from Arabic-speaking countries that are members of the Arab League who have emigrated to Australia. In this multicentre cross-sectional study, we recruited 382 Arabic-speaking immigrants who were born in any of the 22 countries of the Arab League and who had...
Not enough known about fenofibrate's kidney effects in people with Type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Apr 2024
Globally ≈10% of adults have diabetes, with 80% in disadvantaged regions, hence low-cost renoprotective agents are desirable. Fenofibrate demonstrated microvascular benefits in several cardiovascular end-point diabetes trials, but knowledge of effects in late-stage kidney disease is limited. We report new FIELD substudy data and call for further kidney outcomes data.
Short, frequent, light-intensity walking activity improves postprandial vascular-inflammatory biomarkers in people with type 1 diabetes: The SIT-LESS randomized controlled trial.
DIABETES, OBESITY & METABOLISM - 01 Apr 2024
To examine the effect of interrupting prolonged sitting with short, frequent, light-intensity activity on postprandial cardiovascular markers in people with type 1 diabetes (T1D). In a randomized crossover trial, 32 adults with T1D (mean ± SD age 28 ± 5 years, glycated haemoglobin 67.9 ± 12.6 mmol/mol, 17 women) completed two 7-h laboratory visits separated by >7 days. Participants either remai...
Clinical Outcomes of Renal Transplant Recipients Undergoing Percutaneous Coronary Intervention.
HEART, LUNG & CIRCULATION - 01 Apr 2024
Clinical outcomes of patients with renal transplant (RT) undergoing percutaneous coronary intervention (PCI) remain poorly elucidated. Between 2014 and 2021, data were analysed for the following three groups of patients undergoing PCI enrolled in a multicentre Australian registry: (1) RT recipients (n=226), (2) patients on dialysis (n=992), and (3) chronic kidney disease (CKD) patients (estimat...
Tracking of serum lipid levels from childhood to adulthood: Systematic review and meta-analysis.
ATHEROSCLEROSIS - 01 Apr 2024
The utility of lipid screening in pediatric settings for preventing adult atherosclerotic cardiovascular diseases partly depends on the lifelong tracking of lipid levels. This systematic review aimed to quantify the tracking of lipid levels from childhood and adolescence to adulthood. We systematically searched MEDLINE, Embase, Web of Science, and Google Scholar in March 2022. The protocol was ...
The association between sodium glucose cotransporter-2 inhibitors vs dipeptidyl peptidase-4 inhibitors and renal outcomes in people discharged from hospital with type 2 diabetes: A population-based cohort study.
JOURNAL OF DIABETES - 01 Apr 2024
We investigated the association between post-hospital discharge use of sodium glucose cotransporter-2 inhibitors (SGLT-2is) compared to dipeptidyl peptidase-4 inhibitors (DPP-4is) and the incidence of hospitalization for acute renal failure (ARF) and chronic kidney disease (CKD) in people with type 2 diabetes. We conducted a retrospective cohort study using linked hospital and prescription data...
Proteomic profiling of small extracellular vesicles derived from mouse pancreatic cancer and stellate cells: Role in pancreatic cancer.
PROTEOMICS - 03 Apr 2024
Small extracellular vesicles (sEVs) are cell-derived vesicles evolving as important elements involved in all stages of cancers. sEVs bear unique protein signatures that may serve as biomarkers. Pancreatic cancer (PC) records a very poor survival rate owing to its late diagnosis and several cancer cell-derived proteins have been reported as candidate biomarkers. However, given the pivotal role p...
Randomized Trial of a Selective Aldose Reductase Inhibitor in Patients With Diabetic Cardiomyopathy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 03 Apr 2024
Progression to symptomatic heart failure is a complication of type 2 diabetes; heart failure onset in this setting is commonly preceded by deterioration in exercise capacity. The study sought to determine whether AT-001, a highly selective aldose reductase inhibitor, can stabilize exercise capacity among individuals with diabetic cardiomyopathy (DbCM) and reduced peak oxygen uptake (Vo<sub>2</s...
Noninvasive Techniques for Tracking Biological Aging of the Cardiovascular System: JACC Family Series.
JACC. CARDIOVASCULAR IMAGING - 04 Apr 2024
Population aging is one of the most important demographic transformations of our time. Increasing the "health span"-the proportion of life spent in good health-is a global priority. Biological aging comprises molecular and cellular modifications over many years, which culminate in gradual physiological decline across multiple organ systems and predispose to age-related illnesses. Cardiovascular...
Quantifying the Lymphatic Transport of Model Therapeutics from the Brain in Rats.
05 Apr 2024
In recent years, the drainage of fluids, immune cells, antigens, fluorescent tracers, and other solutes from the brain has been demonstrated to occur along lymphatic outflow pathways to the deep cervical lymph nodes in the neck. To the best of our knowledge, no studies have evaluated the lymphatic transport of therapeutics from the brain. The objective of this study was to determine the lymphat...
The Role of Comorbidities in Predicting Functional Improvement After Transcatheter Aortic Valve Implantation.
HEART, LUNG & CIRCULATION - 05 Apr 2024
Patients undergoing transcatheter aortic valve implantation (TAVI) have a high comorbidity burden. We sought to stratify patients into functional outcomes using the Kansas City Cardiomyopathy Questionnaire (KCCQ-12), a patient-reported outcome with benefits over both the New York Heart Association (NYHA) classification and the original 23-item KCCQ, and to evaluate the importance of comorbiditi...
Associations of 24 h time-use compositions of sitting, standing, physical activity and sleeping with optimal cardiometabolic risk and glycaemic control: The Maastricht Study.
DIABETOLOGIA - 24 Apr 2024
The associations of sitting, standing, physical activity and sleep with cardiometabolic health and glycaemic control markers are interrelated. We aimed to identify 24 h time-use compositions associated with optimal metabolic and glycaemic control and determine whether these varied by diabetes status. Thigh-worn activPAL data from 2388 participants aged 40-75 years (48.7% female; mean age 60.1 [...
Extracellular vesicles-An omics view.
PROTEOMICS - 26 Apr 2024
A comparison of wavelet-based action potential detection from the NeuroAmp and the Iowa Bioengineering Nerve Traffic Analysis system.
JOURNAL OF NEUROPHYSIOLOGY - 17 Apr 2024
Microneurographic recordings of muscle sympathetic nerve activity (MSNA) reflects postganglionic sympathetic axonal activity directed toward the skeletal muscle vasculature. Recordings are typically evaluated for spontaneous bursts of MSNA; however, the filtering and integration of raw neurograms to obtain multi-unit bursts conceals the underlying c-fiber discharge behavior. The continuous wave...
Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer's disease.
ISCIENCE - 16 Feb 2024
Alzheimer's disease (AD) is associated with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles (NFT). We characterized the behavioral, metabolic and lipidomic phenotype of the 5xFADxTg30 mouse model which contains overexpression of both Aβ and tau. Our results independently reproduce several phenotypic traits described previously for this model, w...
Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer's disease.
NPJ METABOLIC HEALTH AND DISEASE - 01 Jan 2024
Alzheimer's disease (AD) is influenced by a variety of modifiable risk factors, including a person's dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affecting AD progression, only a few studies have explored KD's metabolic impact, especially on blood and cerebrospinal fluid (CSF). Our study involved participants at risk for AD, either cogn...
Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment.
ADV HEALTHC MATER - 10 Jan 2024
Brain cancers, especially glioblastoma multiforme (GBM), are associated with poor prognosis due to the limited efficacy of current therapies. Nanomedicine has emerged as a versatile technology to treat various diseases, including cancers, and has played an indispensable role in combatting the COVID-19 pandemic as evidenced by the role that lipid nanocarrier-based vaccines have played. The tunab...
