Publications
Now showing items 3461-3480 of 5385 records
Reply to the Editor- Mediterranean diet and wine intake could improve atrial function in patients with atrial fibrillation.
HEART RHYTHM - 01 Aug 2019
Response by Climie et al to Letter Regarding Article "Individual and Neighborhood Deprivation and Carotid Stiffness: The Paris Prospective Study III".
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Aug 2019
Effects of empagliflozin treatment on cardiac function and structure in patients with type 2 diabetes: a cardiac magnetic resonance study.
INTERNAL MEDICINE JOURNAL - 01 Aug 2019
The effects of empagliflozin on cardiac structure and function are not known.To examine the changes in cardiac structure and function following the addition of empagliflozin in patients with type 2 (T2D) diabetes using cardiac magnetic resonance (CMR) imaging.Twenty patients attending a specialist diabetes service recommended for treatment with empagliflozin, and 8 control patients with T2D on ...
New insights about post-exercise albuminuria in hypertensive patients.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 01 Aug 2019
Comorbid elevated symptoms of anxiety and depression in adults with type 1 or type 2 diabetes: Results from the International Diabetes MILES Study.
JOURNAL OF DIABETES AND ITS COMPLICATIONS - 01 Aug 2019
We examined: (a) the prevalence of comorbid elevated symptoms of anxiety/depression; (b) its demographic/clinical correlates; (c) associations with self-care behaviors, by diabetes type.Cross-sectional self-report data of 6590 adults with diabetes (42% type 1; 58% type 2) from the Australian and Dutch Diabetes MILES studies were used. Elevated symptoms of anxiety/depression were defined as GAD-...
Physical activity recommendations for avoiding hypertension and its complications: try harder!
JOURNAL OF HYPERTENSION - 01 Aug 2019
Hypertension, white-coat hypertension and masked hypertension in Australia: findings from the Australian Diabetes, Obesity, and Lifestyle Study 3.
JOURNAL OF HYPERTENSION - 01 Aug 2019
The Australian Diabetes, Obesity, and Lifestyle Study is a national, population-based examination of ∼11 000 adults with a third follow-up phase at 12 years. The aim was to use ambulatory blood pressure monitoring (ABPM) in a subsample (n = 508) of the main Australian Diabetes third follow-up cohort to determine the proportion with established, masked or white-coat hypertension in city and regi...
Dysferlin deficiency alters lipid metabolism and remodels the skeletal muscle lipidome in mice.
JOURNAL OF LIPID RESEARCH - 01 Aug 2019
Defects in the gene coding for dysferlin, a membrane-associated protein, affect many tissues, including skeletal muscles, with a resultant myopathy called dysferlinopathy. Dysferlinopathy manifests postgrowth with a progressive loss of skeletal muscle function, early intramyocellular lipid accumulation, and a striking later replacement of selective muscles by adipocytes. To better understand th...
Global Longitudinal Shortening: A Positive Step Towards Reducing Confusion Surrounding Global Longitudinal Strain.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2019
Impaired Cardiac Reserve and Abnormal Vascular Load Limit Exercise Capacity in Chronic Thromboembolic Disease.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2019
This study was a comprehensive evaluation of cardiopulmonary function in patients with chronic thromboembolic (pulmonary vascular) disease (CTED) during exercise.Exertional dyspnea is frequent following pulmonary embolism, but only a minority of patients eventually develops chronic thromboembolic pulmonary hypertension (CTEPH). Better understanding of the factors that limit exercise capacity in...
Persistent Impairment in Cardiopulmonary Fitness after Breast Cancer Chemotherapy.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 01 Aug 2019
Anthracycline chemotherapy (AC) is associated with acute reductions in cardiopulmonary fitness (V˙O2peak). We sought to determine whether changes in V˙O2peak and cardiac function persisted at 12 months post-AC completion, and whether changes in cardiac function explain the heightened long-term heart failure risk.Women with breast cancer scheduled for AC (n = 28) who participated in a nonrandomi...
Exome sequencing of Finnish isolates enhances rare-variant association power.
NATURE - 01 Aug 2019
Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and in isolation following a series of bottlenecks, individuals of these populations have numerous deleterious alleles at a relatively high frequency. Here...
High-intensity interval training in chronic kidney disease: A randomized pilot study.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS - 01 Aug 2019
High-intensity interval training (HIIT) increases mitochondrial biogenesis and cardiorespiratory fitness in chronic disease populations, however has not been studied in people with chronic kidney disease (CKD). The aim of this study was to compare the feasibility, safety, and efficacy of HIIT with moderate-intensity continuous training (MICT) in people with CKD.Fourteen individuals with stage 3...
Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability.
THROMBOSIS AND HAEMOSTASIS - 01 Aug 2019
Microvesicles (MVs) are small cell-derived vesicles, which are mainly released by activated cells. They are part of a communication network delivering biomolecules, for example, inflammatory molecules, via the blood circulation to remote cells in the body. Platelet-derived MVs are known to induce vascular inflammation. Research on the mediators and mechanisms of their inflammatory effects has a...
Cardiovascular effects of caffeinated beverages.
TRENDS IN CARDIOVASCULAR MEDICINE - 01 Aug 2019
Caffeine is the world's most popular 'drug', with tea and coffee a ubiquitous part of daily life. As a psychoactive stimulant, there are potential concerns regarding adverse cardiovascular squeal. Cardiovascular conditions, encompassing hypertension, coronary artery disease, rhythm disorders and heart failure affect billions of patients worldwide. We aim to provide a patient-centered comprehens...
Reply to letter by Frey et al. regarding the article: Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar.
EUROPEAN HEART JOURNAL - 30 Jul 2019
Sex-Based Mhrt Methylation Chromatinizes MeCP2 in the Heart.
ISCIENCE - 26 Jul 2019
In the heart, primary microRNA-208b (pri-miR-208b) and Myheart (Mhrt) are long non-coding RNAs (lncRNAs) encoded by the cardiac myosin heavy chain genes. Although preclinical studies have shown that lncRNAs regulate gene expression and are protective for pathological hypertrophy, the mechanism underlying sex-based differences remains poorly understood. In this study, we examined DNA- and RNA-me...
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
SCIENCE (NEW YORK, N.Y.) - 26 Jul 2019
Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart disease. By genetically engineering mice, we deleted the enzyme dihydroceramide desaturase 1 (DES1), which normally inserts a conserved double bond into the backbone of ceramides and other predominant sphingolipids. Ablation of DES1 from whole animals or tissue-specific deletion in the liver and/or ad...
Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells.
PLOS PATHOGENS - 01 Jul 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors. Here we show that exosomes containing HIV-1 protein Nef (exNef) are rapidly taken up by macrophages releasing Nef into the cell interior. This caused down-regulation of ABCA1, reduction of cholesterol efflux and ...
A Retrospective Evaluation of Risk of Peripartum Cardiac Dysfunction in Survivors of Childhood, Adolescent and Young Adult Malignancies.
CANCERS - 24 Jul 2019
Long-term survivors of childhood, adolescent and young adult (AYA) malignancies with past exposure to potentially cardiotoxic treatments are at risk of peripartum cardiac dysfunction. Incidence and risk factors for peripartum cardiac dysfunction and maternal cardiac outcomes in this population were investigated. Eligible long-term survivors were aged <30 years at cancer diagnosis, with ≥1 pregn...
