Publications
Now showing items 3641-3660 of 5385 records
Physiological and pathophysiological firing properties of single postganglionic sympathetic neurons in humans.
JOURNAL OF NEUROPHYSIOLOGY - 01 Mar 2018
It has long been known from microneurographic recordings in human subjects that the activity of postganglionic sympathetic axons occurs as spontaneous bursts, with muscle sympathetic nerve activity (MSNA) exhibiting strong cardiac rhythmicity via the baroreflex and skin sympathetic nerve activity showing much weaker cardiac modulation. Here we review the firing properties of single sympathetic ...
Effects of breaking up sitting on adolescents' postprandial glucose after consuming meals varying in energy: a cross-over randomised trial.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 01 Mar 2018
To explore the impact of uninterrupted sitting versus sitting with resistance-type activity breaks on adolescents' postprandial glucose responses while consuming a diet varying in energy.Cross-over randomised trial.Thirteen healthy participants (16.4±1.3years) completed a four-treatment cross-over trial: (1) uninterrupted sitting+high-energy diet; (2) sitting with breaks+high-energy diet; (3) u...
What's Old Is New Again: A Reminder of the Importance of Left Ventricular Geometry and Function as Markers of Risk.
JACC. CARDIOVASCULAR IMAGING - 01 Mar 2018
The Many Dimensions of Diastolic Function: A Curse or a Blessing?
JACC. CARDIOVASCULAR IMAGING - 01 Mar 2018
Current and future antiplatelet therapies: emphasis on preserving haemostasis.
NATURE REVIEWS. CARDIOLOGY - 01 Mar 2018
Antiplatelet drugs, such as aspirin, P2Y antagonists, and glycoprotein (GP) IIb/IIIa inhibitors, have proved to be successful in reducing the morbidity and mortality associated with arterial thrombosis. These agents are, therefore, the cornerstone of therapy for patients with acute coronary syndromes. However, these drugs all carry an inherent risk of bleeding, which is associated with adverse ...
Trajectories of BMI change impact glucose and insulin metabolism.
NUTRITION, METABOLISM, AND CARDIOVASCULAR DISEASES : NMCD - 01 Mar 2018
The aim of this study was to examine, in a community setting, whether trajectory of weight change over twelve years is associated with glucose and insulin metabolism at twelve years.Participants were 532 community-living middle-aged and elderly adults from the Personality and Total Health (PATH) Through Life study. They spanned the full weight range (underweight/normal/overweight/obese). Latent...
Randomized Controlled Trials or Observational Studies? It Depends on the Research Question.
OBESITY SURGERY - 01 Mar 2018
Post-infarct cardiac injury, protection and repair: roles of non-cardiomyocyte multicellular and acellular components.
SCIENCE CHINA. LIFE SCIENCES - 01 Mar 2018
Following myocardial infarction (MI), cardiomyocytes and infarct size are the focus of our attention when evaluating the extent of cardiac injury, efficacy of therapies or success in repairing the damaged heart by stem cell therapy. Numerous interventions have been shown by pre-clinical studies to be effective in limiting infarct size, and yet clinical trials designed accordingly have yielded d...
The relationship between excessive daytime sleepiness, disability, and mortality, and implications for life expectancy.
SLEEP MEDICINE - 01 Mar 2018
To assess the relationship between excessive daytime sleepiness (EDS), disability, mortality, and life expectancy (with and without disability) in a cohort of middle-aged American adults.The Wisconsin Longitudinal Study, a life-course study on 10,317 high school graduates from Wisconsin, was used to assess the odds ratio (OR) between EDS in 2004 for prevalent and incident disability to 2011 thr...
Patient-Related Determinants of Glycaemic Control in People with Type 2 Diabetes in the Gulf Cooperation Council Countries: A Systematic Review.
JOURNAL OF DIABETES RESEARCH - 01 Jan 2018
The aim of this systematic review is to assess patient-related factors affecting glycaemic control among people with type 2 diabetes in the Arabian Gulf Council countries. MEDLINE, Embase, PsycINFO, CINAHL, and Cochrane CENTRAL databases were searched from their date of inception to May 2016. Two researchers independently identified eligible studies and assessed the risk of bias. A total of 13 ...
Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2018
It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs in the absence of viral or bacterial pathogens, accompanies numerous disease states, none more so than the complications that arise as a result of hyperglycaemia. Individuals with type 1 or type 2 diabetes mellitus (T1D, T2D) are at incre...
Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 13 Feb 2018
Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites for MI and stroke subtypes.This study sought to investigate the associations of plasma metabolic markers with risks of incident MI, ischemic stroke (IS), and intracerebral hemorrhage (ICH).In a nested case-control st...
Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 14 Feb 2018
We previously showed that medium chain acyl-coenzyme A dehydrogenase (MCAD, key regulator of fatty acid oxidation) is positively modulated in the heart by the cardioprotective kinase, phosphoinositide 3-kinase (PI3K(p110α)). Disturbances in cardiac metabolism are a feature of heart failure (HF) patients and targeting metabolic defects is considered a potential therapeutic approach. The specific...
Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'.
NATURE COMMUNICATIONS - 07 Feb 2018
Mild cognitive impairment impacts health outcomes of patients with atrial fibrillation undergoing a disease management intervention.
OPEN HEART - 01 Jan 2018
Mild cognitive impairment (MCI) is prevalent in atrial fibrillation (AF) and has the potential to contribute to poor outcomes. We investigated the influence of MCI on survival and rehospitalisation in patients with chronic forms of AF undergoing a home-based, AF-specific disease management intervention (home-based intervention (HBI)) or standard management (SM).The Montreal Cognitive Assessment...
Metabolic characterization of menopause: cross-sectional and longitudinal evidence.
BMC MEDICINE - 06 Feb 2018
Women who experience menopause are at higher cardiometabolic risk and often display adverse changes in metabolic biomarkers compared with pre-menopausal women. It remains elusive whether the changes in cardiometabolic biomarkers during the menopausal transition are due to ovarian aging or chronological aging. Well-conducted longitudinal studies are required to determine this. The aim of this st...
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.
NATURE COMMUNICATIONS - 06 Feb 2018
Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required for host defense, limiting their therapeutic use. Here, we report a novel monoclonal antibody, anti-M7, that specifically blocks the interaction of the integrin Mac-1 with ...
Validation of Predictive Score of 30-Day Hospital Readmission or Death in Patients With Heart Failure.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Feb 2018
Existing prediction algorithms for the identification of patients with heart failure (HF) at high risk of readmission or death after hospital discharge are only modestly effective. We sought to validate a recently developed predictive model of 30-day readmission or death in HF using an Australia-wide sample of patients. This study used data from 1,046 patients with HF at teaching hospitals in 5...
Australian Trends in Procedural Characteristics and Outcomes in Patients Undergoing Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Feb 2018
Over the last decade, systems of care for ST-elevation myocardial infarction (STEMI) have evolved to try to improve outcomes and timely access to percutaneous coronary intervention (PCI). There have also been advances in PCI techniques and adjunctive pharmacotherapies. In this study, we sought to determine temporal changes in practices and clinical outcomes of PCI in patients with STEMI. We pro...
Weight Loss and Exercise Alter the High-Density Lipoprotein Lipidome and Improve High-Density Lipoprotein Functionality in Metabolic Syndrome.
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Feb 2018
High-density lipoprotein (HDL) lipid composition and function may better reflect cardiovascular risk than HDL cholesterol concentration. This study characterized the relationships between HDL composition, metabolism, and function in metabolic syndrome (MetS) patients and how changes in composition after weight loss (WL) and exercise treatments are related to function.Plasma samples from MetS pa...
