Publications
Now showing items 341-360 of 4599 records
Mineralocorticoid receptor signalling in primary aldosteronism.
THE JOURNAL OF ENDOCRINOLOGY - 01 Jul 2023
Primary Aldosteronism, or Conn Syndrome, is the most common endocrine cause of hypertension. It is associated with a higher risk of cardiovascular, metabolic and renal diseases, as well as a lower quality of life than for hypertension due to other causes. The multi-systemic effects of primary aldosteronism can be attributed to aldosterone-mediated activation of the mineralocorticoid receptor in...
Acute effects of single and repeated mild traumatic brain injury on levels of neurometabolites, lipids, and mitochondrial function in male rats.
FRONTIERS IN MOLECULAR NEUROSCIENCE - 01 Jan 2023
Mild traumatic brain injuries (mTBIs) are the most common form of acquired brain injury. Symptoms of mTBI are thought to be associated with a neuropathological cascade, potentially involving the dysregulation of neurometabolites, lipids, and mitochondrial bioenergetics. Such alterations may play a role in the period of enhanced vulnerability that occurs after mTBI, such that a second mTBI will ...
Epidemiology, outcomes and predictors of mortality in patients transported by ambulance for dyspnoea: A population-based cohort study.
EMERGENCY MEDICINE AUSTRALASIA : EMA - 01 Feb 2023
There are currently limited data to inform the management of patients transported by emergency medical services (EMS) with dyspnoea. We aimed to describe the incidence, aetiology and outcomes of patients transported by EMS for dyspnoea using a large population-based sample and to identify factors associated with 30-day mortality.Consecutive EMS attendances for dyspnoea in Victoria, Australia fr...
Dynamic aspects of ventricular interaction during exercise in HFpEF and in pre-capillary pulmonary hypertension.
ESC HEART FAILURE - 01 Feb 2023
The contribution of adverse ventricular interdependence remains undervalued in heart failure or pulmonary vascular disease, and not much is known about its dynamic nature during exercise and respiration. In this study, we evaluated ventricular interaction during exercise in patients with heart failure with preserved ejection fraction (HFpEF) and patients with chronic thromboembolic pulmonary hy...
Use of clinical scores in young Australian adults for prediction of atherosclerosis in middle age.
BMC CARDIOVASCULAR DISORDERS - 03 Feb 2023
We sought to apply a simple cardiovascular health tool not requiring laboratory tests (the Fuster-BEWAT score, FBS) to predict subclinical atherosclerosis. This study included 2657 young adults (< 40 years of age). In the prognostic group (n = 894, followed for 13 years until aged 40-50 years at follow-up), the primary outcome was presence of carotid plaque measured by carotid ultrasound at fol...
Relating QRS voltages to left ventricular mass and body composition in elite endurance athletes.
01 Mar 2023
Electrocardiogram (ECG) QRS voltages correlate poorly with left ventricular mass (LVM). Body composition explains some of the QRS voltage variability. The relation between QRS voltages, LVM and body composition in endurance athletes is unknown.Elite endurance athletes from the Pro@Heart trial were evaluated with 12-lead ECG for Cornell and Sokolow-Lyon voltage and product. Cardiac magnetic reso...
Diagnosis and management of arrhythmias in pregnancy.
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 21 Jul 2022
Arrhythmias are the most common cardiac complications occurring in pregnancy. Although the majority of palpitations in pregnancy may be explained by atrial or ventricular premature complexes, the full spectrum of arrhythmias can occur. In this article, we establish a systematic approach to the evaluation and management of arrhythmias in pregnancy. Haemodynamically unstable arrhythmias warrant u...
Impaired biventricular contractile reserve in patients with diastolic dysfunction: insights from exercise stress echocardiography.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 21 Jul 2022
Cardiac output limitation is a fundamental feature of heart failure with preserved ejection fraction (HFpEF) but the relative contribution of its determinants in symptomatic vs. asymptomatic stages are not well characterized. We aimed to gain insight into disease mechanisms by performing comprehensive comparative non-invasive exercise imaging in patients across the disease spectrum.We performed...
New Cardiovascular Risk Assessment Techniques for Primary Prevention: JACC Review Topic of the Week.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 26 Jul 2022
Risk factor-based models fail to accurately estimate risk in select populations, in particular younger individuals. A sizable number of people are also classified as being at intermediate risk, for whom the optimal preventive strategy could be more precise. Several personalized risk prediction tools, including coronary artery calcium scoring, polygenic risk scores, and metabolic risk scores may...
Cardioprotective actions of nitroxyl donor Angeli's salt are preserved in the diabetic heart and vasculature in the face of nitric oxide resistance.
BRITISH JOURNAL OF PHARMACOLOGY - 01 Aug 2022
The risk of fatal cardiovascular events is increased in patients with type 2 diabetes mellitus (T2DM). A major contributor to poor prognosis is impaired nitric oxide (NO•) signalling at the level of tissue responsiveness, termed NO• resistance. This study aimed to determine if T2DM promotes NO• resistance in the heart and vasculature and whether tissue responsiveness to nitroxyl (HNO) is affect...
Breast arterial calcification and epicardial adipose tissue volume, but not density are independently associated with cardiovascular risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 01 Aug 2022
Mammographically detected breast arterial calcification (BAC) has been proposed as surrogate marker for coronary artery disease (CAD) in women. Epicardial adipose tissue (EAT) and peri-coronary adipose tissue (PCAT) are inflammatory fat depots linked to atherogenesis. BAC has demonstrated association with inflammation, therefore we aimed to determine the association between BAC, EAT and PCAT.Si...
Outcomes of the first global multidisciplinary consensus meeting including persons living with obesity to standardize patient-reported outcome measurement in obesity treatment research.
OBESITY REVIEWS : AN OFFICIAL JOURNAL OF THE INTERNATIONAL ASSOCIATION FOR THE STUDY OF OBESITY - 01 Aug 2022
Quality of life is a key outcome that is not rigorously measured in obesity treatment research due to the lack of standardization of patient-reported outcomes (PROs) and PRO measures (PROMs). The S.Q.O.T. initiative was founded to Standardize Quality of life measurement in Obesity Treatment. A first face-to-face, international, multidisciplinary consensus meeting was conducted to identify the k...
Cuffless blood pressure measuring devices: review and statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability.
JOURNAL OF HYPERTENSION - 01 Aug 2022
Many cuffless blood pressure (BP) measuring devices are currently on the market claiming that they provide accurate BP measurements. These technologies have considerable potential to improve the awareness, treatment, and management of hypertension. However, recent guidelines by the European Society of Hypertension do not recommend cuffless devices for the diagnosis and management of hypertensio...
Circulating short-chain fatty acids in hypertension: a reflection of various hypertensive phenotypes.
JOURNAL OF HYPERTENSION - 01 Aug 2022
Hypertension is the most common chronic condition globally, contributing to an increased risk of cardiovascular disease and premature death. Despite advances in treatment options, approximately 10% of patients have resistant hypertension, characterized by elevated blood pressure that does not respond to treatment. The gut microbiome is now increasingly recognized to play a role in the developme...
The association of attained age, age at diagnosis, and duration of type 2 diabetes with the long-term risk for major diabetes-related complications.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Aug 2022
We evaluated the associations of age and duration of type 2 diabetes with major diabetes-related complications.We included 1.1 million people with type 2 diabetes from the Australian diabetes registry, followed from 2010 to 2019. We estimated the incidence of hospitalization or death from myocardial infarction (MI), stroke, and heart failure (HF), and hospitalisation for lower extremity amputat...
Diagnostic and Prognostic Value of Myocardial Work Indices for Identification of Cancer Therapy-Related Cardiotoxicity.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2022
Echocardiographic global longitudinal strain (GLS) is a useful measure for detection of cancer treatment-related cardiac dysfunction (CTRCD) but is influenced by blood pressure changes. This limitation may be overcome by assessment of myocardial work (MW), which incorporates blood pressure into the calculation.This work aims to determine whether myocardial work indices (MWIs) can help diagnose ...
Improving the Characterization of Stage A and B Heart Failure by Adding Global Longitudinal Strain.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2022
Current guidelines distinguish stage B heart failure (SBHF) (asymptomatic left ventricular [LV] dysfunction) from stage A heart failure (SAHF) (asymptomatic with heart failure [HF] risk factors) on the basis of myocardial infarction, LV remodeling (hypertrophy or reduced ejection fraction [EF]) or valvular disease. However, subclinical HF with preserved EF may not be identified with these crite...
Atrial Fibrillation and Stress: A 2-Way Street?
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Aug 2022
The accumulating literature linking stress with negative health outcomes, including cardiovascular disease (CVD), is extensively reported yet poorly defined. Stress is associated with a higher risk of hypertension, acute myocardial infarction, arrhythmogenesis, and heart failure. Stress mediates its effect through direct neuronal, endocrine, autonomic, and immune processes and indirectly by mod...
Insights From Simultaneous Left and Right Atrial Septal Mapping in Patients With Persistent Atrial Fibrillation.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Aug 2022
The interatrial septum (IAS) is thought to be involved in the mechanism of persistent atrial fibrillation (PeAF). Simultaneous contact mapping of both sides of the IAS has not been performed previously.The purpose of this study was to describe wave front (WF) activation patterns and extent of left and right atrial septal electrical dissociation in patients with PeAF.Simultaneous mapping of both...
Nurse-Provided Lung and Inferior Vena Cava Assessment in Patients With Heart Failure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 02 Aug 2022
Residual congestion detected using handheld ultrasound may be associated with increased risk of readmission and death after hospitalization for acute decompensated heart failure (ADHF). However, effective application necessitates routine use by nonexperts delivering clinical care.The objective of this study was to determine the ability of heart failure (HF) nurses to deliver a predischarge lung...
