Publications
Now showing items 3441-3460 of 5385 records
Physical Activity and Cancer Incidence in Alberta's Tomorrow Project: Results from a Prospective Cohort of 26,538 Participants.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 01 Aug 2018
Physical activity (PA) has been associated with lower risks of several cancers. We examined the association between total and domain-specific PA and risk of all and site-specific cancer risk. We analyzed baseline data from Alberta's Tomorrow Project. Specifically, adults ages 35-69 years who completed the Past Year Total Physical Activity Questionnaire were included ( = 26,538). For each activi...
Impact of Baseline Hemodynamics on the Effects of a Transcatheter Interatrial Shunt Device in Heart Failure With Preserved Ejection Fraction.
CIRCULATION. HEART FAILURE - 01 Aug 2018
Background Interatrial shunt device (IASD) effects have been described in patients with heart failure and ejection fractions (EFs) ≥40%. However, baseline characteristics that correlate with greatest hemodynamic effects are unknown. On the basis of fundamental principles, we hypothesized that larger pressure gradients between left and right atria would yield greater shunt flow and greater hemod...
Modulation of renal sympathetic innervation: recent insights beyond blood pressure control.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 01 Aug 2018
Renal afferent and efferent sympathetic nerves are involved in the regulation of blood pressure and have a pathophysiological role in hypertension. Additionally, several conditions that frequently coexist with hypertension, such as heart failure, obstructive sleep apnea, atrial fibrillation, renal dysfunction, and metabolic syndrome, demonstrate enhanced sympathetic activity. Renal denervation ...
Renal sympathetic denervation restores aortic distensibility in patients with resistant hypertension: data from a multi-center trial.
CLINICAL RESEARCH IN CARDIOLOGY : OFFICIAL JOURNAL OF THE GERMAN CARDIAC SOCIETY - 01 Aug 2018
Renal sympathetic denervation (RDN) is under investigation as a treatment option in patients with resistant hypertension (RH). Determinants of arterial compliance may, however, help to predict the BP response to therapy. Aortic distensibility (AD) is a well-established parameter of aortic stiffness and can reliably be obtained by CMR. This analysis sought to investigate the effects of RDN on AD...
Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism.
DIABETES, OBESITY & METABOLISM - 01 Aug 2018
The induction of heat shock protein 72 (Hsp72) via heating, genetic manipulation or pharmacological activation is metabolically protective in the setting of obesity-induced insulin resistance across mammalian species. In this study, we set out to determine whether the overexpression of Hsp72, specifically in skeletal muscle, can protect against high-fat diet (HFD)-induced obesity and insulin re...
Trends in age- and sex-specific prevalence and incidence of cardiovascular disease in Western Australia.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 01 Aug 2018
Background Temporal trends in incidence and mortality of cardiovascular disease (CVD) have been well described, with recent data suggesting declining improvements in those aged under 55 years. However, little is known about the combined impact of incidence and mortality trends on disease prevalence, an important indicator of disease burden and cost. We analysed changes in age-specific and age-s...
Inverse Association Between Myocardial B-Type Natriuretic Peptide Release and Functional Capacity in Healthy Humans.
HEART, LUNG & CIRCULATION - 01 Aug 2018
B-type natriuretic peptide (BNP) has been found to be inversely related to peak oxygen consumption (peak VO) in various patient populations. However, in these studies, circulating plasma BNP, i.e. the net effect of release and elimination, rather than cardiac BNP release has been measured. We assessed the relationship between the transcardiac BNP gradient [ΔBNP, i.e. the difference between BNP ...
Renal Denervation-Ready for Prime Time!? The Steep SPYRAL Stairs to RADIANCE in Hypertension Treatment.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Aug 2018
Cohort Profile: The Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 01 Aug 2018
Enhancing self-care strategies in heart failure through patient-reported outcome measures.
INTERNAL MEDICINE JOURNAL - 01 Aug 2018
Heart failure (HF) is a major cause of morbidity and mortality, requiring collaborative patient-centred care. Patient engagement is fundamental to long-term management; patient-reported outcome measures are an increasingly recognised method of assessing medical interventions. A qualitative study of 31 patients with HF found they were twice as likely to use their own management strategies includ...
Changing environment of hyperglycemia in pregnancy: Gestational diabetes and diabetes mellitus in pregnancy.
JOURNAL OF DIABETES - 01 Aug 2018
The diagnosis and treatment of gestational diabetes mellitus (GDM) have been in a state of flux since the World Health Organization accepted and endorsed the International Diabetes and Pregnancy Study Group's diagnostic pathway and criteria in 2013. These new diagnostic criteria identify an increasing number of women at risk of hyperglycemia in pregnancy (HGiP). Maternal hyperglycemia represent...
Functional properties of human muscle spindles.
JOURNAL OF NEUROPHYSIOLOGY - 01 Aug 2018
Muscle spindles are ubiquitous encapsulated mechanoreceptors found in most mammalian muscles. There are two types of endings, primary and secondary, and both are sensitive to changes in muscle length and velocity, with the primary endings having a greater dynamic sensitivity. Unlike other mechanoreceptors in the somatosensory system, muscle spindles are unique in possessing motor innervation, v...
Impact of abnormal longitudinal rotation on the assessment of right ventricular systolic function in patients with severe pulmonary hypertension.
JOURNAL OF THORACIC DISEASE - 01 Aug 2018
Assessment of right ventricular (RV) function plays an important role in patients with cardiopulmonary disease, and current guidelines recommend parameters including tricuspid annular plane systolic excursion (TAPSE) and right ventricular systolic excursion velocity (RVS') to assess RV longitudinal function. We assessed the hypothesis that the previously undescribed motion of RV longitudinal ro...
Imaging in Cardio-Oncology: Where Are We and Where Should We Be Going?
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2018
Research to Practice: Assessment of Left Ventricular Global Longitudinal Strain for Surveillance of Cancer Chemotherapeutic-Related Cardiac Dysfunction.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2018
Rationale and Design of the Strain Surveillance of Chemotherapy for Improving Cardiovascular Outcomes: The SUCCOUR Trial.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2018
This study sought to evaluate the hypothesis that global longitudinal strain (GLS) guidance of cardioprotective therapy would improve cardiac function of at-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care.The conventional criteria for diagnosis of chemotherapy-related cardiac dysfunction (CTRCD) are dependent on the recognition of heart failure symptoms a...
Single Versus Standard Multiview Assessment of Global Longitudinal Strain for the Diagnosis of Cardiotoxicity During Cancer Therapy.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2018
The goal of this study was to compare echocardiographic measurements of global longitudinal strain (GLS) (using 3 apical views) with single-view longitudinal strain (LS, 4- or 2-chamber [4CV_LS and 2CV_LS, respectively]) for detection of cancer-therapy related cardiotoxicity.GLS is useful for the detection of cardiotoxicity, but the need for repeated measurements poses a significant burden on b...
Regression of Diffuse Ventricular Fibrosis Following Restoration of Sinus Rhythm With Catheter Ablation in Patients With Atrial Fibrillation and Systolic Dysfunction: A Substudy of the CAMERA MRI Trial.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Aug 2018
This study sought to determine if diffuse ventricular fibrosis improves in patients with atrial fibrillation (AF)-mediated cardiomyopathy following the restoration of sinus rhythm.AF coexists in 30% of heart failure (HF) patients and may be an underrecognized reversible cause of left ventricular systolic dysfunction. Myocardial fibrosis is the hallmark of adverse cardiac remodeling in HF, yet i...
Salt intake and dietary sources of salt on weekdays and weekend days in Australian adults.
PUBLIC HEALTH NUTRITION - 01 Aug 2018
To assess if there is a difference in salt intake (24 h urine collection and dietary recall) and dietary sources of salt (Na) on weekdays and weekend days.A cross-sectional study of adults who provided one 24 h urine collection and one telephone-administered 24 h dietary recall.Community-dwelling adults living in the State of Victoria, Australia.Adults (n 598) who participated in a health surve...
Bronchiectasis in indigenous and non-indigenous residents of Australia and New Zealand.
RESPIROLOGY (CARLTON, VIC.) - 01 Aug 2018
Bronchiectasis not associated with cystic fibrosis is an increasingly recognized chronic lung disease. In Oceania, indigenous populations experience a disproportionately high burden of disease. We aimed to describe the natural history of bronchiectasis and identify risk factors associated with premature mortality within a cohort of Aboriginal Australians, New Zealand Māori and Pacific Islanders...
