Publications
Now showing items 3461-3480 of 5702 records
Thromboembolic and Bleeding Complications in Transcatheter Aortic Valve Implantation: Insights on Mechanisms, Prophylaxis and Therapy.
JOURNAL OF CLINICAL MEDICINE - 25 Feb 2019
Transcatheter aortic valve implantation (TAVI) has emerged as an important alternative to surgical aortic valve repair (SAVR) for patients with severe aortic stenosis. This rapidly advancing field has produced new-generation devices being delivered with small delivery sheaths, embolic protection devices and improved retrieval features. Despite efforts to reduce the rate of thrombotic complicati...
Patterns of objectively assessed sedentary time and physical activity among Japanese workers: a cross-sectional observational study.
BMJ OPEN - 24 Feb 2019
To examine patterns of sedentary behaviour and physical activity, among Japanese workers with differing occupational activity types.A cross-sectional observational study in 2013-2015.Two local communities in Japan.Full-time workers aged 40-64 years (n=345; 55% men) and who lived in two cities.From accelerometer data for 7 days, mean overall sedentary time, prolonged bouts of sedentary time and ...
TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis.
ISCIENCE - 22 Feb 2019
Circulating tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) levels are reduced in patients with cardiovascular disease, and TRAIL gene deletion in mice exacerbates atherosclerosis and inflammation. How TRAIL protects against atherosclerosis and why levels are reduced in disease is unknown. Here, multiple strategies were used to identify the protective source of TRAIL and i...
Lipoprotein(a) Removal Still a Mystery.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 19 Feb 2019
See Article by Shapiro et al.
Sedentary Behavior and Prevalent Diabetes in 6,166 Older Women: The Objective Physical Activity and Cardiovascular Health Study.
THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES - 15 Feb 2019
We examined associations of sedentary time and sedentary accumulation patterns (ie, how sedentary time is accumulated) with prevalent diabetes in an ethnically diverse cohort of older women.Community-dwelling women aged 63-99 (n = 6,116; median age = 79) wore ActiGraph GT3X+ accelerometers 24 h/day for up to 7 days from which we derived average daily sedentary time and three measures of sedenta...
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies.
EUROPEAN HEART JOURNAL - 14 Feb 2019
There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after 'recalibration', a method that adapts risk algorithms to take account of differences in the risk characteristics of the populations being studied.Using individual-participant data on ...
Dietary Fat and Blood Pressure.
CURRENT HYPERTENSION REPORTS - 12 Feb 2019
Do dietary fats lower blood pressure? This review covers total fats, individual fatty acids and foods that provide specific fats.Evidence for blood pressure lowering is stronger for supplements providing individual marine fatty acids than for fish intake since data on fish consumption are scarce. Such effects are more readily apparent in hypertensive than normal subjects. Biological mechanisms ...
Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar.
EUROPEAN HEART JOURNAL - 07 Feb 2019
In patients with non-ischaemic cardiomyopathy (NICM), the mortality benefit of a primary prevention implantable cardioverter-defibrillator (ICD) has been challenged. Left ventricular (LV) scar identified by cardiac magnetic resonance (CMR) imaging is associated with a high risk of malignant arrhythmia in NICM. We aimed to determine the impact of LV scar on the mortality benefit from a primary p...
Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases.
THERANOSTICS - 01 Jan 2019
: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypothesizing that activated platelets in the tumor microenvironment provide a targeting epitope for tumor-directed chemotherapy, we developed an antibody-drug conjugate (ADC), comprised of a single-chain antibody (scFv) against the platelet integrin GPIIb/IIIa (scFv) linked to the potent chemotherapeutic micro...
The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes.
AMERICAN JOURNAL OF PHYSIOLOGY. ENDOCRINOLOGY AND METABOLISM - 01 Feb 2019
Mitochondrial dynamics refers to the constant remodeling of mitochondrial populations by multiple cellular pathways that help maintain mitochondrial health and function. Disruptions in mitochondrial dynamics often lead to mitochondrial dysfunction, which is frequently associated with disease in rodents and humans. Consistent with this, obesity is associated with reduced mitochondrial function i...
Self-monitoring of blood pressure to guide titration of antihypertensive medication-a new era in hypertension management?
CARDIOVASCULAR DIAGNOSIS AND THERAPY - 01 Feb 2019
The haematopoietic stem cell niche: a new player in cardiovascular disease?
CARDIOVASCULAR RESEARCH - 01 Feb 2019
Haematopoiesis, the process of blood production, can be altered during the initiation or progression of many diseases. Cardiovascular disease (CVD) has been shown to be heavily influenced by changes to the haematopoietic system, including the types and abundance of immune cells produced. It is now well established that innate immune cells are increased in people with CVD, and the mechanisms con...
Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy.
DIABETES - 01 Feb 2019
Targeting cell division autoantigen 1 (CDA1) is postulated to attenuate the profibrotic actions of transforming growth factor-β in diabetic nephropathy. This study has identified a regulatory protein for CDA1 and has then used genetic and pharmacological approaches to test in vivo whether strategies to target this pathway would lead to reduced renal injury. A novel protein, named CDA1BP1 (CDA1 ...
HDAC inhibitors and cardioprotection: Homing in on a mechanism of action.
EBIOMEDICINE - 01 Feb 2019
The Australian Cardiovascular Alliance-Towards an Integrated Whole-of-Nation Strategy to Address Our Major Health Burden.
HEART, LUNG & CIRCULATION - 01 Feb 2019
Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping.
HEART RHYTHM - 01 Feb 2019
Regular alcohol intake is an important modifiable risk factor associated with atrial fibrillation (AF) and left atrial (LA) dilation.The purpose of this study was to determine the impact of different degrees of alcohol consumption on atrial remodeling using high-density electroanatomic mapping.We enrolled 75 patients before AF ablation to undergo high-density LA mapping (CARTO, Biosense Webster...
Pregnancy And Neonatal Diabetes Outcomes in Remote Australia: the PANDORA study-an observational birth cohort.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 01 Feb 2019
In Australia's Northern Territory, 33% of babies are born to Indigenous mothers, who experience high rates of hyperglycemia in pregnancy. We aimed to determine the extent to which pregnancy outcomes for Indigenous Australian women are explained by relative frequencies of diabetes type [type 2 diabetes (T2DM) and gestational diabetes (GDM)].This prospective birth cohort study examined participan...
Hypothyroidism and renal impairment: an easily missed diagnosis.
INTERNAL MEDICINE JOURNAL - 01 Feb 2019
Platelet Depletion is Effective in Ameliorating Anxiety-Like Behavior and Reducing the Pro-Inflammatory Environment in the Hippocampus in Murine Experimental Autoimmune Encephalomyelitis.
JOURNAL OF CLINICAL MEDICINE - 01 Feb 2019
The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself as well as psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence of increased anxiety-like behavior in experimental autoimmune encephalomyelitis (EAE), an accepted MS model. Due to the recently described critical role of pla...
Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA.
JOURNAL OF VISUALIZED EXPERIMENTS : JOVE - 01 Feb 2019
The development of messenger RNA (mRNA)-based therapeutics for the treatment of various diseases becomes more and more important because of the positive properties of in vitro transcribed (IVT) mRNA. With the help of IVT mRNA, the de novo synthesis of a desired protein can be induced without changing the physiological state of the target cell. Moreover, protein biosynthesis can be precisely con...
