Publications
Now showing items 381-400 of 4875 records
Impact of Early Versus Delayed Atrial Fibrillation Catheter Ablation on Atrial Arrhythmia Recurrences.
EUROPEAN HEART JOURNAL - 16 Apr 2023
Catheter ablation is an effective strategy in atrial fibrillation (AF). However, its timing in the course of management remains unclear. The aim of this study was to determine if an early versus delayed AF ablation strategy is associated with differences in arrhythmia outcomes during 12-month follow-up.One hundred patients with symptomatic AF referred to a tertiary centre for management were ra...
Projecting the incidence and costs of major cardiovascular and kidney complications of type 2 diabetes with widespread SGLT2i and GLP-1 RA use: a cost-effectiveness analysis.
DIABETOLOGIA - 01 Apr 2023
Whether sodium-glucose co-transporter 2 inhibitors (SGLT2is) or glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are cost-effective based solely on their cardiovascular and kidney benefits is unknown. We projected the health and economic outcomes due to myocardial infarction (MI), stroke, heart failure (HF) and end-stage kidney disease (ESKD) among people with type 2 diabetes, with and wit...
A systematic review of global autopsy rates in all-cause mortality and young sudden death.
HEART RHYTHM - 01 Apr 2023
Autopsy is the gold standard method for determining cause of death. Young sudden death (SD) is a prototype condition in which autopsy is universally recommended. The aim of this review was to quantify real-world global rates of autopsy in either all-cause death or young SD. A systematic review was conducted. Rates of autopsy in all-cause death and in young SD were determined in each country usi...
Inotropic therapy in patients with advanced heart failure. A clinical consensus statement from the Heart Failure Association of the European Society of Cardiology.
EUROPEAN JOURNAL OF HEART FAILURE - 01 Apr 2023
This clinical consensus statement reviews the use of inotropic support in patients with advanced heart failure. The current guidelines only support use of inotropes in the setting of acute decompensated heart failure with evidence of organ malperfusion or shock. However, inotropic support may be reasonable in other patients with advanced heart failure without acute severe decompensation. The cl...
Mitochondrial damage in a Takotsubo syndrome-like mouse model mediated by activation of β-adrenoceptor-Hippo signaling pathway.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Apr 2023
Takotsubo syndrome (TTS) is characterized by short-term contractile dysfunction with its mechanism undefined. We showed that activation of cardiac Hippo pathway mediates mitochondrial dysfunction and that stimulation of β-adrenoceptors (βAR) activates Hippo pathway. Here, we investigated the role of βAR-Hippo signaling in mediating mitochondrial dysfunction in isoproterenol (Iso)-induced TTS-li...
Declining Recognition of Chest Pain as a Cardiac Symptom Should Act as a Shot in The Arm.
HEART, LUNG & CIRCULATION - 01 Apr 2023
Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor.
SIGNAL TRANSDUCTION AND TARGETED THERAPY - 22 Jul 2022
Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-producing β-cells in the pancreas. An unmet need in diabetes management, current therapy is focussed on transplantation. While the reprogramming of progenitor cells into functional insulin-producing β-cells has also been proposed this remains controversial and poorly understood. The challenge is determining why def...
Intestinal microbiota regulates diabetes and cancer progression by IL-1β and NOX4 dependent signaling cascades.
CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - 01 Sep 2022
Diabetes changes the host microbiota, a condition known as dysbiosis. Dysbiosis is an important factor for the pathogenesis of diabetes and colorectal cancer (CRC). We aimed at identifying the microbial signature associated with diabetes and CRC; and identifying the signaling mechanism altered by dysbiosis and leading to CRC progression in diabetes. MKR mice that can spontaneously develop type ...
Factors Contributing to the Change in Overweight/Obesity Prevalence Among Indian Adults: A multivariate decomposition analysis of data from the National Family Health Surveys.
ADVANCES IN THERAPY - 01 Dec 2023
Concerns over the escalating burden of non-communicable diseases call for the redressal of behavioral risk factors like increased body mass index. Most studies have failed to quantify the contribution of socio-demographic characteristics in a linear trend. The present study aims to estimate the current prevalence of overweight and obesity in Indian adults and the contribution of different socio...
Improving traffic-related air pollution estimates by modelling minor road traffic volumes.
ENVIRONMENTAL POLLUTION (BARKING, ESSEX : 1987) - 01 Dec 2023
Accurately estimating annual average daily traffic (AADT) on minor roads is essential for assessing traffic-related air pollution (TRAP) exposure, particularly in areas where most people live. Our study assessed the direct and indirect external validity of three methods used to estimate AADT on minor roads in Melbourne, Australia. We estimated the minor road AADT using a fixed-value approach (a...
Evolution and transmission of antibiotic resistance is driven by Beijing lineage in Vietnam.Mycobacterium tuberculosis
MICROBIOLOGY SPECTRUM - 12 Dec 2023
Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that genetic line...
Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in male mice with obesity.
NATURE COMMUNICATIONS - 15 Jan 2024
There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer's disease. The role of amyloid beta 42 (Aβ<sub>42</sub>) in these diverse chronic diseases is obscure. Here we show that adipose tissue releases Aβ<sub>42</sub>, which is increased from adipose tissue of male mice with obesity and is associated with higher plasma Aβ<sub>42</sub>. Inc...
Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.
THE JOURNAL OF CLINICAL INVESTIGATION - 15 Feb 2023
Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust replication in large-scale genome-wide association studies. To understand the role of DNA methylation, it is important to have the prevailing genomic view to distinguish key sequence elements that influence gene expression. This is particularly challenging for DN because genome-wide methylation patterns are ...
Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms.
CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - 01 Nov 2022
Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the ovalbumin (OVA)-induced chronic allergic airways murine model, with key hallmarks of asthma. Histological analysis indicated that LSF prevented or reversed OVA-induced epithelial thickening, collagen deposition, goble...
Trends in Intra-Aortic Balloon Pump Use in Cardiogenic Shock After the SHOCK-II Trial.
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Mar 2023
Myocardial infarction complicated by cardiogenic shock (MI-CS) has a poor prognosis, even with early revascularization. Previously, intra-aortic balloon pump (IABP) use was thought to improve outcomes, but the IABP-SHOCK-II (Intra-aortic Balloon Pump in Cardiogenic Shock-II study) trial found no survival benefit. We aimed to determine the trends in IABP use in patients who underwent percutaneou...
Pericoronary Adipose Tissue as a Marker of Cardiovascular Risk: JACC Review Topic of the Week.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 07 Mar 2023
Vascular inflammation is a key driver in atherosclerotic progression and plaque rupture. Recent evidence has shown that coronary computed tomography provides a noninvasive method of quantifying coronary inflammation by mapping changes in pericoronary adipose tissue (PCAT) radiodensity, which are associated with cardiovascular diseases. However, there are significant knowledge gaps in the perfor...
Morbidity and utilisation of healthcare services among people with cardiometabolic disease in three diverse regions of rural India.
CHRONIC ILLNESS - 01 Dec 2023
To assess the prevalence and determinants of cardiometabolic disease (CMD), and the factors associated with healthcare utilisation, among people with CMD.Using a cross-sectional design, 11,657 participants were recruited from randomly selected villages in 3 regions located in Kerala and Andhra Pradesh from 2014 to 2016. Multivariable logistic regression was used to identify factors independentl...
Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status.
ESC HEART FAILURE - 01 Dec 2023
Heart failure (HF) is a common cause of morbidity and mortality, related to a broad range of sociodemographic, lifestyle, cardiometabolic, and comorbidity risk factors, which may differ according to the presence of atherosclerotic cardiovascular disease (ASCVD). We assessed the association between incident HF with baseline status across these domains, overall and separated according to ASCVD st...
Clinical outcomes of 10 years of cardiac screening in elite New Zealand athletes.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 01 Dec 2023
To report findings from the High Performance Sport New Zealand cardiac screening programme, including comparisons between sexes and ethnicities.Retrospective cohort study.Elite Olympic-sport athletes were screened (2012-2022) with personal/family history, physical examination, resting 12-lead ECG and followed from the date of first screening until July 2022. An audit reviewed screening records,...
Postpartum uptake of diabetes screening tests in women with gestational diabetes: The PANDORA study.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 01 Mar 2023
To determine rates and predictors of postpartum diabetes screening among Aboriginal and/or Torres Strait Islander and non-Indigenous women with gestational diabetes mellitus (GDM).PANDORA is a prospective longitudinal cohort of women recruited in pregnancy. Postpartum diabetes screening rates at 12 weeks (75-g oral glucose tolerance test (OGTT)) and 6, 12 and 18 months (OGTT, glycated haemoglob...
