Publications
Now showing items 3481-3500 of 5702 records
Modified redox signaling in vasculature after chronic infusion of the insulin receptor antagonist, S961.
MICROCIRCULATION (NEW YORK, N.Y. : 1994) - 01 Feb 2019
Type 2 diabetes and associated vascular complications cause substantial morbidity and mortality. It is important to investigate mechanisms and test therapies in relevant physiological models, yet few animal models adequately recapitulate all aspects of the human condition.We sought to determine the potential of using an insulin receptor antagonist, S961, in mice for investigating vascular patho...
The pulmonary microvasculature entraps induced vascular progenitor cells (iVPCs) systemically delivered after cardiac ischemia-reperfusion injury: Indication for preservation of heart function via paracrine effects beyond engraftment.
MICROCIRCULATION (NEW YORK, N.Y. : 1994) - 01 Feb 2019
Stem cell-based regenerative therapies have been intensively studied with the aim to define an ideal cell type for the treatment of myocardial infarction. We tested systemically delivered, platelet-targeted induced vascular progenitor cells (iVPCs) to study their potential to salvage damaged myocardium after ischemia-reperfusion injury.Using a mouse model of ischemia-reperfusion injury, we test...
Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-κB and AMPK signaling pathways.
PHYTOTHERAPY RESEARCH : PTR - 01 Feb 2019
Macrophage activation plays a central role in neoatherosclerosis and in-stent restenosis after percutaneous coronary intervention (PCI). Galectin-3, mainly expressed on macrophages, is an important regulator of inflammation. This study aimed to investigate the effects of berberine (BBR) on oxidized low-density lipoprotein (ox-LDL)-induced macrophage activation and galectin-3 expression and thei...
Exceptional human longevity is associated with a specific plasma phenotype of ether lipids.
REDOX BIOLOGY - 01 Feb 2019
A lipid profile resistant to oxidative damage is an inherent trait associated with animal lifespan. However, there is a lack of lipidomic studies on human longevity. Here we use mass spectrometry based technologies to detect and quantify 137 ether lipids to define a phenotype of healthy humans with exceptional lifespan. Ether lipids were chosen because of their antioxidant properties and abilit...
Multiplex Droplet Digital PCR Assay for Quantification of Human T-Cell Leukemia Virus Type 1 Subtype c DNA Proviral Load and T Cells from Blood and Respiratory Exudates Sampled in a Remote Setting.
JOURNAL OF CLINICAL MICROBIOLOGY - 01 Feb 2019
During human T-cell leukemia virus type 1 (HTLV-1) infection, the frequency of cells harboring an integrated copy of viral cDNA, the proviral load (PVL), is the main risk factor for progression of HTLV-1-associated diseases. Accurate quantification of provirus by droplet digital PCR (ddPCR) is a powerful diagnostic tool with emerging uses for monitoring viral expression. Current ddPCR technique...
Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia.
THE JOURNAL OF INFECTIOUS DISEASES - 29 Jan 2019
The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase i...
Proof of concept for quantitative urine NMR metabolomics pipeline for large-scale epidemiology and genetics.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 25 Jan 2019
Quantitative molecular data from urine are rare in epidemiology and genetics. NMR spectroscopy could provide these data in high throughput, and it has already been applied in epidemiological settings to analyse urine samples. However, quantitative protocols for large-scale applications are not available.We describe in detail how to prepare urine samples and perform NMR experiments to obtain qua...
Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy.
THE JOURNAL OF BIOLOGICAL CHEMISTRY - 25 Jan 2019
Autophagy is critical for maintaining cellular function via clearance of excess nutrients and damaged organelles. In pancreatic β-cells, it helps counter the endoplasmic reticulum (ER) stress that impairs insulin secretory capacity during Type 2 diabetes. Chronic exposure of β-cells to saturated fatty acids (FAs) such as palmitate stimulates ER stress and modulates autophagy, but the effects of...
Real-world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register.
JOURNAL OF DIABETES - 25 Jan 2019
In Australia's Northern Territory, Indigenous mothers account for 33% of births and have high rates of hyperglycemia in pregnancy. The prevalence of type 2 diabetes (T2D) in pregnancy is up to 10-fold higher in Indigenous than non-Indigenous Australian mothers, and the use of metformin is common. We assessed birth outcomes in relation to metformin use during pregnancy from a clinical register.T...
The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.
SCIENTIFIC REPORTS - 24 Jan 2019
Apolipoprotein E (apoE) is the key regulator of plasma lipids, mediating altered functionalities in lipoprotein metabolism - affecting the risk of coronary artery (CAD) and Alzheimer's diseases, as well as longevity. Searching pathways influenced by apoE prior to adverse manifestations, we utilized a metabolome dataset of 228 nuclear-magnetic-resonance-measured serum parameters with a 10-year f...
Risk stratification for coronary artery disease in multi-ethnic populations: Are there broader considerations for cost efficiency?
WORLD JOURNAL OF METHODOLOGY - 18 Jan 2019
Coronary artery disease (CAD) screening and diagnosis are core cardiac specialty services. From symptoms, autopsy correlations supported reductions in coronary blood flow and dynamic epicardial and microcirculatory coronaries artery disease as etiologies. While angina remains a clinical diagnosis, most cases require correlation with a diagnostic modality. At the onset of the evidence building p...
Sex-Specific Lifestyle and Biomedical Risk Factors for Chronic Disease among Early-Middle, Middle and Older Aged Australian Adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 15 Jan 2019
Evidence suggests age and sex differences in risk factors for chronic disease. This study examined lifestyle and biomedical risk factors among men (m) and women (w) in early-middle (25⁻51 years), middle (52⁻64) and older (65+) adulthood. Cross-sectional data from the 2011⁻2012 Australian Health Survey (n = 3024) were analysed. Self-reported dietary, activity, sleep behaviours and collected biom...
Natural movement: A space syntax theory linking urban form and function with walking for transport.
HEALTH & PLACE - 11 Jan 2019
Walking to get to and from local destinations including shops, services, and transit stops is a major source of adults' health-related physical activity. Research has been using space syntax measures in examining how urban form is related to such routine walking for transport. This paper proposes to apply a theory of space syntax, natural movement, which posits street layout as a primary factor...
K3.1 Channels Promote Cardiac Fibrosis Through Mediating Inflammation and Differentiation of Monocytes Into Myofibroblasts in Angiotensin II -Treated Rats.Ca
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 08 Jan 2019
Background Cardiac fibrosis is a core pathological process associated with heart failure. The recruitment and differentiation of primitive fibroblast precursor cells of bone marrow origin play a critical role in pathological interstitial cardiac fibrosis. The K3.1 channels are expressed in both ventricular fibroblasts and circulating mononuclear cells in rats and are upregulated by angiotensin ...
A nurse-led model of care within an emergency department reduces representation rates for frail aged care residents.
AGING CLINICAL AND EXPERIMENTAL RESEARCH - 07 Jan 2019
Hospital Emergency Departments (EDs) experience high presentation rates from older adults residing in Aged Care Facilities (ACFs), yet very few intervention studies have addressed the care needs of this population group. We designed and implemented a nurse-led model of care for older adults from ACFs, and determined its impact on patient outcomes.This 12-month pre-post intervention study was co...
Which frailty scale for patients admitted via Emergency Department? A cohort study.
ARCHIVES OF GERONTOLOGY AND GERIATRICS - 01 Jan 2001
To determine the prevalence of frailty in Emergency Departments (EDs); examine the ability of frailty to predict poor outcomes post-discharge; and identify the most appropriate instrument for routine ED use.In this prospective study we simultaneously assessed adults 65+yrs admitted and/or spent one night in the ED using Fried, the Clinical Frailty Scale (CFS), and SUHB (Stable, Unstable, Help t...
Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.
CARDIOLOGY JOURNAL - 01 Jan 2019
Geographical differences in patient characteristics, management and outcomes in heart failure (HF) trials are well recognized. The aim of this study was to assess the consistency of the treat- ment effect of coenzyme Q10 (CoQ10) in the European sub-population of Q-SYMBIO, a randomized double-blind multinational trial of treatment with CoQ10, in addition to standard therapy in chronic HF.Patient...
New insights into the anorexia of ageing: from prevention to treatment.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE - 01 Jan 2019
Undernutrition in older adults is associated with frailty, functional decline, and mortality. The 'anorexia of ageing' is the age-related appetite and weight loss underpinning such undernutrition. This review examines the latest evidence for its prevention and treatment.Existing nutritional therapies for the anorexia of ageing include supporting nutritional intake with fortified food or supplem...
Targeted screening for prediabetes and undiagnosed diabetes in a community setting in India.
DIABETES & METABOLIC SYNDROME - 01 Jan 2001
Data to support the use of risk scores in screening programs to detect people with prediabetes and undiagnosed diabetes in low- and middle-income countries are limited. We evaluated a targeted screening program involving a diabetes risk score in a community setting in India in terms of its uptake, yield, and costs.In the Kerala Diabetes Prevention Program, 2586 individuals (age 30-60 years) wit...
Lifestyle factors and macro- and micro-vascular complications among people with type 2 diabetes in Saudi Arabia.
DIABETES & METABOLIC SYNDROME - 01 Jan 2001
The aim of this study is to identify lifestyle factors that place people with type 2 diabetes in Saudi Arabia at a greater risk of macro- and microvascular complications.A survey was conducted among adults with type 2 diabetes who attended diabetes centres in three major cities in Saudi Arabia. Participants were interviewed and their medical files were reviewed for lab test results and document...
