Publications
Now showing items 3881-3900 of 5702 records
Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : JASN - 01 May 2018
The failure of spontaneous resolution underlies chronic inflammatory conditions, including microvascular complications of diabetes such as diabetic kidney disease. The identification of endogenously generated molecules that promote the physiologic resolution of inflammation suggests that these bioactions may have therapeutic potential in the context of chronic inflammation. Lipoxins (LXs) are l...
May measurement month 2017-a concerted global effort to raise awareness of elevated blood pressure.
JOURNAL OF HUMAN HYPERTENSION - 01 May 2018
Visit-to-visit (long-term) and ambulatory (short-term) blood pressure variability to predict mortality in an elderly hypertensive population.
JOURNAL OF HYPERTENSION - 01 May 2018
To explore the association of different types of blood pressure (BP) variability measures estimated from either short-term ambulatory reading-to-reading or long-term clinic visit-to-visit BP records with long-term survival in an elderly treated hypertensive population.A subset of patients (n = 508) aged at least 65-years was studied from the Second Australian National Blood Pressure study. We e...
Catheter Ablation: First-Line Therapy for Atrial Fibrillation in Systolic Heart Failure?
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 May 2018
High prevalence of diabetes among migrants in the United Arab Emirates using a cross-sectional survey.
SCIENTIFIC REPORTS - 01 May 2018
In 2011, the United Arab Emirates (UAE) had the 10th highest diabetes prevalence globally, but this was based on data that excluded migrants who comprise 80% of the population. This study assessed diabetes prevalence across the UAE population. A random sample of migrants was recruited from the visa renewal centers. Data were collected using interviews, anthropometric measurements and fasting bl...
Bad words: why language counts in our work with bariatric patients.
SURGERY FOR OBESITY AND RELATED DISEASES : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY FOR BARIATRIC SURGERY - 01 May 2018
Language is powerful. Our words convey our impressions, attitudes, and worldview. Language not only reflects, but also shapes, the way that we think. In the field of bariatric-metabolic surgery, it is critical for clinicians to choose our language thoughtfully. In this paper, we demonstrate the importance of language choices in our clinical work and our professional communications; explore the ...
Effects of Providing High-Fat versus High-Carbohydrate Meals on Daily and Postprandial Physical Activity and Glucose Patterns: a Randomised Controlled Trial.
NUTRIENTS - 30 Apr 2018
We determined the effects of altering meal timing and diet composition on temporal glucose homeostasis and physical activity measures. Eight sedentary, overweight/obese men (mean ± SD, age: 36 ± 4 years; BMI: 29.8 ± 1.8 kg/m²) completed two × 12-day (12-d) measurement periods, including a 7-d habitual period, and then 5 d of each diet (high-fat diet [HFD]: 67:15:18% f...
Maternal age and offspring developmental vulnerability at age five: A population-based cohort study of Australian children.
PLOS MEDICINE - 01 Apr 2018
In recent decades, there has been a shift to later childbearing in high-income countries. There is limited large-scale evidence of the relationship between maternal age and child outcomes beyond the perinatal period. The objective of this study is to quantify a child's risk of developmental vulnerability at age five, according to their mother's age at childbirth.Linkage of population-level peri...
Sex Differences in the Impact of Body Mass Index on the Risk of Future Atrial Fibrillation: Insights From the Longitudinal Population-Based Tromsø Study.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 19 Apr 2018
Atrial fibrillation (AF) prevalence is increasing, and body mass index (BMI) is a risk factor for AF. However, sex differences in the impact of BMI on AF risk have not been fully elucidated.Data from the fourth survey (1994-1995) of the Tromsø Study (Norway) were used to investigate the association of single-measurement BMI on future AF risk. To analyze the influence of BMI changes on AF risk, ...
Recent novel approaches to limit oxidative stress and inflammation in diabetic complications.
CLINICAL & TRANSLATIONAL IMMUNOLOGY - 01 Jan 2018
Diabetes is considered a major burden on the healthcare system of Western and non-Western societies with the disease reaching epidemic proportions globally. Diabetic patients are highly susceptible to developing micro- and macrovascular complications, which contribute significantly to morbidity and mortality rates. Over the past decade, a plethora of research has demonstrated that oxidative str...
SGLT-2 Inhibition: Novel Therapeutics for Reno-and Cardioprotection in Diabetes Mellitus.
CURRENT DIABETES REVIEWS - 17 Apr 2018
The sodium glucose co-transporter 2 (SGLT2) is primarily located within S1 of the renal proximal tubule being responsible for approximately 90% of glucose re-uptake in the kidney. Inhibition of SGLT2 is an exciting new pharmacological approach for the reduction of blood glucose in type 2 diabetic patients via inhibition of tubular glucose reabsorption. In addition to lowering glucose, this grou...
A Conformational Change in C-Reactive Protein Enhances Leukocyte Recruitment and Reactive Oxygen Species Generation in Ischemia/Reperfusion Injury.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2018
C-reactive protein circulates as a pentameric protein (pCRP). pCRP is a well-established diagnostic marker as plasma levels rise in response to tissue injury and inflammation. We recently described pro-inflammatory properties of CRP, which are mediated by conformational changes from pCRP to bioactive isoforms expressing pro-inflammatory neo-epitopes [pCRP* and monomeric C-reactive protein (mCRP...
Patients' perceived needs of osteoarthritis health information: A systematic scoping review.
PLOS ONE - 01 Jan 2018
Optimal management of osteoarthritis requires active patient participation. Understanding patients' perceived health information needs is important in order to optimize health service delivery and health outcomes in osteoarthritis. We aimed to review the existing literature regarding patients' perceived health information needs for OA.A systematic scoping review was performed of publications in...
Droplet digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 15 Apr 2018
micro-RNAs have shown promise as potential biomarkers for acute myocardial infarction and ischemia-reperfusion injury (I/R). Most recently droplet digital polymerase chain reaction (ddPCR) has been introduced as a more reliable and reproducible method for detecting micro-RNAs.We aimed to demonstrate the improved technical performance and diagnostic potential of ddPCR by measuring micro-RNAs in ...
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.
LANCET (LONDON, ENGLAND) - 14 Apr 2018
Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease.We did a combined analysis of individual-participant data from three large-sca...
Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications For Heart Failure Prevention.
CIRCULATION - 10 Apr 2018
Poor fitness in middle age is a risk factor for heart failure, particularly heart failure with a preserved ejection fraction. The development of heart failure with a preserved ejection fraction is likely mediated through increased left ventricular (LV) stiffness, a consequence of sedentary aging. In a prospective, parallel group, randomized controlled trial, we examined the effect of 2 years of...
Iso-Osmolar Iodixanol Induces Less Increase in Circulating Endothelial Microparticles and Less Endothelial Apoptosis Compared with Low-Osmolar Iohexol.In Vivo
CONTRAST MEDIA & MOLECULAR IMAGING - 01 Jan 2018
There is no consensus on whether iodixanol is superior to iohexol. This study aimed to compare the effects of iodixanol and iohexol on circulating endothelial microparticles (EMPs) in stable coronary artery disease (CAD) patients with diabetes mellitus (DM), and also their cytotoxic effects on human umbilical vein endothelial cells (HUVECs) .in vitro100 CAD patients with DM were randomly assign...
Dual-Targeted Theranostic Delivery of miRs Arrests Abdominal Aortic Aneurysm Development.
MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY - 04 Apr 2018
Abdominal aortic aneurysm (AAA) is an often deadly disease without medical, non-invasive treatment options. The upregulation of vascular cell adhesion molecule-1 (VCAM-1) on aortic endothelium provides an early target epitope for a novel biotechnological theranostic approach. MicroRNA-126 was used as a therapeutic agent, based on its capability to downregulate VCAM-1 expression in endothelial c...
Associations of neighbourhood walkability indices with weight gain.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 03 Apr 2018
Inconsistent associations of neighbourhood walkability with adults' body weight have been reported. Most studies examining the relationships of walkability and adiposity are cross-sectional in design. We examined the longitudinal relationships of two walkability indices - conventional walkability and space syntax walkability, and their individual components, with weight change among adults over...
Guidelines for experimental models of myocardial ischemia and infarction.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Apr 2018
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and wh...
